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1. 发明授权

US08143267B2 Analgesic combination of oxycodone and nimesulide 有权
标题翻译：羟考酮和尼美舒利的止痛组合
公开(公告)号：US08143267B2
公开(公告)日：2012-03-27
申请号：US10057630
申请日：2002-01-25
申请人： Ronald M. Burch , Richard S Sackler , Paul D Goldenheim
发明人： Ronald M. Burch , Richard S Sackler , Paul D Goldenheim
IPC分类号： A61K31/485
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of nimesulide and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically acceptable salt thereof, said two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising orally administering to the patient an oral dosage form comprising two analgesic compounds consisting of nimesulide and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically acceptable salt thereof, said two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含由尼美舒利和/或其至少一种药学上可接受的盐和羟考酮和/或其至少一种药学上可接受的盐组成的两种止痛化合物和/或其药学上可接受的盐，所述两种镇痛化合物的量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人类或其他哺乳动物疼痛的方法，其包括向患者口服施用包含由尼美舒利和/或其至少一种药学上可接受的盐组成的两种镇痛化合物和羟考酮和/或至少一种其药学上可接受的盐，所述两种镇痛化合物的量足以在人类患者中提供镇痛作用。

2. 发明授权

US06921541B2 Formulations and methods for providing prolonged local anesthesia 失效
标题翻译：提供延长局部麻醉的制剂和方法
公开(公告)号：US06921541B2
公开(公告)日：2005-07-26
申请号：US10237387
申请日：2002-09-09
申请人： Mark Chasin , Paul Goldenheim , Richard Sackler , Joseph Tigner , Ronald M Burch
发明人： Mark Chasin , Paul Goldenheim , Richard Sackler , Joseph Tigner , Ronald M Burch
IPC分类号： A61K9/107 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/52 , A61K31/135 , A61K31/415 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/36 , A61K47/42 , A61P25/02 , A61P43/00
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/0024 , A61K9/1647 , A61K31/445 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/57 , A61K31/715 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/817 , Y10S514/818 , Y10S514/93 , A61K31/565 , A61K31/435 , A61K31/415 , A61K31/35 , A61K31/245 , A61K31/235 , A61K31/19 , A61K31/165 , A61K31/14 , A61K2300/00
摘要： A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
摘要翻译：一种用于在患者中诱导持续局部局部麻醉的制剂和方法，包括包含局部麻醉剂和有效量的生物相容性，可生物降解的受控释放材料的底物，其延长了局部麻醉剂从基质释放以获得可逆局部麻醉，植入或注射到患者体内，以及药学上可接受的，即无毒的非糖皮质激素增强剂，其有效地延长局部麻醉的持续时间比在不含增强剂的情况下可获得的时间长。

3. 发明授权

US06552031B1 Synergistic analgesic combination of oxycodone and rofecoxib 有权
标题翻译：羟考酮与罗非昔布的止痛组合
公开(公告)号：US06552031B1
公开(公告)日：2003-04-22
申请号：US09154354
申请日：1998-09-17
申请人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
发明人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
IPC分类号： A01N4342
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxcodone or a pharmaceutically acceptable salt thereof, said combination in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxycodone or a pharmaceutically acceptable salt thereof such that the dosing interval of the rofecoxib overlaps with the dosing interval of the oxycodone, said combination in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含罗非考昔或其药学上可接受的盐的剂量和羟考酮或其药学上可接受的盐的剂量的组合，所述组合的量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人类或其他哺乳动物疼痛的方法，其包括向患者施用罗非考昔或其药学上可接受的盐的剂量和一定剂量的羟考酮或其药学上可接受的盐，使得给药间隔罗非昔布与羟考酮的给药间隔重叠，所述组合的量足以在人类患者中提供镇痛作用。

