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1. 发明申请

US20090042179A1 Fluorescence Reflection Imaging Device with Two Wavelengths 审中-公开
标题翻译：具有两个波长的荧光反射成像装置
公开(公告)号：US20090042179A1
公开(公告)日：2009-02-12
申请号：US11795975
申请日：2006-01-20
申请人： Philippe Peltie , Michel Berger , Roland Sauze , Stephane Bonnet
发明人： Philippe Peltie , Michel Berger , Roland Sauze , Stephane Bonnet
IPC分类号： C12Q1/00 , G01J3/42 , G06T7/40
CPC分类号： G01N21/64 , A61B1/00186 , A61B1/043 , A61B1/0638
摘要： A first light source has a first wavelength corresponding to an excitation wavelength of a fluorophore. The excitation wavelength and an emission wavelength of the fluorophore delineate a predetermined interval. A second light source has a second wavelength offset with respect to the first wavelength so as to be outside said predetermined interval. The offset between the first and second wavelengths is comprised between 30 nm and 100 nm. A camera comprises a filter opaque to the first and second wavelengths and transparent to the emission wavelength and to wavelengths substantially higher than the higher of the first and second wavelengths. The light sources and camera are synchronized to alternately activate one of the light sources and make the camera alternately acquire a fluorescence image and a background noise image.
摘要翻译：第一光源具有对应于荧光团的激发波长的第一波长。荧光团的激发波长和发射波长描绘预定间隔。第二光源相对于第一波长具有第二波长偏移，以便在所述预定间隔之外。第一和第二波长之间的偏移在30nm和100nm之间。照相机包括对第一和第二波长不透明并且对于发射波长透明且对于高于第一和第二波长较高的波长的滤光器。光源和相机被同步以交替地激活光源中的一个并使相机交替地获取荧光图像和背景噪声图像。

2. 发明授权

US09494604B2 Device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma 有权
标题翻译：用于表征诸如血液或血浆的流体的凝结或沉降动力学的装置
公开(公告)号：US09494604B2
公开(公告)日：2016-11-15
申请号：US12469200
申请日：2009-05-20
申请人： Patrick Pouteau , Magalie Faivre , Philippe Peltie , Anne Planat-Chretien
发明人： Patrick Pouteau , Magalie Faivre , Philippe Peltie , Anne Planat-Chretien
IPC分类号： G01N33/00 , B01L3/00 , G01N33/86 , G01N33/49 , G01N21/49 , G01N21/75 , G06T7/00
CPC分类号： G01N33/86 , G01N21/49 , G01N21/75 , G01N33/4905 , G01N2201/06113 , G01N2201/12 , G06T7/0016 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024
摘要： A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma is provided. The method includes illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images. The processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.
摘要翻译：提供了表征全血，血液分数或血浆等流体的凝固或沉降动力学的方法。该方法包括用相干光束照射流体的样品; 获取由样本和空间相干光束之间的相互作用产生的斑点图案的时间序列; 并处理图像的时间序列。处理步骤包括计算表示该系列的两个或多个图像之间的散斑图案的变化的函数。本发明还提供了一种用于实现这种方法的装置。

3. 发明授权

US06861515B2 Analysis of biological targets using a biochip comprising a fluorescent marker 失效
标题翻译：使用包含荧光标记的生物芯片分析生物靶
公开(公告)号：US06861515B2
公开(公告)日：2005-03-01
申请号：US10203780
申请日：2001-02-22
申请人： Marc Cuzin , Philippe Peltie , Marc Fontecave , Jean-Luc Decout , Cécile Dueymes
发明人： Marc Cuzin , Philippe Peltie , Marc Fontecave , Jean-Luc Decout , Cécile Dueymes
IPC分类号： G01N21/64 , C12Q1/68 , C40B40/06 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/566 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00576 , B01J2219/00608 , B01J2219/00693 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C12Q2565/549 , C12Q2565/107 , C12Q2565/101
摘要： This invention relates to an analytical support containing a plurality of oligonucleotides fixed on this support, where each of the nucleotides is marked by a fluorescent compound that presents a variation of fluorescence on the hybridization of each marked oligonucleotide with at complementary oligonucleotide. This support makes it possible to carry out an analysis of biological targets by measuring the variation of fluorescence in order to determine the hybridization of the targets with the oligonucleotides of the support.
摘要翻译：本发明涉及一种分析载体，其包含固定在该载体上的多个寡核苷酸，其中每个核苷酸由荧光化合物标记，所述荧光化合物在每个标记的寡核苷酸与互补寡核苷酸的杂交上呈现荧光变化。该支持使得可以通过测量荧光的变化来进行生物学靶标的分析，以确定靶与载体的寡核苷酸的杂交。

