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1. 发明授权

US07848795B2 Determination of sleep depth 有权
标题翻译：睡眠深度的确定
公开(公告)号：US07848795B2
公开(公告)日：2010-12-07
申请号：US11438637
申请日：2006-05-22
申请人： Pekka Meriläinen , Markku Paloheimo , Juha Virtanen , Hanna Viertiö-Oja , Petteri Lapinlampi
发明人： Pekka Meriläinen , Markku Paloheimo , Juha Virtanen , Hanna Viertiö-Oja , Petteri Lapinlampi
IPC分类号： A61B5/04
CPC分类号： A61B5/0535 , A61B5/0484 , A61B5/0496 , A61B5/4812
摘要： The invention relates to a mechanism for determining the depth of sleep of a subject. In order to obtain information about the continuum of the depth of sleep in a user-friendly way without a need for high computational power, EEG signal data is obtained from a subject, REM sleep periods of the subject are detected, and a measure indicative of irregularity in the EEG signal data is derived. Based on the measure and the depicted REM sleep periods, a sleep depth index and state information are produced, where the index is indicative of the depth of sleep of the subject and the state information indicates whether or not the EEG signal data is obtained during a REM sleep period. The detection of the REM periods may be based on a bioimpedance measured from EEG electrodes simultaneously with the EEG measurement or on EOG signal data measured from the subject.
摘要翻译：本发明涉及一种用于确定受试者睡眠深度的机制。为了以用户友好的方式获得关于睡眠深度的连续性的信息，而不需要高计算能力，从受试者获得EEG信号数据，检测对象的REM睡眠周期，并且指示导出EEG信号数据的不规则性。基于测量和检测到的REM睡眠周期，产生睡眠深度指数和状态信息，其中索引指示被摄体的睡眠深度，并且状态信息指示是否在期间获得EEG信号数据 REM睡眠期。 REM周期的检测可以基于与EEG测量同时测量的EEG电极的生物阻抗或从受试者测量的EOG信号数据。

2. 发明申请

US20070270706A1 Determination of sleep depth 有权
标题翻译：睡眠深度的确定
公开(公告)号：US20070270706A1
公开(公告)日：2007-11-22
申请号：US11438637
申请日：2006-05-22
申请人： Pekka Merilainen , Markku Paloheimo , Juha Virtanen , Hanna Viertio-Oja , Petteri Lapinlampi
发明人： Pekka Merilainen , Markku Paloheimo , Juha Virtanen , Hanna Viertio-Oja , Petteri Lapinlampi
IPC分类号： A61B5/04
CPC分类号： A61B5/0535 , A61B5/0484 , A61B5/0496 , A61B5/4812
摘要： The invention relates to a mechanism for determining the depth of sleep of a subject. In order to obtain information about the continuum of the depth of sleep in a user-friendly way without a need for high computational power, EEG signal data is obtained from a subject, REM sleep periods of the subject are detected, and a measure indicative of irregularity in the EEG signal data is derived. Based on the measure and the detected REM sleep periods, a sleep depth index and state information are produced, where the index is indicative of the depth of sleep of the subject and the state information indicates whether or not the EEG signal data is obtained during a REM sleep period. The detection of the REM periods may be based on a bioimpedance measured from EEG electrodes simultaneously with the EEG measurement or on EOG signal data measured from the subject.
摘要翻译：本发明涉及一种用于确定受试者睡眠深度的机制。为了以用户友好的方式获得关于睡眠深度的连续性的信息，而不需要高计算能力，从受试者获得EEG信号数据，检测对象的REM睡眠周期，并且指示导出EEG信号数据的不规则性。基于测量和检测到的REM睡眠周期，产生睡眠深度指数和状态信息，其中索引指示被摄体的睡眠深度，并且状态信息指示是否在期间获得EEG信号数据 REM睡眠期。 REM周期的检测可以基于与EEG测量同时测量的EEG电极的生物阻抗或从受试者测量的EOG信号数据。

