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1. 发明申请

US20100074913A1 Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres 审中-公开
标题翻译：口服肠道疫苗，用抗生物降解 - 生物相容性微球中包裹的抗原对抗肠道病毒生物体引起的疾病
公开(公告)号：US20100074913A1
公开(公告)日：2010-03-25
申请号：US12584967
申请日：2009-09-15
申请人： Edgar C. Boedeker , Frederick J. Cassels , Daniel L. Jarboe , Robert H. Reid
发明人： Edgar C. Boedeker , Frederick J. Cassels , Daniel L. Jarboe , Robert H. Reid
IPC分类号： A61K39/00 , A61P37/04
CPC分类号： C07K14/245 , A61K9/1647 , A61K38/00 , A61K39/39 , A61K2039/55555 , Y02A50/466 , Y02A50/484
摘要： This invention is directed to oral-intestinal vaccines and their use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.
摘要翻译：本发明涉及口腔肠道疫苗及其使用抗生物降解 - 生物相容性微球中包封的抗原的肠道致病生物体引起的疾病。

2. 发明授权

US07604811B1 Oral-intestinal vaccines against diseases caused by enteropathic organisms using antigens encapsulated within biodegradable-biocompatible microspheres 失效
标题翻译：口服肠道疫苗，用抗生物降解 - 生物相容性微球包裹的抗原对抗肠病生物引起的疾病
公开(公告)号：US07604811B1
公开(公告)日：2009-10-20
申请号：US08762757
申请日：1996-12-10
申请人： Daniel L. Jarboe , Robert H. Reid , Edgar C. Boedeker , Frederick J. Cassels
发明人： Daniel L. Jarboe , Robert H. Reid , Edgar C. Boedeker , Frederick J. Cassels
IPC分类号： A61K38/108 , A61K38/04 , C07K5/00 , C07K7/00
CPC分类号： C07K14/245 , A61K9/1647 , A61K38/00 , A61K39/39 , A61K2039/55555 , Y02A50/466 , Y02A50/484
摘要： This invention is directed to oral-intestinal vaccines and their use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.
摘要翻译：本发明涉及口腔肠道疫苗及其使用抗生物降解 - 生物相容性微球中包封的抗原的肠道致病生物体引起的疾病。

3. 发明授权

US06844010B1 Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包封的生物活性物质进行治疗和预防感染
公开(公告)号：US06844010B1
公开(公告)日：2005-01-18
申请号：US09618577
申请日：2000-07-18
申请人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
发明人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/02 , A61K39/108 , A61K39/29 , F23G5/50 , G05B23/02
CPC分类号： A61K39/292 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K38/09 , A61K38/1729 , A61K39/00 , A61K39/0258 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , C12N2730/10134 , Y02A50/464 , Y02A50/474 , Y02A50/48 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊由多肽或其他生物活性剂的核心组成，其包封在聚（丙交酯/乙交酯）共聚物的基质中，其可以含有药学上可接受的佐剂，作为被覆盖的游离羧基端基和封端的共轭物形式范围从100/0至1/99。

4. 发明授权

US6165989A Era of Streptococcus pneumoniae 失效
标题翻译：肺炎链球菌的时代
公开(公告)号：US6165989A
公开(公告)日：2000-12-26
申请号：US935307
申请日：1997-09-22
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Robert King Stodola , Phillip N Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Robert King Stodola , Phillip N Zarfos
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/09 , A61K39/395 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/00 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/04 , C07K14/315 , C12N1/21 , C12N9/16 , C12N15/00 , C12N15/31 , C12N15/55 , C12P21/02 , C12R1/46 , G01N33/15 , G01N33/566 , C07H21/00 , C12N15/63
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/16
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用时代多肽筛选抗菌化合物的方法。

