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1. 发明申请

US20100055169A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
标题翻译：阳离子脂肪及其用途
公开(公告)号：US20100055169A1
公开(公告)日：2010-03-04
申请号：US12557230
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K9/127 , A61K31/7088 , A61K38/00 , C11C3/00
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/6911 , C07C217/28 , C07C219/06 , C07C233/18 , C07C235/08 , C07C271/16 , C12N15/88
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
摘要翻译：公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。

2. 发明申请

US20100104629A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
公开(公告)号：US20100104629A1
公开(公告)日：2010-04-29
申请号：US12557294
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K9/127 , A61K39/00 , A61K38/02 , A61K31/7088 , A61K47/22 , A61K47/18 , C07D207/08 , C07D317/28 , C07D317/26 , C07C229/34 , C07C217/48 , C07C217/28
CPC分类号： A61K9/1272 , C07C205/43 , C07C217/28 , C07C229/34 , C07C235/08 , C07C271/16 , C07D207/04 , C07D207/08 , C07D207/12 , C07D207/14 , C07D211/22 , C07D213/74 , C07D233/54 , C07D233/60 , C07D239/22 , C07D241/12 , C07D243/08 , C07D265/30 , C07D295/088 , C07D295/108 , C07D317/18 , C07D317/28 , C07D403/04 , C07D405/06
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

3. 发明申请

US20100063135A1 POLYETHYLENE GLYCOL LIPID CONJUGATES AND USES THEREOF 审中-公开
公开(公告)号：US20100063135A1
公开(公告)日：2010-03-11
申请号：US12556886
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , William E. Kohlbrenner , Leiming Li , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , William E. Kohlbrenner , Leiming Li , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K31/7105 , C07C229/00 , C07F9/02 , C07C233/01 , C07H21/02 , C07K17/00 , A61K31/56 , A61K31/225 , A61K31/40
CPC分类号： A61K9/0019 , A61K9/0004 , A61K9/1271 , A61K9/1272 , A61K31/225 , A61K31/40 , A61K31/7105
摘要： Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

4. 发明申请

US20100055168A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
公开(公告)号：US20100055168A1
公开(公告)日：2010-03-04
申请号：US12557188
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K9/127 , C07C229/00 , A61K47/14 , A61K38/16 , A61K31/7088 , A61K38/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , C07C45/29 , C07C45/515 , C07C205/43 , C07C217/28 , C07C219/06 , C07C235/08 , C07C271/16 , C07D295/088 , C07D317/04 , C12N15/88 , C07C47/277 , C07C49/255 , C07C49/175
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

5. 发明申请

US20060031945A1 Inducible expression systems for modulating the expression of target genes in eukaryotic cells and non-human animals 审中-公开
公开(公告)号：US20060031945A1
公开(公告)日：2006-02-09
申请号：US10913245
申请日：2004-08-06
申请人： Yu Shen , Stephen Fesik , Xiaoyu Lin
发明人： Yu Shen , Stephen Fesik , Xiaoyu Lin
IPC分类号： A01K67/00 , C12N5/02 , C07H21/02
CPC分类号： C12N9/1247 , A01K67/0271 , A01K2217/05 , A01K2217/058 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2830/003
摘要： The present invention relates to inducible expression systems and to compositions and methods for modulating the expression of at least one target gene in an eukaryotic cell and non-human animal.

6. 发明授权

US06687747B1 System and network interoperations using a MIB-based object-oriented signaling protocol 失效
标题翻译：使用基于MIB的面向对象的信令协议的系统和网络互操作
公开(公告)号：US06687747B1
公开(公告)日：2004-02-03
申请号：US09429552
申请日：1999-10-28
申请人： Bill Huang , Jing Yang , Yu Shen , Spero Koulouras
发明人： Bill Huang , Jing Yang , Yu Shen , Spero Koulouras
IPC分类号： G06F1300
CPC分类号： H04L41/0213 , H04L41/0233
摘要： A process of providing operation oriented common signaling information services supports a plurality of different types of network distributed signaling functions in a network. The process includes the steps of: instantiating a class of network objects in a plurality of network entities forming a community, each of the network entities in the community having at least one of the network objects of the class, the class of network objects for modeling a corresponding one of the network distributed signaling functions; and providing a transparent operation oriented interface between the network objects of the network entities of the community, the operation oriented interface enabling interoperations between the network objects. At least one of the network objects is associated with a corresponding managed object that is mapped to the corresponding network object by public attributes of the corresponding network object. Each of the network objects includes external methods for accessing managed objects associated with other ones of the network objects via the transparent operation oriented interface. The external methods perform network operations, and are operative to invoke the performance of network operations by other ones of the network objects in the community.
摘要翻译：提供面向操作的公共信令信息服务的过程支持网络中的多种不同类型的网络分布式信令功能。该过程包括以下步骤：在形成社区的多个网络实体中实例化一类网络对象，社区中的每个网络实体具有该类中的至少一个网络对象，用于建模的网络对象类别相应的一个网络分布式信令功能; 并在社区网络实体的网络对象之间提供透明的面向操作的接口，面向操作的接口实现网络对象之间的互操作。网络对象中的至少一个与通过相应网络对象的公共属性映射到相应网络对象的对应管理对象相关联。每个网络对象包括用于经由面向透明操作的接口访问与其他网络对象相关联的被管理对象的外部方法。外部方法执行网络操作，并且可操作地调用社区中其他网络对象的网络操作的性能。

