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1. 发明授权

US06556009B2 Accelerated magnetic resonance imaging using a parallel spatial filter 有权
公开(公告)号：US06556009B2
公开(公告)日：2003-04-29
申请号：US09735263
申请日：2000-12-11
申请人： Peter Kellman , Elliot McVeigh
发明人： Peter Kellman , Elliot McVeigh
IPC分类号： G01V300
CPC分类号： G01R33/5611 , G01R33/5619
摘要： An apparatus and method for accelerating magnetic resonance imaging by decreasing the number of sequential phase encodes (undersampling). Image reconstruction of undersampled k-space data can cause ghost artifacts to be produced in the resulting sequence of images. A combination of temporal and spatial filters are used to substantially suppress the ghost artifacts. Additionally, the spatial filter receives spatial filter coefficients used in the filtering process. The spatial filter coefficients are adaptively or dynamically generated so that the coefficients are provided to the spatial filter while generating the sequence of images.

2. 发明授权

US07154268B2 Method and apparatus to improve an MRI image using regularization 有权
标题翻译：使用正则化改善MRI图像的方法和装置
公开(公告)号：US07154268B2
公开(公告)日：2006-12-26
申请号：US10492897
申请日：2002-10-17
申请人： Peter Kellman , Elliot McVeigh
发明人： Peter Kellman , Elliot McVeigh
IPC分类号： G01V3/00
CPC分类号： G01R33/56554 , G01R33/5608 , G01R33/5611 , G01R33/56545
摘要： An MRI imaging system includes at least one processor and a plurality of coils to acquire a plurality of k-space samples of a target to image. The system includes a machine-readable media comprising instructions which, when executed by the processor, result in determining a plurality of different regularization matrices for a plurality of different regions of an image of the target. The regularization matrices are applied in the determination of a plurality of unmixing matrices for the regions. The unmixing matrices are applied to produce the image without ghost artifacts, from a plurality of MRI images produced from the plurality of k-space samples and each comprising ghost artifacts.
摘要翻译： MRI成像系统包括至少一个处理器和多个线圈，以获取目标到图像的多个k空间样本。该系统包括机器可读介质，其包括指令，当由处理器执行该指令时，导致确定目标图像的多个不同区域的多个不同的正则化矩阵。正则化矩阵应用于确定区域的多个解混合矩阵。应用解混合矩阵以从多个k空间样本产生的多个MRI图像中产生没有鬼影伪像的图像，并且每个都包含重影伪像。

3. 发明授权

US06771067B2 Ghost artifact cancellation using phased array processing 有权
标题翻译：使用相控阵处理的Ghost artifact取消
公开(公告)号：US06771067B2
公开(公告)日：2004-08-03
申请号：US09825617
申请日：2001-04-03
申请人： Peter Kellman , Elliot McVeigh
发明人： Peter Kellman , Elliot McVeigh
IPC分类号： G01V300
CPC分类号： G01R33/565 , G01R33/5611 , G01R33/56509 , G01R33/56527 , G01R33/56536
摘要： A ghost artifact cancellation technique is disclosed. Phased array combining is used to cancel ghosts caused by a variety of distortion mechanisms, including space-variant distortions, such as local flow or off-resonance. The technique uses a constrained optimization that optimizes signal-to-noise ratio (SNR) subject to the constraint of nulling ghost artifacts at known locations. In one aspect multi-coil, k-space data is passed through a converter to convert the k-space data to image domain. After the conversion, the images contain ghost artifacts. The images are then passed through one or more phased array combiners. Each phased array combiner separates the superimposed ghosts to produce an image without ghosts. These images may then be aligned by means of shifting and combined by a variety of means to improve the final image quality. In another aspect, the phase encode order is varied in time to produce ghosts with time varying phase. The series of images are then used to adaptively compute the phased array combiner and output combiner coefficients. The developed technique may be used with phase encode orders which reduce image distortion.
摘要翻译：公开了一种鬼影消除技术。相控阵组合用于消除由各种失真机制引起的重影，包括空间变异失真，如局部流动或非共振。该技术使用受限优化，其优化信噪比（SNR），受限于已知位置处的虚像伪影的约束。在一个方面，多线圈，k空间数据通过转换器将k空间数据转换成图像域。转换后，图像包含鬼影。然后，图像通过一个或多个相控阵列组合器。每个相控阵列组合器分离叠加的重影以产生没有鬼影的图像。然后这些图像可以通过移位对齐，并通过各种手段组合以提高最终的图像质量。在另一方面，相位编码顺序在时间上变化以产生具有时变相位的重影。然后使用该系列图像来自适应地计算相控阵列组合器和输出组合器系数。所开发的技术可以与降低图像失真的相位编码顺序一起使用。

