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1. 发明授权

US08158402B2 Acetoin high-yield Bacillus pumilus strain 有权
标题翻译：乙草胺高产芽孢杆菌菌株
公开(公告)号：US08158402B2
公开(公告)日：2012-04-17
申请号：US11667567
申请日：2005-11-04
申请人： Ping Xu , Zijun Xiao , Yi Du , Zhonghao Wei
发明人： Ping Xu , Zijun Xiao , Yi Du , Zhonghao Wei
IPC分类号： C12N1/20 , C12P7/26 , C12P1/00
CPC分类号： C12P7/26 , C12N1/20 , C12R1/07
摘要： A high-yield bacterial strain for producing acetoin named Bacillus pumilus XH195 has been deposited in a microorganism deposit center in Germany. The deposit number is DSM 16187. The bacteria of the strain are rod-shaped, 1.5 μm to 3.0 μm in length, and 0.6 μm to 0.7 μm in diameter. The colony color of the bacterial strain is yellow or white. The strain has the typical fatty acid profile of Bacillus and its physiological and biochemical characteristics align with those of Bacillus pumilus. When the bacteria of strain were cultured at 37° C. for 60 hours with shaking, the yield of acetoin could reach 63.0 g/L or 58.1 g/L, when glucose or sucrose was used as the substrate, respectively.
摘要翻译：用于生产称为短小芽孢杆菌XH195的丙酮丁酸的高产菌株已经存放在德国的微生物保藏中心。保藏号为DSM16187.菌株细菌为棒状，长度为1.5〜3.0μm，直径为0.6〜0.7μm。菌株的菌落颜色是黄色或白色。该菌株具有芽孢杆菌的典型脂肪酸谱，其生理和生化特性与短小芽孢杆菌的一致。当菌株细菌在37℃下振荡培养60小时时，分别使用葡萄糖或蔗糖作为底物时，乙偶姻的产量可达63.0g / L或58.1g / L。

2. 发明授权

US08067212B2 Bacillus pumilus strain for high yield of tetramethylpyrazine 有权
标题翻译：短小芽孢杆菌菌株用于高产量的四甲基吡嗪
公开(公告)号：US08067212B2
公开(公告)日：2011-11-29
申请号：US12302275
申请日：2007-05-25
申请人： Ping Xu , Zijun Xiao , Zhonghao Wei , Yi Du
发明人： Ping Xu , Zijun Xiao , Zhonghao Wei , Yi Du
IPC分类号： C12P17/00 , C12N1/20
CPC分类号： C12R1/07 , C12P17/12 , Y10S435/832
摘要： This invention provides a high-yield bacterial strain for producing tetramethylpyrazine named Bacillus pumilus RX3-17. The strain has been deposited in China Center for Type Culture Collection on Apr. 19, 2006. The deposit number is CCTCC M 206043. The bacterial strain, isolated from soil, is rod-shaped, 1.5 μm to 3.0 μm in length and 0.6 μm to 0.7 μm in diameter. The colony color of the strain is milky-white. The strain has typical physiological and biochemical characteristics of Bacillus pumilus. The 16s rDNA sequence of this strain shares a similarity of 99% with other Bacillus pumilus strains. This invention belongs to the domain of biotechnology. The strain can be applied to the production of tetramethylpyrazine with glucose as the substrate, solving the bottleneck of low yield in bacterial tetramethylpyrazine fermentation.
摘要翻译：本发明提供了用于生产称为短小芽孢杆菌RX3-17的四甲基吡嗪的高产菌株。该菌株已于2006年4月19日保藏在中国型号培养物中心中心。沉积物编号为CCTCC M 206043.从土壤中分离的细菌菌株为棒状，长度为1.5〜3.0μm，0.6μm 直径为0.7μm。菌株的菌落颜色是乳白色的。该菌株具有典型的生物和生化特性的短小芽孢杆菌。该菌株的16s rDNA序列与其他短小芽孢杆菌菌株具有99％的相似性。本发明属于生物科技领域。该菌株可用于以葡萄糖为底物生产四甲基吡嗪，解决细菌四甲基吡嗪发酵中低产量的瓶颈。

