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1. 发明授权

US08478404B2 Output circuit for both cardiac contractile electrostimulation and non-contractile neural modulation 有权
标题翻译：输出电路用于心脏收缩电刺激和非收缩神经调制
公开(公告)号：US08478404B2
公开(公告)日：2013-07-02
申请号：US13099546
申请日：2011-05-03
申请人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
发明人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61N1/36057 , A61N1/36114 , A61N1/36117 , A61N1/36125
摘要： An apparatus comprises an electrostimulation energy storage capacitor, a circuit path that provides pacing stimulation from the capacitor through the load, a constant current neural stimulation circuit that is switchable into the circuit path to provide neural stimulation through the load and switchable out of the circuit path to provide the pacing stimulation through the load, and a control circuit configured to selectively enable delivery of the pacing stimulation or the constant current neural stimulation.
摘要翻译：一种装置包括电刺激能量存储电容器，电路通过负载从电容器提供起搏刺激的恒定电流神经刺激电路，其可切换到电路路径中以通过负载提供神经刺激并且可从电路路径切换以通过负载提供起搏刺激，以及控制电路，其被配置为选择性地实现起搏刺激或恒定电流神经刺激的传递。

2. 发明申请

US20110276103A1 OUTPUT CIRCUIT FOR BOTH CARDIAC CONTRACTILE ELECTROSTIMULATION AND NON-CONTRACTILE NEURAL MODULATION 有权
标题翻译：输出电路用于两种心脏电生理电生理和非承压神经调节
公开(公告)号：US20110276103A1
公开(公告)日：2011-11-10
申请号：US13099546
申请日：2011-05-03
申请人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
发明人： Keith R. Maile , Ramprasad Vijayagopal , Nicholas J. Stessman , Firmin Musungu
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61N1/36057 , A61N1/36114 , A61N1/36117 , A61N1/36125
摘要： An apparatus comprises an electrostimulation energy storage capacitor, a circuit path that provides pacing stimulation from the capacitor through the load, a constant current neural stimulation circuit that is switchable into the circuit path to provide neural stimulation through the load and switchable out of the circuit path to provide the pacing stimulation through the load, and a control circuit configured to selectively enable delivery of the pacing stimulation or the constant current neural stimulation.
摘要翻译：一种装置包括电刺激能量存储电容器，电路通过负载从电容器提供起搏刺激的恒定电流神经刺激电路，其可切换到电路路径中以通过负载提供神经刺激并且可从电路路径切换以通过负载提供起搏刺激，以及控制电路，其被配置为选择性地实现起搏刺激或恒定电流神经刺激的传递。

3. 发明申请

US20130138170A1 MANAGING CROSS THERAPY SENSING IN A MULTIPLE THERAPY IMPLANTABLE DEVICE 有权
标题翻译：在多个治疗手段中管理交叉治疗感觉
公开(公告)号：US20130138170A1
公开(公告)日：2013-05-30
申请号：US13660388
申请日：2012-10-25
申请人： David J. Ternes , Douglas J. Brandner , Ramprasad Vijayagopal , Nicholas J. Stessman , William J. Linder , Keith R. Maile , Abhi V. Chavan
发明人： David J. Ternes , Douglas J. Brandner , Ramprasad Vijayagopal , Nicholas J. Stessman , William J. Linder , Keith R. Maile , Abhi V. Chavan
IPC分类号： A61N1/365
CPC分类号： A61N1/3605 , A61B5/0428 , A61B5/4836 , A61B5/686 , A61B5/7217 , A61N1/36142 , A61N1/3704
摘要： An apparatus comprises a cardiac signal sensing circuit configured to sense an electrical cardiac signal from at least one of an atrium or ventricle of a heart of a subject, a therapy circuit configured to provide electrical pacing therapy and electrical autonomic neural modulation therapy to the subject, and a control circuit. The control circuit is configured to initiate delivery of the autonomic modulation neural therapy, and the control circuit includes a signal detection circuit configured to detect delivery of the autonomic neural modulation therapy in the sensed cardiac signal. The control circuit is configured to change, in response to detecting the delivery, a sensitivity of the cardiac signal sensing circuit during delivery of the autonomic neural modulation therapy.
摘要翻译：一种装置包括心脏信号感测电路，其被配置为感测来自受试者心脏的心房或心室中的至少一个的电心脏信号，被配置为向受试者提供电起搏治疗和电自主神经调节疗法的治疗电路，和控制电路。控制电路被配置为启动自主调制神经治疗的传递，并且控制电路包括被配置为检测所感测的心脏信号中的自主神经调节治疗的传递的信号检测电路。控制电路被配置为响应于检测到传送而改变在传送自主神经调制疗法期间心脏信号感测电路的灵敏度。

