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1. 发明授权

US5942241A Formulations and methods for providing prolonged local anesthesia 失效
标题翻译：提供延长局部麻醉的制剂和方法
公开(公告)号：US5942241A
公开(公告)日：1999-08-24
申请号：US793861
申请日：1997-06-16
申请人： Mark Chasin , Richard Sackler , Ronald M. Burch , Paul Goldenheim , Joseph Tigner
发明人： Mark Chasin , Richard Sackler , Ronald M. Burch , Paul Goldenheim , Joseph Tigner
IPC分类号： A61K9/107 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/52 , A61K31/135 , A61K31/415 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/36 , A61K47/42 , A61P25/02 , A61P43/00
CPC分类号： A61K31/704 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/36 , A61K9/0019 , A61K9/1647 , A61K9/0024 , Y10S514/817 , Y10S514/818 , Y10S514/93
摘要： A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
摘要翻译： PCT No.PCT / US96 / 10439 Sec。 371日期：1997年6月16日 102（e）日期1996年6月16日PCT提交1996年6月7日PCT公布。公开号WO96 / 41616 日期1996年12月27日一种用于在患者中诱导持续局部局部麻醉的制剂和方法，包括含有局部麻醉剂和有效量的生物相容性，可生物降解的控制释放材料的底物，其延长局部麻醉剂从基质释放以获得植入或注射到患者中时的可逆局部麻醉，以及药学上可接受的，即无毒的非糖皮质激素增强剂，其有效地延长局部麻醉的持续时间长于可从底物获得的时间长增强剂。

2. 发明授权

US06524607B1 Formulations and methods for providing prolonged local anesthesia 失效
标题翻译：提供延长局部麻醉的制剂和方法
公开(公告)号：US06524607B1
公开(公告)日：2003-02-25
申请号：US09523361
申请日：2000-03-10
申请人： Paul Goldenheim , Mark Chasin , Richard Sackler , Ronald M. Burch , Joseph Tigner
发明人： Paul Goldenheim , Mark Chasin , Richard Sackler , Ronald M. Burch , Joseph Tigner
IPC分类号： A61K952
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/0024 , A61K9/1647 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/817 , Y10S514/818 , Y10S514/93 , A61K31/565 , A61K31/435 , A61K31/415 , A61K31/35 , A61K31/245 , A61K31/235 , A61K31/19 , A61K31/165 , A61K31/14 , A61K2300/00
摘要： A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
摘要翻译：一种用于在患者中诱导持续局部局部麻醉的制剂和方法，包括包含局部麻醉剂和有效量的生物相容性，可生物降解的受控释放材料的底物，其延长了局部麻醉剂从基质释放以获得可逆局部麻醉，植入或注射到患者体内，以及药学上可接受的，即无毒的非糖皮质激素增强剂，其有效地延长局部麻醉的持续时间比在不含增强剂的情况下可获得的时间长。

3. 发明授权

US06521259B1 Formulations and methods for providing prolonged local anesthesia 失效
标题翻译：提供延长局部麻醉的制剂和方法
公开(公告)号：US06521259B1
公开(公告)日：2003-02-18
申请号：US09523360
申请日：2000-03-10
申请人： Mark Chasin , Richard Sackler , Ronald M. Burch , Paul Goldenheim , Joseph Tigner
发明人： Mark Chasin , Richard Sackler , Ronald M. Burch , Paul Goldenheim , Joseph Tigner
IPC分类号： A61K914
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/0024 , A61K9/1647 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/817 , Y10S514/818 , Y10S514/93 , A61K31/565 , A61K31/435 , A61K31/415 , A61K31/35 , A61K31/245 , A61K31/235 , A61K31/19 , A61K31/165 , A61K31/14 , A61K2300/00
摘要： A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when inplanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
摘要翻译：一种用于在患者中诱导持续局部局部麻醉的制剂和方法，包括包含局部麻醉剂和有效量的生物相容性，可生物降解的受控释放材料的底物，其延长了局部麻醉剂从基质释放以获得可逆局部麻醉，植入或注射到患者中，以及药学上可接受的，即无毒的非糖皮质激素增强剂，其有效地延长局部麻醉的持续时间比在不含增强剂的情况下可获得的时间长。

4. 发明授权

US06514516B1 Formulations and methods for providing prolonged local anesthesia 失效
公开(公告)号：US06514516B1
公开(公告)日：2003-02-04
申请号：US09342964
申请日：1999-06-29
申请人： Mark Chasin , Richard Sackler , Ronald M. Burch , Paul Goldenheim , Joseph Tigner
发明人： Mark Chasin , Richard Sackler , Ronald M. Burch , Paul Goldenheim , Joseph Tigner
IPC分类号： A61K952
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/0024 , A61K9/1647 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/817 , Y10S514/818 , Y10S514/93 , A61K31/565 , A61K31/435 , A61K31/415 , A61K31/35 , A61K31/245 , A61K31/235 , A61K31/19 , A61K31/165 , A61K31/14 , A61K2300/00
摘要： A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.

