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1. 发明授权

US09494604B2 Device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma 有权
标题翻译：用于表征诸如血液或血浆的流体的凝结或沉降动力学的装置
公开(公告)号：US09494604B2
公开(公告)日：2016-11-15
申请号：US12469200
申请日：2009-05-20
申请人： Patrick Pouteau , Magalie Faivre , Philippe Peltie , Anne Planat-Chretien
发明人： Patrick Pouteau , Magalie Faivre , Philippe Peltie , Anne Planat-Chretien
IPC分类号： G01N33/00 , B01L3/00 , G01N33/86 , G01N33/49 , G01N21/49 , G01N21/75 , G06T7/00
CPC分类号： G01N33/86 , G01N21/49 , G01N21/75 , G01N33/4905 , G01N2201/06113 , G01N2201/12 , G06T7/0016 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024
摘要： A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma is provided. The method includes illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images. The processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.
摘要翻译：提供了表征全血，血液分数或血浆等流体的凝固或沉降动力学的方法。该方法包括用相干光束照射流体的样品; 获取由样本和空间相干光束之间的相互作用产生的斑点图案的时间序列; 并处理图像的时间序列。处理步骤包括计算表示该系列的两个或多个图像之间的散斑图案的变化的函数。本发明还提供了一种用于实现这种方法的装置。

2. 发明申请

US20130070071A1 Single-Use Bispectral Optical Head for Videoendoscope and Associated Videoendoscope 审中-公开
标题翻译：用于视频内窥镜和相关视频内窥镜的单次使用双谱光学头
公开(公告)号：US20130070071A1
公开(公告)日：2013-03-21
申请号：US13420467
申请日：2012-03-14
申请人： Philippe PELTIE , Jérôme BOUTET , Philippe RIZO
发明人： Philippe PELTIE , Jérôme BOUTET , Philippe RIZO
IPC分类号： H04N7/18
CPC分类号： H04N7/18 , A61B1/00186 , A61B1/043 , A61B1/05 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0684 , G02B23/243 , G02B23/2469 , G02B23/2484 , G02B23/26
摘要： In the field of videoendoscopes for medical or industrial use, a videoendoscope has a bispectral optical head comprising a microcamera, white light lighting means and fluorescence light lighting means. The optical head is linked by appropriate electrical and optical connectors to the other elements of the videoendoscope. Preferably, it comprises inexpensive standard elements and is packaged in a single-use sterile packaging. There are different possible embodiments depending on whether the optical head comprises a single sensor or two sensors, depending on whether the device operates in continuous mode or in sequential mode and, finally, depending on whether the light sources are incorporated in the optical head or external thereto, the light being then routed by means of optical fibres.
摘要翻译：在用于医疗或工业用途的视频内窥镜领域中，视频内窥镜具有包括微型摄像机，白光照明装置和荧光灯照明装置的双谱光学头。光头通过适当的电气和光学连接器连接到视频内窥镜的其他元件。优选地，其包括廉价的标准元件并且包装在一次性无菌包装中。取决于装置是以连续模式还是以顺序模式操作，取决于光学头是包括单个传感器还是两个传感器，存在不同的可能实施例，最后，取决于光源是否并入光学头或外部然后光被光纤路由。

3. 发明授权

US06861515B2 Analysis of biological targets using a biochip comprising a fluorescent marker 失效
标题翻译：使用包含荧光标记的生物芯片分析生物靶
公开(公告)号：US06861515B2
公开(公告)日：2005-03-01
申请号：US10203780
申请日：2001-02-22
申请人： Marc Cuzin , Philippe Peltie , Marc Fontecave , Jean-Luc Decout , Cécile Dueymes
发明人： Marc Cuzin , Philippe Peltie , Marc Fontecave , Jean-Luc Decout , Cécile Dueymes
IPC分类号： G01N21/64 , C12Q1/68 , C40B40/06 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/566 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00576 , B01J2219/00608 , B01J2219/00693 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C12Q2565/549 , C12Q2565/107 , C12Q2565/101
摘要： This invention relates to an analytical support containing a plurality of oligonucleotides fixed on this support, where each of the nucleotides is marked by a fluorescent compound that presents a variation of fluorescence on the hybridization of each marked oligonucleotide with at complementary oligonucleotide. This support makes it possible to carry out an analysis of biological targets by measuring the variation of fluorescence in order to determine the hybridization of the targets with the oligonucleotides of the support.
摘要翻译：本发明涉及一种分析载体，其包含固定在该载体上的多个寡核苷酸，其中每个核苷酸由荧光化合物标记，所述荧光化合物在每个标记的寡核苷酸与互补寡核苷酸的杂交上呈现荧光变化。该支持使得可以通过测量荧光的变化来进行生物学靶标的分析，以确定靶与载体的寡核苷酸的杂交。