4. 发明申请

US20060284615A1 Method for spectrally selective B1 insensitive T2 preparation contrast enhancement for high field magnetic resonance imaging 有权
标题翻译：用于高场磁共振成像的频谱选择性B1不敏感T2制备对比增强的方法
公开(公告)号：US20060284615A1
公开(公告)日：2006-12-21
申请号：US11409511
申请日：2006-04-20
申请人： Reza Nazafat , J. Derbyshire , Ronald Ouwerkerk , Matthias Stuber , Elliot McVeigh
发明人： Reza Nazafat , J. Derbyshire , Ronald Ouwerkerk , Matthias Stuber , Elliot McVeigh
IPC分类号： G01V3/00
CPC分类号： G01R33/5635 , A61B5/0402 , A61B5/055 , A61B5/7285 , G01R33/5602
摘要： A T2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic reverse half passage pulse is applied followed by a predetermined delay. An adiabatic full passage pulse is applied followed by a substantially equal delay, followed by an adiabatic half passage pulse. Fat signal suppression is achieved by increasing or decreasing either the first delay or the second delay.
摘要翻译：制备序列使用具有两个基本相等的延迟的分段BIR-4绝热脉冲，并且对B＆lt; 1＆gt;场变化不敏感，并且可以同时抑制具有低比吸收率的脂肪信号（特区）。施加绝热的反向半通脉冲，然后施加预定的延迟。施加绝热的全通脉冲，然后施加基本相等的延迟，随后是绝热的半通脉冲。通过增加或减少第一延迟或第二延迟来实现脂肪信号抑制。

5. 发明申请

US20060100506A1 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
标题翻译：磁共振引导电生理和消融手术的系统和方法
公开(公告)号：US20060100506A1
公开(公告)日：2006-05-11
申请号：US11314241
申请日：2005-12-22
申请人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。可以提供转向装置用于在MR引导下转导侵入性导管。可以使用其他烧蚀方法，如激光，超声和低温。

6. 发明授权

US07848788B2 Magnetic resonance imaging probe 有权
标题翻译：磁共振成像探头
公开(公告)号：US07848788B2
公开(公告)日：2010-12-07
申请号：US10123065
申请日：2002-04-11
申请人： Steve Tulley , Albert C. Lardo , Parag Karmarkar , Elliot McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley , Ergin Atalar , Xiaoming Yang
发明人： Steve Tulley , Albert C. Lardo , Parag Karmarkar , Elliot McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley , Ergin Atalar , Xiaoming Yang
IPC分类号： A61B5/055
CPC分类号： G01R33/34084 , A61M25/09 , G01R33/287 , G01R33/34053 , G01R33/3657 , H01Q1/36 , H01Q1/362 , H01Q1/40 , H01Q1/42 , H01Q1/44 , H01Q11/08
摘要： Herein is disclosed a magnetic resonance imaging probe, having a probe shaft including a magnetic resonance antenna, and a spring tip attached to a distal end of the antenna.
摘要翻译：本文公开了一种磁共振成像探头，其具有包括磁共振天线的探针轴以及连接到天线远端的弹簧尖端。

7. 发明申请

US20080058635A1 MRI-GUIDED THERAPY METHODS AND RELATED SYSTEMS 有权
公开(公告)号：US20080058635A1
公开(公告)日：2008-03-06
申请号：US11924877
申请日：2007-10-26
申请人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/055 , A61B18/12
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

