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1. 发明授权

US07618807B2 Apparatus for electrophoretic in situ tissue staining 有权
标题翻译：电泳原位组织染色装置
公开(公告)号：US07618807B2
公开(公告)日：2009-11-17
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42 , C12M3/00
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

2. 发明申请

US20070086917A1 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING FIXED SLIDE PLATFORMS 审中-公开
标题翻译：具有固定滑动平台的自动分子病理学设备
公开(公告)号：US20070086917A1
公开(公告)日：2007-04-19
申请号：US11558257
申请日：2006-11-09
申请人： Charles LEMME , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
发明人： Charles LEMME , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
IPC分类号： G01N33/00
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。或者，幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。

3. 发明申请

US20060093520A1 Automated molecular pathology apparatus having fixed slide platforms 有权
标题翻译：具有固定滑动平台的自动分子病理装置
公开(公告)号：US20060093520A1
公开(公告)日：2006-05-04
申请号：US11293489
申请日：2005-12-02
申请人： Charles Lemme , William Richards , Wayne Showalter
发明人： Charles Lemme , William Richards , Wayne Showalter
IPC分类号： G01N35/00
CPC分类号： G01N1/312 , Y10T436/112499 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤溶液带到载玻片上。

4. 发明申请

US20050135972A1 Method and apparatus for modifying pressure within a fluid dispenser 审中-公开
标题翻译：用于改变流体分配器内的压力的方法和装置
公开(公告)号：US20050135972A1
公开(公告)日：2005-06-23
申请号：US10913932
申请日：2004-08-06
申请人： Charles Lemme , Vincent Rizzo , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles Lemme , Vincent Rizzo , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： G01N1/31 , G01N35/00 , G01N35/10 , B01L3/00
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.
摘要翻译：提供了一种用于自动生物反应系统的方法和装置。在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

5. 发明申请

US20050250211A1 Automated high volume slide processing system 有权
公开(公告)号：US20050250211A1
公开(公告)日：2005-11-10
申请号：US11181625
申请日：2005-07-13
申请人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC分类号： B01L9/00 , G01N1/31 , G01N1/36 , G01N35/00
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.

6. 发明申请

US20050074890A1 Electrophoretic in situ tissue staining 审中-公开
标题翻译：电泳原位组织染色
公开(公告)号：US20050074890A1
公开(公告)日：2005-04-07
申请号：US10848775
申请日：2004-05-18
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： A61N1/30 , A61N1/32 , G01N1/30 , G01N31/22 , G01N33/53 , G01N33/567
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

7. 发明授权

US07378055B2 Automated molecular pathology apparatus having fixed slide platforms 有权
标题翻译：具有固定滑动平台的自动分子病理装置
公开(公告)号：US07378055B2
公开(公告)日：2008-05-27
申请号：US10424372
申请日：2003-04-28
申请人： Charles Lemme , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
发明人： Charles Lemme , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
IPC分类号： G01N35/10
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。或者，幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。

8. 发明申请

US20080038836A1 AUTOMATED HIGH VOLUME SLIDE STAINING SYSTEM 有权
标题翻译：自动高容积滑动系统
公开(公告)号：US20080038836A1
公开(公告)日：2008-02-14
申请号：US11876059
申请日：2007-10-22
申请人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter
发明人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter
IPC分类号： G01N35/00
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.
摘要翻译：一种自动滑块处理装置，包括以堆叠方式布置的多个工作站，以及用于在各个工作站之间运送滑块的运输/升降机。

9. 发明申请

US20080020450A1 Apparatus for Electrophoretic In Situ Tissue Staining 有权
标题翻译：电泳原位组织染色装置
公开(公告)号：US20080020450A1
公开(公告)日：2008-01-24
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

10. 发明申请

US20050186114A1 Automated high volume slide processing system 有权
标题翻译：自动化大容量幻灯片处理系统
公开(公告)号：US20050186114A1
公开(公告)日：2005-08-25
申请号：US11116676
申请日：2005-04-27
申请人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC分类号： B01L9/00 , G01N1/31 , G01N1/36 , G01N35/00
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译：提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。还提供了一种用于自动处理幻灯片的方法。

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