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1. 发明申请

US20070010723A1 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US20070010723A1
公开(公告)日：2007-01-11
申请号：US11174763
申请日：2005-07-05
申请人： Kimmo Uutela , Matti Huiku , Juha Virtanen
发明人： Kimmo Uutela , Matti Huiku , Juha Virtanen
IPC分类号： A61B5/00
CPC分类号： G06F19/3431 , A61B5/0006 , A61B5/0205 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/04001 , A61B5/04004 , A61B5/0402 , A61B5/0452 , A61B5/0476 , A61B5/4035 , A61B5/4821 , A61B5/4824 , A61B5/4839 , A61B5/7275 , A61B5/7282 , G06F19/00 , G06F19/34 , G06K9/00523 , G16H50/20 , G16H50/30 , Y10S128/92
摘要： The invention relates to the determination of the clinical state of a subject. A respective adaptive transform is applied to at least one measurement signal acquired from the subject, each adaptive transform being dependent on previously acquired history data, and a diagnostic index is formed, which is dependent on the transformed measurement signal(s) and serves as a measure of the clinical state of the subject. In order to reliably evaluate the clinical state of a subject on a fixed diagnostic scale during changes in the state of the subject, some or all of the previously acquired history data on which an adaptive transform is currently dependent is replaced with other previously acquired history data when a predetermined event is detected. The predetermined event is indicative of a change in the respective measurement signal, and the introduction of the said other previously acquired history data sets the transform ready for the change.
摘要翻译：本发明涉及确定受试者的临床状态。相应的自适应变换被应用于从对象获取的至少一个测量信号，每个自适应变换依赖于先前获取的历史数据，并且形成诊断索引，其依赖于变换的测量信号并且用作测量受试者的临床状态。为了在受试者的状态改变期间可靠地评估受试者在固定诊断量表上的临床状态，其中自适应变换当前依赖的先前获取的历史数据中的一些或全部被替换为其他先前获取的历史数据当检测到预定事件时。预定事件表示各测量信号的变化，并且所述其它先前获取的历史数据的引入将变换准备就绪。

2. 发明授权

US08574156B2 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US08574156B2
公开(公告)日：2013-11-05
申请号：US11174763
申请日：2005-07-05
申请人： Kimmo Uutela , Matti Huiku , Juha Virtanen
发明人： Kimmo Uutela , Matti Huiku , Juha Virtanen
IPC分类号： A61B5/00 , A61B5/0476 , A61B5/04 , G06F19/00
CPC分类号： G06F19/3431 , A61B5/0006 , A61B5/0205 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/04001 , A61B5/04004 , A61B5/0402 , A61B5/0452 , A61B5/0476 , A61B5/4035 , A61B5/4821 , A61B5/4824 , A61B5/4839 , A61B5/7275 , A61B5/7282 , G06F19/00 , G06F19/34 , G06K9/00523 , G16H50/20 , G16H50/30 , Y10S128/92
摘要： The invention relates to the determination of the clinical state of a subject. A respective adaptive transform is applied to at least one measurement signal acquired from the subject, each adaptive transform being dependent on previously acquired history data, and a diagnostic index is formed, which is dependent on the transformed measurement signal(s) and serves as a measure of the clinical state of the subject. In order to reliably evaluate the clinical state of a subject on a fixed diagnostic scale during changes in the state of the subject, some or all of the previously acquired history data on which an adaptive transform is currently dependent is replaced with other previously acquired history data when a predetermined event is detected. The predetermined event is indicative of a change in the respective measurement signal, and the introduction of the said other previously acquired history data sets the transform ready for the change.
摘要翻译：本发明涉及确定受试者的临床状态。相应的自适应变换被应用于从对象获取的至少一个测量信号，每个自适应变换依赖于先前获取的历史数据，并且形成诊断索引，其依赖于变换的测量信号并且用作测量受试者的临床状态。为了在受试者的状态改变期间可靠地评估受试者在固定诊断量表上的临床状态，其中自适应变换当前依赖的先前获取的历史数据中的一些或全部被替换为其他先前获得的历史数据当检测到预定事件时。预定事件表示各测量信号的变化，并且所述其它先前获取的历史数据的引入将变换准备就绪。

