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1. 发明申请

US20070270706A1 Determination of sleep depth 有权
标题翻译：睡眠深度的确定
公开(公告)号：US20070270706A1
公开(公告)日：2007-11-22
申请号：US11438637
申请日：2006-05-22
申请人： Pekka Merilainen , Markku Paloheimo , Juha Virtanen , Hanna Viertio-Oja , Petteri Lapinlampi
发明人： Pekka Merilainen , Markku Paloheimo , Juha Virtanen , Hanna Viertio-Oja , Petteri Lapinlampi
IPC分类号： A61B5/04
CPC分类号： A61B5/0535 , A61B5/0484 , A61B5/0496 , A61B5/4812
摘要： The invention relates to a mechanism for determining the depth of sleep of a subject. In order to obtain information about the continuum of the depth of sleep in a user-friendly way without a need for high computational power, EEG signal data is obtained from a subject, REM sleep periods of the subject are detected, and a measure indicative of irregularity in the EEG signal data is derived. Based on the measure and the detected REM sleep periods, a sleep depth index and state information are produced, where the index is indicative of the depth of sleep of the subject and the state information indicates whether or not the EEG signal data is obtained during a REM sleep period. The detection of the REM periods may be based on a bioimpedance measured from EEG electrodes simultaneously with the EEG measurement or on EOG signal data measured from the subject.
摘要翻译：本发明涉及一种用于确定受试者睡眠深度的机制。为了以用户友好的方式获得关于睡眠深度的连续性的信息，而不需要高计算能力，从受试者获得EEG信号数据，检测对象的REM睡眠周期，并且指示导出EEG信号数据的不规则性。基于测量和检测到的REM睡眠周期，产生睡眠深度指数和状态信息，其中索引指示被摄体的睡眠深度，并且状态信息指示是否在期间获得EEG信号数据 REM睡眠期。 REM周期的检测可以基于与EEG测量同时测量的EEG电极的生物阻抗或从受试者测量的EOG信号数据。

2. 发明授权

US07848795B2 Determination of sleep depth 有权
标题翻译：睡眠深度的确定
公开(公告)号：US07848795B2
公开(公告)日：2010-12-07
申请号：US11438637
申请日：2006-05-22
申请人： Pekka Meriläinen , Markku Paloheimo , Juha Virtanen , Hanna Viertiö-Oja , Petteri Lapinlampi
发明人： Pekka Meriläinen , Markku Paloheimo , Juha Virtanen , Hanna Viertiö-Oja , Petteri Lapinlampi
IPC分类号： A61B5/04
CPC分类号： A61B5/0535 , A61B5/0484 , A61B5/0496 , A61B5/4812
摘要： The invention relates to a mechanism for determining the depth of sleep of a subject. In order to obtain information about the continuum of the depth of sleep in a user-friendly way without a need for high computational power, EEG signal data is obtained from a subject, REM sleep periods of the subject are detected, and a measure indicative of irregularity in the EEG signal data is derived. Based on the measure and the depicted REM sleep periods, a sleep depth index and state information are produced, where the index is indicative of the depth of sleep of the subject and the state information indicates whether or not the EEG signal data is obtained during a REM sleep period. The detection of the REM periods may be based on a bioimpedance measured from EEG electrodes simultaneously with the EEG measurement or on EOG signal data measured from the subject.
摘要翻译：本发明涉及一种用于确定受试者睡眠深度的机制。为了以用户友好的方式获得关于睡眠深度的连续性的信息，而不需要高计算能力，从受试者获得EEG信号数据，检测对象的REM睡眠周期，并且指示导出EEG信号数据的不规则性。基于测量和检测到的REM睡眠周期，产生睡眠深度指数和状态信息，其中索引指示被摄体的睡眠深度，并且状态信息指示是否在期间获得EEG信号数据 REM睡眠期。 REM周期的检测可以基于与EEG测量同时测量的EEG电极的生物阻抗或从受试者测量的EOG信号数据。

