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1. 发明授权

US10556931B2 Broad spectrum conjugate vaccine to prevent klebsiella pneumoniae and pseudomonas aeruginosa infections 有权
公开(公告)号：US10556931B2
公开(公告)日：2020-02-11
申请号：US15842068
申请日：2017-12-14
申请人： Raphael Simon , Alan Cross , Sharon Tennant
发明人： Raphael Simon , Alan Cross , Sharon Tennant
IPC分类号： A61K39/02 , C07K14/21 , A61K39/104 , C07K14/26 , A61K39/108 , A61K47/64 , A61K39/00 , A61K47/61
摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and O12. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

2. 发明申请

US20170260240A1 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS 有权
公开(公告)号：US20170260240A1
公开(公告)日：2017-09-14
申请号：US15509041
申请日：2015-09-18
申请人： Raphael Simon , Alan Cross , Sharon Tennant
发明人： Raphael Simon , Alan Cross , Sharon Tennant
IPC分类号： C07K14/26 , A61K39/104 , A61K39/108 , C07K14/21
CPC分类号： C07K14/26 , A61K39/0266 , A61K39/104 , A61K39/116 , A61K47/4833 , A61K47/61 , A61K47/646 , A61K2039/70 , C07K14/21 , C07K2319/00
摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O5 polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

3. 发明申请

US20140224189A1 Post surgical treatment for quadrupeds 有权
标题翻译：手术治疗四足
公开(公告)号：US20140224189A1
公开(公告)日：2014-08-14
申请号：US13998591
申请日：2013-11-15
申请人： Laura Mary Hamilton , Marlene H. Palmer , Alan Cross , David G. Douglas
发明人： Laura Mary Hamilton , Marlene H. Palmer , Alan Cross , David G. Douglas
IPC分类号： A01K13/00
CPC分类号： A01K13/006 , A61D9/00
摘要： The present invention relates to a protective garment for dogs and cats or other quadrupeds. Specifically, the garment is designed to protect wounds, incisions, surgical sites, and related lesions on the animal's body including thoracic and pelvic limbs, truncal area, and head and neck. Additionally the garment is designed to allow attachment of drain suction and similar medical devices.
摘要翻译：本发明涉及用于狗和猫或其他四足动物的防护服。具体来说，服装设计用于保护动物身体上的伤口，切口，手术部位和相关病变，包括胸部和盆腔四肢，截面区域，头颈部。此外，衣服被设计成允许排水抽吸和类似医疗装置的附接。

4. 发明授权

US08300869B2 Lighting and audio communication system 有权
标题翻译：照明和音频通信系统
公开(公告)号：US08300869B2
公开(公告)日：2012-10-30
申请号：US12752560
申请日：2010-04-01
申请人： Bruce Marlin , Alan Cross , Brad Diedrich , Loyd L. Ivey
发明人： Bruce Marlin , Alan Cross , Brad Diedrich , Loyd L. Ivey
IPC分类号： H04R1/02 , H04R9/06 , F21V33/00 , H04R1/00 , H04R9/00
CPC分类号： H04R1/028 , F21S8/026 , F21V33/0056 , F21Y2115/10
摘要： A lighting and communication system with a horn enclosure for recessed ceiling panel or wall mounting, including a speaker with a horn expansion area to direct sound waves from the speaker to a horn enclosure front, at least one light enclosure located within the horn enclosure, the light enclosure defining a light cavity which is separated from said horn expansion area, with a light source inside the light cavity. The light source can be an LED array, which is capable of displaying text, colors or patterns in response to a control system signal.
摘要翻译：一种照明和通信系统，其具有用于凹陷天花板或墙壁安装的喇叭外壳，包括具有喇叭扩展区域的扬声器，以将来自扬声器的声波引导到喇叭外壳前面，至少一个位于喇叭外壳内的灯罩，限定了与所述喇叭扩展区分离的光腔的光罩，在光腔内部具有光源。光源可以是LED阵列，其能够响应于控制系统信号显示文本，颜色或图案。

