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1. 发明授权

US08624027B2 Combination therapy for treating cancer and diagnostic assays for use therein 有权
标题翻译：用于治疗癌症的组合疗法和用于其中的诊断测定法
公开(公告)号：US08624027B2
公开(公告)日：2014-01-07
申请号：US12630957
申请日：2009-12-04
申请人： Omar Jameel Shah , Yu Shen , Xiaoyu Lin , Mark Anderson , Xiaoli Huang , Junling Li , Leiming Li
发明人： Omar Jameel Shah , Yu Shen , Xiaoyu Lin , Mark Anderson , Xiaoli Huang , Junling Li , Leiming Li
IPC分类号： C07D295/00 , A61K31/4965
CPC分类号： A61K45/06 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/635 , A61K31/675 , C07D295/155 , C07D487/08 , C07D491/08 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G06F19/00
摘要： The present disclosure relates to a combination of therapeutic agents for use in treating a patient a subject suffering from cancer. In addition, the present disclosure also relates to diagnostic assays useful in classification of patients for treatment with one or more therapeutic agents.
摘要翻译：本公开涉及用于治疗患有癌症的受试者的患者的治疗剂的组合。此外，本公开还涉及对用于用一种或多种治疗剂治疗的患者分类中有用的诊断测定法。

2. 发明申请

US20100227838A1 Combination Therapy for Treating Cancer and Diagnostic Assays for Use Therein 有权
标题翻译：用于治疗癌症的组合治疗和其中使用的诊断测定
公开(公告)号：US20100227838A1
公开(公告)日：2010-09-09
申请号：US12630957
申请日：2009-12-04
申请人： Omar Jameel Shah , Yu Shen , Xiaoyu Lin , Mark Anderson , Xiaoli Huang , Junling Li , Leiming Li
发明人： Omar Jameel Shah , Yu Shen , Xiaoyu Lin , Mark Anderson , Xiaoli Huang , Junling Li , Leiming Li
IPC分类号： A61K31/675 , C12Q1/68 , A61P35/00 , A61K31/5377 , A61K31/497
CPC分类号： A61K45/06 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/635 , A61K31/675 , C07D295/155 , C07D487/08 , C07D491/08 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G06F19/00
摘要： The present disclosure relates to a combination of therapeutic agents for use in treating a patient a subject suffering from cancer. In addition, the present disclosure also relates to diagnostic assays useful in classification of patients for treatment with one or more therapeutic agents.
摘要翻译：本公开涉及用于治疗患有癌症的受试者的患者的治疗剂的组合。此外，本公开还涉及对用于用一种或多种治疗剂治疗的患者分类中有用的诊断测定法。

3. 发明授权

US08807133B2 Resuscitator and aspirator technology 有权
标题翻译：复苏机和吸气技术
公开(公告)号：US08807133B2
公开(公告)日：2014-08-19
申请号：US13009722
申请日：2011-01-19
申请人： Mark Anderson
发明人： Mark Anderson
IPC分类号： A61D7/04 , A61D1/08 , A61M16/06 , A61M16/00
CPC分类号： A61D7/04 , A61D1/08 , A61M1/0066 , A61M16/0057 , A61M16/0072 , A61M16/0084 , A61M16/06 , A61M2205/073 , A61M2250/00
摘要： An aspiration and resuscitation system which is useable to perform aspiration and/or resuscitation procedures on living beings, particularly small animals, and most particularly newborn small animals such as puppies and kittens. The system includes an aspirator and a resuscitator. Each includes a separable pump and animal interface mask. Further disclosed are aspiration and resuscitation methods using the disclosed apparatus.
摘要翻译：一种吸气和复苏系统，可用于对生物，特别是小型动物，特别是新生小动物（如小狗和小猫）进行抽吸和/或复苏程序。该系统包括吸气器和复苏器。每个都包括一个可分离的泵和动物界面面罩。进一步公开了使用所公开的装置的抽吸和复苏方法。

