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1. 发明授权

US08041431B2 System and method for in situ trimming of oscillators in a pair of implantable medical devices 有权
标题翻译：用于在一对可植入医疗装置中对振荡器进行原位修剪的系统和方法
公开(公告)号：US08041431B2
公开(公告)日：2011-10-18
申请号：US12350080
申请日：2009-01-07
申请人： Paul Huelskamp , Thomas J. Harris , Binh C. Tran , Ramprasad Vijayagopal
发明人： Paul Huelskamp , Thomas J. Harris , Binh C. Tran , Ramprasad Vijayagopal
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/37217
摘要： A system and method for in situ trimming of oscillators in a pair of implantable medical devices is provided. Each frequency over a range of oscillator trim frequencies for an initiating implantable medical device is selected and a plurality of commands are sent via an acoustic transducer in situ over the frequency selected. Each frequency over a range of oscillator trim frequencies for a responding implantable medical device is selected and a response to each of the commands received is sent via an acoustic transducer in situ over the frequency selected. The responses received by the initiating implantable medical device are evaluated and a combination of the oscillator trim frequencies for both implantable medical devices that together exhibit a strongest acoustic wave is identified. Oscillators in both implantable medical devices are trimmed to the oscillator trim frequencies in the combination identified.
摘要翻译：提供了一种用于在一对可植入医疗装置中对振荡器进行原位修整的系统和方法。选择用于起始可植入医疗装置的振荡器调整频率范围内的每个频率，并且通过所选择的频率上的原位声发射器发送多个命令。选择用于响应的可植入医疗装置的振荡器微调频率范围内的每个频率，并且通过所选择的频率上的声学换能器发送对接收的每个命令的响应。评估起始可植入医疗装置接收到的响应，并且识别出共同显示最强声波的两个可植入医疗装置的振荡器修整频率的组合。两种植入式医疗设备中的振荡器都被修整为识别的组合中的振荡器修整频率。

2. 发明申请

US20090177251A1 System And Method For In Situ Trimming Of Oscillators In A Pair Of Implantable Medical Devices 有权
标题翻译：用于在一对植入式医疗设备中振荡器的原位修整的系统和方法
公开(公告)号：US20090177251A1
公开(公告)日：2009-07-09
申请号：US12350080
申请日：2009-01-07
申请人： Paul Huelskamp , Thomas J. Harris , Binh C. Tran , Ramprasad Vijayagopal
发明人： Paul Huelskamp , Thomas J. Harris , Binh C. Tran , Ramprasad Vijayagopal
IPC分类号： A61N1/08
CPC分类号： A61N1/37288 , A61N1/37217
摘要： A system and method for in situ trimming of oscillators in a pair of implantable medical devices is provided. Each frequency over a range of oscillator trim frequencies for an initiating implantable medical device is selected and a plurality of commands are sent via an acoustic transducer in situ over the frequency selected. Each frequency over a range of oscillator trim frequencies for a responding implantable medical device is selected and a response to each of the commands received is sent via an acoustic transducer in situ over the frequency selected. The responses received by the initiating implantable medical device are evaluated and a combination of the oscillator trim frequencies for both implantable medical devices that together exhibit a strongest acoustic wave is identified. Oscillators in both implantable medical devices are trimmed to the oscillator trim frequencies in the combination identified.
摘要翻译：提供了一种用于在一对可植入医疗装置中对振荡器进行原位修整的系统和方法。选择用于起始可植入医疗装置的振荡器调整频率范围内的每个频率，并且通过所选择的频率上的原位声发射器发送多个命令。选择用于响应的可植入医疗装置的振荡器微调频率范围内的每个频率，并且通过所选择的频率上的声学换能器发送对接收的每个命令的响应。评估起始可植入医疗装置接收到的响应，并且识别出共同显示最强声波的两个可植入医疗装置的振荡器修整频率的组合。两种植入式医疗设备中的振荡器都被修整为识别的组合中的振荡器修整频率。