5. 发明申请

US20080173261A1 REDUCING HEAT TRANSFER SURFACE AREA REQUIREMENTS OF DIRECT FIRED HEATERS WITHOUT DECREASING RUN LENGTH 失效
标题翻译：直接燃烧加热器的换热表面面积要求不减少运行长度
公开(公告)号：US20080173261A1
公开(公告)日：2008-07-24
申请号：US11656033
申请日：2007-01-22
申请人： Alan Cross
发明人： Alan Cross
IPC分类号： F22B7/04
CPC分类号： F22B21/345 , C10G9/20
摘要： This invention relates to the design of direct fired heaters which consist of vertically oriented refractory lined enclosures containing tubular heat transfer elements, the elements partially surrounding a cluster of burners. The burners fire gaseous fuel and generate high temperature combustion products which allow for the transfer of heat , by radiation and convection, from the combustion products to the heat transfer elements and the continuous flow of process fluid contained therein. The transferred heat raises the temperature of the fluid from the design temperature at the inlet to the design temperature at the outlet, at a heat transfer rate commensurate with the temperature differential existing at any given location. The surface area requirements of the heat transfer elements and that of the enclosure surrounding the heat transfer elements is significantly reduced by limiting top to bottom recirculation of burner generated combustion products, thereby increasing overall temperature differentials and heat transfer rates between combustion products and process fluid. Gains in heating surface reduction are not accompanied by losses in heater run length because low process fluid temperatures and high inside heat transfer coefficients are provided, which minimize process fluid film temperature in areas where high heat transfer rates prevail.
摘要翻译：本发明涉及直接燃烧加热器的设计，其由垂直取向的含有管状传热元件的耐火材料衬里的外壳组成，该元件部分地围绕燃烧器簇。燃烧器燃烧气体燃料并产生高温燃烧产物，其允许通过辐射和对流从燃烧产物传递到传热元件的热量以及其中所含的工艺流体的连续流动。转移的热量将流体的温度从出口处的设计温度升高到出口处的设计温度，其传热速率与任何给定位置处存在的温度差相当。通过限制燃烧器产生的燃烧产物的顶部至底部再循环，传热元件和围绕传热元件的外壳的表面积要求显着降低，从而增加燃烧产物和过程流体之间的总温差和传热速率。由于提供了低加工流体温度和较高的内部传热系数，因此加热表面减少的增益不会伴随加热器运行长度的损失，从而使传热率高的区域的工艺流体膜温度最小化。

6. 发明授权

US07395785B1 Reducing heat transfer surface area requirements of direct fired heaters without decreasing run length 失效
标题翻译：直接燃烧加热器的传热面积要求降低，而不会减少行程长度
公开(公告)号：US07395785B1
公开(公告)日：2008-07-08
申请号：US11656033
申请日：2007-01-22
申请人： Alan Cross
发明人： Alan Cross
IPC分类号： F22B7/04
CPC分类号： F22B21/345 , C10G9/20
摘要： This invention relates to the design of direct fired heaters which consist of vertically oriented refractory lined enclosures containing tubular heat transfer elements, the elements partially surrounding a cluster of burners. The burners fire gaseous fuel and generate high temperature combustion products which allow for the transfer of heat, by radiation and convection, from the combustion products to the heat transfer elements and the continuous flow of process fluid contained therein. The transferred heat raises the temperature of the fluid from the design temperature at the inlet to the design temperature at the outlet, at a heat transfer rate commensurate with the temperature differential existing at any given location. The surface area requirements of the heat transfer elements and that of the enclosure surrounding the heat transfer elements is significantly reduced by limiting firebox recirculation of burner generated combustion products, thereby increasing overall temperature differentials and heat transfer rates between combustion products and process fluid. Gains in heating surface reduction are not accompanied by losses in heater run length because low process fluid temperatures and high inside heat transfer coefficients are provided, which minimize process fluid film temperature in areas where high heat transfer rates prevail.
摘要翻译：本发明涉及直接燃烧加热器的设计，其由垂直取向的含有管状传热元件的耐火材料衬里的外壳组成，该元件部分地围绕燃烧器簇。燃烧器燃烧气体燃料并产生高温燃烧产物，其允许通过辐射和对流从燃烧产物传递到传热元件的热量以及其中所含的工艺流体的连续流动。转移的热量将流体的温度从出口处的设计温度升高到出口处的设计温度，其传热速率与任何给定位置处存在的温度差相当。通过限制燃烧器产生的燃烧产物的燃烧箱再循环，从而显着降低了传热元件和围绕传热元件的外壳的表面积要求，从而提高了燃烧产物和过程流体之间的总温差和传热速率。由于提供了低加工流体温度和较高的内部传热系数，因此加热表面减少的增益不会伴随加热器运行长度的损失，从而使传热率高的区域的工艺流体膜温度最小化。

