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1. 发明授权

US07809431B2 Method of optically imaging biological tissues by using fluorescence, in particular for defining regions of interest in tissues to be analyzed by tomography 有权
标题翻译：通过使用荧光光学地成像生物组织的方法，特别是通过层析成像来定义要分析的组织中的感兴趣区域
公开(公告)号：US07809431B2
公开(公告)日：2010-10-05
申请号：US11736333
申请日：2007-04-17
申请人： Isabelle Texier-Nogues , Philippe Peltie , Emilie Heinrich , Rolande Blanc
发明人： Isabelle Texier-Nogues , Philippe Peltie , Emilie Heinrich , Rolande Blanc
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B2503/40
摘要： The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography.The method according to the invention comprises the following steps: a) introducing at least one fluorescent marker into the tissue(s); b) exciting the marker by incident light and detecting emission bands relating to fluorescence emitted by the marker in response to that excitation; then c) analyzing the fluorescence in these emission bands; and the step b) comprising: sequentially exciting said marker at n different incident excitation wavelengths λi, said marker being adapted to be excited by at least two of the wavelengths λi and to emit in response to each wavelength λi a series Si of m simultaneous emission bands Bj having different maximum wavelengths λ′j that are substantially the same from one series Si to another; and detecting these series Si in order to deduce therefrom an estimate of the three-dimensional location of said marker in the tissue(s) and/or the mean absorption coefficients of the tissue(s) for the excitation wavelengths λi.
摘要翻译：本发明涉及一种对至少一个生物组织进行光学成像的方法，特别是通过层析成像来限定要分析的组织的感兴趣区域。根据本发明的方法包括以下步骤：a）将至少一种荧光标记物引入组织; b）通过入射光激发标记，并响应于该激发检测与标记物发射的荧光相关的发射带; 然后c）分析这些发射带中的荧光; 并且步骤b）包括：在n个不同的入射激发波长λ1处顺序地激励所述标记，所述标记适于被至少两个波长λ1激发，并且响应于每个波长λ1发射m个同时发射的串联Si 带Bj具有不同的最大波长λ'j，其从一个串联的Si到另一个串联大致相同; 并且检测这些系列Si以从其推导出组织中所述标记的三维位置的估计和/或激发波长λi的组织的平均吸收系数。

2. 发明授权

US10092506B2 Encapsulation of lipophilic or amphiphilic therapeutic agents in nano-emulsion 有权
公开(公告)号：US10092506B2
公开(公告)日：2018-10-09
申请号：US13058850
申请日：2009-08-14
申请人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
发明人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K9/00 , A61K47/69 , A61K41/00 , A61K9/107 , B82Y5/00
摘要： The present invention relates to a therapeutic agent formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises further to the therapeutic agent, at least one amphiphilic lipid and at least one solubilizing lipid, and in which the aqueous phase comprises at least one polyalkoxylated cosurfactant.The invention also relates to a preparation method and use of this formulation.

3. 发明授权

US08546598B2 Silane compounds having a cyclic carbon chain including an alkyne function for functionalizing solid substrates and immobilizing biological molecules on said substrates 失效
标题翻译：具有环状碳链的硅烷化合物，其包括用于官能化固体底物并将生物分子固定在所述基材上的炔官能团
公开(公告)号：US08546598B2
公开(公告)日：2013-10-01
申请号：US13257326
申请日：2010-03-16
申请人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
发明人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
IPC分类号： C07F7/04 , C40B60/00 , C12M1/34
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —O— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译：本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。本发明的硅烷化合物对应于式XEAZ，其中X是甲硅烷基，E是有机间隔基团，A是单键或-CONH-，-NHCO-，-OCH 2 CONH-，-NHCOCH 2 O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。本发明特别适用于医药领域。

