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1. 发明申请

US20100119454A1 Use of the conserved Drosophila NPFR1 system for uncovering interacting genes and pathways important in nociception and stress response 审中-公开
标题翻译：使用保守的果蝇NPFR1系统揭示相互作用的基因和通路在伤害感受和应激反应中重要
公开(公告)号：US20100119454A1
公开(公告)日：2010-05-13
申请号：US12590159
申请日：2009-11-03
申请人： Ping Shen , Jie Xu , Mo Li
发明人： Ping Shen , Jie Xu , Mo Li
IPC分类号： A61K49/00 , A01K67/00 , C12Q1/02 , C12N5/00
CPC分类号： A61K49/0008 , A01K67/0339 , A01K2217/058 , A01K2217/072 , A01K2227/706 , A01K2267/03 , C07K14/43581 , C07K14/705 , G01N33/5017 , G01N33/5085
摘要： The present disclosure provides methods of identifying compositions capable of inhibiting responses to stressors in an organism, as well as recombinant cells and organisms useful in identifying compositions capable of inhibiting responses to stressors in an organism.
摘要翻译：本公开提供了鉴定能够抑制对生物体中的应激源的反应的组合物的方法，以及可用于鉴定能够抑制对生物体中的应激物的反应的组合物的重组细胞和生物体的方法。

2. 发明授权

US09925481B2 Filter cartridge endplate with integrated flow structure 有权
公开(公告)号：US09925481B2
公开(公告)日：2018-03-27
申请号：US14372834
申请日：2012-02-23
申请人： Penghua Hou , Yiyun Zhang , Ping Shen , Kevin C. South , Ismail Bagci , Charles W. Hawkins , Gerard Malgorn , Zemin Jiang
发明人： Penghua Hou , Yiyun Zhang , Ping Shen , Kevin C. South , Ismail Bagci , Charles W. Hawkins , Gerard Malgorn , Zemin Jiang
IPC分类号： B01D35/00 , B01D35/28 , B01D27/00 , B01D27/06 , B01D29/07 , B01D35/30 , B01D29/58 , B01D29/23
CPC分类号： B01D35/30 , B01D29/23 , B01D29/58 , B01D2201/291 , B01D2201/295
摘要： A filter cartridge endplate (12) is described herein that has an integrated flow structure. For example, the integrated flow structure has concentric flow portions disposed at a center of the endplate (12), where a separator (10) is built into the endplate (12) that separates fluid flow. The endplate (12) includes a plate with a major surface, a separator (10) that protrudes axially away from the major surface. The separator (10) includes a first flow portion (14) and a second flow portion (16), where the first flow portion (14) is disposed radially inward relative to the second flow portion (16). The first flow portion (14) includes a channel (22) and the second flow portion includes a channel (24). The respective channels (22,24) are configured to allow axial fluid flow relative to the plate, and configured to allow fluid flow that is localized toward the center of the plate (12).

3. 发明申请

US20110052099A1 FOLDABLE BAMBOO BAG AND METHOD OF CONSTRUCTING THE SAME 审中-公开
标题翻译：可折叠的BAMBOO袋及其构造方法
公开(公告)号：US20110052099A1
公开(公告)日：2011-03-03
申请号：US12551564
申请日：2009-09-01
申请人： Ping Shen
发明人： Ping Shen
IPC分类号： B65D33/06
CPC分类号： A45C3/001 , A45C7/0077
摘要： A bag, such as a grocery bag, a gift bag, etc., is formed of bamboo, and other fabric preferably bio-degradable fabric or non-woven material. The bamboo bag is foldable or can be rolled. It includes a continuous panel of bamboo that extends from the top of one side, downwards and then back up to the top of the other side should then form a somewhat U-shape. The bottom of this “U” will form a somewhat semi-rigid bottom that will fold inwards which allows the bag to be rolled up. The space is enclosed by two side panels and the inside of the bag may be covered with a fabric or non-woven material.
摘要翻译：诸如杂货袋，礼品袋等的袋子由竹子和其它织物优选生物可降解织物或无纺布材料形成。竹袋可折叠或可滚动。它包括从一侧的顶部，向下延伸到另一侧的顶部的连续的竹板，然后应该形成一个U形。这个“U”的底部将形成一个稍微半刚性的底部，它会向内折叠，这样可以使袋子卷起来。该空间由两个侧板包围，袋的内部可以用织物或无纺布材料覆盖。