3. 发明申请

US20070055114A1 Measurement of responsiveness of a subject with lowered level of consciousness 有权
标题翻译：测量具有较低意识水平的受试者的反应性
公开(公告)号：US20070055114A1
公开(公告)日：2007-03-08
申请号：US11211137
申请日：2005-08-24
申请人： Hanna Viertio-Oja , Kimmo Uutela , Petteri Lapinlampi
发明人： Hanna Viertio-Oja , Kimmo Uutela , Petteri Lapinlampi
IPC分类号： A61B5/00 , A61B5/04 , A61B19/00
CPC分类号： A61B5/4821 , A61B5/0484 , A61B5/0488 , A61B5/4839 , A61B5/7203
摘要： The invention relates to a method and apparatus for measuring the responsiveness of a subject with lowered level of consciousness. Physiological signal data is obtained from the subject and a first measure indicative of the level of consciousness of the subject is derived from the physiological signal data. In order to obtain an objective measure of the responsiveness of the subject and to improve the specificity of patient monitoring, a sequence of the first measure is recorded without inducing arousals in the subject and a second measure indicative of a responsiveness of the subject is determined based on the recorded sequence. The determination of the second measure may be independent of the unintentional stimuli that cause arousals in the patient or the stimuli causing such arousals in the clinical environment may be detected to find out their effect on the first measure.
摘要翻译：本发明涉及一种用于测量具有较低意识水平的受试者的反应性的方法和装置。从受检者获得生理信号数据，并且从生理信号数据导出指示受试者的意识水平的第一度量。为了获得对受试者的反应性的客观测量并提高患者监测的特异性，记录第一测量的顺序而不诱导受试者的觉醒，并且基于主体的响应性确定第二个度量记录序列。第二措施的确定可以独立于在患者中引起觉醒的无意刺激，或者可以检测到引起临床环境中的这种觉醒的刺激，以发现它们对第一测量的影响。

4. 发明申请

US20080009753A1 Separation of natural and drug-induced sleep of a subject 失效
标题翻译：分离受试者的天然和药物诱发的睡眠
公开(公告)号：US20080009753A1
公开(公告)日：2008-01-10
申请号：US11473223
申请日：2006-06-22
申请人： Petteri Lapinlampi , Mika Sarkela
发明人： Petteri Lapinlampi , Mika Sarkela
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/0205 , A61B5/02416 , A61B5/04014 , A61B5/1106 , A61B5/1455 , A61B5/4035 , A61B5/4806 , A61B5/4809 , A61B5/4812
摘要： The invention relates to a mechanism for detecting whether a sleep state of a subject is due to natural sleep or induced by drugs. An indicator indicative of the activation of the autonomic nervous system of the subject is derived based on cardiovascular signal data measured from the subject and the indicator is employed to identify whether the sleep of the subject is drug-induced sleep or natural sleep. The identification is performed upon detection of a sleep state.
摘要翻译：本发明涉及一种用于检测受试者的睡眠状态是由于自然睡眠还是由药物引起的机制。指示受试者自主神经系统活化的指示是基于从受试者测量的心血管信号数据得出的，并且使用该指标来鉴定受试者的睡眠是否是药物诱导的睡眠或自然睡眠。在检测到睡眠状态时进行识别。

