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1. 发明授权

US06958809B2 Reagent-less whole-blood glucose meter 有权
标题翻译：无试剂全血糖仪
公开(公告)号：US06958809B2
公开(公告)日：2005-10-25
申请号：US10055875
申请日：2002-01-21
申请人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
发明人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
IPC分类号： A61B5/00 , G01N21/35 , G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

2. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

3. 发明授权

US06959211B2 Device for capturing thermal spectra from tissue 失效
标题翻译：用于从组织中捕获热谱的装置
公开(公告)号：US06959211B2
公开(公告)日：2005-10-25
申请号：US10213730
申请日：2002-08-06
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
IPC分类号： A61B5/00 , G01N21/01 , G01N21/03 , G01N21/35
CPC分类号： A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/6824 , G01J3/0286 , G01J3/0291 , G01N21/01 , G01N21/35 , G01N2021/0389 , G01N2201/021 , G01N2201/0245
摘要： A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

4. 发明授权

US06631282B2 Device for isolating regions of living tissue 失效
标题翻译：用于隔离活组织区域的装置
公开(公告)号：US06631282B2
公开(公告)日：2003-10-07
申请号：US09970021
申请日：2001-10-02
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
IPC分类号： A61B500
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

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