4. 发明申请

US20110160806A1 IMPLANTABLE MEDICAL DEVICE SWITCHING POWER SUPPLY INCLUDING MULTIPLE MODES 有权
标题翻译：可移植医疗设备切换电源，包括多种模式
公开(公告)号：US20110160806A1
公开(公告)日：2011-06-30
申请号：US12956375
申请日：2010-11-30
申请人： Michael J. Lyden , Nicholas J. Stessman
发明人： Michael J. Lyden , Nicholas J. Stessman
IPC分类号： A61N1/08
CPC分类号： A61N1/08
摘要： An implantable or other ambulatory medical device can include a magnetic field detector, such as configured to detect an intense magnetic field. In an example, the ambulatory or implantable medical device can include an inductive switching supply, such as including one or more of a peak current comparator, or a zero current comparator. In an example, the ambulatory or implantable medical device can include a controller circuit, configured to control a switch, such as to controllably charge an inductor included in the inductive switching supply.
摘要翻译：可植入或其他动态医疗装置可以包括磁场检测器，诸如被配置为检测强磁场。在一个示例中，移动或可植入的医疗设备可以包括感应开关电源，例如包括峰值电流比较器或零电流比较器中的一个或多个。在一个示例中，移动或可植入医疗装置可以包括控制器电路，其被配置为控制开关，例如可控制地对感应开关电源中包括的电感器充电。

5. 发明授权

US07509167B2 MRI detector for implantable medical device 有权
标题翻译：用于植入式医疗器械的MRI检测器
公开(公告)号：US07509167B2
公开(公告)日：2009-03-24
申请号：US11276159
申请日：2006-02-16
申请人： Nicholas J. Stessman
发明人： Nicholas J. Stessman
IPC分类号： A61N1/362
CPC分类号： A61N1/3718
摘要： An implantable medical device with an inductive switching regulator having an inductor with a ferromagnetic core is described. The device incorporates a core saturation detector for detecting saturation in the inductor core indicating the presence of a magnetic field such as produced by an MRI scan. The device is configured to alter its behavior when core saturation is detected such as by entering an MRI mode that may include cessation of therapy, fixed-rate bradycardia pacing, and/or disablement of tachyarrhythmia therapy.
摘要翻译：描述了具有感应开关调节器的可植入医疗装置，其具有带有铁磁芯的电感器。该装置包括用于检测电感器芯中的饱和度的核心饱和度检测器，指示存在诸如通过MRI扫描产生的磁场。该装置被配置为当检测到核心饱和时改变其行为，例如通过进入可以包括停止治疗，固定速率心动过缓起搏和/或停止快速性心律失常治疗的MRI模式。

6. 发明授权

US06463326B1 Rate adaptive cardiac rhythm management device using transthoracic impedance 有权
标题翻译：评价自适应心律管理装置使用经胸阻抗
公开(公告)号：US06463326B1
公开(公告)日：2002-10-08
申请号：US09492912
申请日：2000-01-20
申请人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
发明人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
IPC分类号： A61N1365
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient's heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.
摘要翻译：心律管理（CRM）设备检测经胸阻抗，提取通气或其他信息，并相应地调整CRM治疗的递送率。交替方向电流脉冲刺激的四相序列周期性地递送到患者的胸部。使用加权解调提取经胸阻抗信号。信号处理提取通气信息，并使用自适应低通滤波器去除心脏搏动信息。自适应滤波器截止频率基于患者的心率; 为更高的心率提供更高的截止频率。峰/谷检测表示潮气量，其被集成以提取每分钟通气（MV）。形成短期和长期平均数，并比较建立MV指标利率。当噪声测量超过阈值时，速率调整将忽略MV信息。当检测到遥测脉冲或其他干扰信号时，干扰避免电路延迟了刺激的传递。

