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1. 再颁专利

USRE40786E1 Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres 失效
标题翻译：使用封装在可生物降解的生物相容性微球内的抗原对细胞内病原体进行疫苗接种
公开(公告)号：USRE40786E1
公开(公告)日：2009-06-23
申请号：US09586747
申请日：2000-06-02
申请人： Paul R. Burnett , John E. van Hamont , Robert H. Reid , Jean A. Setterstrom , Thomas C. Van Cott , Deborah L. Birx
发明人： Paul R. Burnett , John E. van Hamont , Robert H. Reid , Jean A. Setterstrom , Thomas C. Van Cott , Deborah L. Birx
IPC分类号： A61K38/00 , A61K9/00 , A61K9/16 , A61K9/50 , C07K14/195 , C07K14/245
CPC分类号： A61K9/1647 , A61K9/5031 , A61K38/00 , C07K14/245
摘要： This invention relates to parenteral and mucosal vaccines against diseases caused by intercellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).
摘要翻译：本发明涉及使用封装在可生物降解的生物相容性微球（基质）内的抗原的细胞间病原体引起的疾病的肠胃外和粘膜疫苗。

2. 发明授权

US5762965A Vaccines against intracellular pathogens using antigens encapsulated within biodegradble-biocompatible microspheres 失效
标题翻译：使用包封在生物相容性生物相容性微球内的抗原对细胞内病原体进行疫苗接种
公开(公告)号：US5762965A
公开(公告)日：1998-06-09
申请号：US598874
申请日：1996-02-09
申请人： Paul R. Burnett , John E. Van Hamont , Robert H. Reid , Jean A. Setterstrom , Thomas C. Van Cott , Debrah L. Birx
发明人： Paul R. Burnett , John E. Van Hamont , Robert H. Reid , Jean A. Setterstrom , Thomas C. Van Cott , Debrah L. Birx
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K38/00 , C07K14/245 , A61F13/00 , A61K9/14 , A61K9/66
CPC分类号： A61K9/1647 , A61K39/39 , A61K9/5031 , C07K14/245 , A61K2039/55555 , A61K38/00
摘要： This invention relates to parenteral and mucosal vaccines against diseases aused by intracellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).
摘要翻译：本发明涉及使用封装在可生物降解的生物相容性微球（基质）内的抗原的细胞内病原体引起的疾病的肠胃外和粘膜疫苗。

3. 发明授权

US06844010B1 Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包封的生物活性物质进行治疗和预防感染
公开(公告)号：US06844010B1
公开(公告)日：2005-01-18
申请号：US09618577
申请日：2000-07-18
申请人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
发明人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/02 , A61K39/108 , A61K39/29 , F23G5/50 , G05B23/02
CPC分类号： A61K39/292 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K38/09 , A61K38/1729 , A61K39/00 , A61K39/0258 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , C12N2730/10134 , Y02A50/464 , Y02A50/474 , Y02A50/48 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊由多肽或其他生物活性剂的核心组成，其包封在聚（丙交酯/乙交酯）共聚物的基质中，其可以含有药学上可接受的佐剂，作为被覆盖的游离羧基端基和封端的共轭物形式范围从100/0至1/99。

4. 发明授权

US07033608B1 “Burst-free” sustained release poly-(lactide/glycolide) microspheres 失效
标题翻译： “无爆发”持续释放聚（丙交酯/乙交酯）微球
公开(公告)号：US07033608B1
公开(公告)日：2006-04-25
申请号：US09337945
申请日：1999-06-22
申请人： Ramasubbu Jevanthi , John E. Van Hamont , Phil Friden , Robert H. Reid , F. Donald Roberts , Charles E. McQueen , Jean A. Setterstrom
发明人： Ramasubbu Jevanthi , John E. Van Hamont , Phil Friden , Robert H. Reid , F. Donald Roberts , Charles E. McQueen , Jean A. Setterstrom
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K9/5031
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊包含多肽核心或其他生物活性剂，其包封在聚（丙交酯/乙交酯）共聚物基质中，作为未封端（游离羧基端基）和封端形式的混合物，其比例范围为100/0至 1/99。

5. 发明授权

US5417986A Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres 失效
标题翻译：使用包封在可生物降解的生物相容性微球内的抗原由肠病原体生物引起的疾病的疫苗
公开(公告)号：US5417986A
公开(公告)日：1995-05-23
申请号：US867301
申请日：1992-04-10
申请人： Robert H. Reid , Edgar C. Boedeker , John E. van Hamont , Jean A. Setterstrom
发明人： Robert H. Reid , Edgar C. Boedeker , John E. van Hamont , Jean A. Setterstrom
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/39 , C07K14/245 , A61K9/66 , A61K9/26
CPC分类号： A61K39/0258 , A61K39/12 , A61K39/292 , A61K39/39 , A61K2039/541 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K38/00 , C12N2730/10134
摘要： This invention is directed to oral parenteral and intestinal vaccines and eir use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.
摘要翻译：本发明涉及口服肠胃外和肠道疫苗及其用于使用包封在可生物降解的生物相容性微球体内的抗原由肠病原体生物引起的疾病的用途。

6. 发明授权

US06309669B1 Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包封的生物活性物质进行治疗和预防感染
公开(公告)号：US06309669B1
公开(公告)日：2001-10-30
申请号：US08789734
申请日：1997-01-27
申请人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
发明人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
IPC分类号： A61K952
CPC分类号： A61K39/292 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K38/09 , A61K38/1729 , A61K39/00 , A61K39/0258 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , C12N2730/10134 , Y02A50/464 , Y02A50/474 , Y02A50/48 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊包含多肽或其他生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其可以含有药学上可接受的佐剂，作为上覆游离羧基端基和封端形式的共混物范围从100/0至1/99。