5. 发明授权

US06699908B2 Methods for providing safe local anesthesia 失效
标题翻译：方法提供安全的局部麻醉
公开(公告)号：US06699908B2
公开(公告)日：2004-03-02
申请号：US09963256
申请日：2001-09-26
申请人： Richard S. Sackler , Paul D. Goldenheim , Mark Chasin , Ronald M. Burch , Robert F. Reder , Joseph Tigner
发明人： Richard S. Sackler , Paul D. Goldenheim , Mark Chasin , Ronald M. Burch , Robert F. Reder , Joseph Tigner
IPC分类号： A61K31195
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/1647 , A61K31/167 , A61K31/245 , A61K31/47 , Y10S514/818
摘要： Methods and formulations for inducing substantially safer local anesthesia in a patient are provided. The methods comprise administering, to a patient in need thereof, a substrate containing a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material to safely obtain a reversible nerve blockade when implanted or injected in a patient.
摘要翻译：提供了用于在患者体内诱导基本上更安全的局部麻醉的方法和制剂。所述方法包括向需要其的患者施用含有局部麻醉剂和有效量的生物相容的可生物降解的控制释放材料的基质，以在植入或注射入患者时安全地获得可逆神经阻断。

6. 发明申请

US20120252794A1 ANALGESIC COMBINATION OF OPIOID ANALGESIC AND CYCLOOXYGENASE-2 INHIBITOR 审中-公开
标题翻译：阿片类药物和CYCLOOXYGENASE-2抑制剂的分析组合
公开(公告)号：US20120252794A1
公开(公告)日：2012-10-04
申请号：US13461036
申请日：2012-05-01
申请人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
发明人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
IPC分类号： A61K31/485 , A61P25/04 , A61K31/5415
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： The invention relates to the use of a combination of an opioid analgesic together with a COX-2 inhibitor.
摘要翻译：本发明涉及阿片类止痛剂与COX-2抑制剂的组合的用途。

7. 发明申请

US20090054527A1 Administration of capsaicinoids 审中-公开
标题翻译：管理辣椒素
公开(公告)号：US20090054527A1
公开(公告)日：2009-02-26
申请号：US12228226
申请日：2008-08-11
申请人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
发明人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
IPC分类号： A61K31/135
CPC分类号： A61K31/165 , A61K31/05 , A61K31/16 , A61K31/167 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , C07C231/02 , A61K2300/00 , C07C233/20
摘要： Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering a vasodilator.
摘要翻译：在某些实施方案中公开了一种在有需要的人或动物的部位缓解疼痛的方法，包括通过注射或渗入施用一定剂量的辣椒素并共同施用血管扩张剂。

8. 发明授权

US08143267B2 Analgesic combination of oxycodone and nimesulide 有权
标题翻译：羟考酮和尼美舒利的止痛组合
公开(公告)号：US08143267B2
公开(公告)日：2012-03-27
申请号：US10057630
申请日：2002-01-25
申请人： Ronald M. Burch , Richard S Sackler , Paul D Goldenheim
发明人： Ronald M. Burch , Richard S Sackler , Paul D Goldenheim
IPC分类号： A61K31/485
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of nimesulide and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically acceptable salt thereof, said two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising orally administering to the patient an oral dosage form comprising two analgesic compounds consisting of nimesulide and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically acceptable salt thereof, said two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含由尼美舒利和/或其至少一种药学上可接受的盐和羟考酮和/或其至少一种药学上可接受的盐组成的两种止痛化合物和/或其药学上可接受的盐，所述两种镇痛化合物的量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人类或其他哺乳动物疼痛的方法，其包括向患者口服施用包含由尼美舒利和/或其至少一种药学上可接受的盐组成的两种镇痛化合物和羟考酮和/或至少一种其药学上可接受的盐，所述两种镇痛化合物的量足以在人类患者中提供镇痛作用。

9. 发明授权

US06552031B1 Synergistic analgesic combination of oxycodone and rofecoxib 有权
标题翻译：羟考酮与罗非昔布的止痛组合
公开(公告)号：US06552031B1
公开(公告)日：2003-04-22
申请号：US09154354
申请日：1998-09-17
申请人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
发明人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
IPC分类号： A01N4342
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxcodone or a pharmaceutically acceptable salt thereof, said combination in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxycodone or a pharmaceutically acceptable salt thereof such that the dosing interval of the rofecoxib overlaps with the dosing interval of the oxycodone, said combination in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含罗非考昔或其药学上可接受的盐的剂量和羟考酮或其药学上可接受的盐的剂量的组合，所述组合的量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人类或其他哺乳动物疼痛的方法，其包括向患者施用罗非考昔或其药学上可接受的盐的剂量和一定剂量的羟考酮或其药学上可接受的盐，使得给药间隔罗非昔布与羟考酮的给药间隔重叠，所述组合的量足以在人类患者中提供镇痛作用。

10. 发明申请

US20090117167A1 Injectable capsaicin with vasocontrictor adjunctive agent 审中-公开
标题翻译：注射辣椒素与血管紧张素辅助剂
公开(公告)号：US20090117167A1
公开(公告)日：2009-05-07
申请号：US12288033
申请日：2008-10-16
申请人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
发明人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
IPC分类号： A61K9/00 , A61K31/164 , A61K31/4985 , A61K31/404 , A61K31/4164 , A61K31/445 , A61P29/00
CPC分类号： A61K31/165 , A61K31/05 , A61K31/16 , A61K31/167 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , C07C231/02 , A61K2300/00 , C07C233/20
摘要： Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering a vasoconstrictor.
摘要翻译：在某些实施方案中公开了一种在有需要的人或动物的部位缓解疼痛的方法，包括通过注射或渗入施用一定剂量的类辣椒素并共同引起血管收缩剂。

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