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1. 发明申请

US20070150047A1 Implantable medical device with bioabsorbable coating 有权
标题翻译：具有生物可吸收涂层的植入式医疗器械
公开(公告)号：US20070150047A1
公开(公告)日：2007-06-28
申请号：US11599859
申请日：2006-11-15
申请人： Patrick Ruane , Waleska Perez-Segarra , Anthony Ragheb , Neal Fearnot , William Voorhees , Brian Bates , Thomas Osborne
发明人： Patrick Ruane , Waleska Perez-Segarra , Anthony Ragheb , Neal Fearnot , William Voorhees , Brian Bates , Thomas Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/146 , A61L31/16 , A61L33/022 , A61L2300/602 , A61L2300/608 , A61L2420/08 , A61N5/1002
摘要： Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.
摘要翻译：提供涂覆的可植入医疗装置的方法。所述方法包括将包含生物活性的第一层定位在结构的至少一部分上，并将至少一个多孔层定位在第一层之上。至少一个多孔层具有足以提供生物活性的受控释放的厚度。

2. 发明申请

US20070203520A1 Endovascular filter 审中-公开
标题翻译：血管内过滤器
公开(公告)号：US20070203520A1
公开(公告)日：2007-08-30
申请号：US11654278
申请日：2007-01-16
申请人： Dennis Griffin , Arne Molgaard-Nielsen , Anthony Ragheb , Raymond Leonard , Neal Fearnot , William Voorhees , Thomas Kozma , Brian Bates , Thomas Osborne
发明人： Dennis Griffin , Arne Molgaard-Nielsen , Anthony Ragheb , Raymond Leonard , Neal Fearnot , William Voorhees , Thomas Kozma , Brian Bates , Thomas Osborne
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0086 , A61F2250/0067
摘要： Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.
摘要翻译：包括具有远端（18）的多个支柱（14）的血管内过滤器（10），其适于在部署之后将过滤器锚定到血管壁，例如通过具有倒钩（20），如果需要，该过滤器适于被检索。支架远端（18）涂覆有抗增殖剂（40），其抑制过滤器周围的组织的向内生长，从而允许过滤器在延长的时间段后无损伤地取出和去除，从而延长可回收的使用寿命过滤。可选地，过滤器的近端（22）也可以如此涂覆，或整个过滤器。

3. 发明申请

US20070168012A1 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20070168012A1
公开(公告)日：2007-07-19
申请号：US11604539
申请日：2006-11-27
申请人： Anthony Ragheb , Brian Bates , Neal Fearnot , Thomas Kozma , William Voorhees
发明人： Anthony Ragheb , Brian Bates , Neal Fearnot , Thomas Kozma , William Voorhees
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.
摘要翻译：提供涂覆的可植入医疗装置的方法。所述方法包括将包含生物活性的第一层定位在结构的至少一部分上，并将至少一个多孔层定位在第一层之上。至少一个多孔层具有足以提供生物活性的受控释放的厚度。

4. 发明申请

US20060195176A1 Coated implantable medical device 审中-公开
标题翻译：涂层可植入医疗器械
公开(公告)号：US20060195176A1
公开(公告)日：2006-08-31
申请号：US11410354
申请日：2006-04-25
申请人： Brian Bates , Anthony Ragheb , Neal Fearnot , Thomas Kozma , William Voorhees
发明人： Brian Bates , Anthony Ragheb , Neal Fearnot , Thomas Kozma , William Voorhees
IPC分类号： A61F2/82
CPC分类号： A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 μg/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 μm to about 5 μm.
摘要翻译：提供生物活性涂层医疗器械，包括涂层血管支架。医疗器械涂层可以包括位于医疗器械表面的至少一部分上的涂层，并且可以包括甲基丙烯酸丁酯聚合物或乙烯 - 乙酸乙烯酯共聚物与可以用作免疫抑制剂和生物活性物质的生物活性材料抗增生剂。任选地，多层涂层还可以包括粘合促进层，其包括定位在涂层和医疗器件表面之间的聚对二甲苯，包含位于涂层的至少一部分上的甲基丙烯酸丁酯的多孔层，或两者。涂层优选包含在医疗装置的外表面上的生物活性材料的约0.5和2.0杯/平方毫米之间。生物活性材料可以被吸收到涂层中，其可以具有在约0.5μm至约5μm之间的厚度。