7. 发明申请

US20080004507A1 DATA COLLECTION DEVICE, SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR COLLECTING DATA RELATED TO THE DISPENSING OF CONTRAST MEDIA 审中-公开
标题翻译：数据采集设备，系统，方法和计算机程序产品，用于收集与对比介质分配相关的数据
公开(公告)号：US20080004507A1
公开(公告)日：2008-01-03
申请号：US11738833
申请日：2007-04-23
申请人： Robert Williams , Steven Hartman , Tito Tengco , Clark Godfrey , Alan Cross-Hansen
发明人： Robert Williams , Steven Hartman , Tito Tengco , Clark Godfrey , Alan Cross-Hansen
IPC分类号： A61B5/00
CPC分类号： A61B5/411 , A61B5/00 , A61B5/055 , A61B6/481 , A61B8/481 , G16H40/20 , G16H40/63
摘要： The present invention comprises devices, systems, methods, and computer program products for managing data related to the dispensing of contrast media as part of a medical procedure. The device and system provide a controller that is capable of communicating with a dispensing device so as to extract, arrange, process, and present a data set (e.g., a usage data set) from the dispensing device to a user such that the user may selectively monitor statistics related to the administration of contrast media, saline, or other consumables used during one or more dispensing operations. The method and computer program product for managing data related to the dispensing of contrast media may further allow for extraction, arrangement, processing, and presentation of the data set via the controller, via a user interface that is operably engaged with the dispensing device and/or via a computer network that may be in communication with the dispensing device.
摘要翻译：本发明包括用于管理与作为医疗过程的一部分的造影剂分配有关的数据的装置，系统，方法和计算机程序产品。该装置和系统提供一种能够与分配装置进行通信以便从分配装置向用户提取，布置，处理和呈现数据集（例如，使用数据集）的控制器，使得用户可以选择性地监测与在一次或多次分配操作期间使用的造影剂，盐水或其他消耗品的施用相关的统计数据。用于管理与分配造影剂相关的数据的方法和计算机程序产品还可以允许经由控制器经由与分配装置可操作地接合的用户界面提取，布置，处理和呈现数据集和/ 或经由可能与分配装置通信的计算机网络。

8. 发明申请

US20060159702A1 Vaccine against Gram-negative bacterial infections 失效
标题翻译：疫苗对革兰氏阴性细菌感染
公开(公告)号：US20060159702A1
公开(公告)日：2006-07-20
申请号：US11375215
申请日：2006-03-15
申请人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K39/116
CPC分类号： A61K39/095 , A61K39/0258 , A61K2039/522 , Y02A50/474 , Y10S424/803 , Y10S530/806 , Y10S530/825
摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
摘要翻译：有效诱导产生免疫第二受试者的抗体的抗体被动物抗革兰氏阴性细菌感染和LPS介导的病理学的疫苗包含在源自大肠杆菌的纯化的，解毒的LPS之间形成的非共价多价复合物，以及来源于脑膜炎奈瑟氏球菌的纯化外膜蛋白。相同的疫苗也将主动免疫宿主受试者免受革兰氏阴性细菌感染和LPS介导的病理学。脑膜炎球菌感染被包括在受疫苗保护的革兰氏阴性细菌感染中。

9. 发明授权

US06902743B1 Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包裹的生物活性物质的治疗和预防感染
公开(公告)号：US06902743B1
公开(公告)日：2005-06-07
申请号：US09055505
申请日：1998-04-06
申请人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K9/16 , A61K9/50 , A61K38/17 , A61K9/14 , A61K39/40 , A61K9/48 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/1611 , A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K38/1709 , Y02A50/414 , Y02A50/423 , Y02A50/478 , Y02A50/48 , Y02A50/491
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。该微胶囊包含多肽或其它生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其具有90/10至40/60的丙交酯/乙交酯的摩尔组成，其可含有药学上可接受的佐剂，作为未加帽的游离羧基端基和封端形式的混合物，其比例为100/0至1/99。

10. 发明申请

US20150335709A1 Colostrum Composition Enriched in Anti-Endotoxin Antibodies 审中-公开
标题翻译：初乳组合物富含抗内毒素抗体
公开(公告)号：US20150335709A1
公开(公告)日：2015-11-26
申请号：US14815553
申请日：2015-07-31
申请人： Alan Cross , Zeil Rosenberg
发明人： Alan Cross , Zeil Rosenberg
IPC分类号： A61K38/17 , A61K39/40 , C07K16/12 , A61J1/03
CPC分类号： A61K38/1709 , A61J1/035 , A61K39/02 , A61K39/40 , A61K2039/505 , A61K2039/545 , A61K2039/55594 , C07K16/04 , C07K16/1203 , C07K16/1228 , C07K2317/12
摘要： The present invention provides a colostrum formulation enriched in broadly cross-reactive anti-endotoxin antibodies. Further provided is a method for reducing endotoxemia and blocking the onset of sepsis in patients comprising administering to the patients a colostrum formulation enriched with anti-endotoxin antibodies. Further provided is a method for treating an individual for hemolytic uremic syndrome or of protecting an individual against hemolytic uremic syndrome, comprising the step of administering to the patient an effective amount of the composition of the present invention.
摘要翻译：本发明提供了富含广泛交叉反应性抗内毒素抗体的初乳制剂。还提供了一种降低内毒素血症并阻断患者败血症发作的方法，包括向患者施用富含抗内毒素抗体的初乳制剂。还提供了一种治疗个体溶血性尿毒症综合征或保护个体免受溶血性尿毒症综合征的方法，其包括向患者施用有效量的本发明组合物的步骤。

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