4. 发明申请

US20110190639A1 Bi-Spectral Peroperative Optical Probe 审中-公开
标题翻译：双光谱全光学探头
公开(公告)号：US20110190639A1
公开(公告)日：2011-08-04
申请号：US13019119
申请日：2011-02-01
申请人： Philippe PELTIE , Michel BERGER
发明人： Philippe PELTIE , Michel BERGER
IPC分类号： A61B6/00
CPC分类号： A61B5/0059
摘要： Optical probes for medical applications are provided. The probe is devised so as to be able to be held in one hand. A basic version of the probe includes: a first excitation lighting source suitable for causing a fluorescence radiation of predetermined substances; a second visible lighting source, the first and the second source being devised so as to illuminate a common zone termed the intervention zone; a first photosensitive matrix sensor; and a second photosensitive matrix sensor. The first and second photosensitive matrix sensors are devised in such a way that, when the optical probe is arranged a predetermined distance from the intervention zone, the image in the visible spectrum of the said zone is formed on the photosensitive surface of the first matrix sensor and the image in the fluorescence spectrum of the said zone is formed on the photosensitive surface of the second sensor. A first variant of the probe includes only a single optical objective, a second variant only a single photosensitive matrix sensor, and a third variant makes it possible to work under polarized light.
摘要翻译：提供用于医疗应用的光学探针。探针被设计成能够一只手握住。探针的基本版本包括：适于引起预定物质的荧光辐射的第一激发光源; 第二可见光源，设计第一和第二源以照亮被称为介入区的公共区; 第一光敏矩阵传感器; 和第二光敏矩阵传感器。第一和第二光敏矩阵传感器被设计成使得当光学探针与干涉区域布置预定距离时，所述区域的可见光谱中的图像形成在第一矩阵传感器的感光表面上并且所述区域的荧光光谱中的图像形成在第二传感器的感光表面上。探头的第一变型仅包括单一光学物镜，第二变型仅包含单个光敏矩阵传感器，而第三变体使得可以在偏振光下工作。

5. 发明授权

US07809431B2 Method of optically imaging biological tissues by using fluorescence, in particular for defining regions of interest in tissues to be analyzed by tomography 有权
标题翻译：通过使用荧光光学地成像生物组织的方法，特别是通过层析成像来定义要分析的组织中的感兴趣区域
公开(公告)号：US07809431B2
公开(公告)日：2010-10-05
申请号：US11736333
申请日：2007-04-17
申请人： Isabelle Texier-Nogues , Philippe Peltie , Emilie Heinrich , Rolande Blanc
发明人： Isabelle Texier-Nogues , Philippe Peltie , Emilie Heinrich , Rolande Blanc
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B2503/40
摘要： The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography.The method according to the invention comprises the following steps: a) introducing at least one fluorescent marker into the tissue(s); b) exciting the marker by incident light and detecting emission bands relating to fluorescence emitted by the marker in response to that excitation; then c) analyzing the fluorescence in these emission bands; and the step b) comprising: sequentially exciting said marker at n different incident excitation wavelengths λi, said marker being adapted to be excited by at least two of the wavelengths λi and to emit in response to each wavelength λi a series Si of m simultaneous emission bands Bj having different maximum wavelengths λ′j that are substantially the same from one series Si to another; and detecting these series Si in order to deduce therefrom an estimate of the three-dimensional location of said marker in the tissue(s) and/or the mean absorption coefficients of the tissue(s) for the excitation wavelengths λi.
摘要翻译：本发明涉及一种对至少一个生物组织进行光学成像的方法，特别是通过层析成像来限定要分析的组织的感兴趣区域。根据本发明的方法包括以下步骤：a）将至少一种荧光标记物引入组织; b）通过入射光激发标记，并响应于该激发检测与标记物发射的荧光相关的发射带; 然后c）分析这些发射带中的荧光; 并且步骤b）包括：在n个不同的入射激发波长λ1处顺序地激励所述标记，所述标记适于被至少两个波长λ1激发，并且响应于每个波长λ1发射m个同时发射的串联Si 带Bj具有不同的最大波长λ'j，其从一个串联的Si到另一个串联大致相同; 并且检测这些系列Si以从其推导出组织中所述标记的三维位置的估计和/或激发波长λi的组织的平均吸收系数。

