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1. 发明授权

US5217879A Infectious Sindbis virus vectors 失效
标题翻译：传染性辛德毕斯病毒载体
公开(公告)号：US5217879A
公开(公告)日：1993-06-08
申请号：US815602
申请日：1991-12-27
申请人： Henry V. Huang , Robin Levis , Charles M. Rice , Sondra Schlesinger , Ping Shen , Cheng Xiong
发明人： Henry V. Huang , Robin Levis , Charles M. Rice , Sondra Schlesinger , Ping Shen , Cheng Xiong
IPC分类号： C12N7/01 , C12N15/86
CPC分类号： C12N15/86 , C12N2760/18843
摘要： Compositions and methods are disclosed for expressing heterologous coding sequences in host cells. The compositions include infectious Sindbis virus RNA molecules containing at least one heterologous coding sequence inserted within the structural region of the Sindbis virus genome. RNA molecules consisting essentially of a Sindbis virus junction region are also provided. Methods utilizing the novel compositions of the present invention to express heterologous coding sequences in transformed host cells are provided. Methods for producing infectious Sindbis virus particles containing infectious Sindbis virus RNA molecules comprising at least one heterologous coding sequence are provided.This invention was made with government support under grant numbers AI24134, AI11377 and AG05681 awarded by the National Institutes of Health. The government has certain rights in the invention.
摘要翻译：公开了用于在宿主细胞中表达异源编码序列的组合物和方法。组合物包括感染性的辛德比斯病毒RNA分子，其含有插入在辛德比斯病毒基因组的结构区域内的至少一个异源编码序列。还提供了基本上由辛德毕斯病毒连接区组成的RNA分子。提供了利用本发明新组合物在转化的宿主细胞中表达异源编码序列的方法。提供了包含至少一种异源编码序列的含感染性辛德毕斯病毒RNA分子的感染性辛德比斯病毒颗粒的方法。

2. 发明授权

US06943246B2 3′terminal sequence of hepatitis C virus genome and diagnostic and therapeutic uses thereof 失效
标题翻译：丙型肝炎病毒基因组的3'末端序列及其诊断和治疗用途
公开(公告)号：US06943246B2
公开(公告)日：2005-09-13
申请号：US10158314
申请日：2002-05-30
申请人： Charles M. Rice , Alexander A. Kolykhalov
发明人： Charles M. Rice , Alexander A. Kolykhalov
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K38/21 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P31/00 , A61P31/12 , A61P31/20 , A61P35/00 , C07K14/18 , C12N5/08 , C12N5/10 , C12N7/00 , C12N15/09 , C12Q1/70 , G01N33/566 , G01N33/576 , C07H71/04 , A61K39/29
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K2319/00 , C12N2770/24222 , C12Q1/707
摘要： The invention relates to the discovery of a novel RNA sequence at the 3′ terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3′ sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
摘要翻译：本发明涉及在丙型肝炎病毒（HCV）基因组RNA的3'末端序列上发现新的RNA序列。本发明包括3'序列，其补体及其用于基于核酸的诊断和用于开发和评估新型抗HCV疗法的用途。在HCV基因型之间保守的该序列元件可能对于病毒复制是必需的，并且是构建能够产生感染性RNA，后代病毒或复制能力的HCV复制子的全长HCV cDNA克隆所必需的。这种功能性克隆是用于评价治疗方法的有用工具，以及用于开发用于针对HCV接种的候选减毒或灭活的HCV衍生物的底物。

3. 发明授权

US06297003B1 Methods for the detection of a novel hepatitis C virus (HCV) terminal 3′ noncoding region 失效
标题翻译：检测新型丙型肝炎病毒（HCV）终端3'非编码区的方法
公开(公告)号：US06297003B1
公开(公告)日：2001-10-02
申请号：US08897126
申请日：1997-07-18
申请人： Charles M. Rice , Alexander A. Kolykhalov
发明人： Charles M. Rice , Alexander A. Kolykhalov
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K2319/00 , C12N2770/24222 , C12Q1/707
摘要： The invention relates to the discovery of a novel RNA sequence at the 3′ terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3′ sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
摘要翻译：本发明涉及在丙型肝炎病毒（HCV）基因组RNA的3'末端序列上发现新的RNA序列。本发明包括3'序列，其补体及其用于基于核酸的诊断和用于开发和评估新型抗HCV疗法的用途。在HCV基因型之间保守的该序列元件可能对于病毒复制是必需的，并且是构建能够产生感染性RNA，后代病毒或复制能力的HCV复制子的全长HCV cDNA克隆所必需的。这种功能性克隆是用于评价治疗方法的有用工具，以及用于开发用于针对HCV接种的候选减毒或灭活的HCV衍生物的底物。