3. 发明申请

US20090275108A1 BACILLUS PUMILUS STRAIN FOR HIGH YIELD OF TETRAMETHYLPYRAZINE 有权
标题翻译：用于甲基四氢吡喃高效的巴氏酵母菌株
公开(公告)号：US20090275108A1
公开(公告)日：2009-11-05
申请号：US12302275
申请日：2007-05-25
申请人： Ping Xu , Zijun Xiao , Zhonghao Wei , Yi Du
发明人： Ping Xu , Zijun Xiao , Zhonghao Wei , Yi Du
IPC分类号： C12N1/20
CPC分类号： C12R1/07 , C12P17/12 , Y10S435/832
摘要： This invention provides a high-yield bacterial strain for producing tetramethylpyrazine named Bacillus pumilus RX3-17. The strain has been deposited in China Center for Type Culture Collection on Apr. 19, 2006. The deposit number is CCTCC M 206043. The bacterial strain, isolated from soil, is rod-shaped, 1.5 μm to 3.0 μm in length and 0.6 μm to 0.7 μm in diameter. The colony color of the strain is milky-white. The strain has typical physiological and biochemical characteristics of Bacillus pumilus. The 16s rDNA sequence of this strain shares a similarity of 99% with other Bacillus pumilus strains. This invention belongs to the domain of biotechnology. The strain can be applied to the production of tetramethylpyrazine with glucose as the substrate, solving the bottleneck of low yield in bacterial tetramethylpyrazine fermentation.
摘要翻译：本发明提供了用于生产称为短小芽孢杆菌RX3-17的四甲基吡嗪的高产菌株。该菌株于2006年4月19日存放于中国型号培养物保藏中心。存款编号为CCTCC M 206043.从土壤中分离出的菌株为棒状，长度为1.5〜3.0μm，长度为0.6μm 直径为0.7毫米。菌株的菌落颜色是乳白色的。该菌株具有典型的生物和生化特性的短小芽孢杆菌。该菌株的16s rDNA序列与其他短小芽孢杆菌菌株具有99％的相似性。本发明属于生物技术领域。该菌株可用于以葡萄糖为底物生产四甲基吡嗪，解决细菌四甲基吡嗪发酵中低产量的瓶颈。

4. 发明申请

US20090215152A1 Acetoin high-yield bacillus pumilus strain 有权
标题翻译：醋芽孢杆菌高产芽孢杆菌菌株
公开(公告)号：US20090215152A1
公开(公告)日：2009-08-27
申请号：US11667567
申请日：2005-11-04
申请人： Ping Xu , Zijun Xiao , Yi Du , Zhonghao Wei
发明人： Ping Xu , Zijun Xiao , Yi Du , Zhonghao Wei
IPC分类号： C12N1/20
CPC分类号： C12P7/26 , C12N1/20 , C12R1/07
摘要： A high-yield bacterial strain for producing acetoin named Bacillus pumilus XH195 has been deposited in a microorganism deposit center in Germany. The deposit number is DSM 16187. The bacteria of the strain are rod-shaped, 1.5 μm to 3.0 μm in length, and 0.6 μm to 0.7 μm in diameter. The colony color of the bacterial strain is yellow or white. The strain has the typical fatty acid profile of Bacillus and its physiological and biochemical characteristics align with those of Bacillus pumilus. When the bacteria of strain were cultured at 37° C. for 60 hours with shaking, the yield of acetoin could reach 63.0 g/L or 58.1 g/L, when glucose or sucrose was used as the substrate, respectively.
摘要翻译：用于生产称为短小芽孢杆菌XH195的丙酮丁酸的高产菌株已经存放在德国的微生物保藏中心。存款编号为DSM16187.菌株的细菌为棒状，长度为1.5μm至3.0μm，直径为0.6μm至0.7μm。菌株的菌落颜色是黄色或白色。该菌株具有芽孢杆菌的典型脂肪酸谱，其生理和生化特性与短小芽孢杆菌的一致。当菌株细菌在37℃下振荡培养60小时时，分别使用葡萄糖或蔗糖作为底物时，乙偶姻的产量可达63.0g / L或58.1g / L。

