专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130253426A1 ELUTING MEDICAL DEVICES 有权
标题翻译：医用器械
公开(公告)号：US20130253426A1
公开(公告)日：2013-09-26
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Krazler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Krazler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译：本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

2. 发明授权

US08288121B2 Methods and compositions for a microemulsion-based tissue treatment 有权
标题翻译：用于微乳液组织处理的方法和组合物
公开(公告)号：US08288121B2
公开(公告)日：2012-10-16
申请号：US12165020
申请日：2008-06-30
申请人： Brian H. Kram , Christopher Bieniarz , Paul D. Drumheller
发明人： Brian H. Kram , Christopher Bieniarz , Paul D. Drumheller
IPC分类号： G01N1/30 , C12Q1/00 , B01F3/00
CPC分类号： G01N1/30
摘要： The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of intermediary alcohol dehydration or alcohol rehydration compositions.
摘要翻译：本发明涉及用于随后组织染色的石蜡包埋生物样品脱蜡的方法和组合物。组合物是微乳液，其可以包括水/油/表面活性剂微乳液，以及任选的辅助表面活性剂。微乳液能够在不使用二甲苯或甲苯的情况下脱蜡，并且还可以在不使用中间醇脱水或醇补液组合物的情况下进行溶剂交换。

3. 发明申请

US20110039960A1 Expandable Functional TFE Copolymer Fine Powder, the Expanded Functional Products Obtained Therefrom and Reaction of the Expanded Products 有权
标题翻译：可扩展功能性TFE共聚物细粉，膨胀产品获得的膨胀功能产品和扩展产品的反应
公开(公告)号：US20110039960A1
公开(公告)日：2011-02-17
申请号：US12886817
申请日：2010-09-21
申请人： Ping Xu , Jack J. Hegenbarth , Rachel Radspinner , Paul D. Drumheller , William B. Johnson , Wen K. Liu , Xin Kang Chen
发明人： Ping Xu , Jack J. Hegenbarth , Rachel Radspinner , Paul D. Drumheller , William B. Johnson , Wen K. Liu , Xin Kang Chen
IPC分类号： C08J9/16 , C08F214/26
CPC分类号： A61L31/041 , A61L31/048 , A61L31/16 , B01D67/0093 , B01D71/32 , B01J39/18 , B29C55/005 , B29K2027/18 , B29K2105/04 , B29K2995/0092 , C08F14/26 , C08F214/26 , C08F214/262 , C08F214/265 , C08F220/28 , C08F220/50 , C08F228/02 , C08J5/2237 , C08J9/28 , C08J9/35 , C08J2201/0502 , C08J2327/18 , C08L27/18 , C08L2205/02 , Y10T428/31544 , C08L2666/04 , C08F2/22
摘要： A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.
摘要翻译：描述了一种功能性TFE共聚物细粉末，其中TFE共聚物是TFE和至少一种官能共聚单体的聚合物，并且其中TFE共聚物具有垂直于聚合物链的官能团。功能性TFE共聚物细粉末树脂是可挤出和可膨胀的糊状物。还描述了制备功能性TFE共聚物的方法。膨胀的功能性TFE共聚物材料可以在膨胀后进行后反应。

4. 发明申请

US20100233266A1 ARTICLES AND METHODS OF TREATING VASCULAR CONDITIONS 审中-公开
标题翻译：治疗血管病症的文章和方法
公开(公告)号：US20100233266A1
公开(公告)日：2010-09-16
申请号：US12404083
申请日：2009-03-13
申请人： Robert L. Cleek , Paul D. Drumheller , Theresa A. Holland
发明人： Robert L. Cleek , Paul D. Drumheller , Theresa A. Holland
IPC分类号： A61K9/10 , A61M37/00 , A61K31/56
CPC分类号： A61K9/06 , A61K9/0024 , A61K31/565 , A61K31/573 , A61K45/06 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/40 , A61L27/50 , A61L27/52 , A61L27/54 , A61L29/14 , A61L29/145 , A61L29/16 , A61L2300/416 , A61L2300/802
摘要： The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.
摘要翻译：本发明涉及使用具有触变性，混浊的含生物活性剂的凝胶材料治疗血管病症的制品和方法，其能够在植入部位重新建立流体流时基本上从植入部位移除。