3. 发明申请

US20110230745A1 Motion Artifact Rejection Microelectrode 有权
标题翻译：运动神器抑制微电极
公开(公告)号：US20110230745A1
公开(公告)日：2011-09-22
申请号：US12725865
申请日：2010-03-17
申请人： Shankar Chandrasekaran , Juha Virtanen , Shivappa Goravar
发明人： Shankar Chandrasekaran , Juha Virtanen , Shivappa Goravar
IPC分类号： A61B5/04 , A61B5/0476
CPC分类号： A61B5/0408 , A61B5/0428 , A61B5/685 , A61B5/721 , A61B2562/0219 , A61B2562/028 , A61B2562/125
摘要： An electrode system for the measurement of biopotential signals includes a substrate. A microelectrode is coupled to the substrate. An accelerometer is coupled to the substrate. A biopotential amplifier is electrically coupled to the microelectrode and acceleration measurement circuit is electrically coupled to the accelerometer. A method of measuring a biopotential from a patient includes sensing a biopotential with a microelectrode. The biopotential is amplified with an amplifier in electrical communication with the microelectrode. A movement of the electrode is sensed with an accelerometer integrated with the electrode substrate. The sensed biopotential and the sensed movement are provided to an electronic controller. Portions of the sensed biopotential that correspond to sensed movement are identified as artifact contaminated portions.
摘要翻译：用于测量生物电位信号的电极系统包括基底。微电极耦合到衬底。加速度传感器耦合到基板。生物电位放大器电耦合到微电极，并且加速度测量电路电耦合到加速度计。从患者测量生物潜力的方法包括用微电极感测生物电位。生物电位用与微电极电连通的放大器放大。用与电极基板一体化的加速度计感测电极的移动。感测到的生物电势和感测的运动被提供给电子控制器。对应于感测到的移动的感测生物电位的部分被识别为伪影污染部分。

4. 发明授权

US07844324B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US07844324B2
公开(公告)日：2010-11-30
申请号：US11674732
申请日：2007-02-14
申请人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
发明人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

5. 发明申请

US20080194981A1 Measurement of EEG Reactivity 有权
标题翻译：测量脑电反应
公开(公告)号：US20080194981A1
公开(公告)日：2008-08-14
申请号：US11674732
申请日：2007-02-14
申请人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
发明人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
IPC分类号： A61B5/0476
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

6. 发明申请

US20070112278A1 Measurement of EEG reactivity 有权
公开(公告)号：US20070112278A1
公开(公告)日：2007-05-17
申请号：US11273574
申请日：2005-11-14
申请人： Hanna Viertio-Oja , Mika Sarkela , Juha Virtanen , Tapani Salmi
发明人： Hanna Viertio-Oja , Mika Sarkela , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/00 , A61B5/05 , A61B5/04
CPC分类号： A61B5/0484
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.

7. 发明申请

US20070010723A1 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US20070010723A1
公开(公告)日：2007-01-11
申请号：US11174763
申请日：2005-07-05
申请人： Kimmo Uutela , Matti Huiku , Juha Virtanen
发明人： Kimmo Uutela , Matti Huiku , Juha Virtanen
IPC分类号： A61B5/00
CPC分类号： G06F19/3431 , A61B5/0006 , A61B5/0205 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/04001 , A61B5/04004 , A61B5/0402 , A61B5/0452 , A61B5/0476 , A61B5/4035 , A61B5/4821 , A61B5/4824 , A61B5/4839 , A61B5/7275 , A61B5/7282 , G06F19/00 , G06F19/34 , G06K9/00523 , G16H50/20 , G16H50/30 , Y10S128/92
摘要： The invention relates to the determination of the clinical state of a subject. A respective adaptive transform is applied to at least one measurement signal acquired from the subject, each adaptive transform being dependent on previously acquired history data, and a diagnostic index is formed, which is dependent on the transformed measurement signal(s) and serves as a measure of the clinical state of the subject. In order to reliably evaluate the clinical state of a subject on a fixed diagnostic scale during changes in the state of the subject, some or all of the previously acquired history data on which an adaptive transform is currently dependent is replaced with other previously acquired history data when a predetermined event is detected. The predetermined event is indicative of a change in the respective measurement signal, and the introduction of the said other previously acquired history data sets the transform ready for the change.
摘要翻译：本发明涉及确定受试者的临床状态。相应的自适应变换被应用于从对象获取的至少一个测量信号，每个自适应变换依赖于先前获取的历史数据，并且形成诊断索引，其依赖于变换的测量信号并且用作测量受试者的临床状态。为了在受试者的状态改变期间可靠地评估受试者在固定诊断量表上的临床状态，其中自适应变换当前依赖的先前获取的历史数据中的一些或全部被替换为其他先前获取的历史数据当检测到预定事件时。预定事件表示各测量信号的变化，并且所述其它先前获取的历史数据的引入将变换准备就绪。