4. 发明申请

US20150096932A1 Filter Cartridge Endplate with Integrated Flow Structure 有权
标题翻译：带集成流量结构的滤芯式端板
公开(公告)号：US20150096932A1
公开(公告)日：2015-04-09
申请号：US14372834
申请日：2012-02-23
申请人： Penghua Hou , Yiyun Zhang , Ping Shen , Kevin C. South , Ismail Bagci , Charles W. Hawkins , Gerard Malgorn , Zemin Jiang
发明人： Penghua Hou , Yiyun Zhang , Ping Shen , Kevin C. South , Ismail Bagci , Charles W. Hawkins , Gerard Malgorn , Zemin Jiang
IPC分类号： B01D35/30 , B01D29/23
CPC分类号： B01D35/30 , B01D29/23 , B01D29/58 , B01D2201/291 , B01D2201/295
摘要： A filter cartridge endplate (12) is described herein that has an integrated flow structure. For example, the integrated flow structure has concentric flow portions disposed at a center of the endplate (12), where a separator (10) is built into the endplate (12) that separates fluid flow. The endplate (12) includes a plate with a major surface, a separator (10) that protrudes axially away from the major surface. The separator (10) includes a first flow portion (14) and a second flow portion (16), where the first flow portion (14) is disposed radially inward relative to the second flow portion (16). The first flow portion (14) includes a channel (22) and the second flow portion includes a channel (24). The respective channels (22,24) are configured to allow axial fluid flow relative to the plate, and configured to allow fluid flow that is localized toward the center of the plate (12).
摘要翻译：本文描述了具有集成流动结构的过滤器滤芯端板（12）。例如，集成流动结构具有设置在端板（12）的中心处的同心流动部分，其中分离器（10）内置在分离流体流动的端板（12）中。端板（12）包括具有主表面的板，从主表面轴向突出的隔板（10）。分离器（10）包括第一流动部分（14）和第二流动部分（16），其中第一流动部分（14）相对于第二流动部分（16）径向向内设置。第一流动部分（14）包括通道（22），第二流动部分包括通道（24）。相应的通道（22,24）构造成允许相对于板的轴向流体流动，并且构造成允许朝向板（12）的中心定位的流体流动。

5. 发明申请

US20050118290A1 Compositions and method for treatment of steroid/nuclear receptor-mediated diseases 审中-公开
标题翻译：用于治疗类固醇/核受体介导的疾病的组合物和方法
公开(公告)号：US20050118290A1
公开(公告)日：2005-06-02
申请号：US10727020
申请日：2003-12-02
申请人： Eu Leong Yong , Toon Ng , Ping Shen , Wan Heng , Yinhan Gong
发明人： Eu Leong Yong , Toon Ng , Ping Shen , Wan Heng , Yinhan Gong
IPC分类号： A23L1/30 , A61K31/352 , A61K36/00 , A61K36/481 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61K35/78
CPC分类号： A61K36/481
摘要： Compositions and method for treatment of steroid/nuclear receptor-mediated diseases. The present invention relates to non-aqueous extracts of Astragalus Membranaceus (HQ) and to compositions thereof. Also provided is a method for the treatment of PPAR-mediated physiological conditions comprising administering to a subject an effective amount of at least one of the above mentioned extracts and also a method for augmenting or synergising the activity of ligands of steroid/nuclear receptors comprising administering to a subject an effective amount of at least one of: an extract of Astragalus Membranaceus (HQ) or a flavonoid compound; in the presence of at least one ligand of steroid/nuclear receptors.
摘要翻译：用于治疗类固醇/核受体介导的疾病的组合物和方法。本发明涉及黄芪（HQ）的非水提取物及其组合物。还提供了用于治疗PPAR介导的生理病症的方法，包括向受试者施用有效量的至少一种上述提取物，以及增加或协同类固醇/核受体配体的活性的方法，包括施用向主题提供有效量的以下至少一种：黄芪提取物（HQ）或类黄酮化合物; 在存在至少一种类固醇/核受体的配体的情况下。

6. 发明授权

US5217879A Infectious Sindbis virus vectors 失效
标题翻译：传染性辛德毕斯病毒载体
公开(公告)号：US5217879A
公开(公告)日：1993-06-08
申请号：US815602
申请日：1991-12-27
申请人： Henry V. Huang , Robin Levis , Charles M. Rice , Sondra Schlesinger , Ping Shen , Cheng Xiong
发明人： Henry V. Huang , Robin Levis , Charles M. Rice , Sondra Schlesinger , Ping Shen , Cheng Xiong
IPC分类号： C12N7/01 , C12N15/86
CPC分类号： C12N15/86 , C12N2760/18843
摘要： Compositions and methods are disclosed for expressing heterologous coding sequences in host cells. The compositions include infectious Sindbis virus RNA molecules containing at least one heterologous coding sequence inserted within the structural region of the Sindbis virus genome. RNA molecules consisting essentially of a Sindbis virus junction region are also provided. Methods utilizing the novel compositions of the present invention to express heterologous coding sequences in transformed host cells are provided. Methods for producing infectious Sindbis virus particles containing infectious Sindbis virus RNA molecules comprising at least one heterologous coding sequence are provided.This invention was made with government support under grant numbers AI24134, AI11377 and AG05681 awarded by the National Institutes of Health. The government has certain rights in the invention.
摘要翻译：公开了用于在宿主细胞中表达异源编码序列的组合物和方法。组合物包括感染性的辛德比斯病毒RNA分子，其含有插入在辛德比斯病毒基因组的结构区域内的至少一个异源编码序列。还提供了基本上由辛德毕斯病毒连接区组成的RNA分子。提供了利用本发明新组合物在转化的宿主细胞中表达异源编码序列的方法。提供了包含至少一种异源编码序列的含感染性辛德毕斯病毒RNA分子的感染性辛德比斯病毒颗粒的方法。