7. 发明授权

US08335563B2 MRI detector for implantable medical device 有权
标题翻译：用于植入式医疗器械的MRI检测器
公开(公告)号：US08335563B2
公开(公告)日：2012-12-18
申请号：US12409766
申请日：2009-03-24
申请人： Nicholas J. Stessman
发明人： Nicholas J. Stessman
IPC分类号： A61N1/362
CPC分类号： A61N1/3718
摘要： An implantable medical device with an inductive switching regulator having an inductor with a ferromagnetic core is described. The device incorporates a core saturation detector for detecting saturation in the inductor core indicating the presence of a magnetic field such as produced by an MRI scan. The device is configured to alter its behavior when core saturation is detected such as by entering an MRI mode that may include cessation of therapy, fixed-rate bradycardia pacing, and/or disablement of tachyarrhythmia therapy.
摘要翻译：描述了具有感应开关调节器的可植入医疗装置，其具有带有铁磁芯的电感器。该装置包括用于检测电感器芯中的饱和度的核心饱和度检测器，指示存在诸如通过MRI扫描产生的磁场。该装置被配置为当检测到核心饱和时改变其行为，例如通过进入可以包括停止治疗，固定速率心动过缓起搏和/或停止快速性心律失常治疗的MRI模式。

8. 发明授权

US07191005B2 System and method for measuring battery current 有权
标题翻译：用于测量电池电流的系统和方法
公开(公告)号：US07191005B2
公开(公告)日：2007-03-13
申请号：US11065008
申请日：2005-02-24
申请人： Nicholas J. Stessman
发明人： Nicholas J. Stessman
IPC分类号： A61N1/378
CPC分类号： G01D3/08 , A61N1/3708
摘要： Systems, devices and methods are provided for measuring battery current. According to one aspect, a medical device is provided that comprises a battery, a pulse generator, and a current measuring device. The pulse generator draws a pulse generator current from the power source, and the current measuring device determines the pulse generator current or tracks charge depletion from the battery. The current measuring device comprises an oscillator and a counter. The oscillator produces an oscillating output with a frequency of oscillation dependent on the pulse generator current, and the counter provides an oscillation count for the oscillating output. The current measuring device is capable of being calibrated while continuously determining the pulse generator current. In one embodiment, the current measuring device includes at least two current sources, each including an operational amplifier that has an autozeroing feature.
摘要翻译：系统，设备和方法用于测量电池电流。根据一个方面，提供一种包括电池，脉冲发生器和电流测量装置的医疗装置。脉冲发生器从电源抽取脉冲发生器电流，并且电流测量装置确定脉冲发生器电流或跟踪电池的电荷消耗。电流测量装置包括振荡器和计数器。振荡器根据脉冲发生器电流产生具有振荡频率的振荡输出，并且计数器为振荡输出提供振荡计数。电流测量装置能够在连续确定脉冲发生器电流的同时进行校准。在一个实施例中，电流测量装置包括至少两个电流源，每个电流源包括具有自动调零特征的运算放大器。

9. 发明授权

US6161042A Rate adaptive cardiac rhythm management device using transthoracic impedance 有权
公开(公告)号：US6161042A
公开(公告)日：2000-12-12
申请号：US316690
申请日：1999-05-21
申请人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
发明人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient's heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.

10. 发明授权

US06076015A Rate adaptive cardiac rhythm management device using transthoracic impedance 失效
公开(公告)号：US06076015A
公开(公告)日：2000-06-13
申请号：US032731
申请日：1998-02-27
申请人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
发明人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient's heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.

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