5. 发明申请

US20090186399A1 STREPTOMYCES STRAIN AND THE METHOD OF CONVERTING FERULIC ACID TO VANILLIN BY USING THE SAME 审中-公开
标题翻译：溶菌酶菌株及其使用方法将葡萄糖转化成VANILLIN
公开(公告)号：US20090186399A1
公开(公告)日：2009-07-23
申请号：US12302502
申请日：2007-06-25
申请人： Ping Xu , Dongliang Hua , Shan Lin , Lifu Song , Cuiqing Ma , Zhaobin Zhang , Yi Du , Hong Chen , Lin Gan , Zhonghao Wei , Yiyong Zeng
发明人： Ping Xu , Dongliang Hua , Shan Lin , Lifu Song , Cuiqing Ma , Zhaobin Zhang , Yi Du , Hong Chen , Lin Gan , Zhonghao Wei , Yiyong Zeng
IPC分类号： C12N1/20
CPC分类号： C12R1/465 , C12P7/24
摘要： A method of vanillin production from ferulic acid with a high concentration by biotransformation using a Streptomyces sp. strain is claimed in this invention. This strain is named as Streptomyces sp. V-1, which has been deposited in China Center for Type Culture Collection on Jul. 12, 2006 with the number of CCTCC M 206065. Using this strain, high concentration of vanillin fermentation broth is obtained from ferulic acid by biotransformation in GY biotransformation medium. With the addition of macroporous adsorbent resin DM11, the concentration of vanillin can be greatly improved. The advantage of this invention is less environmental pollution, high product concentration, less by-product, short processing cycle, low production cost, simple product extraction, clean production process, product environmental friendly, safe and reliable, which solves many difficulties in the vanillin production from botanical raw material extraction or chemical synthesis, and therefore it has good application prospect.
摘要翻译：通过使用链霉菌（Streptomyces sp。）通过生物转化从高浓度的阿魏酸生产香草醛的方法。应变在本发明中要求保护。该菌株被命名为Streptomyces sp。 V-1已于2006年7月12日以CCTCC M 206065号存于中国型号培养物中心中心。使用该菌株，通过生物转化在GY生物转化培养基中从阿魏酸获得高浓度的香草醛发酵液。通过添加大孔吸附树脂DM11，可以大大提高香草醛的浓度。本发明的优点是环境污染少，产品浓缩少，加工周期短，生产成本低，产品提取简单，生产过程简单，产品环保，安全可靠，解决了香草醛中的许多困难生产从植物原料提取或化学合成，因此具有良好的应用前景。

6. 发明授权

US09322049B2 Activation and activators of SirT6 有权
标题翻译： SirT6的激活和激活者
公开(公告)号：US09322049B2
公开(公告)日：2016-04-26
申请号：US13516198
申请日：2010-12-14
申请人： Anthony Sauve , Ping Xu
发明人： Anthony Sauve , Ping Xu
IPC分类号： A61K31/70 , A61K31/185 , C12Q1/48
CPC分类号： C12Q1/48 , G01N2333/91142 , G01N2500/04
摘要： The invention provides a method of increasing a deacetylated activity of SIRT6 by contacting SIRT6 with an agent that binds SIRT6 and reduces the Km of SIRT6 for a substrate, thereby increasing the deacetylase activity of SIRT6. The invention also provides compounds of the formulas (II) and (III).
摘要翻译：本发明提供了通过使SIRT6与结合SIRT6的试剂接触并降低底物的SIRT6的Km，从而增加SIRT6的脱乙酰酶活性而提高SIRT6脱乙酰化活性的方法。本发明还提供式（II）和（III）的化合物。

7. 发明授权

US08658707B2 Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products 有权
标题翻译：可扩展的功能性TFE共聚物细粉末，由其获得的扩展的功能产物和扩展产物的反应
公开(公告)号：US08658707B2
公开(公告)日：2014-02-25
申请号：US12886817
申请日：2010-09-21
申请人： Ping Xu , Jack J. Hegenbarth , Rachel Radspinner , Paul D. Drumheller , William B. Johnson , Wen K. Liu , Xin Kang Chen
发明人： Ping Xu , Jack J. Hegenbarth , Rachel Radspinner , Paul D. Drumheller , William B. Johnson , Wen K. Liu , Xin Kang Chen
IPC分类号： C08J9/16 , C08F214/26 , C08F228/02 , C08F220/50 , C08F220/28
CPC分类号： A61L31/041 , A61L31/048 , A61L31/16 , B01D67/0093 , B01D71/32 , B01J39/18 , B29C55/005 , B29K2027/18 , B29K2105/04 , B29K2995/0092 , C08F14/26 , C08F214/26 , C08F214/262 , C08F214/265 , C08F220/28 , C08F220/50 , C08F228/02 , C08J5/2237 , C08J9/28 , C08J9/35 , C08J2201/0502 , C08J2327/18 , C08L27/18 , C08L2205/02 , Y10T428/31544 , C08L2666/04 , C08F2/22
摘要： A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.
摘要翻译：描述了一种功能性TFE共聚物细粉末，其中TFE共聚物是TFE和至少一种官能共聚单体的聚合物，并且其中TFE共聚物具有垂直于聚合物链的官能团。功能性TFE共聚物细粉末树脂是可挤出和可膨胀的糊状物。还描述了制备功能性TFE共聚物的方法。膨胀的功能性TFE共聚物材料可以在膨胀后进行后反应。