4. 发明授权

US08541604B2 Process for the functionalization of biological molecules 有权
标题翻译：生物分子功能化的过程
公开(公告)号：US08541604B2
公开(公告)日：2013-09-24
申请号：US12905393
申请日：2010-10-15
申请人： Aude Bernardin , David Bonnaffe , Isabelle Texier-Nogues
发明人： Aude Bernardin , David Bonnaffe , Isabelle Texier-Nogues
IPC分类号： C07D311/82 , C07C229/32
CPC分类号： C07C221/00 , C07B2200/11 , C07C2601/18 , C07D311/82 , C07F7/1804 , C07C225/14
摘要： The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.
摘要翻译：本发明针对1,3-偶极环加成型的新型偶联方法，其特别用于生物分子的功能化，例如蛋白质，酶或核酸，只要其可以进行在水性介质中和在环境温度下。

5. 发明申请

US20100284932A1 FLUORESCENT EMULSIONS FOR OPTICAL IMAGING 有权
标题翻译：用于光学成像的荧光乳液
公开(公告)号：US20100284932A1
公开(公告)日：2010-11-11
申请号：US12527314
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jerome Bibette , Anabela Da Silva
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jerome Bibette , Anabela Da Silva
IPC分类号： C09K11/06 , A61B5/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

6. 发明授权

US09421281B2 Target vector with activable imaging function 有权
标题翻译：具有可激活成像功能的目标矢量
公开(公告)号：US09421281B2
公开(公告)日：2016-08-23
申请号：US11996208
申请日：2006-07-18
申请人： Isabelle Texier-Nogues , Jean-Luc Coll , Pascal Dumy , Didier Boturyn , Marie Favrot
发明人： Isabelle Texier-Nogues , Jean-Luc Coll , Pascal Dumy , Didier Boturyn , Marie Favrot
IPC分类号： A61K49/00 , A61K47/48
CPC分类号： A61K49/0056 , A61K47/62 , A61K49/0002 , A61K49/0032 , A61K49/0041 , A61K49/0052
摘要： The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.
摘要翻译：本发明涉及体内成像的分子探针结构领域。更具体地，本发明涉及提供可在细胞内环境中活化的成像功能的分子结构。本发明的荧光探针能够特别地形成某些目标组织的图像，同时保持低的背景噪声水平，并且优选地，在靶组织获得时间上增加的成像信号。

7. 发明授权

US09289517B2 Fluorescent emulsion of indocyanine green 有权
标题翻译：吲哚菁绿的荧光乳液
公开(公告)号：US09289517B2
公开(公告)日：2016-03-22
申请号：US13058851
申请日：2009-08-14
申请人： Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
发明人： Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K49/0034
摘要： The present invention relates to a formulation of indocyanine green in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises indocyanine green, at least one amphiphilic lipid and at least one solubilizing lipid.It relates also to a process for the preparation and to the use of the formulation.
摘要翻译：本发明涉及纳米乳液形式的靛青绿的制剂，其包含连续水相和至少一种分散的油相，其中油相包含靛青绿，至少一种两亲脂质和至少一种增溶脂质。它还涉及制备和使用制剂的方法。

8. 发明授权

US08652360B2 Semiconductor nanocrystals 有权
标题翻译：半导体纳米晶体
公开(公告)号：US08652360B2
公开(公告)日：2014-02-18
申请号：US12555022
申请日：2009-09-08
申请人： Isabelle Texier-Nogues , Aude Bernardin
发明人： Isabelle Texier-Nogues , Aude Bernardin
IPC分类号： H01B1/00 , H01B1/12 , H01R4/42
CPC分类号： G01N33/587 , B82Y15/00 , C07D249/16 , C07D498/08 , G01N33/588
摘要： The present invention aims to provide a method of use for surface-modifying a semiconductor nanocrystal comprising at least the steps consisting in having a semiconductor nanocrystal, the organic coating layer of which is provided, at the outer surface of the nanocrystal, with at least one reactive group G1 that reacts according to a cycloaddition reaction of click chemistry type; and bringing said nanocrystal together with an adjoining material provided at the surface with at least one G2 group complementary to the G1 group with respect to said click chemistry reaction, under conditions favorable to the interaction of said G1 and G2 groups, characterized in that said G1 and G2 groups are respectively an azide and a strained cycloalkynyl radical, or vice versa.
摘要翻译：本发明旨在提供一种用于表面修饰半导体纳米晶体的方法，该方法至少包括在纳米晶体的外表面具有半导体纳米晶体的步骤，其中所述半导体纳米晶体在其纳米晶体的外表面上具有至少一个根据点击化学类型的环加成反应反应的反应性基团G1; 以及在有利于所述G1和G2基团的相互作用的条件下，使所述纳米晶体与在表面处提供有相对于所述点击化学反应互补的至少一个G2基团的邻接材料一起引入，其特征在于所述G1 和G2基团分别是叠氮化物和应变的环炔基基团，反之亦然。