5. 发明申请

US20090247893A1 METHOD AND APPARATUS FOR MEASURING RESPONSIVENESS OF A SUBJECT 审中-公开
标题翻译：用于测量受试者反应的方法和装置
公开(公告)号：US20090247893A1
公开(公告)日：2009-10-01
申请号：US12056928
申请日：2008-03-27
申请人： Petteri Lapinlampi , Mika Sarkela
发明人： Petteri Lapinlampi , Mika Sarkela
IPC分类号： A61B5/0476 , A61B5/0488
CPC分类号： A61B5/0476 , A61B5/04845 , A61B5/0488 , A61B5/4821 , A61B5/726
摘要： The invention relates to a method and apparatus for measuring the responsiveness of a subject. Physiological signal data is obtained from a subject through at least one electrode attached to the skin of the subject and a first measure is derived from the physiological signal data, the first measure being indicative of signal energy in the physiological signal data on a frequency band where EMG activity appears. Recorded sequence of the first measure is subjected as input data to a morphological pattern extraction operation. The output data of the operation is indicative of presence of predetermined response waveforms in the input data and a measure of responsiveness is determined based on the output data.
摘要翻译：本发明涉及一种用于测量受试者的反应性的方法和装置。生理信号数据是通过至少一个连接到受试者皮肤的电极从对象获得的，并且第一个测量是根据生理信号数据得出的，第一个测量指示频带上的生理信号数据中的信号能量， EMG活动出现。将第一测量的记录序列作为输入数据进行形态模式提取操作。操作的输出数据表示输入数据中存在预定的响应波形，并且基于输出数据确定响应度的度量。

6. 发明授权

US07630758B2 Separation of natural and drug-induced sleep of a subject 失效
标题翻译：分离受试者的天然和药物诱发的睡眠
公开(公告)号：US07630758B2
公开(公告)日：2009-12-08
申请号：US11473223
申请日：2006-06-22
申请人： Petteri Lapinlampi , Mika Sarkela
发明人： Petteri Lapinlampi , Mika Sarkela
IPC分类号： A61B5/00
CPC分类号： A61B5/0205 , A61B5/02416 , A61B5/04014 , A61B5/1106 , A61B5/1455 , A61B5/4035 , A61B5/4806 , A61B5/4809 , A61B5/4812
摘要： The invention relates to a mechanism for detecting whether a sleep state of a subject is due to natural sleep or induced by drugs. An indicator indicative of the activation of the autonomic nervous system of the subject is derived based on cardiovascular signal data measured from the subject and the indicator is employed to identify whether the sleep of the subject is drug-induced sleep or natural sleep. The identification is performed upon detection of a sleep state.
摘要翻译：本发明涉及一种用于检测受试者的睡眠状态是由于自然睡眠还是由药物引起的机制。指示受试者自主神经系统活化的指示是基于从受试者测量的心血管信号数据得出的，并且使用该指标来鉴定受试者的睡眠是否是药物诱导的睡眠或自然睡眠。在检测到睡眠状态时进行识别。

7. 发明授权

US07725173B2 Measurement of responsiveness of a subject with lowered level of consciousness 有权
标题翻译：测量具有较低意识水平的受试者的反应性
公开(公告)号：US07725173B2
公开(公告)日：2010-05-25
申请号：US11211137
申请日：2005-08-24
申请人： Hanna E. Viertiö-Oja , Kimmo Uutela , Petteri Lapinlampi
发明人： Hanna E. Viertiö-Oja , Kimmo Uutela , Petteri Lapinlampi
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/0484 , A61B5/0488 , A61B5/4839 , A61B5/7203
摘要： The invention relates to a method and apparatus for measuring the responsiveness of a subject with lowered level of consciousness. Physiological signal data is obtained from the subject and a first measure indicative of the level of consciousness of the subject is derived from the physiological signal data. In order to obtain an objective measure of the responsiveness of the subject and to improve the specificity of patient monitoring, a sequence of the first measure is recorded without inducing arousals in the subject and a second measure indicative of a responsiveness of the subject is determined based on the recorded sequence. The determination of the second measure may be independent of the unintentional stimuli that cause arousals in the patient or the stimuli causing such arousals in the clinical environment may be detected to find out their effect on the first measure.
摘要翻译：本发明涉及一种用于测量具有较低意识水平的受试者的反应性的方法和装置。从受检者获得生理信号数据，并且从生理信号数据导出指示受试者的意识水平的第一度量。为了获得对受试者的反应性的客观测量并提高患者监测的特异性，记录第一测量的顺序而不诱导受试者的觉醒，并且基于主体的响应性确定第二个度量记录序列。第二措施的确定可以独立于在患者中引起觉醒的无意刺激，或者可以检测到引起临床环境中的这种觉醒的刺激，以发现它们对第一测量的影响。

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