6. 发明申请

US20090042179A1 Fluorescence Reflection Imaging Device with Two Wavelengths 审中-公开
标题翻译：具有两个波长的荧光反射成像装置
公开(公告)号：US20090042179A1
公开(公告)日：2009-02-12
申请号：US11795975
申请日：2006-01-20
申请人： Philippe Peltie , Michel Berger , Roland Sauze , Stephane Bonnet
发明人： Philippe Peltie , Michel Berger , Roland Sauze , Stephane Bonnet
IPC分类号： C12Q1/00 , G01J3/42 , G06T7/40
CPC分类号： G01N21/64 , A61B1/00186 , A61B1/043 , A61B1/0638
摘要： A first light source has a first wavelength corresponding to an excitation wavelength of a fluorophore. The excitation wavelength and an emission wavelength of the fluorophore delineate a predetermined interval. A second light source has a second wavelength offset with respect to the first wavelength so as to be outside said predetermined interval. The offset between the first and second wavelengths is comprised between 30 nm and 100 nm. A camera comprises a filter opaque to the first and second wavelengths and transparent to the emission wavelength and to wavelengths substantially higher than the higher of the first and second wavelengths. The light sources and camera are synchronized to alternately activate one of the light sources and make the camera alternately acquire a fluorescence image and a background noise image.
摘要翻译：第一光源具有对应于荧光团的激发波长的第一波长。荧光团的激发波长和发射波长描绘预定间隔。第二光源相对于第一波长具有第二波长偏移，以便在所述预定间隔之外。第一和第二波长之间的偏移在30nm和100nm之间。照相机包括对第一和第二波长不透明并且对于发射波长透明且对于高于第一和第二波长较高的波长的滤光器。光源和相机被同步以交替地激活光源中的一个并使相机交替地获取荧光图像和背景噪声图像。

7. 发明申请

US20080068619A1 Optical Device for Measuring the Thickness of an at Least Partially Transparent Medium 有权
标题翻译：用于测量至少部分透明介质厚度的光学装置
公开(公告)号：US20080068619A1
公开(公告)日：2008-03-20
申请号：US11629355
申请日：2006-06-24
申请人： Franck Vial , Philippe Peltie , Angelo Guiga
发明人： Franck Vial , Philippe Peltie , Angelo Guiga
IPC分类号： G01B11/28
CPC分类号： B60R16/0237 , G01B11/0625
摘要： The inventive optical device for measuring the thickness of a medium which is at least partially transparent for an incident beam and covers a second medium comprises a laser for generating the light incident beam in such a way that a beam reflected by the first medium surface and a beam scattered by the second medium surface are formed. The device comprises a photosensitive linear array for detecting the reflected beam and the scattered beam and a processing circuit which is connected to the linear array and enables to measure a space between the reflected beam and the scattered beam and to determine the thickness of the first medium according to the measured space. The processing circuit determines a distance between the linear array and the surface of the second medium from the position of at least one beam and corrects the valve of the thickness of the first medium according to the distance.
摘要翻译：用于测量入射光束至少部分透明并覆盖第二介质的介质的厚度的本发明的光学装置包括用于产生光入射光束的激光，使得由第一介质表面反射的光束和形成由第二介质表面散射的光束。该装置包括用于检测反射光束和散射光束的感光线性阵列和连接到线性阵列并且能够测量反射光束和散射光束之间的空间并且确定第一介质的厚度的处理电路根据测量的空间。处理电路从至少一个光束的位置确定线阵列和第二介质表面之间的距离，并根据该距离校正第一介质厚度的阀。

8. 发明申请

US20120044494A1 METHOD FOR ESTIMATING THE AMOUNT OF ENTITIES DEPOSITED ON MICROPARTICLES IN SUSPENSION IN A SOLUTION, ASSOCIATED DEVICE AND USE OF SAID DEVICE 有权
标题翻译：用于估计在解决方案中的微型计算机上存在的实体的数量的方法，相关设备和使用设备
公开(公告)号：US20120044494A1
公开(公告)日：2012-02-23
申请号：US13188861
申请日：2011-07-22
申请人： Vincent POHER , Frederic FANTONI , Veronique MOURIER , Philippe PELTIE , Frederic RONZON , Christian VALENTIN
发明人： Vincent POHER , Frederic FANTONI , Veronique MOURIER , Philippe PELTIE , Frederic RONZON , Christian VALENTIN
IPC分类号： G01N21/00
CPC分类号： G01N21/51 , G01N15/06 , G01N21/29 , G01N21/553
摘要： The invention relates to a method for estimating the amount of entities deposited on microparticles in suspension in a solution, and also to an associated device. The method comprises the following steps: (a) the solution is illuminated with a light source; (b) an optical signal formed by the scattering, in the solution, of the illuminating light is detected; (c) the optical signal obtained in step (b) is analyzed in order to obtain an indicator relating to this signal; (d) the indicator obtained in step (c) is compared with a reference indicator, obtained for a reference solution, the comparison making it possible to estimate the amount of entities deposited on the microparticles.
摘要翻译：本发明涉及一种用于估计沉积在微粒悬浮于溶液中的实体的量以及相关装置的方法。该方法包括以下步骤：（a）用光源照射溶液; （b）检测在溶液中散射照明光所形成的光信号; （c）分析步骤（b）中获得的光信号，以获得与该信号相关的指示符; （d）将步骤（c）中获得的指标与参考溶液获得的参考指标进行比较，该比较使得可以估计沉积在微粒上的实体的量。