4. 发明授权

US07345745B2 Optical device for measuring the displacement velocity of a first moving element with respect to a second element 有权
标题翻译：用于测量第一移动元件相对于第二元件的位移速度的光学装置
公开(公告)号：US07345745B2
公开(公告)日：2008-03-18
申请号：US11629211
申请日：2005-06-24
申请人： Viviane Cattin , Philippe Peltie , Bruno Flament , William Fourcault
发明人： Viviane Cattin , Philippe Peltie , Bruno Flament , William Fourcault
IPC分类号： G01P3/36
CPC分类号： G01S17/48 , G01P3/68 , G01P3/806 , G01S7/497 , G01S17/58
摘要： An optical device for measuring the displacement velocity of a first movable element in relation to a second element which is fixed to one of said elements and comprises two lasers transmitting two incident beams towards the other elements. The device including photosensitive linear arrays for front and rear detection which are substantially perpendicular to each other. Additional front and rear photosensitive linear arrays are disposed at a distance from the photosensitive front and rear linear arrays. A processing circuit is connected to the photosensitive linear arrays and determines the longitudinal and/or transversal displacement velocity of the movable element. The circuit also determines the distance between the device and the other element by means of optical triangulation and corrects the longitudinal and/or transversal displacement velocity value according of the said distance.
摘要翻译：一种光学装置，用于测量第一可移动元件相对于固定到所述元件之一的第二元件的位移速度，并包括将两个入射光束朝向其它元件透射的两个激光器。该装置包括基本上彼此垂直的用于前后检测的光敏线性阵列。附加的前后感光线性阵列设置在与感光前线和后线阵列一定距离处。处理电路连接到感光线性阵列并确定可移动元件的纵向和/或横向位移速度。电路还通过光学三角测量法确定器件与另一元件之间的距离，并根据所述距离校正纵向和/或横向位移速度值。

5. 发明授权

US06255677B1 Chip-based analysis device comprising electrodes with localized heating 失效
标题翻译：基于芯片的分析装置，其包括具有局部加热的电极
公开(公告)号：US06255677B1
公开(公告)日：2001-07-03
申请号：US09111773
申请日：1998-07-08
申请人： Patrice Caillat , Philippe Peltie , Thierry Livache
发明人： Patrice Caillat , Philippe Peltie , Thierry Livache
IPC分类号： H01L2714
CPC分类号： G01N33/53 , B01J2219/00495 , B01J2219/00529 , B01J2219/00585 , B01J2219/00608 , B01J2219/00614 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , C40B60/14 , G01N21/66 , G01N27/3276 , H05B3/26 , H05B2203/002 , H05B2203/013
摘要： The invention concerns an analysis device including at least one chip (110) equipped with a plurality of analysis electrodes (112). In accordance with the invention, the device also includes means of individual heating (150) of the analysis electrodes. The invention can be used for the analysis of chemical or biological products, for example in an antigen/antibody recognition or DNA/DNA analysis.
摘要翻译：本发明涉及包括配备有多个分析电极（112）的至少一个芯片（110）的分析装置。根据本发明，该装置还包括分析电极单独加热（150）的装置。本发明可用于化学或生物产品的分析，例如在抗原/抗体识别或DNA / DNA分析中。