7. 发明申请

US20140124459A1 NO FILTER NO RUN FEATURE FOR FILTER 审中-公开
标题翻译：无过滤器无过滤功能
公开(公告)号：US20140124459A1
公开(公告)日：2014-05-08
申请号：US14112615
申请日：2011-05-11
申请人： Hanhao Li , Ping Shen , Penghua Hou , Chunxi Wang
发明人： Hanhao Li , Ping Shen , Penghua Hou , Chunxi Wang
IPC分类号： B01D35/157 , F16K1/14
CPC分类号： B01D35/1573 , B01D29/21 , B01D29/96 , B01D35/153 , B01D46/2414 , B01D2201/291 , B01D2201/4046 , F16K1/14 , F16K15/04 , F16K15/044 , F16K15/046
摘要： A filter cartridge is provided that is designed to actuate a valve that controls fluid flow into an outlet for discharging filtered fluid. The valve receives a ball at a first position which is axially movable between the first position and a second position. If a filter cartridge is not installed or an inappropriately designed filter cartridge is installed, the ball is moved from the first position to the second position to seal an outlet opening of the outlet. If the described filter cartridge is installed, the ball is retained at the first position by a holding member and the valve allows filtered fluid flow into the outlet opening.
摘要翻译：提供了一种过滤器滤芯，其被设计成致动一个控制流体流入出口以排出过滤流体的阀门。阀在第一位置处接收球，该第一位置可在第一位置和第二位置之间轴向移动。如果未安装过滤器滤芯或安装了不适当设计的过滤器滤芯，则球从第一位置移动到第二位置以密封出口的出口。如果安装了所描述的过滤器滤芯，则球通过保持构件保持在第一位置，并且阀允许过滤的流体流入出口。

8. 发明申请

US20070213280A1 Steroidal Saponins Compound, the Process for Producing the Same and the Use Thereof 审中-公开
标题翻译：甾体皂苷化合物，其生产方法及其用途
公开(公告)号：US20070213280A1
公开(公告)日：2007-09-13
申请号：US10599156
申请日：2005-03-22
申请人： Xinsheng Yao , Lianda Li , Naili Wang , Rongli Zhang , Haifeng Chen , Ping Shen , Gexia Qu
发明人： Xinsheng Yao , Lianda Li , Naili Wang , Rongli Zhang , Haifeng Chen , Ping Shen , Gexia Qu
IPC分类号： A61K31/7048 , C07H15/24 , C07J17/00
CPC分类号： A61K31/7048 , C07J71/00
摘要： The present invention relates to a steroidal saponins compound, and the preparation and application in curing cardiovascular diseases, such as miocardial infarction, etc. The chemical structure of the steroidal saponins compound is as (I) or (II): wherein, R1=β-D-glucose; R2=straight or bifurcate sugar chains; R3═H or CH3. In this invention, by various ways of separation, the steroidal saponins compound with chemical structure of (I) or (II) could be extracted, synthesized or semi-synthesized process from traditional Chinese medicine and natural products. Oral dosage drug or non-oral dosage drug was produced by the single steroidal saponins compound or the mixture of these compounds in vary ratio, the drug can be used to prevention and cure the diseases miocardial infarction, coronary artery disease, heart angina, arrhythmia, blood losing of cardiac muscle, hypertension, hyperlipaemia and ropy blood, etc. In structure (I) and (II), R1=β-D-glucose; R2=straight or bifurcate sugar chains; R3═H or CH
摘要翻译：本发明涉及一种类固醇皂苷化合物，以及其治疗心血管疾病如心肌梗塞等的制备和应用。甾体皂苷化合物的化学结构为（I）或（II）：其中R _{1 =β-D-葡萄糖; R 2 =直链或双叉糖; R 3 -H或CH 3 3。在本发明中，通过各种分离方式，可以从中药和天然产物中提取，合成或半合成的具有（I）或（II）化学结构的甾体皂苷化合物。口服药物或非口服药物由单一甾体皂苷化合物或这些化合物的混合物产生不同比例，该药物可用于预防和治疗心肌梗塞，冠状动脉疾病，心绞痛，心律失常，血液中失去心肌，高血压，高脂血症和血红蛋白等。在结构（I）和（II）中，R 1 =β-D-葡萄糖; R 2 =直链或双叉糖; R 3 -H或CH}

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