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1. 发明授权

US07420672B2 Method and apparatus for conducting Raman spectroscopy 有权
标题翻译：用于进行拉曼光谱的方法和装置
公开(公告)号：US07420672B2
公开(公告)日：2008-09-02
申请号：US11820706
申请日：2007-06-20
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.
摘要翻译：本文公开了拉曼探针，其包括：（a）第一光纤，用于从光源接收激发激发光并将其传输; （b）第一滤光器，用于接收来自第一光纤的光，并适于通过激光激发光并阻止与光相关联的寄生信号; （c）第二过滤器，用于接收来自第一过滤器的光，并适于将光引向样本; 和（d）用于接收来自第二滤光器的光的聚焦装置，将光聚焦在样本上以产生拉曼信号，并将拉曼信号返回到第二滤光器。第二滤波器进一步配置成使得当第二滤波器从聚焦装置接收拉曼信号时，第二滤波器在将拉曼信号引导到第二光纤之前滤除不期望的激光激发光。

2. 发明授权

US08107069B2 Method and apparatus for conducting Raman spectroscopy 有权
标题翻译：用于进行拉曼光谱的方法和装置
公开(公告)号：US08107069B2
公开(公告)日：2012-01-31
申请号：US12556200
申请日：2009-09-09
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： The apparatus disclosed herein features: (a) a handheld, portable spectrometer that includes a radiation source configured to direct incident radiation to a sample, a detector configured to receive signal radiation from the sample, and a housing enclosing the radiation source and the detector; (b) an extended member attachable to the housing and having an interior channel to define a path for directing radiation from the source to the sample and for receiving radiation from the sample at the detector; (c) and a vial receptacle configured to hold a different sample and positioned to receive radiation from the source, where the detector is positioned to receive radiation from the different sample and the housing is configured to support the vial receptacle and attach to the extended member at the same time.
摘要翻译：本文公开的装置特征在于：（a）手持式便携式光谱仪，其包括被配置为将入射辐射引导到样品的辐射源，被配置为从样品接收信号辐射的检测器和包围辐射源和检测器的壳体; （b）可附接到壳体并具有内部通道以限定用于将辐射从源引导到样品并用于在检测器处接收来自样品的辐射的路径的延伸构件; （c）和小瓶容器，其被配置为保持不同的样品并定位成接收来自所述源的辐射，其中所述检测器被定位成接收来自所述不同样品的辐射，并且所述壳体被配置为支撑所述小瓶容器并附接到所述延伸构件与此同时。

3. 发明授权

US07636157B2 Method and apparatus for conducting Raman spectroscopy 有权
标题翻译：用于进行拉曼光谱的方法和装置
公开(公告)号：US07636157B2
公开(公告)日：2009-12-22
申请号：US11117940
申请日：2005-04-29
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.
摘要翻译：本文公开了拉曼探针，其包括：（a）第一光纤，用于从光源接收激发激发光并将其传输; （b）第一滤光器，用于接收来自第一光纤的光，并适于通过激光激发光并阻止与光相关联的寄生信号; （c）第二过滤器，用于接收来自第一过滤器的光，并适于将光引向样本; 和（d）用于接收来自第二滤光器的光的聚焦装置，将光聚焦在样本上以产生拉曼信号，并将拉曼信号返回到第二滤光器。第二滤波器进一步配置成使得当第二滤波器从聚焦装置接收拉曼信号时，第二滤波器在将拉曼信号引导到第二光纤之前滤除不期望的激光激发光。