4. 发明授权

US3938311A Yarn stop-motion device 失效
标题翻译：纱线停止运动装置
公开(公告)号：US3938311A
公开(公告)日：1976-02-17
申请号：US472829
申请日：1974-05-23
申请人： Charles M. Rice
发明人： Charles M. Rice
IPC分类号： D01H13/18 , D01H13/16
CPC分类号： D01H13/188 , Y10T225/393
摘要： A yarn stop-motion device for use with a yarn-processing apparatus comprising yarn break-detector means and yarn-severing means positioned close to each other and preferably combined in a single unit. This device is characterized in that the point at which the yarn break is detected by the device and the point at which the yarn is severed by the device are both positioned above or on the same side of the yarn-processing apparatus associated with the device.
摘要翻译：一种与纱线处理装置一起使用的纱线停止运动装置，包括断纱检测装置和彼此靠近并优选组合在一个单元中的纱线切断装置。该装置的特征在于，通过装置检测到纱线断裂的点和由装置切断纱线的点都位于与装置相关联的纱线处理装置的同一侧上或与纱线处理装置相同的一侧。

5. 发明申请

US20080213750A1 HCV Variants and Related Methods 有权
标题翻译： HCV变异及相关方法
公开(公告)号：US20080213750A1
公开(公告)日：2008-09-04
申请号：US11960391
申请日：2007-12-19
申请人： Charles M. Rice , Keril J. Blight
发明人： Charles M. Rice , Keril J. Blight
IPC分类号： C12Q1/70 , C12N15/00 , C12N15/82 , C12N5/02 , C12N5/00
CPC分类号： C12Q1/707
摘要： HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. Expression vectors comprising the above polynucleotides and HCV variants are also described, as are the provision of cells and host cells comprising the expression vectors. Methods for identifying a cell line that is permissive for infection with HCV are also provided, as are vaccines comprising the above polynucleotides in a pharmaceutically acceptable carrier. Additionally, methods for inducing immunoprotection to HCV in a primate are described, as are methods for testing a compound for inhibiting HCV replication.
摘要翻译：描述了HCV变体。变体包括包含非天然存在的HCV序列和HCV变体的多核苷酸，其具有转染效率和能够存活大于具有野生型多蛋白编码区的HCV的亚临床的能力。还描述了包含上述多核苷酸和HCV变体的表达载体，以及提供包含表达载体的细胞和宿主细胞。还提供了鉴定用于感染HCV的细胞系的方法，以及在药学上可接受的载体中包含上述多核苷酸的疫苗。此外，还描述了在灵长类动物中诱导HCV的免疫保护的方法，以及用于测试抑制HCV复制的化合物的方法。

6. 发明授权

US07338759B1 HCV variants 有权
标题翻译： HCV变体
公开(公告)号：US07338759B1
公开(公告)日：2008-03-04
申请号：US10276051
申请日：2001-05-23
申请人： Charles M. Rice , Keril J. Blight
发明人： Charles M. Rice , Keril J. Blight
IPC分类号： C12Q1/70 , C12Q1/68 , C12N15/09 , C12P21/00 , C12N7/02 , C12N5/10 , C07H21/00
CPC分类号： A61K39/12 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2770/24222 , C12N2770/24243 , C12N2770/24251 , C12Q1/18 , G01N2333/18 , G01N2500/10
摘要： HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. Expression vectors comprising the above polynucleotides and HCV variants are also described, as are the provision of cells and host cells comprising the expression vectors. Methods for identifying a cell line that is permissive for infection with HCV are also provided, as are vaccines comprising the above polynucleotides in a pharmaceutically acceptable carrier. Additionally, methods for inducing immunoprotection to HCV in a primate are described, as are methods for testing a compound for inhibiting HCV replication.
摘要翻译：描述了HCV变体。变体包括包含非天然存在的HCV序列和HCV变体的多核苷酸，其具有转染效率和能够存活大于具有野生型多蛋白编码区的HCV的亚临床的能力。还描述了包含上述多核苷酸和HCV变体的表达载体，以及提供包含表达载体的细胞和宿主细胞。还提供了鉴定用于感染HCV的细胞系的方法，以及在药学上可接受的载体中包含上述多核苷酸的疫苗。此外，还描述了在灵长类动物中诱导HCV的免疫保护的方法，以及用于测试抑制HCV复制的化合物的方法。