5. 发明申请

US20070050010A1 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20070050010A1
公开(公告)日：2007-03-01
申请号：US11515395
申请日：2006-09-01
申请人： Brian Bates , Anthony Ragheb , Neal Fearnot , William Voorhees , Thomas Kozma , David Grewe , Darin Schaeffer
发明人： Brian Bates , Anthony Ragheb , Neal Fearnot , William Voorhees , Thomas Kozma , David Grewe , Darin Schaeffer
IPC分类号： A61F2/86 , A61F2/06
CPC分类号： A61F2/91 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

6. 发明申请

US20050222677A1 Coated implantable medical device 失效
标题翻译：涂层可植入医疗器械
公开(公告)号：US20050222677A1
公开(公告)日：2005-10-06
申请号：US11137275
申请日：2005-05-25
申请人： Brian Bates , Anthony Ragheb , Neil Fearnot , Thomas Kozma , William Voorhees
发明人： Brian Bates , Anthony Ragheb , Neil Fearnot , Thomas Kozma , William Voorhees
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61K51/12 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/02 , A61N5/10
CPC分类号： A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

7. 发明申请

US20070288087A1 Artificial valve prosthesis 有权
标题翻译：人工瓣膜假体
公开(公告)号：US20070288087A1
公开(公告)日：2007-12-13
申请号：US11807879
申请日：2007-05-30
申请人： Neal Fearnot , Alan Leewood , Ram Paul , Blayne Roeder , William Voorhees
发明人： Neal Fearnot , Alan Leewood , Ram Paul , Blayne Roeder , William Voorhees
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/005 , A61F2220/0058
摘要： A self-expanding or otherwise expandable artificial valve prostheses for deployment within a body passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame, a supporting member and a valve leaflet. The portion of the valve leaflet is supported by the supporting member and is positioned away from the wall of the body passageway when the device is deployed within the body passageway.
摘要翻译：用于展开在身体通道（例如患者的血管或导管）内的自膨胀或其他可膨胀的人造瓣膜假体。瓣膜假体包括具有外框架，支撑构件和瓣膜小叶的支撑结构。瓣膜小叶的部分由支撑构件支撑，并且当装置展开在身体通道内时，其被定位成远离身体通道的壁。

8. 发明授权

US07290066B2 Methods and structure for improved transfer rate performance in a SAS wide port environment 失效
标题翻译：在SAS宽端口环境中提高传输速率性能的方法和结构
公开(公告)号：US07290066B2
公开(公告)日：2007-10-30
申请号：US10803301
申请日：2004-03-18
申请人： William Voorhees , Mark Slutz , David Uddenberg
发明人： William Voorhees , Mark Slutz , David Uddenberg
IPC分类号： G06F3/00 , G06F13/00 , G06F13/364
CPC分类号： G06F13/387
摘要： Methods and associated structure for utilizing multiple ports or PHYs comprising a SAS wide port to improve transmission bandwidth utilization for a single large I/O request. In one aspect hereof, a large I/O request is broken into a plurality of smaller I/O requests to be distributed over multiple PHYs or ports of a configured wide SAS port. The number of smaller I/O requests may be any number up to the maximum number of PHYs or ports comprising the SAS wide port. In another aspect hereof, the size of a large I/O request may be compared against a threshold value to determine whether the large request should be broken into smaller requests. The threshold value may be determined in accordance with features and aspects hereof either statically or dynamically based on workloads assigned to, and utilization of, the configured SAS wide port.
摘要翻译：用于利用包括SAS宽端口的多个端口或PHY的方法和相关结构来提高单个大I / O请求的传输带宽利用率。在一个方面，大的I / O请求被分解成多个较小的I / O请求，以分布在配置的宽SAS端口的多个PHY或端口上。较小I / O请求的数量可以是包括SAS宽端口的PHY或端口的最大数量的任何数字。在本文的另一方面，可以将大I / O请求的大小与阈值进行比较，以确定大请求是否应被分解成更小的请求。可以根据其特征和方面根据分配给和配置的SAS宽端口的工作负载静态地或动态地确定阈值。

