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1. 发明申请

US20090186399A1 STREPTOMYCES STRAIN AND THE METHOD OF CONVERTING FERULIC ACID TO VANILLIN BY USING THE SAME 审中-公开
标题翻译：溶菌酶菌株及其使用方法将葡萄糖转化成VANILLIN
公开(公告)号：US20090186399A1
公开(公告)日：2009-07-23
申请号：US12302502
申请日：2007-06-25
申请人： Ping Xu , Dongliang Hua , Shan Lin , Lifu Song , Cuiqing Ma , Zhaobin Zhang , Yi Du , Hong Chen , Lin Gan , Zhonghao Wei , Yiyong Zeng
发明人： Ping Xu , Dongliang Hua , Shan Lin , Lifu Song , Cuiqing Ma , Zhaobin Zhang , Yi Du , Hong Chen , Lin Gan , Zhonghao Wei , Yiyong Zeng
IPC分类号： C12N1/20
CPC分类号： C12R1/465 , C12P7/24
摘要： A method of vanillin production from ferulic acid with a high concentration by biotransformation using a Streptomyces sp. strain is claimed in this invention. This strain is named as Streptomyces sp. V-1, which has been deposited in China Center for Type Culture Collection on Jul. 12, 2006 with the number of CCTCC M 206065. Using this strain, high concentration of vanillin fermentation broth is obtained from ferulic acid by biotransformation in GY biotransformation medium. With the addition of macroporous adsorbent resin DM11, the concentration of vanillin can be greatly improved. The advantage of this invention is less environmental pollution, high product concentration, less by-product, short processing cycle, low production cost, simple product extraction, clean production process, product environmental friendly, safe and reliable, which solves many difficulties in the vanillin production from botanical raw material extraction or chemical synthesis, and therefore it has good application prospect.
摘要翻译：通过使用链霉菌（Streptomyces sp。）通过生物转化从高浓度的阿魏酸生产香草醛的方法。应变在本发明中要求保护。该菌株被命名为Streptomyces sp。 V-1已于2006年7月12日以CCTCC M 206065号存于中国型号培养物中心中心。使用该菌株，通过生物转化在GY生物转化培养基中从阿魏酸获得高浓度的香草醛发酵液。通过添加大孔吸附树脂DM11，可以大大提高香草醛的浓度。本发明的优点是环境污染少，产品浓缩少，加工周期短，生产成本低，产品提取简单，生产过程简单，产品环保，安全可靠，解决了香草醛中的许多困难生产从植物原料提取或化学合成，因此具有良好的应用前景。

2. 发明申请

US20130143286A1 BACILLUS COAGULANS STRAINS AND THEIR APPLICATIONS IN L-LACTIC ACID PRODUCTION 有权
标题翻译：巴豆果酱菌株及其在L-酸生产中的应用
公开(公告)号：US20130143286A1
公开(公告)日：2013-06-06
申请号：US13698708
申请日：2010-11-22
申请人： Ping XU , Limin Wang , Bo Zhao , Cuiqing Ma , Fei Su , Fei Tao , Hongzhi Tang
发明人： Ping XU , Limin Wang , Bo Zhao , Cuiqing Ma , Fei Su , Fei Tao , Hongzhi Tang
IPC分类号： C12N15/75
CPC分类号： C12N15/75 , C12P7/56 , C12P2203/00 , C12R1/07
摘要： The invention is concerned with the strains of B. coagulans for lactic acid production and the related methods, in which the carbon sources are pentose or hexose or the agricultural or industrial wastes containing pentose or hexose or a mixture of both. According to the invention, the highest amount of L-lactic acid produced from glucose is 173 g/L, the optical purity is over 99%, the yield is up to 0.98, and the productivity is up to 2.4 g/L per hour. The highest amount of L-lactic acid produced from xylose is 195 g/L, the optical purity is over 99%, the yield is up to 0.98, and the productivity is up to 2.7 g/L per hour. The highest amount of L-lactic acid produced from reducing sugars in xylitol byproducts is 106 g/L, the optical purity is over 99%, and the productivity is up to 2.08 g/L per hour. The B. coagulans strains XZL4 (DSM No. 23183) and XZL9 (DSM No. 23184) of the invention can directly utilize various reducing sugars in xylitol byproducts to produce high amounts of L-lactic acid, which improves the production efficiency at low costs, and the strains are, thus, appropriate for industrial productions.
摘要翻译：本发明涉及用于乳酸生产的凝固芽孢杆菌菌株及其相关方法，其中碳源为戊糖或己糖，或者含有戊糖或己糖的农业或工业废物或两者的混合物。根据本发明，葡萄糖产生的L-乳酸量最高为173g / L，光学纯度超过99％，产率高达0.98，生产率高达2.4g / L。由木糖产生的L-乳酸含量最高为195g / L，光学纯度超过99％，产率高达0.98，生产率高达2.7g / L。由木糖醇副产物中的还原糖产生的最大量的L-乳酸为106g / L，光学纯度为99％以上，生产率高达每小时2.08g / L。本发明的凝结芽孢杆菌菌株XZL4（DSM No.23183）和XZL9（DSM No.23184）可以直接利用木糖醇副产物中的各种还原糖来生产大量的L-乳酸，以低成本提高生产效率，因此适用于工业生产。