4. 发明授权

US08751514B2 System and method for adapting an internet filter 有权
标题翻译：适应互联网过滤器的系统和方法
公开(公告)号：US08751514B2
公开(公告)日：2014-06-10
申请号：US13219415
申请日：2011-08-26
申请人： Harold Kester , Dan Ruskin , Chris Lee , Mark Anderson
发明人： Harold Kester , Dan Ruskin , Chris Lee , Mark Anderson
IPC分类号： G06F17/30
CPC分类号： H04L63/0227 , G06F17/30864 , Y10S707/99936
摘要： A system and method for updating a filtering system which controls access to a website/page between a local area network (LAN) and an Internet. The LAN includes an Internet gateway system coupled to a workstation and configured to receive a URL request. The system controls access to the website/page associated with the URL based on one or more categories that are associated with the URL. The Internet gateway system can determine the category that is associated with the URL by referencing a master database or requesting the category from a database factory. The database factory can receive URLs from multiple Internet gateway systems. The database factory determines whether the identifier was previously categorized by the database factory and provides the category to the Internet gateway system. Once the Internet gateway system has the category, it applies rules associated with the category and user to filter access to the requested website/page.
摘要翻译：一种用于更新控制对局域网（LAN）和因特网之间的网页/页面的访问的过滤系统的系统和方法。 LAN包括耦合到工作站并被配置为接收URL请求的因特网网关系统。该系统基于与URL相关联的一个或多个类别来控制对与URL相关联的网站/页面的访问。互联网网关系统可以通过引用主数据库或从数据库工厂请求类别来确定与URL相关联的类别。数据库工厂可以从多个互联网网关系统接收URL。数据库工厂确定该标识符是否以前由数据库工厂分类，并将类别提供给Internet网关系统。一旦Internet网关系统具有类别，它将应用与该类别和用户相关联的规则来过滤对所请求的网站/页面的访问。

5. 发明授权

US08347949B2 Elimination of shrinkage cavity in cast ingots 有权
标题翻译：消除铸锭中的收缩腔
公开(公告)号：US08347949B2
公开(公告)日：2013-01-08
申请号：US13333469
申请日：2011-12-21
申请人： Mark Anderson , Todd F. Bischoff , James Boorman , Wayne J. Fenton , David Sinden , John Steven Tingey , Robert Bruce Wagstaff
发明人： Mark Anderson , Todd F. Bischoff , James Boorman , Wayne J. Fenton , David Sinden , John Steven Tingey , Robert Bruce Wagstaff
IPC分类号： B22D11/049
CPC分类号： B22D11/049 , B22D11/10 , B22D11/18 , B22D11/185 , B22D11/186 , B22D19/10 , B22D41/18
摘要： An exemplary embodiment provides a method of eliminating a shrinkage cavity in a metal ingot cast by direct chill casting. The method involves casting an upright ingot having an upper surface at an intended height. Upon completion of the casting, the lower tip of the spout is maintained below the molten metal near the center of the upper surface. The metal flow through the spout is terminated and a partial shrinkage cavity is allowed to form as metal of the ingot shrinks and contracts. Before the partial cavity exposes the lower tip of the spout, the cavity is preferably over-filled with molten metal, while avoiding spillage of molten metal, and then the flow of metal through the spout is terminated. These steps are repeated until no further contraction of the metal causes any part of the upper surface to contract below the intended ingot height.
摘要翻译：示例性实施例提供了一种通过直接冷却铸造来消除铸造金属铸锭中的收缩腔的方法。该方法包括将具有上表面的竖直铸锭铸造在预期高度。铸造完成时，喷嘴的下端保持在靠近上表面中心的熔融金属的下方。通过喷口的金属流动被终止，并且允许部分收缩腔形成为金属的锭收缩并收缩。在部分腔体暴露喷嘴的下端之前，优选地，空腔被熔融金属过度填充，同时避免熔融金属的溢出，然后终止通过喷嘴的金属流。重复这些步骤，直到金属的进一步收缩导致上表面的任何部分收缩到低于预期的锭高度。