9. 发明授权

US07345745B2 Optical device for measuring the displacement velocity of a first moving element with respect to a second element 有权
标题翻译：用于测量第一移动元件相对于第二元件的位移速度的光学装置
公开(公告)号：US07345745B2
公开(公告)日：2008-03-18
申请号：US11629211
申请日：2005-06-24
申请人： Viviane Cattin , Philippe Peltie , Bruno Flament , William Fourcault
发明人： Viviane Cattin , Philippe Peltie , Bruno Flament , William Fourcault
IPC分类号： G01P3/36
CPC分类号： G01S17/48 , G01P3/68 , G01P3/806 , G01S7/497 , G01S17/58
摘要： An optical device for measuring the displacement velocity of a first movable element in relation to a second element which is fixed to one of said elements and comprises two lasers transmitting two incident beams towards the other elements. The device including photosensitive linear arrays for front and rear detection which are substantially perpendicular to each other. Additional front and rear photosensitive linear arrays are disposed at a distance from the photosensitive front and rear linear arrays. A processing circuit is connected to the photosensitive linear arrays and determines the longitudinal and/or transversal displacement velocity of the movable element. The circuit also determines the distance between the device and the other element by means of optical triangulation and corrects the longitudinal and/or transversal displacement velocity value according of the said distance.
摘要翻译：一种光学装置，用于测量第一可移动元件相对于固定到所述元件之一的第二元件的位移速度，并包括将两个入射光束朝向其它元件透射的两个激光器。该装置包括基本上彼此垂直的用于前后检测的光敏线性阵列。附加的前后感光线性阵列设置在与感光前线和后线阵列一定距离处。处理电路连接到感光线性阵列并确定可移动元件的纵向和/或横向位移速度。电路还通过光学三角测量法确定器件与另一元件之间的距离，并根据所述距离校正纵向和/或横向位移速度值。

10. 发明申请

US20070249943A1 METHOD OF OPTICALLY IMAGING BIOLOGICAL TISSUES BY USING FLUORESCENCE, IN PARTICULAR FOR DEFINING REGIONS OF INTEREST IN TISSUES TO BE ANALYZED BY TOMOGRAPHY 有权
标题翻译：通过使用荧光光学成像生物组织的方法，特别是用于定义通过TOMOGRAPHA分析的组织中的兴趣区域
公开(公告)号：US20070249943A1
公开(公告)日：2007-10-25
申请号：US11736333
申请日：2007-04-17
申请人： Isabelle TEXIER-NOGUES , Philippe PELTIE , Emilie HEINRICH , Rolande BLANC
发明人： Isabelle TEXIER-NOGUES , Philippe PELTIE , Emilie HEINRICH , Rolande BLANC
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B2503/40
摘要： The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography. The method according to the invention comprises the following steps: a) introducing at least one fluorescent marker into the tissue(s); b) exciting the marker by incident light and detecting emission bands relating to fluorescence emitted by the marker in response to that excitation; then c) analyzing the fluorescence in these emission bands; and the step b) comprising: sequentially exciting said marker at n different incident excitation wavelengths λi, said marker being adapted to be excited by at least two of the wavelengths λi and to emit in response to each wavelength λi a series Si of m simultaneous emission bands Bj having different maximum wavelengths λ′j that are substantially the same from one series Si to another; and detecting these series Si in order to deduce therefrom an estimate of the three-dimensional location of said marker in the tissue(s) and/or the mean absorption coefficients of the tissue(s) for the excitation wavelengths λi.
摘要翻译：本发明涉及一种对至少一个生物组织进行光学成像的方法，特别是通过层析成像来限定要分析的组织的感兴趣区域。根据本发明的方法包括以下步骤：a）将至少一种荧光标记物引入组织; b）通过入射光激发标记，并响应于该激发检测与标记物发射的荧光相关的发射带; 然后c）分析这些发射带中的荧光; 并且步骤b）包括：在n个不同的入射激发波长λ1上顺序地激发所述标记，所述标记适于被波长λ1中的至少两个激发，并且响应于具有不同最大波长λ'SUB的m个同时发射带B SUB的每个波长λi的序列S i i i发射。 > j ，其从一个系列S SUB到另一个系列是基本相同的; 并且检测这些系列S i，以便从其推导出组织中所述标记的三维位置的估计和/或组织的平均吸收系数激发波长λ1。

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