5. 发明授权

US3955304A Fishing lure 失效
标题翻译：钓鱼诱惑
公开(公告)号：US3955304A
公开(公告)日：1976-05-11
申请号：US599377
申请日：1975-07-28
申请人： Robert H. Reid
发明人： Robert H. Reid
IPC分类号： A01K85/00
CPC分类号： A01K85/00
摘要： A fishing lure exhibiting a combined traversing action and spray inducing surfing has a streamlined body with a flat top and a trailing flexible skirt. The body is diamond shaped in one cross-section and has a leader receiving aperture extending longitudinally therethrough. A long cylindrical weight is positioned symmetrically between the body sides and eccentrically between the flat top and leader receiving aperture.
摘要翻译：具有组合的横动作用和喷雾诱发冲浪的钓鱼诱饵具有流线型的身体，其具有平坦的顶部和拖尾的柔性裙部。身体在一个横截面上是菱形的，并且具有纵向延伸穿过其中的引导件接收孔。长圆柱形重量对称地定位在主体侧面之间，并且偏心地位于平顶部和引导件接收孔之间。

6. 发明授权

US07033608B1 “Burst-free” sustained release poly-(lactide/glycolide) microspheres 失效
标题翻译： “无爆发”持续释放聚（丙交酯/乙交酯）微球
公开(公告)号：US07033608B1
公开(公告)日：2006-04-25
申请号：US09337945
申请日：1999-06-22
申请人： Ramasubbu Jevanthi , John E. Van Hamont , Phil Friden , Robert H. Reid , F. Donald Roberts , Charles E. McQueen , Jean A. Setterstrom
发明人： Ramasubbu Jevanthi , John E. Van Hamont , Phil Friden , Robert H. Reid , F. Donald Roberts , Charles E. McQueen , Jean A. Setterstrom
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K9/5031
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊包含多肽核心或其他生物活性剂，其包封在聚（丙交酯/乙交酯）共聚物基质中，作为未封端（游离羧基端基）和封端形式的混合物，其比例范围为100/0至 1/99。

7. 发明授权

US06902743B1 Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包裹的生物活性物质的治疗和预防感染
公开(公告)号：US06902743B1
公开(公告)日：2005-06-07
申请号：US09055505
申请日：1998-04-06
申请人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K9/16 , A61K9/50 , A61K38/17 , A61K9/14 , A61K39/40 , A61K9/48 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/1611 , A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K38/1709 , Y02A50/414 , Y02A50/423 , Y02A50/478 , Y02A50/48 , Y02A50/491
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。该微胶囊包含多肽或其它生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其具有90/10至40/60的丙交酯/乙交酯的摩尔组成，其可含有药学上可接受的佐剂，作为未加帽的游离羧基端基和封端形式的混合物，其比例为100/0至1/99。

8. 发明授权

US5693343A Microparticle carriers of maximal uptake capacity by both M cells and non-M cells 失效
标题翻译： M细胞和非M细胞的最大摄取能力的微粒载体
公开(公告)号：US5693343A
公开(公告)日：1997-12-02
申请号：US242960
申请日：1994-05-16
申请人： Robert H. Reid , John E. van Hamont , William R. Brown , Egar C. Boedeker , Curt Thies
发明人： Robert H. Reid , John E. van Hamont , William R. Brown , Egar C. Boedeker , Curt Thies
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/39 , C07K14/245 , A61K47/30
CPC分类号： A61K39/39 , A61K2039/55555 , A61K38/00 , Y10S514/965
摘要： In a solvent extraction process for preparing microspheres of a biodegrade polymer, the improvement comprising: preparing a homogenized antigen-sucrose matrix and adding a solvent to the sucrose-antigen matrix to form a solution; preparing a solution of a biodegradable polymer by adding a solvent to the polymer; adding the biodegradable polymer solution to the antigen-sucrose solution; adding an oil to the polymer-sucrose-antigen solution to form an emulsion having a controlled viscosity that corresponds to a predetermined average particle size of distributions of microspheres of biodegradable polymers; centrifuging the emulsion of controlled viscosity and removing the supernatant to obtain microspheres of a predetermined range of particle size distributions of from about 0.5 to about 7.0 micrometers. An immunostimulating composition comprising an encapsulating-microsphere of the biodegradable polymer has an average particle size distribution such that the majority of the microspheres will be taken up by the villous epithelium section of the intestines of a mammalian subject when administered as a vaccine against diseases caused by enteropathogenic organisms.
摘要翻译：在用于制备可生物降解聚合物的微球的溶剂萃取方法中，改进包括：制备匀浆的抗原 - 蔗糖基质并向蔗糖抗原基质中加入溶剂以形成溶液; 通过向聚合物中加入溶剂来制备可生物降解聚合物的溶液; 将可生物降解的聚合物溶液加入到抗原 - 蔗糖溶液中; 向聚合物 - 蔗糖抗原溶液中加入油以形成具有对应于可生物降解的聚合物微球分布的预定平均粒径的受控粘度的乳液; 将受控粘度的乳液离心并除去上清液以获得约0.5至约7.0微米的预定范围的粒度分布的微球。包含可生物降解聚合物的包封微球体的免疫刺激组合物具有平均粒度分布，使得当作为针对由...引起的疾病引起的疾病的疫苗施用时，大部分微球体将被哺乳动物受试者的肠的绒毛上皮细胞部分吸收肠病原菌