6. 发明授权

US08010552B2 System and method for adapting an internet filter 有权
标题翻译：适应互联网过滤器的系统和方法
公开(公告)号：US08010552B2
公开(公告)日：2011-08-30
申请号：US11624622
申请日：2007-01-18
申请人： Harold Kester , Dan Ruskin , Chris Lee , Mark Anderson
发明人： Harold Kester , Dan Ruskin , Chris Lee , Mark Anderson
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： H04L63/0227 , G06F17/30864 , Y10S707/99936
摘要： A system and method for updating a filtering system which controls access to a website/page between a local area network (LAN) and an Internet. The LAN includes an Internet gateway system coupled to a workstation and configured to receive a URL request. The system controls access to the website/page associated with the URL based on one or more categories that are associated with the URL. The Internet gateway system can determine the category that is associated with the URL by referencing a master database or requesting the category from a database factory. The database factory can receive URLs from multiple Internet gateway systems. The database factory determines whether the identifier was previously categorized by the database factory and provides the category to the Internet gateway system. Once the Internet gateway system has the category, it applies rules associated with the category and user to filter access to the requested website/page.
摘要翻译：一种用于更新控制对局域网（LAN）和因特网之间的网页/页面的访问的过滤系统的系统和方法。 LAN包括耦合到工作站并被配置为接收URL请求的因特网网关系统。该系统基于与URL相关联的一个或多个类别来控制对与URL相关联的网站/页面的访问。互联网网关系统可以通过引用主数据库或从数据库工厂请求类别来确定与URL相关联的类别。数据库工厂可以从多个互联网网关系统接收URL。数据库工厂确定该标识符是否以前由数据库工厂分类，并将类别提供给Internet网关系统。一旦Internet网关系统具有类别，它将应用与该类别和用户相关联的规则来过滤对所请求的网站/页面的访问。

7. 发明授权

US07632815B2 Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease 失效
公开(公告)号：US07632815B2
公开(公告)日：2009-12-15
申请号：US11983987
申请日：2007-11-13
申请人： Mark Anderson
发明人： Mark Anderson
IPC分类号： A61K38/00
CPC分类号： A61K38/16 , A61K31/18 , A61K38/005 , A61K38/10 , C12Q1/485 , G01N33/5088 , G01N33/6893 , G01N2333/58 , G01N2333/912 , G01N2500/00 , G01N2500/10
摘要： The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the administration of the inhibitor treats the structural heart disease in the subject. Also provided are transgenic animal models for treating structural heart disease. Further provided is a means of screening for a compound that can treat structural heart disease.

8. 发明申请

US20090197240A1 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 有权
标题翻译： EXVIVO LUNG CARE的系统和方法
公开(公告)号：US20090197240A1
公开(公告)日：2009-08-06
申请号：US12099715
申请日：2008-04-08
申请人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
发明人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
IPC分类号： A01N1/02 , A61B19/00
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
摘要翻译：维持，评估和提供肺外治疗的方法和系统。所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。

9. 发明申请

US20080090850A1 Herpetic neuralgia topical treatment 审中-公开
标题翻译：疱疹神经痛局部治疗
公开(公告)号：US20080090850A1
公开(公告)日：2008-04-17
申请号：US11974280
申请日：2007-10-12
申请人： Mark Anderson
发明人： Mark Anderson
IPC分类号： A61K31/195 , A61K31/164 , A61K31/52 , A61P25/00 , A61K31/19
CPC分类号： A61K31/164 , A61K31/19 , A61K31/195 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： Compositions and methods for treatment of acute herpetic zoster and post herpetic neuralgia. The compositions comprise the combination of five or six components, namely, a carrier penetrator, an anti-inflammatory agent, a topical analgesic, a nonsteroidal anti-inflammatory penetrator, a direct-application anti-viral agent, and, optionally, an anti-convulsant and calcium-channel blocker. The compositions are formulated to be applied topically to the affected areas.
摘要翻译：用于治疗急性疱疹带状疱疹和疱疹后神经痛的组合物和方法。组合物包含五种或六种组分的组合，即载体穿透剂，抗炎剂，局部止痛剂，非甾体抗炎穿透剂，直接施用抗病毒剂和任选的抗 - 惊厥和钙通道阻滞剂。将组合物配制成局部施用于受影响的区域。

10. 发明申请

US20080004297A1 COMPOUNDS AND THERAPEUTICAL USE THEREOF 失效
标题翻译：化合物及其治疗用途
公开(公告)号：US20080004297A1
公开(公告)日：2008-01-03
申请号：US11773303
申请日：2007-07-03
申请人： Sui Cai , Mark Anderson , Adam Willardsen , Nilantha Sirisoma , Hong Zhang , Kazuyuki Suzuki
发明人： Sui Cai , Mark Anderson , Adam Willardsen , Nilantha Sirisoma , Hong Zhang , Kazuyuki Suzuki
IPC分类号： A61K31/517 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/00 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12
CPC分类号： C07D239/94 , C07D239/72 , C07D403/12
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。

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