4. 发明授权

US08685994B2 Analgesic combination of oxycodone and celecoxib 有权
标题翻译：羟考酮和塞来昔布的止痛组合
公开(公告)号：US08685994B2
公开(公告)日：2014-04-01
申请号：US11698394
申请日：2007-01-26
申请人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
发明人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
IPC分类号： A61K31/4353 , A61K31/415
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of celecoxib and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically acceptable salt thereof, said two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising orally administering to the patient an oral dosage form comprising two analgesic compounds consisting of celecoxib and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically acceptable salt thereof, said two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含由塞来昔布和/或其至少一种药学上可接受的盐和羟考酮和/或其至少一种药学上可接受的盐组成的两种镇痛化合物和/或其药学上可接受的盐，所述两种止痛化合物的量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人类或其他哺乳动物疼痛的方法，其包括向患者口服给予口服剂型，其包含由塞来昔布和/或其至少一种药学上可接受的盐组成的两种镇痛化合物和羟考酮和/或至少一种其药学上可接受的盐，所述两种镇痛化合物的量足以在人类患者中提供镇痛作用。

5. 发明授权

US08193209B2 Analgesic combination of oxycodone and meloxicam 有权
标题翻译：羟考酮与美洛昔康的止痛组合
公开(公告)号：US08193209B2
公开(公告)日：2012-06-05
申请号：US10056347
申请日：2002-01-25
申请人： Ronald M. Burch , Richard S. Sackler , Paul D. Goldenheim
发明人： Ronald M. Burch , Richard S. Sackler , Paul D. Goldenheim
IPC分类号： A61K31/485
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of meloxicam and/or at least one a pharmaceutically acceptable salt thereof and a dose oxycodone and/or at least one a pharmaceutically acceptable salt thereof, the two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a an oral dosage form comprising two analgesic compounds consisting of meloxicam and/or at least one a pharmaceutically acceptable salt thereof and oxycodone and/or at least one a pharmaceutically acceptable salt thereof, the two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含由美洛昔康和/或其至少一种药学上可接受的盐和剂量羟考酮和/或其至少一种药学上可接受的盐组成的两种镇痛化合物和/或其药学上可接受的盐，两种止痛剂化合物的量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人类或其它哺乳动物疼痛的方法，其包括向患者施用口服剂型，其包含由美洛昔康和/或其至少一种药学上可接受的盐和羟可待酮组成的两种止痛化合物和/或至少一种其药学上可接受的盐，两种镇痛化合物的量足以在人类患者中提供镇痛作用。

6. 发明授权

US08188107B2 Analgesic combination of oxycodone and N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide 有权
标题翻译：羟考酮与N- [3-（甲酰氨基）-4-氧代-6-苯氧基-4H-1-苯并吡喃-7-基]甲磺酰胺的镇痛组合
公开(公告)号：US08188107B2
公开(公告)日：2012-05-29
申请号：US10057632
申请日：2002-01-25
申请人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
发明人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
IPC分类号： A61K31/485
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of N-[3 -(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide and/or at least one a pharmaceutically acceptable salt thereof and a-dose oxycodone and/or at least one a pharmaceutically acceptable salt thereof, the two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising orally administering to the patient a an oral dosage form comprising two analgesic compounds consisting of N-[3-(formylamino)-4-oxo-6 -phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide and/or at least one a pharmaceutically acceptable salt thereof and oxycodone and/or at least one a pharmaceutically acceptable salt thereof such that the two analgesic compounds in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含两种由N- [3-（甲酰氨基）-4-氧代-6-苯氧基-4H-1-苯并吡喃-7-基]甲磺酰胺和/或其盐的组合的镇痛化合物和/或其药学上可接受的盐其至少一种其药学上可接受的盐和剂量的羟考酮和/或其至少一种药学上可接受的盐，其量足以在人类患者中提供镇痛作用的两种止痛化合物。还公开了一种有效治疗人或其他哺乳动物疼痛的方法，其包括口服给予患者口服剂型，其包含由N- [3-（甲酰氨基）-4-氧代-6-苯氧基-4H -1-苯并吡喃-7-基]甲磺酰胺和/或其至少一种药学上可接受的盐和羟考酮和/或其至少一种药学上可接受的盐，使得两种镇痛化合物的量足以提供镇痛作用一个人的病人。

