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1. 发明申请

US20070288087A1 Artificial valve prosthesis 有权
标题翻译：人工瓣膜假体
公开(公告)号：US20070288087A1
公开(公告)日：2007-12-13
申请号：US11807879
申请日：2007-05-30
申请人： Neal Fearnot , Alan Leewood , Ram Paul , Blayne Roeder , William Voorhees
发明人： Neal Fearnot , Alan Leewood , Ram Paul , Blayne Roeder , William Voorhees
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/005 , A61F2220/0058
摘要： A self-expanding or otherwise expandable artificial valve prostheses for deployment within a body passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame, a supporting member and a valve leaflet. The portion of the valve leaflet is supported by the supporting member and is positioned away from the wall of the body passageway when the device is deployed within the body passageway.
摘要翻译：用于展开在身体通道（例如患者的血管或导管）内的自膨胀或其他可膨胀的人造瓣膜假体。瓣膜假体包括具有外框架，支撑构件和瓣膜小叶的支撑结构。瓣膜小叶的部分由支撑构件支撑，并且当装置展开在身体通道内时，其被定位成远离身体通道的壁。

2. 发明申请

US20090105813A1 IMPLANTABLE VALVE DEVICE 审中-公开
标题翻译：可植入阀装置
公开(公告)号：US20090105813A1
公开(公告)日：2009-04-23
申请号：US12252918
申请日：2008-10-16
申请人： Sean Chambers , Ram Paul , Norman Jaffe
发明人： Sean Chambers , Ram Paul , Norman Jaffe
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0098
摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.
摘要翻译：描述了阀装置，制造阀装置的方法以及治疗各种静脉相关病症，病症和/或疾病的方法。在一个实施例中，阀装置包括可扩展支撑框架和附接到支撑框架的生物假肢瓣膜。生物假肢瓣膜包括从多叶瓣异种瓣膜收获的小叶和邻接的壁部分。邻接的壁部分包括附件区域，其中小叶附着到血管壁，并且在一些实施例中包括叶片和血管壁之间的附着的天然边缘。

3. 发明申请

US20070027460A1 Implantable remodelable materials comprising magnetic material 审中-公开
标题翻译：包括磁性材料的植入式可重塑材料
公开(公告)号：US20070027460A1
公开(公告)日：2007-02-01
申请号：US11493065
申请日：2006-07-26
申请人： Brian Case , Ram Paul
发明人： Brian Case , Ram Paul
IPC分类号： A61F2/02
CPC分类号： A61L27/02 , A61L27/3629 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/50
摘要： Devices, materials and methods for using the same for modifying or monitoring a valve within a body are provided herein. Devices comprising a magnetic material and magnetically-activated implantable devices are described. Methods of modifying a valve in the body, for a valve within a body vessel are also provided.
摘要翻译：本文提供了用于使用其来改变或监视主体内的阀的装置，材料和方法。描述了包括磁性材料和磁激活可植入装置的装置。还提供了改变身体中的阀，用于体内血管中的阀的方法。

4. 发明申请

US20060276882A1 Medical device including remodelable material attached to frame 审中-公开
标题翻译：医疗设备包括连接到框架上的可重塑材料
公开(公告)号：US20060276882A1
公开(公告)日：2006-12-07
申请号：US11435508
申请日：2006-05-17
申请人： Brian Case , Jacob Flagle , Ram Paul , Sean Chambers
发明人： Brian Case , Jacob Flagle , Ram Paul , Sean Chambers
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Medical devices preferably comprise a remodelable material attached to a frame with a tension that can change upon implantation of the medical device within the lumen of a body vessel. Controlled fracture or bioabsorption of frame material can, in some embodiments, decrease the tension on the remodelable material after implantation. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置优选地包括附着到框架上的可重塑材料，其具有张力，所述张力可以在将医疗装置植入身体容器的内腔中时改变。在一些实施方案中，框架材料的受控断裂或生物吸收可以在植入后降低可重塑材料上的张力。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

5. 发明授权

US10722365B2 Implantable valve device 有权
公开(公告)号：US10722365B2
公开(公告)日：2020-07-28
申请号：US15414794
申请日：2017-01-25
申请人： Sean Chambers , Ram Paul , Norman Jaffe
发明人： Sean Chambers , Ram Paul , Norman Jaffe
IPC分类号： A61F2/24
摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.

6. 发明申请

US20130116720A1 Multi-stage Occlusion Devices 有权
标题翻译：多级闭塞装置
公开(公告)号：US20130116720A1
公开(公告)日：2013-05-09
申请号：US13461260
申请日：2012-05-01
申请人： Elizabeth Theobald , JR Randolph , Dusan Pavcnik , Frederick Keller , Brad Shirley , Sean Chambers , Ram Paul , Rodney M. Thurman , Michael Deckard
发明人： Elizabeth Theobald , JR Randolph , Dusan Pavcnik , Frederick Keller , Brad Shirley , Sean Chambers , Ram Paul , Rodney M. Thurman , Michael Deckard
IPC分类号： A61B17/12
CPC分类号： A61B17/1214 , A61B17/0057 , A61B2017/00597
摘要： An occlusion device has a covering attached to a support frame that includes a disc-shaped member and a crossbar that extends across a central opening defined by the disc-shaped member. The occlusion device has a first, or deployed, configuration in which the crossbar defines a curve that extends from the disc-shaped member, and a second, or resting, configuration in which the disc-shaped member and the crossbar lie substantially in a single plane. Each of the disc-shaped member and the crossbar include a core wire that extends through a lumen of a coil multiple times.
摘要翻译：闭塞装置具有附接到支撑框架的覆盖物，该支撑框架包括圆盘状构件和跨越由盘状构件限定的中心开口延伸的横杆。闭塞装置具有第一或部署的构造，其中横杆限定从盘形构件延伸的曲线，以及第二或静止构造，其中盘形构件和横杆基本上位于单个飞机圆盘状构件和横杆中的每一个都包括多次延伸通过线圈的内腔的芯线。