9. 发明授权

US08592619B2 Bifunctional molecules comprising a cycloalkyne or heterocycloalkyne group and a redox group 有权
标题翻译：包含环炔或杂环炔基和氧化还原基团的双功能分子
公开(公告)号：US08592619B2
公开(公告)日：2013-11-26
申请号：US13257365
申请日：2010-03-16
申请人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
发明人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
IPC分类号： C07F17/02 , H01L45/00 , H01L21/312
CPC分类号： C07F17/02
摘要： The invention relates to compounds comprising a cycloalkyne or heterocycloalkyne group and a redox group. Said compounds are of general formula (I) wherein Z is a cycloalkyne or heterocycloalkyne with at least 8 links, optionally substituted by a halogen atom or a linear or branched C1 to C5 alkyl, A is an organic structure having oxidation-reduction properties, and B is an organic link between the cycloalkyne or heterocycloalkyne cycle and the organic structure A. The invention is especially applicable to the field of molecular electronics.
摘要翻译：本发明涉及包含环炔或杂环炔基和氧化还原基团的化合物。所述化合物具有通式（I），其中Z是具有至少8个连接的环烯烃或杂环炔基，任选被卤素原子或直链或支链C 1至C 5烷基取代，A是具有氧化还原性质的有机结构，和 B是环炔或杂环炔环与有机结构A之间的有机连接。本发明特别适用于分子电子领域。

10. 发明申请

US20120061627A1 FLUORESCENT NANOPARTICLES, METHOD FOR PREPARING SAME, AND APPLICATION THEREOF IN BIOLOGICAL MARKING 审中-公开
标题翻译：荧光纳米颗粒，其制备方法及其在生物标记中的应用
公开(公告)号：US20120061627A1
公开(公告)日：2012-03-15
申请号：US13127460
申请日：2009-11-03
申请人： Peter Reiss , Toufic Jean Daou , Isabelle Texier-Nogues , Liang Li
发明人： Peter Reiss , Toufic Jean Daou , Isabelle Texier-Nogues , Liang Li
IPC分类号： H01B1/00 , C01G15/00 , B82B3/00 , B82B1/00
CPC分类号： C30B29/46 , C09K9/02 , C09K11/612 , C30B29/60
摘要： A method for preparing nanocrystals is disclosed. According to one aspect, the noncrystals include a semiconductor ternary compound consisting of the elements A, B and C. According to another aspect, the nanocrystals include a semiconductor of formula ABC2 optionally coated with a shell, the external portion of which includes a semiconductor of formula ZnS1-xFx, with A representing a metal or metalloid in the oxidation state +I, B representing a metal or metalloid in the oxidation state +III, C representing an element in the oxidation state −II, F representing an element in the oxidation state −II and x being a decimal number such that 0≦x
摘要翻译：公开了制备纳米晶体的方法。根据一个方面，非晶体包括由元素A，B和C组成的半导体三元化合物。根据另一方面，纳米晶体包括任选地涂覆有壳的式ABC2的半导体，其外部部分包括半导体其中A代表处于氧化态的金属或准金属+ I，B代表氧化态中的金属或准金属+ III，C代表氧化态中的元素-II，F代表氧化中的元素状态-II和x是十进制数，使得0＆nlE; x <1。本公开还涉及制备的纳米晶体及其用途。

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