7. 发明申请

US20100227838A1 Combination Therapy for Treating Cancer and Diagnostic Assays for Use Therein 有权
标题翻译：用于治疗癌症的组合治疗和其中使用的诊断测定
公开(公告)号：US20100227838A1
公开(公告)日：2010-09-09
申请号：US12630957
申请日：2009-12-04
申请人： Omar Jameel Shah , Yu Shen , Xiaoyu Lin , Mark Anderson , Xiaoli Huang , Junling Li , Leiming Li
发明人： Omar Jameel Shah , Yu Shen , Xiaoyu Lin , Mark Anderson , Xiaoli Huang , Junling Li , Leiming Li
IPC分类号： A61K31/675 , C12Q1/68 , A61P35/00 , A61K31/5377 , A61K31/497
CPC分类号： A61K45/06 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/635 , A61K31/675 , C07D295/155 , C07D487/08 , C07D491/08 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G06F19/00
摘要： The present disclosure relates to a combination of therapeutic agents for use in treating a patient a subject suffering from cancer. In addition, the present disclosure also relates to diagnostic assays useful in classification of patients for treatment with one or more therapeutic agents.
摘要翻译：本公开涉及用于治疗患有癌症的受试者的患者的治疗剂的组合。此外，本公开还涉及对用于用一种或多种治疗剂治疗的患者分类中有用的诊断测定法。

8. 发明授权

US07420672B2 Method and apparatus for conducting Raman spectroscopy 有权
标题翻译：用于进行拉曼光谱的方法和装置
公开(公告)号：US07420672B2
公开(公告)日：2008-09-02
申请号：US11820706
申请日：2007-06-20
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.
摘要翻译：本文公开了拉曼探针，其包括：（a）第一光纤，用于从光源接收激发激发光并将其传输; （b）第一滤光器，用于接收来自第一光纤的光，并适于通过激光激发光并阻止与光相关联的寄生信号; （c）第二过滤器，用于接收来自第一过滤器的光，并适于将光引向样本; 和（d）用于接收来自第二滤光器的光的聚焦装置，将光聚焦在样本上以产生拉曼信号，并将拉曼信号返回到第二滤光器。第二滤波器进一步配置成使得当第二滤波器从聚焦装置接收拉曼信号时，第二滤波器在将拉曼信号引导到第二光纤之前滤除不期望的激光激发光。

9. 发明申请

US20060031948A1 Inducible expression systems for modulating the expression of target genes in eukaryotic cells and non-human animals 审中-公开
标题翻译：用于调节真核细胞和非人动物中靶基因表达的诱导表达系统
公开(公告)号：US20060031948A1
公开(公告)日：2006-02-09
申请号：US11049915
申请日：2005-02-03
申请人： Yu Shen
发明人： Yu Shen
IPC分类号： A01K67/027 , C12N5/06 , C07H21/04
CPC分类号： C12N9/1247 , A01K67/0271 , A01K2217/05 , A01K2217/058 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2830/003
摘要： The present invention relates to inducible expression systems and to compositions and methods for modulating the expression of at least one target gene in an eukaryotic cell and non-human animal.
摘要翻译：本发明涉及可诱导表达系统以及用于调节真核细胞和非人动物中至少一种靶基因的表达的组合物和方法。

10. 发明授权

US09255842B2 Heroin detection by raman spectroscopy from impure compositions comprising an interfering fluorescent contaminant 有权
标题翻译：由含有干扰性荧光污染物的不纯组合物的拉曼光谱法检测海洛因
公开(公告)号：US09255842B2
公开(公告)日：2016-02-09
申请号：US13529916
申请日：2012-06-21
申请人： Craig Morris Gardner , Michael Derek Hargreaves , Peidong Wang , Yu Shen
发明人： Craig Morris Gardner , Michael Derek Hargreaves , Peidong Wang , Yu Shen
IPC分类号： G01J3/44 , G01N33/94 , G01N21/65 , G01N21/84 , G01N21/94 , G01N21/64
CPC分类号： G01N21/658 , G01J3/44 , G01N21/65 , G01N21/8483 , G01N21/94 , G01N33/9486 , G01N2021/646 , G01N2021/656 , G01N2201/0221 , G01N2201/06113
摘要： A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided.
摘要翻译：一种鉴定海洛因组合物中海洛因存在的方法，其中含有海洛因和至少一种会影响来自海洛因的拉曼信号的荧光染料。该方法可以包括使混合物与溶剂如醇接触，然后使得到的醇组合物与SERS表面接触。然后可以将表面暴露于来自手持拉曼光谱仪的激光以检测来自海洛因的拉曼信号。还提供了一种用于执行该方法的装置。

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