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1. 发明申请

US20070213280A1 Steroidal Saponins Compound, the Process for Producing the Same and the Use Thereof 审中-公开
标题翻译：甾体皂苷化合物，其生产方法及其用途
公开(公告)号：US20070213280A1
公开(公告)日：2007-09-13
申请号：US10599156
申请日：2005-03-22
申请人： Xinsheng Yao , Lianda Li , Naili Wang , Rongli Zhang , Haifeng Chen , Ping Shen , Gexia Qu
发明人： Xinsheng Yao , Lianda Li , Naili Wang , Rongli Zhang , Haifeng Chen , Ping Shen , Gexia Qu
IPC分类号： A61K31/7048 , C07H15/24 , C07J17/00
CPC分类号： A61K31/7048 , C07J71/00
摘要： The present invention relates to a steroidal saponins compound, and the preparation and application in curing cardiovascular diseases, such as miocardial infarction, etc. The chemical structure of the steroidal saponins compound is as (I) or (II): wherein, R1=β-D-glucose; R2=straight or bifurcate sugar chains; R3═H or CH3. In this invention, by various ways of separation, the steroidal saponins compound with chemical structure of (I) or (II) could be extracted, synthesized or semi-synthesized process from traditional Chinese medicine and natural products. Oral dosage drug or non-oral dosage drug was produced by the single steroidal saponins compound or the mixture of these compounds in vary ratio, the drug can be used to prevention and cure the diseases miocardial infarction, coronary artery disease, heart angina, arrhythmia, blood losing of cardiac muscle, hypertension, hyperlipaemia and ropy blood, etc. In structure (I) and (II), R1=β-D-glucose; R2=straight or bifurcate sugar chains; R3═H or CH
摘要翻译：本发明涉及一种类固醇皂苷化合物，以及其治疗心血管疾病如心肌梗塞等的制备和应用。甾体皂苷化合物的化学结构为（I）或（II）：其中R _{1 =β-D-葡萄糖; R 2 =直链或双叉糖; R 3 -H或CH 3 3。在本发明中，通过各种分离方式，可以从中药和天然产物中提取，合成或半合成的具有（I）或（II）化学结构的甾体皂苷化合物。口服药物或非口服药物由单一甾体皂苷化合物或这些化合物的混合物产生不同比例，该药物可用于预防和治疗心肌梗塞，冠状动脉疾病，心绞痛，心律失常，血液中失去心肌，高血压，高脂血症和血红蛋白等。在结构（I）和（II）中，R 1 =β-D-葡萄糖; R 2 =直链或双叉糖; R 3 -H或CH}

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