5. 发明申请

US20080287633A1 Hydrogel Materials 审中-公开
标题翻译：水凝胶材料
公开(公告)号：US20080287633A1
公开(公告)日：2008-11-20
申请号：US11750673
申请日：2007-05-18
申请人： Paul D. Drumheller
发明人： Paul D. Drumheller
IPC分类号： C08F210/02
CPC分类号： A61K9/007 , A61K9/06 , A61K9/12 , A61L24/0031 , C08G65/3324 , C08G65/33306 , C08G65/33337 , C08G65/33358 , C08L2203/02
摘要： The present invention relates to biocompatible crosslinked biomaterials made from polycondensation polymerization reactions involving polynucleophilic-polyelectrophilic precursors that address the limitations of steric hindrance, viscosity, and diffusion currently reducing gelation rates and curing thoroughness of the biomaterials. A cross-linking scheme is utilized in the invention that permits rapid gelation and thorough curing of the biomaterial. The biomaterial is made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble crosslinker having at most one core cyclic structure.
摘要翻译：本发明涉及由涉及多亲核多亲电子前体的缩聚反应制备的生物相容性交联生物材料，其解决当前降低凝胶化速率和固化生物材料的空间位阻，粘度和扩散的限制。在本发明中使用交联方案，其允许生物材料的快速凝胶化和彻底固化。生物材料通过多亲核多亲电子前体的缩聚聚合制成，以形成与具有至多一个核心环状结构的水溶性交联剂交联的水溶性聚合物。

6. 发明授权

US5897955A Materials and methods for the immobilization of bioactive species onto polymeric substrates 有权
标题翻译：将生物活性物质固定在聚合物基材上的材料和方法
公开(公告)号：US5897955A
公开(公告)日：1999-04-27
申请号：US138197
申请日：1998-08-21
申请人： Paul D. Drumheller
发明人： Paul D. Drumheller
IPC分类号： A61L27/34 , C07K17/08 , C12N5/00 , C12N11/08 , B32B27/00 , B32B17/06 , G01N33/53
CPC分类号： C07K17/08 , A61L27/34 , C12N11/08 , C12N5/0068 , C12N2533/30 , C12N2533/50 , Y10T428/249958 , Y10T428/31544
摘要： The present invention is directed to support members having surfaces that are rendered hydrophilic for use as a substrate for the immobilization of bioactive species thereon. The hydrophilic surfaces are chemically stable on the support member. The surfaces are also chemically variable to provide a variety of chemically functional groups for immobilization of bioactive species thereto. The surfaces comprise polymeric surfactants attached onto the surfaces of a support member and covalently cross-linked thereon to form a first layer. Hydrophilic polymers are then attached to the first layer on the support member to form a second layer thereon. The second layer is used to enhance the hydrophilicity of a support member, as well as, to provide a substrate for immobilizing bioactive species thereto. Methods for forming the first and second layers are also provided. In addition, methods for attaching bioactive substances to the hydrophilic polymers are provided.
摘要翻译：本发明涉及具有使其具有亲水性的表面的支撑构件，其用作固定生物活性物质的基底。亲水表面在支撑构件上是化学稳定的。表面也是化学变化的，以提供用于将生物活性物质固定化的各种化学官能团。表面包括附着在支撑构件的表面上并且共价交联在其上以形成第一层的聚合物表面活性剂。然后将亲水性聚合物连接到支撑构件上的第一层上以在其上形成第二层。第二层用于增强支撑构件的亲水性，以及提供用于固定生物活性物质的基底。还提供了形成第一层和第二层的方法。此外，提供了将生物活性物质附着到亲水性聚合物上的方法。

7. 发明授权

US09415193B2 Eluting medical devices 有权
标题翻译：洗脱医疗器械
公开(公告)号：US09415193B2
公开(公告)日：2016-08-16
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
IPC分类号： A61M25/10 , A61L29/08 , A61L29/16
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译：本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