3. 发明申请

US20080242955A1 RELIABILITY IN DETERMINATION OF CLINICAL STATE OF A SUBJECT 审中-公开
标题翻译：确定受试者临床状态的可靠性
公开(公告)号：US20080242955A1
公开(公告)日：2008-10-02
申请号：US11693895
申请日：2007-03-30
申请人： Kimmo Uutela , Borje Rantala , Minna Kymalainen , Matti Huiku , Petri Karkas
发明人： Kimmo Uutela , Borje Rantala , Minna Kymalainen , Matti Huiku , Petri Karkas
IPC分类号： A61B5/00
CPC分类号： A61B5/0402 , A61B5/021 , A61B5/4821 , A61B5/4824 , G16H50/20
摘要： The invention relates to the determination of a diagnostic index indicative of the clinical state, especially nociceptive state, of a subject. In order to improve the quality of the determination process, desired input signals derived from the subject are monitored and the quality of the process is improved based on the monitoring. This is implemented by increasing user awareness of the reliability of the index or by controlling the measurement set-up. Quality information indicative of the reliability of the current index values may be produced based on the input signals. The quality information may then be employed to give an indication of the current reliability of the index and a warning if the reliability of the diagnostic index becomes compromised.
摘要翻译：本发明涉及确定指示受试者的临床状态，特别是伤害感受状态的诊断指标。为了提高确定处理的质量，监视从对象导出的期望的输入信号，并且基于监视提高处理的质量。这是通过提高用户对指标可靠性的认识或通过控制测量设置来实现的。可以基于输入信号来产生指示当前索引值的可靠性的质量信息。然后可以采用质量信息来给出索引的当前可靠性的指示和如果诊断索引的可靠性变得损害的警告。

4. 发明授权

US07294785B2 Patient cable for medical measurements 有权
标题翻译：用于医疗测量的病人电缆
公开(公告)号：US07294785B2
公开(公告)日：2007-11-13
申请号：US10871530
申请日：2004-06-18
申请人： Kimmo Uutela , Sami Miettinen , Tapani Niklander , Juha Virtanen
发明人： Kimmo Uutela , Sami Miettinen , Tapani Niklander , Juha Virtanen
IPC分类号： H01R9/05 , A61B5/05
CPC分类号： A61B5/04286 , A61B5/055 , A61B2562/222 , A61N1/086 , A61N1/3718
摘要： The invention relates to a patient cable for medical measurements performed in connection with Magnetic Resonance Imaging (MRI). In order to eliminate the risk of thermal injuries without compromising the signal-to-noise ratio more than what is required for patient safety, the patient cable comprises two successive cable elements having different resistance characteristics. The second cable element, which is connected by the first cable element to the patient, has a total resistance increased from a normal high-conductivity resistance value of a patient cable to suppress antenna resonances in the second cable element. The first cable element, which is connected to the electrodes on the skin of the patient, has a total resistance substantially greater than that of the second cable element to prevent electromagnetically induced currents from flowing to the patient and to prevent excessive heating of the cable by electromagnetic induction.
摘要翻译：本发明涉及一种用于结合磁共振成像（MRI）进行医疗测量的患者电缆。为了消除热损伤的风险，而不会使信噪比大于患者安全所需的，患者电缆包括具有不同电阻特性的两个连续的电缆元件。通过第一电缆元件连接到患者的第二电缆元件具有从患者电缆的正常高导电电阻值增加的总电阻，以抑制第二电缆元件中的天线谐振。连接到患者皮肤上的电极的第一电缆元件的总电阻基本上大于第二电缆元件的电阻，以防止电磁感应电流流向患者，并且防止电缆过度加热电磁感应。

5. 发明申请

US20100130834A1 MEASUREMENT OF RESPONSIVENESS OF A SUBJECT 审中-公开
标题翻译：测量对象的响应
公开(公告)号：US20100130834A1
公开(公告)日：2010-05-27
申请号：US12323953
申请日：2008-11-26
申请人： Hanna Viertio-Oja , Kimmo Uutela , Juha Virtanen
发明人： Hanna Viertio-Oja , Kimmo Uutela , Juha Virtanen
IPC分类号： A61B5/00
CPC分类号： A61B5/0484 , A61B5/0488 , A61B5/4821
摘要： A method and apparatus for measuring the responsiveness of a subject are disclosed. Based on physiological signal data obtained from a subject, two indices of responsiveness are determined for the subject. The first index is indicative of the responsiveness of the subject to unintentional background stimulation affecting the subject, while the second index is indicative of the responsiveness of the subject to intentional stimulation. The determination of the two indices is such that the indices are commensurable to each other, thereby to allow evaluation of the state of the subject based on the relative magnitudes of the indices.
摘要翻译：公开了一种用于测量受试者的反应性的方法和装置。基于从受试者获得的生理信号数据，确定对象的响应性的两个指标。第一个索引表明受试者对影响受试者的无意的背景刺激的反应性，而第二个指标则指示受试者对故意刺激的反应。两个指标的确定是指数相互相称，从而可以根据指数的相对幅度来评估主体的状态。