8. 发明授权

US08623963B2 High purity perfluoroelastomer composites and a process to produce the same 有权
标题翻译：高纯度全氟弹性体复合材料及其制备方法
公开(公告)号：US08623963B2
公开(公告)日：2014-01-07
申请号：US12353514
申请日：2009-01-14
申请人： Ping Xu , Jack Hegenbarth
发明人： Ping Xu , Jack Hegenbarth
IPC分类号： C08F8/00 , C08J3/05
CPC分类号： C08L29/10 , C08K3/36 , C08L27/12 , C08L27/18 , C08L33/22 , C08L2205/02 , C08L2666/04
摘要： High purity perfluoroelastomer composites and processes for producing the same are provided. High purity composites may be formed from compositions comprising a crosslinkable fluoroelastomer terpolymer of TFE, PAVE, and CNVE, and functionalized PTFE, which may be crosslinked to form crosslinked composites having low metal content and low compression set. Emulsion mixtures for forming the high purity composites are also provided.
摘要翻译：提供了高纯度全氟弹性体复合材料及其制备方法。高纯度复合材料可以由包含TFE，PAVE和CNVE的交联性含氟弹性体三元共聚物和官能化PTFE的组合物形成，其可以交联以形成具有低金属含量和低压缩永久变形的交联复合材料。还提供了用于形成高纯度复合材料的乳液混合物。

9. 外观设计

USD662469S1 Battery charger 有权
公开(公告)号：USD662469S1
公开(公告)日：2012-06-26
申请号：US29404385
申请日：2011-10-20
申请人： Mitch Mulder , Ping Xu
设计人： Mitch Mulder , Ping Xu

10. 发明申请

US20080070421A1 BI-LAYER CAPPING OF LOW-K DIELECTRIC FILMS 失效
标题翻译：低K电介质薄膜的双层封装
公开(公告)号：US20080070421A1
公开(公告)日：2008-03-20
申请号：US11533505
申请日：2006-09-20
申请人： Ping Xu , Christopher Dennis Bencher
发明人： Ping Xu , Christopher Dennis Bencher
IPC分类号： H01L21/469
CPC分类号： H01L21/76829 , C23C16/30 , C23C16/45523 , H01L21/02126 , H01L21/022 , H01L21/02216 , H01L21/02274 , H01L21/0234 , H01L21/02348 , H01L21/02351 , H01L21/02362 , H01L21/3122 , H01L21/31633 , H01L21/76835
摘要： A method is provided for processing a substrate surface by delivering a first gas mixture comprising a first organosilicon compound, a first oxidizing gas, and one or more hydrocarbon compounds into a chamber at deposition conditions sufficient to deposit a first low dielectric constant film on the substrate surface. A second gas mixture having a second organosilicon compound and a second oxidizing gas is delivered into the chamber at deposition conditions sufficient to deposit a second low dielectric constant film on the first low dielectric constant film. The flow rate of the second oxidizing gas into the chamber is increased, and the flow rate of the second organosilicon compound into the chamber is decreased to deposit an oxide rich cap on the second low dielectric constant film.
摘要翻译：提供了一种通过将包含第一有机硅化合物，第一氧化气体和一种或多种烃化合物的第一气体混合物输送到室中的方法来处理衬底表面，该沉积条件足以在衬底上沉积第一低介电常数膜表面。具有第二有机硅化合物和第二氧化气体的第二气体混合物在足以在第一低介电常数膜上沉积第二低介电常数膜的沉积条件下被输送到室中。进入室内的第二氧化气体的流量增加，第二有机硅化合物进入室的流量减少，从而在第二低介电常数膜上沉积氧化物富集盖。

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