9. 发明申请

US20050204197A1 Methods and structure for testing responses from SAS device controllers or expanders 有权
标题翻译：用于测试SAS设备控制器或扩展器的响应的方法和结构
公开(公告)号：US20050204197A1
公开(公告)日：2005-09-15
申请号：US10798680
申请日：2004-03-11
申请人： David Uddenberg , William Voorhees , Mark Slutz
发明人： David Uddenberg , William Voorhees , Mark Slutz
IPC分类号： G06F11/00
CPC分类号： G06F11/2221 , G06F11/263
摘要： Improved methods and structures for testing of SAS components, in situ, in a SAS domain. A first SAS component is adapted to generate stimuli such as error conditions to elicit a response to the error condition from a second SAS component coupled to the first in the intended SAS domain configuration. In one aspect, a SAS device controller generates stimuli applied to a SAS expander coupled thereto and verifies proper response from the SAS expander. In another aspect, a SAS expander generates stimuli applied to a SAS device controller coupled thereto and verifies proper response from the SAS device controller. Stimuli may be generated by custom circuits or firmware/software within the first component. Vendor specific SAS SMP transactions may be used to cause the first component to enter the special verification mode.
摘要翻译：改进了在SAS领域中原位测试SAS组件的方法和结构。第一SAS组件适于产生诸如错误条件的刺激，以从耦合到期望的SAS域配置中的第一SAS组件的第二SAS组件引出对错误状况的响应。在一个方面，SAS设备控制器产生应用于耦合到其上的SAS扩展器的刺激，并验证来自SAS扩展器的适当响应。在另一方面，SAS扩展器产生应用于耦合到其上的SAS设备控制器的刺激，并验证来自SAS设备控制器的适当响应。刺激可以由第一组件内的定制电路或固件/软件产生。可以使用供应商特定的SAS SMP事务来使第一个组件进入特殊的验证模式。

10. 发明申请

US20050193178A1 Systems and methods for flexible extension of SAS expander ports 审中-公开
标题翻译： SAS扩展端口灵活扩展的系统和方法
公开(公告)号：US20050193178A1
公开(公告)日：2005-09-01
申请号：US10788590
申请日：2004-02-27
申请人： William Voorhees , Carl Gygi
发明人： William Voorhees , Carl Gygi
IPC分类号： G06F12/00 , G06F13/38
CPC分类号： G06F13/385
摘要： A multi-chip module (MCM) designed using standard die SAS expander components for rapidly designing a customized SAS expander having a predetermined number of ports. A number of standard expander die circuit components are selected and disposed on a MCM design. Each expander die circuit has a predetermined number of internal ports within the MCM and a predetermined number of ports for coupling to SAS devices external to the MCM. An internal fabric is disposed on the MCM and selectively coupled to internal ports of the SAS expanders to provide the desired number of external ports with desired routing therebetween. The internal fabric may be statically configured or dynamically programmed. The internal fabric routing may provide wide port routes as well as standard port connections.
摘要翻译：使用标准模块SAS扩展器组件设计的多芯片模块（MCM），用于快速设计具有预定数量端口的定制SAS扩展器。多个标准扩展器裸片电路组件被选择和布置在MCM设计上。每个扩展器管芯电路具有MCM内的预定数量的内部端口和用于耦合到MCM外部的SAS设备的预定数量的端口。内部结构布置在MCM上并选择性地耦合到SAS扩展器的内部端口，以提供期望数量的外部端口，其间具有期望的布线。内部结构可以静态配置或动态编程。内部结构路由可以提供宽端口路由以及标准端口连接。

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