7. 发明授权

US06217911B1 sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres 失效
标题翻译：持续释放非甾体，抗炎和利多卡因PLGA微球
公开(公告)号：US06217911B1
公开(公告)日：2001-04-17
申请号：US08675895
申请日：1996-07-05
申请人： William M. Vaugn , John E. Van Hamont , Jean A. Setterstrom
发明人： William M. Vaugn , John E. Van Hamont , Jean A. Setterstrom
IPC分类号： A61K950
CPC分类号： A61K9/5026
摘要： A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months, comprising: a non-steroidal, antiinflammatory drug and a blend of biocompatible, biodegradable poly (lactide/glycolide).
摘要翻译：一种控释微胶囊药物制剂，用于在24小时至2个月的持续时间内无爆发，持续，可编程释放非甾体抗炎药物，包括：非甾体抗炎药物和生物相容性，可生物降解的聚（丙交酯/乙交酯）。

8. 发明授权

US06528097B1 Sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres 失效
标题翻译：持续释放非甾体，抗炎和利多卡因PLGA微球
公开(公告)号：US06528097B1
公开(公告)日：2003-03-04
申请号：US09716856
申请日：2000-11-20
申请人： William M. Vaughn , John E. Van Hamont , Jean A. Setterstrom
发明人： William M. Vaughn , John E. Van Hamont , Jean A. Setterstrom
IPC分类号： A61K950
CPC分类号： A61K9/5026
摘要： A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months, comprising: a non-steroidal, antiinflammatory drug and a blend of biocompatible, biodegradable poly (lactide/glycolide).
摘要翻译：一种控释微胶囊药物制剂，用于在24小时至2个月的持续时间内无爆发，持续，可编程释放非甾体抗炎药物，包括：非甾体抗炎药物和生物相容性，可生物降解的聚（丙交酯/乙交酯）。

9. 发明授权

US06902743B1 Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包裹的生物活性物质的治疗和预防感染
公开(公告)号：US06902743B1
公开(公告)日：2005-06-07
申请号：US09055505
申请日：1998-04-06
申请人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K9/16 , A61K9/50 , A61K38/17 , A61K9/14 , A61K39/40 , A61K9/48 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/1611 , A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K38/1709 , Y02A50/414 , Y02A50/423 , Y02A50/478 , Y02A50/48 , Y02A50/491
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。该微胶囊包含多肽或其它生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其具有90/10至40/60的丙交酯/乙交酯的摩尔组成，其可含有药学上可接受的佐剂，作为未加帽的游离羧基端基和封端形式的混合物，其比例为100/0至1/99。

10. 发明授权

US5705197A Extraction process for producing PLGA microspheres 失效
标题翻译：生产PLGA微球的提取工艺
公开(公告)号：US5705197A
公开(公告)日：1998-01-06
申请号：US698896
申请日：1996-08-16
申请人： John Van Hamont , Curt Thies , Robert H. Reid , Charles E. McQueen , Jean A. Setterstrom
发明人： John Van Hamont , Curt Thies , Robert H. Reid , Charles E. McQueen , Jean A. Setterstrom
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/39 , C07K14/245
CPC分类号： A61K39/39 , A61K9/1647 , A61K9/5031 , A61K2039/55555 , A61K38/00
摘要： A hybrid evaporation-extraction process for preparing microspheres of a p(DL-lactide-to-glycolide) biodegradable polymer, comprising: a. preparing a lyophilized biologically active material-sucrose matrix; adding acetonitrile solvent to biologically active material-sucrose matrix to form a solution; b. preparing a solution of a biodegradable poly (DL-lactide-co-glycolide) polymer by adding acetonitrile solvent to the polymer; c. adding the biodegradable poly (DL-lactide-co-glycolide) polymer acetonitrile solution to the biologically active material-sucrose acetonitrile solution; d. adding with stirring an oil containing lecithin to the poly (DL-lactide-co-glycolide) polymer-sucrose-biologically active material solution to evaporate acetonitrile and form an emulsion containing microspheres of poly (DL-lactide-co-glycolide) biodegradable polymers; e. adding the emulsion from step d. into a solvent selected from heptane, hexane, pentane or isopropanol; and f. collecting microspheres of poly (DL-lactide-co-glycolide) biodegradable polymers of from 1.0 to about 10.0 micrometers after filtration and washing with a fresh solvent selected from heptane, hexane, pentane or isopropanol.
摘要翻译：一种用于制备聚（DL-丙交酯 - 乙交酯）生物可降解聚合物的微球的混合蒸发萃取方法，包括：a。制备冻干的生物活性物质 - 蔗糖基质; 向生物活性物质蔗糖基质中加入乙腈溶剂形成溶液; b。通过向聚合物中加入乙腈溶剂制备可生物降解的聚（DL-丙交酯 - 共 - 乙交酯）聚合物的溶液; C。将可生物降解的聚（DL-丙交酯 - 共 - 乙交酯）聚合物乙腈溶液加入到生物活性物质 - 蔗糖乙腈溶液中; d。在聚（DL-丙交酯 - 共 - 乙交酯）聚合物 - 蔗糖 - 生物活性物质溶液中搅拌加入含有卵磷脂的油以蒸发乙腈并形成含有聚（DL-丙交酯 - 共 - 乙交酯）可生物降解聚合物微球的乳液; e。从步骤d中加入乳液。溶于选自庚烷，己烷，戊烷或异丙醇的溶剂中; 和f。收集过滤后的聚（DL-丙交酯 - 共 - 乙交酯）生物可降解聚合物的微球体为1.0至约10.0微米，并用选自庚烷，己烷，戊烷或异丙醇的新鲜溶剂洗涤。

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