7. 发明授权

US5874565A Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus 失效
标题翻译：核酸包含丙型肝炎病毒的高度保守的新型3末端序列元件
公开(公告)号：US5874565A
公开(公告)日：1999-02-23
申请号：US520678
申请日：1995-08-29
申请人： Charles M. Rice , Alexander A. Kolykhalov
发明人： Charles M. Rice , Alexander A. Kolykhalov
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K38/21 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P31/00 , A61P31/12 , A61P31/20 , A61P35/00 , C07K14/18 , C12N5/08 , C12N5/10 , C12N7/00 , C12N15/09 , C12Q1/70 , G01N33/566 , G01N33/576 , C07H21/02 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： C07K14/005 , C12Q1/707 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2770/24222
摘要： The invention relates to the discovery of a novel RNA sequence at the 3' terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3' sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infections RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
摘要翻译：本发明涉及在丙型肝炎病毒（HCV）基因组RNA的3'末端序列上发现新的RNA序列。本发明包括3'序列，其补体及其用于基于核酸的诊断和用于开发和评估新型抗HCV疗法的用途。在HCV基因型之间保守的该序列元件可能对于病毒复制是必需的，并且构建能够产生感染RNA，后代病毒或复制能力的HCV复制子的全长HCV cDNA克隆所需的序列元件。这种功能性克隆是用于评价治疗方法的有用工具，以及用于开发用于针对HCV接种的候选减毒或灭活的HCV衍生物的底物。

8. 发明授权

US4007519A Indicating device for yarn crimping wheel teeth spacing adjustment 失效
标题翻译：纱线卷曲轮齿间距调整指示装置
公开(公告)号：US4007519A
公开(公告)日：1977-02-15
申请号：US594940
申请日：1975-07-11
申请人： Charles M. Rice
发明人： Charles M. Rice
IPC分类号： D02G1/14
CPC分类号： D02G1/14
摘要： In synthetic yarn texturing using crimping wheels, an indicating device is provided to aid in adjusting the peripheral spacing between the teeth of the wheels.
摘要翻译：在使用卷边轮的合成纱线纹理中，提供指示装置以帮助调节车轮齿之间的周边间距。

9. 发明授权

US07794942B2 Cell lines permissive for HCV replication 有权
标题翻译：允许HCV复制的细胞系
公开(公告)号：US07794942B2
公开(公告)日：2010-09-14
申请号：US11960391
申请日：2007-12-19
申请人： Charles M. Rice , Keril J. Blight
发明人： Charles M. Rice , Keril J. Blight
IPC分类号： C12Q1/68 , C12N15/00 , C12N5/10 , C12N15/51
CPC分类号： C12Q1/707
摘要： HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. Expression vectors comprising the above polynucleotides and HCV variants are also described, as are the provision of cells and host cells comprising the expression vectors. Methods for identifying a cell line that is permissive for infection with HCV are also provided, as are vaccines comprising the above polynucleotides in a pharmaceutically acceptable carrier. Additionally, methods for inducing immunoprotection to HCV in a primate are described, as are methods for testing a compound for inhibiting HCV replication.
摘要翻译：描述了HCV变体。变体包括包含非天然存在的HCV序列和HCV变体的多核苷酸，其具有转染效率和能够存活大于具有野生型多蛋白编码区的HCV的亚临床的能力。还描述了包含上述多核苷酸和HCV变体的表达载体，以及提供包含表达载体的细胞和宿主细胞。还提供了鉴定用于感染HCV的细胞系的方法，以及在药学上可接受的载体中包含上述多核苷酸的疫苗。此外，还描述了在灵长类动物中诱导HCV的免疫保护的方法，以及用于测试抑制HCV复制的化合物的方法。

10. 发明授权

US07235394B1 Functional DNA clone for hepatitis C virus (HCV) and uses thereof 有权
标题翻译：丙型肝炎病毒（HCV）的功能性DNA克隆及其用途
公开(公告)号：US07235394B1
公开(公告)日：2007-06-26
申请号：US10704407
申请日：2003-11-06
申请人： Charles M. Rice , Alexander A. Kolykhalov
发明人： Charles M. Rice , Alexander A. Kolykhalov
IPC分类号： C12N7/00 , C12N7/02 , C12N5/10 , C12P21/00 , C07H21/04
CPC分类号： C12N7/00 , A61K39/00 , C12N2710/24143 , C12N2770/24211 , C12N2770/24222 , C12N2840/203
摘要： The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in therapeutic, vaccine, and diagnostic applications. The invention is also directed to HCV vectors, e.g., for gene therapy of gene vaccines.
摘要翻译：本发明涉及真正的HCV基因组RNA序列的确定，感染性HCV DNA克隆的构建以及将克隆或其衍生物用于治疗，疫苗和诊断应用中的用途。本发明还涉及HCV载体，例如用于基因疫苗的基因治疗。

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