4. 发明申请

US20100290042A1 Use of Free-space Coupling Between Laser Assembly, Optical Probe Head Assembly, Spectrometer Assembly and/or Other Optical Elements for Portable Optical Applications Such as Raman Instruments 审中-公开
标题翻译：在激光装配，光学探针头组件，光谱仪装配和/或用于便携式光学应用的其他光学元件（例如拉曼仪器）中的自由空间耦合的使用
公开(公告)号：US20100290042A1
公开(公告)日：2010-11-18
申请号：US12062688
申请日：2008-04-04
申请人： Daryoosh Vakhshoori , Peili Chen , Masud Azimi , Peidong Wang , Yu Shen , Kevin J. Knopp , Leyun Zhu , Christopher D. Brown , Gregory H. Vander Rhodes
发明人： Daryoosh Vakhshoori , Peili Chen , Masud Azimi , Peidong Wang , Yu Shen , Kevin J. Knopp , Leyun Zhu , Christopher D. Brown , Gregory H. Vander Rhodes
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/0256 , G01J3/0272 , G01J3/0286 , G01J3/0291 , G01N21/65 , G01N2021/656 , G01N2201/0221
摘要： An apparatus includes: a handheld Raman analyzer that can include: a common platform; a laser assembly mounted on a laser platform, the laser platform supported on the common platform by a first material and a second thermally conductive material wherein the first material is softer than the second material; an optical probe head assembly disposed on the common platform, the optical probe head assembly spaced apart from the laser assembly; a spectrometer assembly disposed on the common platform, the spectrometer assembly spaced apart from the optical probe head assembly; and an analysis apparatus configured to identify a specimen based on a Raman signature received from the spectrometer. The laser assembly can be optically coupled to the optical probe head assembly by at least a first free-space coupling region and the optical probe head assembly optically coupled to the spectrometer assembly by at least a second free-space coupling region.
摘要翻译：一种装置包括：手持式拉曼分析仪，其可以包括：公共平台; 安装在激光平台上的激光组件，所述激光平台由第一材料和第二导热材料支撑在所述公共平台上，其中所述第一材料比所述第二材料柔软; 设置在所述公共平台上的光学探针头组件，所述光学探针头组件与所述激光组件间隔开; 设置在公共平台上的光谱仪组件，光谱仪组件与光学探针头组件间隔开; 以及分析装置，被配置为基于从所述光谱仪接收到的拉曼标记来识别样本。激光组件可以通过至少第一自由空间耦合区域光学地耦合到光学探针头组件，并且光学探针头组件通过至少第二自由空间耦合区域光耦合到光谱仪组件。

5. 发明申请

US20100002228A1 Method and Apparatus for Conducting Raman Spectroscopy 有权
标题翻译：用于拉曼光谱的方法和装置
公开(公告)号：US20100002228A1
公开(公告)日：2010-01-07
申请号：US12556200
申请日：2009-09-09
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin J. Knopp , Masud Azimi
IPC分类号： G01J3/44 , G01J3/28
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.
摘要翻译：本文公开了拉曼探针，其包括：（a）第一光纤，用于从光源接收激发激发光并将其传输; （b）第一滤光器，用于接收来自第一光纤的光，并适于通过激光激发光并阻止与光相关联的寄生信号; （c）第二过滤器，用于接收来自第一过滤器的光，并适于将光引向样本; 和（d）用于接收来自第二滤光器的光的聚焦装置，将光聚焦在样本上以产生拉曼信号，并将拉曼信号返回到第二滤光器。第二滤波器进一步配置成使得当第二滤波器从聚焦装置接收拉曼信号时，第二滤波器在将拉曼信号引导到第二光纤之前滤除不期望的激光激发光。

