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1. 发明申请

US20100030137A1 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
公开(公告)号：US20100030137A1
公开(公告)日：2010-02-04
申请号：US12511014
申请日：2009-07-28
申请人： W. Dale Hall , David N. Callicoat , Jennifer H. Gable , James R. Braig , Kenneth G. Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Dale Hall , David N. Callicoat , Jennifer H. Gable , James R. Braig , Kenneth G. Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M5/168
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

2. 发明授权

US07388202B2 Method and apparatus for determining an analyte concentration in a sample having interferents 有权
标题翻译：用于确定具有干扰物的样品中的分析物浓度的方法和装置
公开(公告)号：US07388202B2
公开(公告)日：2008-06-17
申请号：US11256656
申请日：2005-10-21
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01J1/00 , G01N21/35
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

3. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

4. 发明授权

US06731961B2 Method for transforming phase spectra to absorption spectra 失效
公开(公告)号：US06731961B2
公开(公告)日：2004-05-04
申请号：US10291912
申请日：2002-11-08
申请人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
发明人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1491 , G01N21/1717 , G01N21/35 , G01N21/3577 , G01N21/71
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.

5. 发明授权

US08140140B2 Analyte detection system for multiple analytes 有权
标题翻译：多种分析物的分析物检测系统
公开(公告)号：US08140140B2
公开(公告)日：2012-03-20
申请号：US11314176
申请日：2005-12-21
申请人： Bernhard B. Sterling , James R. Braig , Kenneth G. Witte , Peter Rule , Richard Keenan , W. Dale Hall
发明人： Bernhard B. Sterling , James R. Braig , Kenneth G. Witte , Peter Rule , Richard Keenan , W. Dale Hall
IPC分类号： A61B5/1455
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过病人结束所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

6. 发明申请

US20100234703A1 METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的方法和装置
公开(公告)号：US20100234703A1
公开(公告)日：2010-09-16
申请号：US12786244
申请日：2010-05-24
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jenifer H. Gable
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jenifer H. Gable
IPC分类号： A61B5/1455
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： In some embodiments, an apparatus analyzes the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
摘要翻译：在一些实施例中，装置分析体液的组成。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

7. 发明申请

US20100221762A1 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENTS 有权
标题翻译：在具有干扰的样品中测定分析物浓度的方法和装置
公开(公告)号：US20100221762A1
公开(公告)日：2010-09-02
申请号：US12573821
申请日：2009-10-05
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： C12Q1/58 , G06F19/00 , C12Q1/54 , C12Q1/02 , C12Q1/24
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

8. 发明授权

US07722537B2 Method and apparatus for detection of multiple analytes 有权
标题翻译：检测多种分析物的方法和装置
公开(公告)号：US07722537B2
公开(公告)日：2010-05-25
申请号：US11314173
申请日：2005-12-21
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jennifer H. Gable
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , W. Dale Hall , Mark Wechsler , Jennifer H. Gable
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

9. 发明申请

US20090045342A1 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENTS 审中-公开
标题翻译：在具有干扰的样品中测定分析物浓度的方法和装置
公开(公告)号：US20090045342A1
公开(公告)日：2009-02-19
申请号：US12140175
申请日：2008-06-16
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01J5/02
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

10. 发明授权

US06825044B2 Method for adjusting a blood analyte measurement 失效
标题翻译：用于调节血液分析物测量的方法
公开(公告)号：US06825044B2
公开(公告)日：2004-11-30
申请号：US10301927
申请日：2002-11-21
申请人： Peng Zheng , Jennifer H. Gable , W. Dale Hall , Kenneth G. Witte , James R. Braig
发明人： Peng Zheng , Jennifer H. Gable , W. Dale Hall , Kenneth G. Witte , James R. Braig
IPC分类号： G01N2164
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined. The hydration correction process is particularly suitable for determining blood analyte concentrations within human tissue.
摘要翻译：提供了用于确定材料样品中的分析物浓度的装置和方法。在样品中诱导调制温度梯度，并在所选分析物的吸收峰和参考波长处测量发射的红外辐射。调制温度梯度由表面温度调制控制。提供了将表面温度调制与测量的红外辐射的调制相关联的传递函数。检测传递函数的相位和幅度差异。测量，相关和处理与分析物浓度有关的这些相位和幅度差异，以确定材料样品中的分析物浓度。提供了一种用于调节分析物测量的方法。该方法提供用于校准和校正的水合校正过程，从而可以确定材料样品中的分析物浓度。水合校正过程特别适用于测定人体组织内的血液分析物浓度。

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