3. 发明授权

US08290598B2 Method and apparatus for intra-body ultrasound communication 有权
标题翻译：体内超声波通信的方法和装置
公开(公告)号：US08290598B2
公开(公告)日：2012-10-16
申请号：US12703427
申请日：2010-02-10
申请人： Scot C. Boon , Keith R. Maile , William J. Linder , Paul Huelskamp , Ramprasad Vijayagopal
发明人： Scot C. Boon , Keith R. Maile , William J. Linder , Paul Huelskamp , Ramprasad Vijayagopal
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/3727 , H04B11/00 , H04B13/005
摘要： An intra-body ultrasonic signal can be converted into a first electrical signal, a local oscillator signal can be generated in an implantable system. The first electrical signal and the local oscillator signal can be mixed in an implantable system, such as to generate a demodulated signal, processed, such as using a filter. The filtered, demodulated signal can be further processed, such as implantably determining a peak amplitude of the first portion of the demodulated signal received from the filter over a time interval, implantably generating a dynamic tracking threshold that starts at an amplitude proportional the first portion of the demodulated signal and exponentially decays over a time interval, and determining a noise floor in the absence of a received intra-body ultrasonic signal and implantably comparing the peak amplitude and the tracking threshold and generate the digital output based on the difference.
摘要翻译：体内超声波信号可以转换成第一电信号，在可植入系统中可以产生本地振荡器信号。第一电信号和本地振荡器信号可以在可植入系统中混合，例如产生经处理的解调信号，例如使用滤波器。滤波后的解调信号可被进一步处理，诸如可植入地确定在时间间隔上从滤波器接收的解调信号的第一部分的峰值幅度，可植入地产生动态跟踪阈值，该动态跟踪阈值以与第所述解调信号在时间间隔上指数衰减，以及在没有接收到的体内超声波信号的情况下确定噪声基底，并且可植入地比较所述峰值幅度和跟踪阈值，并且基于所述差异生成所述数字输出。

4. 发明申请

US20100204758A1 METHOD AND APPARATUS FOR INTRA-BODY ULTRASOUND COMMUNICATION 有权
标题翻译：用于体内超声波通信的方法和装置
公开(公告)号：US20100204758A1
公开(公告)日：2010-08-12
申请号：US12703427
申请日：2010-02-10
申请人： Scot C. Boon , Keith R. Maile , William J. Linder , Paul Huelskamp , Ramprasad Vijayagopal
发明人： Scot C. Boon , Keith R. Maile , William J. Linder , Paul Huelskamp , Ramprasad Vijayagopal
IPC分类号： A61N1/08
CPC分类号： A61N1/37217 , A61N1/3727 , H04B11/00 , H04B13/005
摘要： An intra-body ultrasonic signal can be converted into a first electrical signal, a local oscillator signal can be generated in an implantable system. The first electrical signal and the local oscillator signal can be mixed in an implantable system, such as to generate a demodulated signal, processed, such as using a filter. The filtered, demodulated signal can be further processed, such as implantably determining a peak amplitude of the first portion of the demodulated signal received from the filter over a time interval, implantably generating a dynamic tracking threshold that starts at an amplitude proportional the first portion of the demodulated signal and exponentially decays over a time interval, and determining a noise floor in the absence of a received intra-body ultrasonic signal and implantably comparing the peak amplitude and the tracking threshold and generate the digital output based on the difference.
摘要翻译：体内超声波信号可以转换成第一电信号，在可植入系统中可以产生本地振荡器信号。第一电信号和本地振荡器信号可以在可植入系统中混合，例如产生经处理的解调信号，例如使用滤波器。滤波后的解调信号可被进一步处理，诸如可植入地确定在时间间隔上从滤波器接收的解调信号的第一部分的峰值幅度，可植入地产生动态跟踪阈值，该动态跟踪阈值以与第所述解调信号在时间间隔上指数衰减，以及在没有接收到的体内超声波信号的情况下确定噪声基底，并且可植入地比较所述峰值幅度和跟踪阈值，并且基于所述差异生成所述数字输出。

