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1. 发明授权

US06682702B2 Apparatus and method for simultaneously conducting multiple chemical reactions 有权
标题翻译：同时进行多次化学反应的装置和方法
公开(公告)号：US06682702B2
公开(公告)日：2004-01-27
申请号：US09938909
申请日：2001-08-24
申请人： Phillip W. Barth , Douglas A. Amorese , Carol T. Schembri
发明人： Phillip W. Barth , Douglas A. Amorese , Carol T. Schembri
IPC分类号： B01L300
CPC分类号： G01N35/028 , G01N2035/00158 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A method and apparatus for simultaneously conducting multiple chemical reactions combine a test sample with a chemical reactant in a plurality of closed reaction chambers to produce reaction products. The method comprises assembling a plate having the test sample in a plurality of spatially arranged wells with a microarray of similarly spatially arranged surface bound chemical reactants to form the sealed apparatus having the plurality of closed reaction chambers. The apparatus is sealed such that it is gas, liquid and/or fluid tight. The seal may be accomplished with a flexible array substrate or a flexible gasket, and one or more of mechanical clamps, external fluid pressure, radiation, heat, vacuum and an adhesive. The sealed apparatus can be subjected to various reaction conditions, such as intense mechanical agitation and a controlled temperature environment. A kit comprises one or more of the elements of the apparatus.
摘要翻译：用于同时进行多个化学反应的方法和装置将测试样品与多个封闭反应室中的化学反应物组合以产生反应产物。该方法包括将具有测试样品的板组装在具有类似空间布置的表面结合的化学反应物的微阵列的多个空间排列的孔中，以形成具有多个封闭反应室的密封装置。该装置被密封，使得其是气体，液体和/或流体密封的。密封可以用柔性阵列基底或柔性垫片以及机械夹具，外部流体压力，辐射，热量，真空和粘合剂中的一种或多种完成。密封装置可以经受各种反应条件，例如强烈的机械搅拌和受控的温度环境。套件包括装置的一个或多个元件。

2. 发明授权

US06399394B1 Testing multiple fluid samples with multiple biopolymer arrays 失效
标题翻译：用多个生物聚合物阵列测试多个流体样品
公开(公告)号：US06399394B1
公开(公告)日：2002-06-04
申请号：US09343645
申请日：1999-06-30
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N110
CPC分类号： B01L3/5025 , B01L3/5027 , B01L9/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0803 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

3. 发明授权

US07537936B2 Method of testing multiple fluid samples with multiple biopolymer arrays 失效
标题翻译：用多个生物聚合物阵列测试多个流体样品的方法
公开(公告)号：US07537936B2
公开(公告)日：2009-05-26
申请号：US11136227
申请日：2005-05-23
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N30/00
CPC分类号： B01L3/502 , B01L3/5025 , B01L7/00 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0803 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

4. 发明授权

US07247497B2 Testing multiple fluid samples with multiple biopolymer arrays 有权
标题翻译：用多个生物聚合物阵列测试多个流体样品
公开(公告)号：US07247497B2
公开(公告)日：2007-07-24
申请号：US10160620
申请日：2002-05-31
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N30/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L9/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0803 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

5. 发明授权

US06461812B2 Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
标题翻译：用于制造生物分子阵列的方法和多储层装置
公开(公告)号：US06461812B2
公开(公告)日：2002-10-08
申请号：US09150507
申请日：1998-09-09
申请人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
发明人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12Q168
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B41J2/14145 , B41J2002/14387 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.
摘要翻译：用于将多个不同生物材料输送到接收表面上的离散位置上的装置，例如制造不同生物材料的阵列，包括孔口构件中的多个孔，至少六个输送腔，其各自与所述孔中的至少一个，多个储存器，每个储存器各自与至少一个输送室流体连通，与每个孔相关联的装置，用于将流体从与所述孔流体导通关系的输送室相推进，以及用于通常排放至少两个储存器的通风口。在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

6. 发明授权

US07026124B2 Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
标题翻译：用于制造生物分子阵列的方法和多储层装置
公开(公告)号：US07026124B2
公开(公告)日：2006-04-11
申请号：US10267913
申请日：2002-10-08
申请人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
发明人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12Q1/68 , C12M1/00 , G01N15/06 , B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B41J2/14145 , B41J2002/14387 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Methods and apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological materials. The apparatus and methods may include a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.
摘要翻译：用于将多种不同生物材料递送到接收表面上的离散位置上的方法和装置，例如制造不同生物材料的阵列。该装置和方法可以包括孔口构件中的多个孔口，至少六个输送腔室，其各自与至少一个孔口形成流体传导关系;多个储存器，每个储存器与至少一个输送室流体连通，与每个孔口相关联的装置，用于将流体从与所述孔口处于流体导通关系的输送室相关联的孔口推进，以及用于通常排放至少两个储存器的通风口。在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