7. 发明授权

US08168629B2 Analgesic combination of tramadol and meloxicam 有权
标题翻译：曲马多和美洛昔康的止痛组合
公开(公告)号：US08168629B2
公开(公告)日：2012-05-01
申请号：US11825938
申请日：2007-07-10
申请人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
发明人： Ronald M. Burch , Paul D. Goldenheim , Richard S. Sackler
IPC分类号： A61K31/54 , A61K31/135
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/415 , A61K31/4353 , A61K31/485 , A61K31/54 , A61K31/12 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition, comprising a combination of a dose of meloxicam or a pharmaceutically acceptable salt thereof and a dose of tramadol or a pharmaceutically acceptable salt thereof, the combination in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a combination of a dose of meloxicam or a pharmaceutically acceptable salt thereof and a dose of tramadol or a pharmaceutically acceptable salt thereof such that the dosing interval of the meloxicam overlaps with the dosing interval of the tramadol, the combination in an amount sufficient to provide an analgesic effect in a human patient.
摘要翻译：公开了一种药物组合物，其包含美洛昔康或其药学上可接受的盐的剂量与曲马多或其药学上可接受的盐的剂量的组合，其量足以在人类患者中提供镇痛作用。还公开了一种有效治疗人或其他哺乳动物疼痛的方法，其包括向患者施用美洛昔康或其药学上可接受的盐的剂量组合以及曲马多或其药学上可接受的盐的剂量，使得给药间隔美洛昔康与曲马多的给药间隔重叠，其量足以在人类患者中提供镇痛作用。

8. 发明申请

US20080262091A1 Infiltration of capsaicin into surgical sites and open wounds 审中-公开
标题翻译：辣椒素渗入手术部位和开放伤口
公开(公告)号：US20080262091A1
公开(公告)日：2008-10-23
申请号：US12077492
申请日：2008-03-18
申请人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
发明人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
IPC分类号： A61K31/16 , A61P25/00
CPC分类号： C07C231/02 , A61K9/0019 , A61K31/05 , A61K31/16 , A61K31/165 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , A61K47/10 , A61K2300/00 , C07C233/20
摘要： The present invention provides compositions and methods for attenuating or relieving pain at a site in a human or animal in need thereof by infiltrating at a surgical site or open wound in a human or animal a dose of capsaicinoid in an amount effective to denervate the surgical site or open wound substantially without eliciting an effect outside the surgical site or open wound.
摘要翻译：本发明提供组合物和方法，用于通过在人或动物的外科手术部位或开放伤口渗透一定剂量的类辣椒素来减轻或减轻需要其的人或动物的部位的疼痛，所述剂量有效地使外科手术部位再合成或开放的伤口基本上不引起手术部位外的作用或开放的伤口。

9. 发明授权

US5189046A Protein kinase C modulators 失效
标题翻译：蛋白激酶C调节剂
公开(公告)号：US5189046A
公开(公告)日：1993-02-23
申请号：US709948
申请日：1991-06-04
申请人： Ronald M. Burch , Raymond J. Patch , Barry G. Shearer , John J. Perumattam
发明人： Ronald M. Burch , Raymond J. Patch , Barry G. Shearer , John J. Perumattam
IPC分类号： C07D207/09 , C07D211/26 , C07D211/60 , C07D401/12
CPC分类号： C07D401/12 , C07D207/09 , C07D211/26 , C07D211/60
摘要： PKC modulating compounds of the formula ##STR1## Also disclosed are pharmaceutical compositions including these compounds which inhibit PKC activity, methods of using these compounds to inhibit PKC activity in mammals, and intermediates useful in preparing the PKC modulating compounds.
摘要翻译： PKC调节下式化合物（I）还公开了包含抑制PKC活性的这些化合物的药物组合物，使用这些化合物抑制哺乳动物PKC活性的方法，以及可用于制备PKC调节化合物的中间体。

10. 发明申请

US20090111792A1 Injectable capsaicin with tricyclic antidepressant adjunctive agent 审中-公开
标题翻译：注射辣椒素与三环抗抑郁药辅助剂
公开(公告)号：US20090111792A1
公开(公告)日：2009-04-30
申请号：US12288020
申请日：2008-10-16
申请人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
发明人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
IPC分类号： A61K31/165 , A61K31/551 , A61K31/553 , A61K31/55 , A61K31/335 , A61K31/5415 , A61P25/00
CPC分类号： A61K31/165 , A61K31/05 , A61K31/16 , A61K31/167 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , C07C231/02 , A61K2300/00 , C07C233/20
摘要： Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering a tricyclic antidepressant.
摘要翻译：在某些实施方案中公开了一种在有需要的人或动物的部位缓解疼痛的方法，包括通过注射或渗入给予一种剂量的辣椒素并共同施用三环类抗抑郁药。

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