8. 发明授权

US06503187B1 Stimulator head and method for attenuating the sound emitted by a stimulator coil 有权
标题翻译：刺激头和衰减由刺激器线圈发出的声音的方法
公开(公告)号：US06503187B1
公开(公告)日：2003-01-07
申请号：US09554812
申请日：2000-05-18
申请人： Risto Ilmoniemi , Jarmo Ruohonen , Janne Kamppuri , Juha Virtanen
发明人： Risto Ilmoniemi , Jarmo Ruohonen , Janne Kamppuri , Juha Virtanen
IPC分类号： A61N202
CPC分类号： A61N2/02
摘要： The present invention relates to a stimulator head of a magnetic stimulator used in the stimulation of living tissue such as the human brain. Such a stimulator bead comprises a stimulator head body (3) suited for mounting the stimulator head on the magnetic stimulator equipment, at least one coil (1) which is connected to said stimulator head body (3) and is designed suitable for generating a stimulating magnetic field, and conductors (7) for passing electric current from said magnetic stimulator into any of said at least one coil (1). According to the invention, the stimulator head includes a housing (2) which is connected to said stimulator head body (3) and is designed to enclose at least one air-tight space (5) which further separates each of said at least one stimulator coil (1) from the other parts of said housing (2) facing the object being stimulated. Further according to the invention, each of said at least one coil (1) is placed in said housing (2), whereby an acoustic insulation can be attained between each of said at least one coil (1) and the object being stimulated by virtue of bringing the pressure in said air-tight space (5) to a substantially low level.
摘要翻译：本发明涉及用于刺激人脑等生物体组织的磁刺激器的刺激头。这种刺激器珠包括适于将刺激头安装在磁刺激器设备上的刺激器头本体（3），连接到所述刺激器头本体（3）的至少一个线圈（1），并被设计成适于产生刺激器磁场和用于使电流从所述磁刺激器传递到所述至少一个线圈（1）中的任何一个的导体（7）。根据本发明，刺激器头包括壳体（2），壳体（2）连接到所述刺激器头部主体（3）并被设计成包围至少一个气密空间（5），所述空气空间进一步分离所述至少一个刺激器所述壳体（2）的面向被刺激物体的其它部分的线圈（1）。此外，根据本发明，所述至少一个线圈（1）中的每一个被放置在所述壳体（2）中，由此可以在所述至少一个线圈（1）中的每一个与被美德所刺激的物体之间达到声学绝缘使所述气密空间（5）中的压力达到基本上低的水平。

9. 发明授权

US08221330B2 Measurement for EEG reactivity 有权
标题翻译： EEG反应性测量
公开(公告)号：US08221330B2
公开(公告)日：2012-07-17
申请号：US12940143
申请日：2010-11-05
申请人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
发明人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

10. 发明授权

US07328062B2 Monitoring of patient's electrical characteristics using a single piece of equipment 有权
标题翻译：使用单件设备监测患者的电气特性
公开(公告)号：US07328062B2
公开(公告)日：2008-02-05
申请号：US10070707
申请日：2001-07-12
申请人： Börje Rantala , Juha Virtanen
发明人： Börje Rantala , Juha Virtanen
IPC分类号： A61B5/0428
CPC分类号： A61B5/0488 , A61B5/0402 , A61B5/0476 , A61B5/0535 , A61B5/1106
摘要： The invention relates to a method and a system for a medical monitoring system, in which method the functions of a patient are measured, and the change in the electric activity of the patient are observed. In the method, the electrocardiogram (EKG), electroencephalogram (EEG), and the impedance cardiograph signal (IKG) are being measured with one piece of measuring equipment.
摘要翻译：本发明涉及一种医疗监视系统的方法和系统，其中测量患者的功能，观察患者的电活动变化。在该方法中，使用一片测量设备测量心电图（EKG），脑电图（EEG）和阻抗心电图信号（IKG）。

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