7. 发明申请

US20080171397A1 Multiple analyte detection systems and methods of detecting multiple analytes 有权
标题翻译：多种分析物检测系统和检测多种分析物的方法
公开(公告)号：US20080171397A1
公开(公告)日：2008-07-17
申请号：US11653568
申请日：2007-01-16
申请人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
发明人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
IPC分类号： G01N21/76
CPC分类号： G01N21/78 , G01N21/253 , G01N21/8483
摘要： A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
摘要翻译：多分析物检测系统包括具有在其上设置的试剂的载体，其中每种试剂能够响应于暴露于相应分析物而光学变化。该系统还包括光电检测器，其被定位成共同检测与每个试剂相互作用的光;处理器，用于响应于总体检测的光来确定每个分析物的存在或不存在;以及指示器，存在或不存在每种分析物。检测多种分析物的方法包括将暴露于相应分析物的样品响应于能够进行光学变化的试剂露出。该方法还包括共同检测与每种试剂相互作用的光，响应于共同检测的光，确定每种分析物的存在或不存在，并指示所确定的每种分析物的存在或不存在。

8. 发明授权

US07300798B2 Chemical arrays 失效
标题翻译：化学阵列
公开(公告)号：US07300798B2
公开(公告)日：2007-11-27
申请号：US10167662
申请日：2001-10-18
申请人： Michel G. M. Perbost , Steven M. Lefkowitz , Roy H. Kanemoto , Carol T. Schembri
发明人： Michel G. M. Perbost , Steven M. Lefkowitz , Roy H. Kanemoto , Carol T. Schembri
IPC分类号： G01N30/00
CPC分类号： B01J19/0046 , Y10T436/110833 , Y10T436/143333 , Y10T436/25
摘要： A method and apparatus for using arrays of polymers each having a pattern of features over a corresponding array region on a surface of a flexible elongated web. In this method each array region may be exposed to a corresponding continuous volume of a sample fluid. A method and apparatus are also provided for reading arrays disposed along a surface of a flexible elongated web. In one such method the web with the arrays thereon may be transported in a lengthwise direction past a reading location at which a characteristic of the features is read, while restraining the web on both surfaces on either side of the reading location to assist in maintaining the reading location flat.
摘要翻译：一种使用聚合物阵列的方法和装置，每个聚合物阵列具有在柔性细长网的表面上的相应阵列区域上的特征图案。在该方法中，每个阵列区域可以暴露于相应的连续体积的样品流体。还提供了一种用于读取沿着柔性细长网的表面设置的阵列的方法和装置。在一种这样的方法中，其上具有阵列的幅材可以沿长度方向传送通过读取特征的特征的读取位置，同时在读取位置的任一侧的两个表面上限制纸幅以帮助维持阅读位置平坦。

9. 发明授权

US06884580B2 Fabricating biopolymer arrays 失效
公开(公告)号：US06884580B2
公开(公告)日：2005-04-26
申请号：US10059957
申请日：2001-11-26
申请人： Michael P. Caren , Carol T. Schembri , Peter G. Webb
发明人： Michael P. Caren , Carol T. Schembri , Peter G. Webb
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B60/14 , C12G1/68 , C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/2575
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

10. 发明授权

US06773676B2 Devices for performing array hybridization assays and methods of using the same 失效
标题翻译：用于进行阵列杂交测定的装置及其使用方法
公开(公告)号：US06773676B2
公开(公告)日：2004-08-10
申请号：US09884792
申请日：2001-06-19
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： B01L300
CPC分类号： G02B21/34 , B01L3/508 , B01L2200/0689 , B01L2300/041 , B01L2300/0809 , G01N21/0332 , Y10T436/2575
摘要： Array hybridization devices and methods for their use are provided. The subject devices are characterized by having a substantially planar bottom surface, a cover, at least one fluid port and at least one adjustable spacing element for adjusting the spacing between an array and the bottom surface. In using the subject devices, an array is placed on the at least one adjustable spacing element in the chamber and the space between the array and the bottom surface is adjusted by moving the at least one adjustable spacing element. The adjusted array is contacted with at least one biological sample introduced into the chamber. The subject inventions find use in a variety of array-based applications, including nucleic acid array hybridizations.
摘要翻译：提供阵列杂交装置及其使用方法。主题装置的特征在于具有基本上平坦的底表面，盖，至少一个流体端口和用于调节阵列和底表面之间的间隔的至少一个可调间隔元件。在使用主体装置时，将阵列放置在腔室中的至少一个可调间隔元件上，并且通过移动至少一个可调间隔元件来调节阵列与底表面之间的空间。经调节的阵列与引入腔室的至少一个生物样品接触。本发明可用于各种基于阵列的应用，包括核酸阵列杂交。

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