6. 发明申请

US20060170917A1 Use of free-space coupling between laser assembly, optical probe head assembly, spectrometer assembly and/or other optical elements for portable optical applications such as Raman instruments 审中-公开
标题翻译：在激光组件，光学探针头组件，光谱仪组件和/或用于便携式光学应用如拉曼仪器的其他光学元件之间使用自由空间耦合
公开(公告)号：US20060170917A1
公开(公告)日：2006-08-03
申请号：US11215526
申请日：2005-08-30
申请人： Daryoosh Vakhshoori , Peili Chen , Masud Azimi , Peidong Wang , Yu Shen , Kevin Knopp , Leyun Zhu , Christopher Brown , Gregory Vander Rhodes
发明人： Daryoosh Vakhshoori , Peili Chen , Masud Azimi , Peidong Wang , Yu Shen , Kevin Knopp , Leyun Zhu , Christopher Brown , Gregory Vander Rhodes
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/0256 , G01J3/0272 , G01J3/0286 , G01J3/0291 , G01N21/65 , G01N2021/656 , G01N2201/0221
摘要： A compact, lightweight, portable optical assembly comprising: a platform; and a plurality of optical elements mounted to the platform; wherein the plurality of optical elements are optically connected to one another with free-space couplings so as to form an optical circuit; and further wherein the platform is sufficiently mechanically robust so as to maintain the free-space optical coupling between the various optical elements. A method for making a compact, lightweight, portable optical assembly, comprising: providing a platform; and mounting a plurality of optical elements to the platform; wherein the plurality of optical elements are mounted to the platform so that they are optically connected to one another with free-space couplings so as to form an optical circuit; and further wherein the platform is sufficiently mechanically robust so as to maintain the free-space optical coupling between the various optical elements.
摘要翻译：一种紧凑，重量轻的便携式光学组件，包括：平台; 以及安装到所述平台的多个光学元件; 其中所述多个光学元件通过自由空间耦合彼此光学连接以形成光学电路; 并且其中所述平台具有足够的机械稳固性，以保持各个光学元件之间的自由空间光学耦合。一种用于制造紧凑，重量轻的便携式光学组件的方法，包括：提供平台; 并将多个光学元件安装到所述平台上; 其中所述多个光学元件安装到所述平台，使得它们通过自由空间耦合彼此光学连接以形成光学电路; 并且其中所述平台具有足够的机械稳固性，以保持各个光学元件之间的自由空间光学耦合。

7. 发明申请

US20050248759A1 Method and apparatus for conducting Raman spectroscopy 有权
公开(公告)号：US20050248759A1
公开(公告)日：2005-11-10
申请号：US11117940
申请日：2005-04-29
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin Knopp , Masud Azimi
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： In another form of the present invention, there is provided a Raman probe comprising: a first optical fiber for receiving laser excitation light from a light source and transmitting the same; a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; a second filter for receiving light from the first filter and adapted to direct the light toward the specimen; focusing apparatus for receiving the light from the second filter, focusing the light on a specimen so as to generate the Raman signal, and returning the Raman signal to the second filter; wherein the second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber; and a second optical fiber for receiving the Raman signal from the second filter and transmitting the same to a light analyzer. In another form of the present invention, there is provided a Raman probe comprising: a light source for generating laser excitation light; focusing apparatus for receiving the laser excitation light from the light source, focusing the laser excitation light on a specimen so as to generate the Raman signal, and returning the Raman signal to a light analyzer; and a light analyzer for analyzing the Raman signature of the specimen, whereby to identify the specimen; wherein the focusing apparatus is configured to permit the specimen to reside in a vial receptacle or at a target location remote from the vial receptacle. In another form of the present invention, there is provided a method for conducting Raman spectroscopy of a specimen, comprising: generating laser excitation light using a light source; passing the laser excitation light through a first filter so as to block spurious signals associated with the light; passing the laser excitation light through a second filter so as to direct the light toward the specimen; receiving the light from the second filter, focusing the light on a specimen so as to generate the Raman signal, and returning the Raman signal to the second filter; wherein the second filter is further configured so that when the second filter receives the Raman signal from the specimen, the second filter filters out unwanted laser excitation light; passing the filtered light received from the second filter to a light analyzer; and analyzing the Raman signature of the specimen so as to identify the specimen. In another form of the present invention, there is provided a Raman probe comprising: a housing; a light source disposed within the housing for generating laser excitation light; focusing apparatus disposed within the housing for receiving the laser excitation light from the light source, focusing the laser excitation light on a specimen so as to generate the Raman signal, and returning the Raman signal to a light analyzer; and a light analyzer disposed within the housing for analyzing the Raman signature of the specimen, whereby to identify the specimen; wherein the focusing apparatus is configured to permit the specimen to reside at a target location remote from the housing; and further comprising an optical shield mounted to the housing so as to be disposed between the specimen and the user, whereby to optically shield the user from the light source. In another form of the present invention, there is provided a Raman probe comprising: a housing; a light source disposed within the housing for generating laser excitation light; focusing apparatus disposed within the housing for receiving the laser excitation light from the light source, focusing the laser excitation light on a specimen so as to generate the Raman signal, and returning the Raman signal to a light analyzer; and a light analyzer disposed within the housing for analyzing the Raman signature of the specimen, whereby to identify the specimen; wherein the focusing apparatus is configured to permit the specimen to reside at a target location remote from the housing; and further comprising a camera mounted to the housing so that its field of view encompasses the target location, and a display mounted to the housing for displaying the image captured by the camera, whereby to permit the user to position the probe relative to the specimen while watching the display.