9. 发明授权

US5417986A Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres 失效
标题翻译：使用包封在可生物降解的生物相容性微球内的抗原由肠病原体生物引起的疾病的疫苗
公开(公告)号：US5417986A
公开(公告)日：1995-05-23
申请号：US867301
申请日：1992-04-10
申请人： Robert H. Reid , Edgar C. Boedeker , John E. van Hamont , Jean A. Setterstrom
发明人： Robert H. Reid , Edgar C. Boedeker , John E. van Hamont , Jean A. Setterstrom
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/39 , C07K14/245 , A61K9/66 , A61K9/26
CPC分类号： A61K39/0258 , A61K39/12 , A61K39/292 , A61K39/39 , A61K2039/541 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K38/00 , C12N2730/10134
摘要： This invention is directed to oral parenteral and intestinal vaccines and eir use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.
摘要翻译：本发明涉及口服肠胃外和肠道疫苗及其用于使用包封在可生物降解的生物相容性微球体内的抗原由肠病原体生物引起的疾病的用途。

10. 再颁专利

USRE41157E1 Microparticle carriers of maximal uptake capacity by both M cells and non-M cells 有权
公开(公告)号：USRE41157E1
公开(公告)日：2010-03-02
申请号：US09451321
申请日：1999-11-30
申请人： Robert H. Reid , John E. VanHamont , William R. Brown , Edgar C. Boedeker , Curt Thies
发明人： Robert H. Reid , John E. VanHamont , William R. Brown , Edgar C. Boedeker , Curt Thies
IPC分类号： A61K9/16 , A61K9/50 , A61K9/14 , A61K47/30
CPC分类号： A61K39/39 , A61K38/00 , A61K2039/55555 , Y10S514/965
摘要： In a solvent extraction process for preparing microspheres of a biodegradable polymer, the improvement comprising: preparing a homogenized antigen-sucrose matrix and adding a solvent to the sucrose-antigen matrix to form a solution; preparing a solution of a biodegradable polymer by adding a solvent to the polymer; adding the biodegradable polymer solution to the antigen-sucrose solution; adding an oil to the polymer-sucrose-antigen solution to form an emulsion having a controlled viscosity that corresponds to a predetermined average particle size of distributions of microspheres of biodegradable polymers; centrifuging the emulsion of controlled viscosity and removing the supernatant to obtain microspheres of a predetermined range of particle size distributions of from about 0.5 to about 7.0 micrometers.In immunostimulating composition comprising an encapsulating-microsphere of the biodegradable polymer has an average particle size distribution such that the majority of the microspheres will be taken up by the villous epithelium section of the intestines of a mammalian subject when administered as a vaccine against diseases caused by entero-pathogenic organisms. A solvent extraction process for preparing microspheres of a biodegradable polymer. The process includes preparing a homogenized antigen-sucrose matrix and adding a solvent to the sucrose-antigen matrix to form a solution. Preparing a solution of a biodegradable polymer by adding a solvent to the polymer. Adding the biodegradable polymer solution to the antigen-sucrose solution. Adding an oil to the polymer-sucrose-antigen solution to form an emulsion having a controlled viscosity that corresponds to a predetermined average particle size of distributions of microspheres of biodegradable polymers. Centrifuging the emulsion of controlled viscosity and removing the supernatant to obtain microspheres of a predetermined range of particle size distributions of from about 0.5 to about 70 micrometers.

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