5. 发明申请

US20130138170A1 MANAGING CROSS THERAPY SENSING IN A MULTIPLE THERAPY IMPLANTABLE DEVICE 有权
标题翻译：在多个治疗手段中管理交叉治疗感觉
公开(公告)号：US20130138170A1
公开(公告)日：2013-05-30
申请号：US13660388
申请日：2012-10-25
申请人： David J. Ternes , Douglas J. Brandner , Ramprasad Vijayagopal , Nicholas J. Stessman , William J. Linder , Keith R. Maile , Abhi V. Chavan
发明人： David J. Ternes , Douglas J. Brandner , Ramprasad Vijayagopal , Nicholas J. Stessman , William J. Linder , Keith R. Maile , Abhi V. Chavan
IPC分类号： A61N1/365
CPC分类号： A61N1/3605 , A61B5/0428 , A61B5/4836 , A61B5/686 , A61B5/7217 , A61N1/36142 , A61N1/3704
摘要： An apparatus comprises a cardiac signal sensing circuit configured to sense an electrical cardiac signal from at least one of an atrium or ventricle of a heart of a subject, a therapy circuit configured to provide electrical pacing therapy and electrical autonomic neural modulation therapy to the subject, and a control circuit. The control circuit is configured to initiate delivery of the autonomic modulation neural therapy, and the control circuit includes a signal detection circuit configured to detect delivery of the autonomic neural modulation therapy in the sensed cardiac signal. The control circuit is configured to change, in response to detecting the delivery, a sensitivity of the cardiac signal sensing circuit during delivery of the autonomic neural modulation therapy.
摘要翻译：一种装置包括心脏信号感测电路，其被配置为感测来自受试者心脏的心房或心室中的至少一个的电心脏信号，被配置为向受试者提供电起搏治疗和电自主神经调节疗法的治疗电路，和控制电路。控制电路被配置为启动自主调制神经治疗的传递，并且控制电路包括被配置为检测所感测的心脏信号中的自主神经调节治疗的传递的信号检测电路。控制电路被配置为响应于检测到传送而改变在传送自主神经调制疗法期间心脏信号感测电路的灵敏度。

6. 发明授权

US08478404B2 Output circuit for both cardiac contractile electrostimulation and non-contractile neural modulation 有权
标题翻译：输出电路用于心脏收缩电刺激和非收缩神经调制
公开(公告)号：US08478404B2
公开(公告)日：2013-07-02
申请号：US13099546
申请日：2011-05-03
申请人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
发明人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61N1/36057 , A61N1/36114 , A61N1/36117 , A61N1/36125
摘要： An apparatus comprises an electrostimulation energy storage capacitor, a circuit path that provides pacing stimulation from the capacitor through the load, a constant current neural stimulation circuit that is switchable into the circuit path to provide neural stimulation through the load and switchable out of the circuit path to provide the pacing stimulation through the load, and a control circuit configured to selectively enable delivery of the pacing stimulation or the constant current neural stimulation.
摘要翻译：一种装置包括电刺激能量存储电容器，电路通过负载从电容器提供起搏刺激的恒定电流神经刺激电路，其可切换到电路路径中以通过负载提供神经刺激并且可从电路路径切换以通过负载提供起搏刺激，以及控制电路，其被配置为选择性地实现起搏刺激或恒定电流神经刺激的传递。

7. 发明申请

US20110276103A1 OUTPUT CIRCUIT FOR BOTH CARDIAC CONTRACTILE ELECTROSTIMULATION AND NON-CONTRACTILE NEURAL MODULATION 有权
标题翻译：输出电路用于两种心脏电生理电生理和非承压神经调节
公开(公告)号：US20110276103A1
公开(公告)日：2011-11-10
申请号：US13099546
申请日：2011-05-03
申请人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
发明人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61N1/36057 , A61N1/36114 , A61N1/36117 , A61N1/36125
摘要： An apparatus comprises an electrostimulation energy storage capacitor, a circuit path that provides pacing stimulation from the capacitor through the load, a constant current neural stimulation circuit that is switchable into the circuit path to provide neural stimulation through the load and switchable out of the circuit path to provide the pacing stimulation through the load, and a control circuit configured to selectively enable delivery of the pacing stimulation or the constant current neural stimulation.
摘要翻译：一种装置包括电刺激能量存储电容器，电路通过负载从电容器提供起搏刺激的恒定电流神经刺激电路，其可切换到电路路径中以通过负载提供神经刺激并且可从电路路径切换以通过负载提供起搏刺激，以及控制电路，其被配置为选择性地实现起搏刺激或恒定电流神经刺激的传递。

8. 发明授权

US08792992B2 Low-power system and methods for neuromodulation 有权
标题翻译：低功率系统和神经调节方法
公开(公告)号：US08792992B2
公开(公告)日：2014-07-29
申请号：US13274448
申请日：2011-10-17
申请人： William J. Linder , Keith R. Maile , Ramprasad Vijayagopal , Ron A. Balczewski
发明人： William J. Linder , Keith R. Maile , Ramprasad Vijayagopal , Ron A. Balczewski
IPC分类号： A61N1/00
CPC分类号： A61N1/36157
摘要： An apparatus comprises an electrostimulation energy storage capacitor, a circuit path communicatively coupled to the electrostimulation energy storage capacitor and configured to provide quasi-constant current neural stimulation through a load from the electrostimulation energy storage capacitor, a current measuring circuit communicatively coupled to the circuit path and configured to obtain a measure of quasi-constant current delivered to the load, and a control circuit communicatively coupled to the current measuring circuit, wherein the control circuit is configured to initiate adjustment of the voltage level of the storage capacitor for a subsequent delivery of quasi-constant current according to a comparison of the measured load current to a specified load current value.
摘要翻译：一种装置包括电刺激能量存储电容器，电路通路连接到所述电刺激能量存储电容器，并且被配置为通过来自所述电刺激能量存储电容器的负载来提供准恒定电流神经刺激;电流测量电路，其通信地耦合到所述电路路径并且被配置为获得传递到负载的准恒定电流的量度，以及通信地耦合到电流测量电路的控制电路，其中控制电路被配置为开始调整存储电容器的电压电平，以便随后传送根据测量的负载电流与指定的负载电流值的比较，准恒定电流。