6. 发明授权

US07809431B2 Method of optically imaging biological tissues by using fluorescence, in particular for defining regions of interest in tissues to be analyzed by tomography 有权
标题翻译：通过使用荧光光学地成像生物组织的方法，特别是通过层析成像来定义要分析的组织中的感兴趣区域
公开(公告)号：US07809431B2
公开(公告)日：2010-10-05
申请号：US11736333
申请日：2007-04-17
申请人： Isabelle Texier-Nogues , Philippe Peltie , Emilie Heinrich , Rolande Blanc
发明人： Isabelle Texier-Nogues , Philippe Peltie , Emilie Heinrich , Rolande Blanc
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B2503/40
摘要： The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography.The method according to the invention comprises the following steps: a) introducing at least one fluorescent marker into the tissue(s); b) exciting the marker by incident light and detecting emission bands relating to fluorescence emitted by the marker in response to that excitation; then c) analyzing the fluorescence in these emission bands; and the step b) comprising: sequentially exciting said marker at n different incident excitation wavelengths λi, said marker being adapted to be excited by at least two of the wavelengths λi and to emit in response to each wavelength λi a series Si of m simultaneous emission bands Bj having different maximum wavelengths λ′j that are substantially the same from one series Si to another; and detecting these series Si in order to deduce therefrom an estimate of the three-dimensional location of said marker in the tissue(s) and/or the mean absorption coefficients of the tissue(s) for the excitation wavelengths λi.
摘要翻译：本发明涉及一种对至少一个生物组织进行光学成像的方法，特别是通过层析成像来限定要分析的组织的感兴趣区域。根据本发明的方法包括以下步骤：a）将至少一种荧光标记物引入组织; b）通过入射光激发标记，并响应于该激发检测与标记物发射的荧光相关的发射带; 然后c）分析这些发射带中的荧光; 并且步骤b）包括：在n个不同的入射激发波长λ1处顺序地激励所述标记，所述标记适于被至少两个波长λ1激发，并且响应于每个波长λ1发射m个同时发射的串联Si 带Bj具有不同的最大波长λ'j，其从一个串联的Si到另一个串联大致相同; 并且检测这些系列Si以从其推导出组织中所述标记的三维位置的估计和/或激发波长λi的组织的平均吸收系数。

7. 发明申请

US20080068619A1 Optical Device for Measuring the Thickness of an at Least Partially Transparent Medium 有权
标题翻译：用于测量至少部分透明介质厚度的光学装置
公开(公告)号：US20080068619A1
公开(公告)日：2008-03-20
申请号：US11629355
申请日：2006-06-24
申请人： Franck Vial , Philippe Peltie , Angelo Guiga
发明人： Franck Vial , Philippe Peltie , Angelo Guiga
IPC分类号： G01B11/28
CPC分类号： B60R16/0237 , G01B11/0625
摘要： The inventive optical device for measuring the thickness of a medium which is at least partially transparent for an incident beam and covers a second medium comprises a laser for generating the light incident beam in such a way that a beam reflected by the first medium surface and a beam scattered by the second medium surface are formed. The device comprises a photosensitive linear array for detecting the reflected beam and the scattered beam and a processing circuit which is connected to the linear array and enables to measure a space between the reflected beam and the scattered beam and to determine the thickness of the first medium according to the measured space. The processing circuit determines a distance between the linear array and the surface of the second medium from the position of at least one beam and corrects the valve of the thickness of the first medium according to the distance.
摘要翻译：用于测量入射光束至少部分透明并覆盖第二介质的介质的厚度的本发明的光学装置包括用于产生光入射光束的激光，使得由第一介质表面反射的光束和形成由第二介质表面散射的光束。该装置包括用于检测反射光束和散射光束的感光线性阵列和连接到线性阵列并且能够测量反射光束和散射光束之间的空间并且确定第一介质的厚度的处理电路根据测量的空间。处理电路从至少一个光束的位置确定线阵列和第二介质表面之间的距离，并根据该距离校正第一介质厚度的阀。