8. 发明申请

US20080024777A1 Method and apparatus for conducting Raman spectroscopy 有权
公开(公告)号：US20080024777A1
公开(公告)日：2008-01-31
申请号：US11820706
申请日：2007-06-20
申请人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin Knopp , Masud Azimi
发明人： Peidong Wang , Daryoosh Vakhshoori , Yu Shen , Kevin Knopp , Masud Azimi
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/1213 , G01N2021/656
摘要： Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.

9. 发明授权

US09255842B2 Heroin detection by raman spectroscopy from impure compositions comprising an interfering fluorescent contaminant 有权
标题翻译：由含有干扰性荧光污染物的不纯组合物的拉曼光谱法检测海洛因
公开(公告)号：US09255842B2
公开(公告)日：2016-02-09
申请号：US13529916
申请日：2012-06-21
申请人： Craig Morris Gardner , Michael Derek Hargreaves , Peidong Wang , Yu Shen
发明人： Craig Morris Gardner , Michael Derek Hargreaves , Peidong Wang , Yu Shen
IPC分类号： G01J3/44 , G01N33/94 , G01N21/65 , G01N21/84 , G01N21/94 , G01N21/64
CPC分类号： G01N21/658 , G01J3/44 , G01N21/65 , G01N21/8483 , G01N21/94 , G01N33/9486 , G01N2021/646 , G01N2021/656 , G01N2201/0221 , G01N2201/06113
摘要： A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided.
摘要翻译：一种鉴定海洛因组合物中海洛因存在的方法，其中含有海洛因和至少一种会影响来自海洛因的拉曼信号的荧光染料。该方法可以包括使混合物与溶剂如醇接触，然后使得到的醇组合物与SERS表面接触。然后可以将表面暴露于来自手持拉曼光谱仪的激光以检测来自海洛因的拉曼信号。还提供了一种用于执行该方法的装置。

10. 发明申请

US20100104629A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
公开(公告)号：US20100104629A1
公开(公告)日：2010-04-29
申请号：US12557294
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K9/127 , A61K39/00 , A61K38/02 , A61K31/7088 , A61K47/22 , A61K47/18 , C07D207/08 , C07D317/28 , C07D317/26 , C07C229/34 , C07C217/48 , C07C217/28
CPC分类号： A61K9/1272 , C07C205/43 , C07C217/28 , C07C229/34 , C07C235/08 , C07C271/16 , C07D207/04 , C07D207/08 , C07D207/12 , C07D207/14 , C07D211/22 , C07D213/74 , C07D233/54 , C07D233/60 , C07D239/22 , C07D241/12 , C07D243/08 , C07D265/30 , C07D295/088 , C07D295/108 , C07D317/18 , C07D317/28 , C07D403/04 , C07D405/06
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

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