3. 发明授权

US08492127B2 Bacillus coagulans strains and their applications in L-lactic acid production 有权
标题翻译：凝结芽孢杆菌菌株及其在L-乳酸生产中的应用
公开(公告)号：US08492127B2
公开(公告)日：2013-07-23
申请号：US13698708
申请日：2010-11-22
申请人： Ping Xu , Limin Wang , Bo Zhao , Cuiqing Ma , Fei Su , Fei Tao , Hongzhi Tang
发明人： Ping Xu , Limin Wang , Bo Zhao , Cuiqing Ma , Fei Su , Fei Tao , Hongzhi Tang
IPC分类号： C12P7/56
CPC分类号： C12N15/75 , C12P7/56 , C12P2203/00 , C12R1/07
摘要： The invention is concerned with the strains of B. coagulans for lactic acid production and the related methods, in which the carbon sources are pentose or hexose or the agricultural or industrial wastes containing pentose or hexose or a mixture of both. According to the invention, the highest amount of L-lactic acid produced from glucose is 173 g/L, the optical purity is over 99%, the yield is up to 0.98, and the productivity is up to 2.4 g/L per hour. The highest amount of L-lactic acid produced from xylose is 195 g/L, the optical purity is over 99%, the yield is up to 0.98, and the productivity is up to 2.7 g/L per hour. The highest amount of L-lactic acid produced from reducing sugars in xylitol byproducts is 106 g/L, the optical purity is over 99%, and the productivity is up to 2.08 g/L per hour. The B. coagulans strains XZL4 (DSM No. 23183) and XZL9 (DSM No. 23184) of the invention can directly utilize various reducing sugars in xylitol byproducts to produce high amounts of L-lactic acid, which improves the production efficiency at low costs, and the strains are, thus, appropriate for industrial productions.
摘要翻译：本发明涉及用于乳酸生产的凝固芽孢杆菌菌株及其相关方法，其中碳源为戊糖或己糖，或者含有戊糖或己糖的农业或工业废物或两者的混合物。根据本发明，葡萄糖产生的L-乳酸量最高为173g / L，光学纯度超过99％，产率高达0.98，生产率高达2.4g / L。由木糖产生的L-乳酸含量最高为195g / L，光学纯度超过99％，产率高达0.98，生产率高达2.7g / L。由木糖醇副产物中的还原糖产生的最大量的L-乳酸为106g / L，光学纯度为99％以上，生产率高达每小时2.08g / L。本发明的凝结芽孢杆菌菌株XZL4（DSM No.23183）和XZL9（DSM No.23184）可以直接利用木糖醇副产物中的各种还原糖来生产大量的L-乳酸，以低成本提高生产效率，因此适用于工业生产。

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