8. 发明授权

US09019496B2 Method for estimating the amount of entities deposited on microparticles in suspension in a solution, associated device and use of said device 有权
标题翻译：用于估计在溶液，相关装置中的悬浮液中沉积在微粒上的实体的量的方法以及所述装置的使用
公开(公告)号：US09019496B2
公开(公告)日：2015-04-28
申请号：US13188861
申请日：2011-07-22
申请人： Vincent Poher , Frederic Fantoni , Veronique Mourier , Philippe Peltie , Frederic Ronzon , Christian Valentin
发明人： Vincent Poher , Frederic Fantoni , Veronique Mourier , Philippe Peltie , Frederic Ronzon , Christian Valentin
IPC分类号： G01N21/00 , G01N21/51 , G01N21/552 , G01N21/29 , G01N15/06
CPC分类号： G01N21/51 , G01N15/06 , G01N21/29 , G01N21/553
摘要： The invention relates to a method for estimating the amount of entities deposited on microparticles in suspension in a solution, and also to an associated device. The method comprises the following steps: (a) the solution is illuminated with a light source; (b) an optical signal formed by the scattering, in the solution, of the illuminating light is detected; (c) the optical signal obtained in step (b) is analyzed in order to obtain an indicator relating to this signal; (d) the indicator obtained in step (c) is compared with a reference indicator, obtained for a reference solution, the comparison making it possible to estimate the amount of entities deposited on the microparticles.
摘要翻译：本发明涉及一种用于估计沉积在微粒悬浮于溶液中的实体的量以及相关装置的方法。该方法包括以下步骤：（a）用光源照射溶液; （b）检测在溶液中散射照明光所形成的光信号; （c）分析步骤（b）中获得的光信号，以获得与该信号相关的指示符; （d）将步骤（c）中获得的指标与参考溶液获得的参考指标进行比较，该比较使得可以估计沉积在微粒上的实体的量。

9. 发明申请

US20100248278A1 METHOD AND A DEVICE FOR CHARACTERIZING THE COAGULATION OR SEDIMENTATION DYNAMICS OF A FLUID SUCH AS BLOOD OR BLOOD PLASMA 有权
标题翻译：用于表征流体如血液或血液等离子体的凝聚或沉默动力学的方法和装置
公开(公告)号：US20100248278A1
公开(公告)日：2010-09-30
申请号：US12469200
申请日：2009-05-20
申请人： Patrick Pouteau , Magalie Faivre , Philippe Peltie , Anne Planat-Chretien
发明人： Patrick Pouteau , Magalie Faivre , Philippe Peltie , Anne Planat-Chretien
IPC分类号： C12Q1/56 , C12Q1/02 , C12M1/34
CPC分类号： G01N33/86 , G01N21/49 , G01N21/75 , G01N33/4905 , G01N2201/06113 , G01N2201/12 , G06T7/0016 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024
摘要： A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma, the method comprising: illuminating a sample of said fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between said sample and said spatially coherent light beam; and processing said time series of images; wherein said processing step includes calculating a function representative of the variation in said speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.
摘要翻译：表征诸如全血，血液分数或血浆的流体的凝结或沉降动力学的方法，所述方法包括：用相干光束照射所述流体的样品; 获取由所述样本和所述空间相干光束之间的相互作用产生的散斑图案的时间序列; 并处理所述时间序列的图像; 其中所述处理步骤包括计算代表该系列的两个或多个图像之间的所述斑纹图案的变化的函数。本发明还提供了一种用于实现这种方法的装置。

10. 发明授权

US07570372B2 Optical device for measuring the thickness of an at least partially transparent medium 有权
标题翻译：用于测量至少部分透明介质的厚度的光学装置
公开(公告)号：US07570372B2
公开(公告)日：2009-08-04
申请号：US11629355
申请日：2006-06-24
申请人： Franck Vial , Philippe Peltie , Angelo Guiga
发明人： Franck Vial , Philippe Peltie , Angelo Guiga
IPC分类号： G01B11/28
CPC分类号： B60R16/0237 , G01B11/0625
摘要： The inventive optical device for measuring the thickness of a medium which is at least partially transparent for an incident beam and covers a second medium comprises a laser for generating the light incident beam in such a way that a beam reflected by the first medium surface and a beam scattered by the second medium surface are formed. The device comprises a photosensitive linear array for detecting the reflected beam and the scattered beam and a processing circuit which is connected to the linear array and enables to measure a space between the reflected beam and the scattered beam and to determine the thickness of the first medium according to the measured space. The processing circuit determines a distance between the linear array and the surface of the second medium from the position of at least one beam and corrects the valve of the thickness of the first medium according to the distance.
摘要翻译：用于测量入射光束至少部分透明并覆盖第二介质的介质的厚度的本发明的光学装置包括用于产生光入射光束的激光，使得由第一介质表面反射的光束和形成由第二介质表面散射的光束。该装置包括用于检测反射光束和散射光束的感光线性阵列和连接到线性阵列并且能够测量反射光束和散射光束之间的空间并且确定第一介质的厚度的处理电路根据测量的空间。处理电路从至少一个光束的位置确定线阵列和第二介质表面之间的距离，并根据该距离校正第一介质厚度的阀。

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