8. 发明申请

US20070225591A1 SPECTRALLY SELECTIVE SUPPRESSION WITH STEADY-STATE FREE PRECESSION 有权
标题翻译：具有稳定状态的频谱选择性抑制
公开(公告)号：US20070225591A1
公开(公告)日：2007-09-27
申请号：US11751479
申请日：2007-05-21
申请人： John Derbyshire , Daniel Herzka , Elliot McVeigh
发明人： John Derbyshire , Daniel Herzka , Elliot McVeigh
IPC分类号： A61B5/055
CPC分类号： G01R33/5613 , G01R33/483 , G01R33/5602 , G01R33/5607
摘要： A method for fat-suppressed imaging is disclosed. Such a method may include storing a first spectral component of an echo signal formed at TR/2 from a sample, suppressing a second spectral component of the echo signal at TR/2, re-exciting the stored spectral component after suppressing the second spectral component, and producing an image of the sample based on the re-excited stored spectral component.
摘要翻译：公开了一种脂肪抑制成像方法。这样的方法可以包括：存储来自样本的在TR / 2处形成的回波信号的第一频谱分量，以TR / 2抑制回波信号的第二频谱分量，在抑制第二频谱分量之后重新激励存储的频谱分量并且基于重新存储的光谱分量产生样本的图像。

9. 发明申请

US20070057671A1 Imaging and reconstruction of partial field of view in phase contrast MRI 有权
标题翻译：相位对比MRI部分视野的成像和重建
公开(公告)号：US20070057671A1
公开(公告)日：2007-03-15
申请号：US11227406
申请日：2005-09-14
申请人： Reza Nezafat , Richard Thompson , Elliot McVeigh
发明人： Reza Nezafat , Richard Thompson , Elliot McVeigh
IPC分类号： G01V3/00
CPC分类号： G01R33/56308 , G01R33/4824 , G01R33/561 , G01R33/56316
摘要： Phase contrast magnetic resonance images are produced using interleaved spiral k-space scanning with a bipolar phase contrast gradient. Spiral scanning is configured so that acquisition impulse response defines a central alias free portion in a partial field of view, and signal acquisition is arranged so that moving spins are contained with this central alias free portion. First and second signals are acquired with alternate phase encodings, and a complex difference of the acquired signals is obtained. The complex difference is substantially free of aliasing artifacts within the central portion.
摘要翻译：使用具有双极相位对比度梯度的交错螺旋k空间扫描产生相位对比磁共振图像。配置螺旋扫描，使得采集脉冲响应在局部视野中定义中心无空闲部分，并且布置信号采集，使得移动自旋包含在该中央无空闲部分中。利用交替的相位编码获取第一和第二信号，并且获得所获取的信号的复差。复杂的差异基本上不存在中心部分内的混叠伪影。

10. 发明授权

US06549800B1 Methods for in vivo magnetic resonance imaging 有权
标题翻译：体内磁共振成像方法
公开(公告)号：US06549800B1
公开(公告)日：2003-04-15
申请号：US09549921
申请日：2000-04-14
申请人： Ergin Atalar , Paul A. Bottomley , Elias Zerhouin , Henry Halperin , Elliot McVeigh , Albert C. Lardo
发明人： Ergin Atalar , Paul A. Bottomley , Elias Zerhouin , Henry Halperin , Elliot McVeigh , Albert C. Lardo
IPC分类号： A61B505
CPC分类号： A61B5/415 , A61B1/273 , A61B1/303 , A61B1/307 , A61B1/31 , A61B5/055 , A61B5/418 , A61B5/42 , A61B5/4381 , A61B10/0275 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/3628 , H01Q1/36 , H01Q1/362 , H01Q1/40 , H01Q1/44 , H01Q11/08
摘要： The systems and methods of the present invention provide for MRI probes adapted for insertion into a plurality of body orifices, in order to evaluate the anatomy of proximate anatomic structures, to diagnose abnormalities thereof and to treat the diagnosed abnormalities. MRI probes are described that are suitable for use in the mediastinum, in the pancreaticohepaticobiliary system, in the tracheobronchopulmonary system, in the head and neck, in the genitourinary system, the gastrointestinal system, the vascular system, and in the evaluation, diagnosis and treatment of internal fluid collections.
摘要翻译：本发明的系统和方法提供适于插入多个体孔的MRI探针，以评估近端解剖结构的解剖结构，诊断其异常并治疗诊断异常。描述了适用于纵隔，胰胆管系统，气管支气管系统，头颈部，泌尿生殖系统，胃肠系统，血管系统以及评估，诊断和治疗中的MRI探针的内部流体收集。

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