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1. 发明授权

US06631282B2 Device for isolating regions of living tissue 失效
标题翻译：用于隔离活组织区域的装置
公开(公告)号：US06631282B2
公开(公告)日：2003-10-07
申请号：US09970021
申请日：2001-10-02
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
IPC分类号： A61B500
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

2. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

3. 发明授权

US06958809B2 Reagent-less whole-blood glucose meter 有权
标题翻译：无试剂全血糖仪
公开(公告)号：US06958809B2
公开(公告)日：2005-10-25
申请号：US10055875
申请日：2002-01-21
申请人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
发明人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
IPC分类号： A61B5/00 , G01N21/35 , G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

4. 发明授权

US06959211B2 Device for capturing thermal spectra from tissue 失效
标题翻译：用于从组织中捕获热谱的装置
公开(公告)号：US06959211B2
公开(公告)日：2005-10-25
申请号：US10213730
申请日：2002-08-06
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
IPC分类号： A61B5/00 , G01N21/01 , G01N21/03 , G01N21/35
CPC分类号： A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/6824 , G01J3/0286 , G01J3/0291 , G01N21/01 , G01N21/35 , G01N2021/0389 , G01N2201/021 , G01N2201/0245
摘要： A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

5. 发明授权

US06198949B1 Solid-state non-invasive infrared absorption spectrometer for the generation and capture of thermal gradient spectra from living tissue 失效
标题翻译：固体非侵入式红外吸收光谱仪，用于生成和捕获活体组织的热梯度光谱
公开(公告)号：US06198949B1
公开(公告)日：2001-03-06
申请号：US09265195
申请日：1999-03-10
申请人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Julian Cortella , David J. Correia , Arthur M. Shulenberger , Charles E. Kramer
发明人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Julian Cortella , David J. Correia , Arthur M. Shulenberger , Charles E. Kramer
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/14532 , G01J3/02 , G01J3/0286 , G01J3/0291 , G01J3/42 , G01J5/061
摘要： A solid-state spectrometer for the non-invasive generation and capture of thermal gradient spectra from human or animal tissue. The spectrometer includes an infrared transmissive thermal mass window for inducing a transient temperature gradient in the tissue by means of conductive heat transfer with the tissue, and a cooling element in operative combination with the thermal mass window for cooling the thermal mass window. Also provided is an infrared sensor for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the tissue, and for providing output signals proportional to the detected infrared emissions. A data capture element is provided for sampling the output signals received from the infrared sensor as the transient temperature gradient progresses into the tissue.
摘要翻译：一种用于非侵入性生成和捕获来自人或动物组织的热梯度光谱的固态光谱仪。光谱仪包括用于通过与组织的导电热传递在组织中诱导瞬时温度梯度的红外透射热质窗口，以及与用于冷却热质量窗口的热质量窗口可操作组合的冷却元件。还提供了一种红外传感器，用于当瞬态温度梯度进入组织时检测从组织发出的红外辐射，并提供与检测到的红外发射成比例的输出信号。提供数据采集元件，用于对瞬态温度梯度进入组织中的红外传感器接收的输出信号进行采样。

6. 发明授权

US06636753B1 Solid-state non-invasive infrared absorption spectrometer for the generation and capture of thermal gradient spectra form living tissue 失效
标题翻译：用于生成和捕获热梯度光谱的固态非侵入式红外吸收光谱仪形成活组织
公开(公告)号：US06636753B1
公开(公告)日：2003-10-21
申请号：US09760423
申请日：2001-01-11
申请人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Julian Cortella , David J. Correia , Arthur M. Shulenberger , Charles E. Kramer
发明人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Julian Cortella , David J. Correia , Arthur M. Shulenberger , Charles E. Kramer
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/14532 , G01J3/02 , G01J3/0286 , G01J3/0291 , G01J3/42 , G01J5/061
摘要： A solid-state spectrometer for the non-invasive generation and capture of thermal gradient spectra from human or animal tissue. The spectrometer includes an infrared transmissive thermal mass window for inducing a transient temperature gradient in the tissue by means of conductive heat transfer with the tissue, and cooling means in operative combination with the thermal mass window for cooling the thermal mass window. Also provided is an infrared sensor means for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the tissue, and for providing output signals proportional to the detected infrared emissions. Data capture means is provided for sampling the output signals received from the infrared sensor means as the transient temperature gradient progresses into the tissue.
摘要翻译：一种用于非侵入性生成和捕获来自人或动物组织的热梯度光谱的固态光谱仪。光谱仪包括红外透射热质窗口，用于通过与组织的导电热传递来诱导组织中的瞬态温度梯度，以及与用于冷却热质量窗口的热质量窗口可操作组合的冷却装置。还提供了一种红外传感器装置，用于当瞬态温度梯度进入组织时检测从组织发出的红外辐射，并提供与检测到的红外发射成比例的输出信号。提供数据捕获装置，用于当瞬态温度梯度进入组织时对从红外传感器装置接收的输出信号进行采样。

7. 发明申请

US20080212071A1 METHOD OF DETERMINING ANALYTE CONCENTRATION IN A SAMPLE USING INFRARED TRANSMISSION DATA 有权
标题翻译：使用红外传输数据确定样品中分析物浓度的方法
公开(公告)号：US20080212071A1
公开(公告)日：2008-09-04
申请号：US11841878
申请日：2007-08-20
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philp C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philp C. Hartstein , Robert D. Gaffney
IPC分类号： G01N21/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

8. 发明授权

US07122154B1 Apparatus for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol 失效
标题翻译：用于检测呼吸酒精的装置，区分肺泡和上呼吸道酒精
公开(公告)号：US07122154B1
公开(公告)日：2006-10-17
申请号：US08363615
申请日：1994-12-23
申请人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
发明人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
IPC分类号： G01N33/497
CPC分类号： A61B5/097 , G01N33/4972 , Y10S436/90 , Y10T436/204165 , Y10T436/204998
摘要： A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.
摘要翻译：一种用于确定受试者呼出的呼吸样品中的肺泡醇浓度成红外感测装置的方法和红外感测装置。通过连续监测酒精和二氧化碳，对二氧化碳标准化酒精度值，计算标准化酒精浓度与二氧化碳浓度之间的差异随时间的推移，检测来自受试者上呼吸道的酒精含量（总和）差异，并将积分差异与阈值进行比较。该技术在二氧化碳的存在之前准确且一致地检测出样品中口腔醇的存在，这种二氧化碳起源于深肺呼吸。

9. 发明授权

US07096124B2 Method of determining an analyte concentration in a sample from an absorption spectrum 失效
标题翻译：从吸收光谱确定样品中分析物浓度的方法
公开(公告)号：US07096124B2
公开(公告)日：2006-08-22
申请号：US11062110
申请日：2005-02-18
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
IPC分类号： G06F19/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
摘要翻译：一种方法确定包含分析物和物质的样品中的分析物浓度。该方法包括提供样品的吸收光谱。吸收光谱具有吸收基线。该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。该方法还包括从吸收光谱中减去物质贡献。因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

10. 发明授权

US07006857B2 Method for determining analyte concentration using periodic temperature modulation and phase detection 失效
公开(公告)号：US07006857B2
公开(公告)日：2006-02-28
申请号：US10426160
申请日：2003-04-28
申请人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trebino , Richard A. King , Casper W. Barnes
发明人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trebino , Richard A. King , Casper W. Barnes
IPC分类号： A61B5/00 , G01N21/71
CPC分类号： A61B5/0059 , G01N21/35
摘要： A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

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