6. 发明申请

US20050027191A1 Patient cable for medical measurements 有权
标题翻译：用于医疗测量的病人电缆
公开(公告)号：US20050027191A1
公开(公告)日：2005-02-03
申请号：US10871530
申请日：2004-06-18
申请人： Kimmo Uutela , Sami Miettinen , Tapani Niklander , Juha Virtanen
发明人： Kimmo Uutela , Sami Miettinen , Tapani Niklander , Juha Virtanen
IPC分类号： A61B5/0428 , A61B5/055 , A61B5/05 , G01V3/00
CPC分类号： A61B5/04286 , A61B5/055 , A61B2562/222 , A61N1/086 , A61N1/3718
摘要： The invention relates to a patient cable for medical measurements performed in connection with Magnetic Resonance Imaging (MRI). In order to eliminate the risk of thermal injuries without compromising the signal-to-noise ratio more than what is required for patient safety, the patient cable comprises two successive cable elements having different resistance characteristics. The second cable element, which is connected by the first cable element to the patient, has a total resistance increased from a normal high-conductivity resistance value of a patient cable to suppress antenna resonances in the second cable element. The first cable element, which is connected to the electrodes on the skin of the patient, has a total resistance substantially greater than that of the second cable element to prevent electromagnetically induced currents from flowing to the patient and to prevent excessive heating of the cable by electromagnetic induction.
摘要翻译：本发明涉及一种用于结合磁共振成像（MRI）进行医疗测量的患者电缆。为了消除热损伤的风险，而不会使信噪比大于患者安全所需的，患者电缆包括具有不同电阻特性的两个连续的电缆元件。通过第一电缆元件连接到患者的第二电缆元件具有从患者电缆的正常高导电电阻值增加的总电阻，以抑制第二电缆元件中的天线谐振。连接到患者皮肤上的电极的第一电缆元件的总电阻基本上大于第二电缆元件的电阻，以防止电磁感应电流流向患者，并且防止电缆过度加热电磁感应。

7. 发明申请

US20080004504A1 System for detecting allergic reactions resulting from a chemical substance given to a patient 审中-公开
标题翻译：用于检测由给予患者的化学物质引起的过敏反应的系统
公开(公告)号：US20080004504A1
公开(公告)日：2008-01-03
申请号：US11480344
申请日：2006-06-30
申请人： Kimmo Uutela , Borje Rantala
发明人： Kimmo Uutela , Borje Rantala
IPC分类号： G06Q50/00 , A61B5/00
CPC分类号： G06Q50/24 , A61B5/411
摘要： System for detecting allergic reactions resulting from a chemical substance given to a patient The system comprises a workstation configured to carry out desired proceedings and physiological measurements of the patient, a detection arrangement for detecting the chemical substance given to the patient, a database having information of allergic symptoms, and a warning/information display. The database is configured to operate with the workstation to obtain results of the physiological measurements carried out, and is further configured to operate with the detection arrangement for detecting the chemical substance given to the patient and the warning/information display in order to generate a warning of allergic reactions from the basis of the information obtained from the physiological measurements and the chemical substance given to the patient.
摘要翻译：用于检测由给予患者的化学物质引起的过敏反应的系统该系统包括一个被配置为执行期望的程序和患者的生理测量的工作站，用于检测给予患者的化学物质的检测装置，具有过敏症状和警告/信息显示。数据库被配置为与工作站一起操作以获得进行的生理测量的结果，并且还被配置为与检测装置一起操作以检测给予患者的化学物质和警告/信息显示，以产生警告根据从生理测量获得的信息和给予患者的化学物质的过敏反应。