8. 发明授权

US08512978B2 Methods and compositions for a microemulsion-based tissue treatment 有权
标题翻译：用于微乳液组织处理的方法和组合物
公开(公告)号：US08512978B2
公开(公告)日：2013-08-20
申请号：US13644655
申请日：2012-10-04
申请人： Brian H. Kram , Christopher Bieniarz , Paul D. Drumheller
发明人： Brian H. Kram , Christopher Bieniarz , Paul D. Drumheller
IPC分类号： G01N1/30 , C12Q1/00 , B01F3/00
CPC分类号： G01N1/30
摘要： The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of intermediary alcohol dehydration or alcohol rehydration compositions.
摘要翻译：本发明涉及用于随后组织染色的石蜡包埋生物样品脱蜡的方法和组合物。组合物是微乳液，其可以包括水/油/表面活性剂微乳液，以及任选的辅助表面活性剂。微乳液能够在不使用二甲苯或甲苯的情况下脱蜡，并且还可以在不使用中间醇脱水或醇补液组合物的情况下进行溶剂交换。

9. 发明申请

US20120035283A9 Expandable Functional TFE Copolymer Fine Powder, the Expanded Functional Products Obtained Therefrom and Reaction of the Expanded Products 有权
标题翻译：可扩展功能性TFE共聚物细粉，膨胀产品获得的膨胀功能产品和扩展产品的反应
公开(公告)号：US20120035283A9
公开(公告)日：2012-02-09
申请号：US12886817
申请日：2010-09-21
申请人： Ping Xu , Jack J. Hegenbarth , Rachel Radspinner , Paul D. Drumheller , William B. Johnson , Wen K. Liu , Xin Kang Chen
发明人： Ping Xu , Jack J. Hegenbarth , Rachel Radspinner , Paul D. Drumheller , William B. Johnson , Wen K. Liu , Xin Kang Chen
IPC分类号： C08J9/16 , C08F214/26
CPC分类号： A61L31/041 , A61L31/048 , A61L31/16 , B01D67/0093 , B01D71/32 , B01J39/18 , B29C55/005 , B29K2027/18 , B29K2105/04 , B29K2995/0092 , C08F14/26 , C08F214/26 , C08F214/262 , C08F214/265 , C08F220/28 , C08F220/50 , C08F228/02 , C08J5/2237 , C08J9/28 , C08J9/35 , C08J2201/0502 , C08J2327/18 , C08L27/18 , C08L2205/02 , Y10T428/31544 , C08L2666/04 , C08F2/22
摘要： A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.
摘要翻译：描述了一种功能性TFE共聚物细粉末，其中TFE共聚物是TFE和至少一种官能共聚单体的聚合物，并且其中TFE共聚物具有垂直于聚合物链的官能团。功能性TFE共聚物细粉末树脂是可挤出和可膨胀的糊状物。还描述了制备功能性TFE共聚物的方法。膨胀的功能性TFE共聚物材料可以在膨胀后进行后反应。

10. 发明申请

US20110065085A1 NOVEL HEPARIN ENTITIES AND METHODS OF USE 审中-公开
标题翻译：新型HEPARIN实体和使用方法
公开(公告)号：US20110065085A1
公开(公告)日：2011-03-17
申请号：US12579308
申请日：2009-10-14
申请人： Roy Biran , Charles D. Claude , Robert L. Cleek , Paul D. Drumheller
发明人： Roy Biran , Charles D. Claude , Robert L. Cleek , Paul D. Drumheller
IPC分类号： C12Q1/527
CPC分类号： A61L33/0011 , A61L27/54 , A61L29/16 , A61L31/022 , A61L31/048 , A61L31/10 , A61L31/16 , A61L33/08 , A61L33/128 , A61L2300/236 , A61L2300/42 , C08L27/12
摘要： The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.
摘要翻译：本发明涉及在操作后保留显着的生物活性的固定的生物活性物质。本发明还包括包含通过至少一个肝素分子结合到底物上的肝素实体的医用底物，其中所述结合的肝素实体是肝素酶-1敏感的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式