9. 发明申请

US20130073008A1 POWER SUPPLY MANAGEMENT FOR IMPLANTABLE NEUROSTIMULATION DEVICES 有权
标题翻译：用于可植入神经病学设备的电源管理
公开(公告)号：US20130073008A1
公开(公告)日：2013-03-21
申请号：US13663003
申请日：2012-10-29
申请人： David J. Ternes , Scott Vanderlinde , Ramprasad Vijayagopal , Scot C. Boon
发明人： David J. Ternes , Scott Vanderlinde , Ramprasad Vijayagopal , Scot C. Boon
IPC分类号： A61N1/36
CPC分类号： A61N1/36153 , A61N1/36135 , A61N1/36157
摘要： An apparatus comprises a therapy circuit that provides a neural stimulation current, an impedance measurement circuit that measures a value of impedance at the output of the therapy circuit, a supply voltage generating circuit that provides an adjustable supply voltage value to the therapy circuit including a first supply voltage value when in a first mode, and a control circuit communicatively coupled to the therapy circuit, the impedance measuring circuit, and the supply voltage generating circuit. The control circuit, upon receiving an indication to exit the first mode, initiates an impedance measurement by the impedance measurement circuit, determines the second supply voltage value using the impedance measurement, and initiates a change from the first supply voltage value to the second supply voltage value. The second supply voltage value is sufficient to operate the therapy circuit and to provide a specified load current value to the measured impedance.
摘要翻译：一种装置，包括提供神经刺激电流的治疗电路，测量治疗电路输出端的阻抗值的阻抗测量电路，向治疗电路提供可调电源电压值的电源电压产生电路，该电源电压值包括第一在第一模式下提供电压值，以及通信地耦合到治疗电路，阻抗测量电路和电源电压产生电路的控制电路。控制电路在接收到退出第一模式的指示时，通过阻抗测量电路启动阻抗测量，使用阻抗测量确定第二电源电压值，并且启动从第一电源电压值到第二电源电压的改变值。第二电源电压值足以操作治疗电路并为测量的阻抗提供规定的负载电流值。

10. 发明申请

US20120116482A1 LOW-POWER SYSTEM AND METHODS FOR NEUROMODULATION 有权
标题翻译：低功率系统和神经网络的方法
公开(公告)号：US20120116482A1
公开(公告)日：2012-05-10
申请号：US13274448
申请日：2011-10-17
申请人： William J. Linder , Keith R. Maile , Ramprasad Vijayagopal , Ron A. Balczewski
发明人： William J. Linder , Keith R. Maile , Ramprasad Vijayagopal , Ron A. Balczewski
IPC分类号： A61N1/372
CPC分类号： A61N1/36157
摘要： An apparatus comprises an electrostimulation energy storage capacitor, a circuit path communicatively coupled to the electrostimulation energy storage capacitor and configured to provide quasi-constant current neural stimulation through a load from the electrostimulation energy storage capacitor, a current measuring circuit communicatively coupled to the circuit path and configured to obtain a measure of quasi-constant current delivered to the load, and a control circuit communicatively coupled to the current measuring circuit, wherein the control circuit is configured to initiate adjustment of the voltage level of the storage capacitor for a subsequent delivery of quasi-constant current according to a comparison of the measured load current to a specified load current value.
摘要翻译：一种装置包括电刺激能量存储电容器，电路通路连接到所述电刺激能量存储电容器，并且被配置为通过来自所述电刺激能量存储电容器的负载来提供准恒定电流神经刺激;电流测量电路，其通信地耦合到所述电路路径并且被配置为获得传递到负载的准恒定电流的量度，以及通信地耦合到电流测量电路的控制电路，其中控制电路被配置为开始调整存储电容器的电压电平，以便随后传送根据测量的负载电流与指定的负载电流值的比较，准恒定电流。

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