8. 发明申请

US20070149953A1 SYSTEM FOR DELIVERING ANESTHESIA DRUGS TO A PATIENT 有权
标题翻译：将麻醉药物递送给患者的系统
公开(公告)号：US20070149953A1
公开(公告)日：2007-06-28
申请号：US11551289
申请日：2006-10-20
申请人： Heli Tolvanen-Laakso , Leena Pesu , Kimmo Uutela , Borje Rantala , Risto Rossi
发明人： Heli Tolvanen-Laakso , Leena Pesu , Kimmo Uutela , Borje Rantala , Risto Rossi
IPC分类号： A61K9/22
CPC分类号： A61M5/142 , A61M5/14546 , A61M5/172 , A61M5/1723 , A61M16/0051 , A61M16/01 , A61M16/021 , A61M2205/3576 , A61M2205/502
摘要： The invention relates to a system for delivering anesthesia drugs to a patient. The system comprises means for feeding anesthesia drugs to the patient treated, a measuring device for measuring at least one parameter relating to the effects of the anesthetic drugs fed to the patient, a patient monitor to show the results measured by the measuring devices, and feeding means for feeding patient demographics to the system. The system further comprises means for visual planning of the anesthesia drug delivery before the drugs are actually fed. The system can also comprise means for anesthesia management for drug interaction during the treatment.
摘要翻译：本发明涉及一种向患者输送麻醉药物的系统。该系统包括用于将麻醉药物喂给所治疗的患者的装置，用于测量与进给患者的麻醉药物的作用有关的至少一个参数的测量装置，患者监护仪，以显示由测量装置测量的结果，以及进食用于将患者人口统计学提供给系统的手段。该系统还包括用于在药物实际进食之前麻醉药物递送的视觉计划的装置。该系统还可以包括用于治疗期间用于药物相互作用的麻醉管理的装置。

9. 发明授权

US08038642B2 System for delivering anesthesia drugs to a patient 有权
标题翻译：向患者输送麻醉药物的系统
公开(公告)号：US08038642B2
公开(公告)日：2011-10-18
申请号：US11551289
申请日：2006-10-20
申请人： Heli Tolvanen-Laakso , Leena Pesu , Kimmo Uutela , Börje Rantala , Risto Rossi
发明人： Heli Tolvanen-Laakso , Leena Pesu , Kimmo Uutela , Börje Rantala , Risto Rossi
IPC分类号： A61N1/30
CPC分类号： A61M5/142 , A61M5/14546 , A61M5/172 , A61M5/1723 , A61M16/0051 , A61M16/01 , A61M16/021 , A61M2205/3576 , A61M2205/502
摘要： The invention relates to a system for delivering anesthesia drugs to a patient. The system comprises means for feeding anesthesia drugs to the patient treated, a measuring device for measuring at least one parameter relating to the effects of the anesthetic drugs fed to the patient, a patient monitor to show the results measured by the measuring devices, and feeding means for feeding patient demographics to the system. The system further comprises means for visual planning of the anesthesia drug delivery before the drugs are actually fed. The system can also comprise means for anesthesia management for drug interaction during the treatment.
摘要翻译：本发明涉及一种向患者输送麻醉药物的系统。该系统包括用于将麻醉药物喂给所治疗的患者的装置，用于测量与进给患者的麻醉药物的作用有关的至少一个参数的测量装置，患者监护仪，以显示由测量装置测量的结果，以及进食用于将患者人口统计学提供给系统的手段。该系统还包括用于在药物实际进食之前麻醉药物递送的视觉计划的装置。该系统还可以包括用于治疗期间用于药物相互作用的麻醉管理的装置。

10. 发明申请

US20080004537A1 METHOD AND SYSTEM FOR MULTI-CHANNEL BIOSIGNAL PROCESSING 审中-公开
标题翻译：多通道生物化学处理方法与系统
公开(公告)号：US20080004537A1
公开(公告)日：2008-01-03
申请号：US11759980
申请日：2007-06-08
申请人： Kimmo Uutela
发明人： Kimmo Uutela
IPC分类号： A61B5/0402
CPC分类号： A61B5/0456 , A61B5/0428 , A61B5/0476 , A61B5/055
摘要： The invention relates to a method and system for obtaining a refined biosignal, typically an electrocardiogram (ECG), of a living being located in a turbulent electromagnetic environment. Reference data indicative of statistical properties of biosignal artifacts generated by the turbulent electromagnetic environment is collected and multiple channels of the biosignal of the patient are measured in the turbulent electromagnetic environment. Artifacts in one or more of the multiple channels are detected using the reference data and parameters are derived for a linear combination of the multiple channels, which is less prone to the artifacts than the measured multiple channels of the biosignal. The refined biosignal is obtained by applying a linear combination to desired signal samples of the multiple channels, the linear combination being defined by the parameters derived.
摘要翻译：本发明涉及一种用于获得位于湍流电磁环境中的生物的精细生物信号（通常为心电图（ECG））的方法和系统。收集指示由湍流电磁环境产生的生物信号伪像的统计特性的参考数据，并在湍流电磁环境中测量患者的生物信号的多个通道。使用参考数据检测多个通道中的一个或多个中的伪像，并且为多通道的线性组合导出参数，该多通道与生物信号的测量多个通道相比较不容易产生伪影。通过将线性组合应用于多个通道的期望信号样本获得精细生物信号，线性组合由所导出的参数定义。

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