7. 发明申请

US20080051879A1 METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用流动修改植入式医疗装置处理通气阀相关条件的方法
公开(公告)号：US20080051879A1
公开(公告)日：2008-02-28
申请号：US11844003
申请日：2007-08-23
申请人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
发明人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2002/068
摘要： Implantable medical devices adapted to modify fluid flow within a body vessel are provided herein. The medical devices may include a fluid flow restricting channel configured to reduce longitudinal fluid flow in a retrograde direction or in an antegrade direction. Preferably, the medical devices are flow-modifying devices that reduce fluid flow through the medical device to a greater extent in a retrograde direction than in an antegrade direction. Methods of treatment comprising the step of implanting a flow-modifying medical device within a body vessel are also provided. Flow-modifying devices are useful, for example, in treating venous valve related conditions.
摘要翻译：本文提供了适于改变体内容器内的流体流动的植入式医疗装置。医疗装置可以包括流体流动限制通道，该流体流动限制通道构造成减小沿逆行方向或顺行方向的纵向流体流动。优选地，医疗装置是流动改变装置，其减少流体通过医疗装置的流体在逆行方向上比在顺行方向上更大程度地流动。还提供了包括在身体容器内植入流动改变医疗装置的步骤的治疗方法。流动改变装置例如在治疗静脉瓣相关病症中是有用的。

8. 发明申请

US20060259115A1 MEDICAL DEVICE DELIVERY SYSTEMS THAT FACILITATE MEDICAL DEVICE PLACEMENT IN THE PRESENCE OF ULTRASONIC WAVES 审中-公开
标题翻译：在超声波存在下使医疗器械放置的医疗装置输送系统
公开(公告)号：US20060259115A1
公开(公告)日：2006-11-16
申请号：US11382966
申请日：2006-05-12
申请人： Brian Case , Ram Paul
发明人： Brian Case , Ram Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/2436 , A61F2250/0015 , A61M37/0092
摘要： Delivery systems, methods of fabricating delivery systems, and methods of implanting intraluminal medical devices at a point of treatment within a body vessel are provided. Delivery systems include an elongate tubular member that has first and second wall portions with different acoustic impedences. An intraluminal medical device is disposed on a mounting region of a dilator and within the elongate tubular member. One of the wall portions of the elongate tubular member is positioned substantially adjacent a functional mechanism of the intraluminal medical device. This positioning facilitates placement of the intraluminal medical device within a body vessel in a particular orientation by observing the differential reflection of ultrasonic waves caused by the different acoustic impedences of the first and second wall portions of the elongate tubular member. Rotatation of the delivery system following and/or during such an observation can be employed to achieve a desired orientation of the intraluminal medical device within the body vessel.
摘要翻译：提供输送系统，制造输送系统的方法以及在体内血管内的处理点植入管腔内医疗器械的方法。递送系统包括具有不同声阻抗的第一和第二壁部分的细长管状构件。管腔内医疗装置设置在扩张器的安装区域上并且在细长管状构件内。细长管状构件的壁部分之一基本上邻近管腔内医疗装置的功能机构。该定位有利于通过观察由细长管状构件的第一和第二壁部分的不同声阻抗引起的超声波的差异反射，便于将管腔内医疗装置以特定取向放置在体容器内。在这种观察之后和/或在这样的观察期间，输送系统的旋转可用于实现体内血管内腔内医疗装置的期望定向。

9. 发明申请

US20080051737A1 MEDICAL DEVICE WITH THERAPEUTIC AGENTS 有权
标题翻译：具有治疗药物的医疗器械
公开(公告)号：US20080051737A1
公开(公告)日：2008-02-28
申请号：US11930722
申请日：2007-10-31
申请人： Ram Paul , Daniel Sirota , Paul Amarant
发明人： Ram Paul , Daniel Sirota , Paul Amarant
IPC分类号： A61M25/00 , A61L29/16
CPC分类号： A61M25/00 , A61M25/0017 , A61M2025/0057
摘要： A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.
摘要翻译：医疗装置适于至少部分植入体内，并且包括沿着装置长度的第一和第二部分。第一治疗剂与第一部分相关联，第二治疗剂与第二部分相关联。第一种治疗剂可以是一种或多种抗增殖剂，例如紫杉醇，紫杉醇衍生物或紫杉醇前药，抗凝血剂，抗血栓形成剂，溶栓剂，纤维蛋白溶解剂或其组合。第二治疗剂可以是一种或多种抗微生物剂，例如一种或多种抗生素。第一和第二治疗剂中的每一个可以被放置在相应部分的一个或多个表面上，或浸渍在该部分内。该装置可以包括用于分隔第一和第二部分的分离器。还提供了制造医疗装置的方法和建立对体内容器的通路的方法。

10. 发明申请

US20070219579A1 DISTAL PROTECTION DEVICE 有权
标题翻译：远程保护装置
公开(公告)号：US20070219579A1
公开(公告)日：2007-09-20
申请号：US11688430
申请日：2007-03-20
申请人： Ram Paul
发明人： Ram Paul
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0093
摘要： The present invention provides, in certain aspects, devices and methods for protecting the body from downstream embolization. In one embodiment, a distal protection device comprises a shaft and a jacket with the shaft being received within the jacket. The device also includes a filter, which is supported by a wire cone that has one end attached to the jacket and an opposite end attached to the shaft. The shaft is rotatable relative to the jacket to reduce the size of the cone for capturing embolic debris within the wire cone. The invention also provides such devices in combination with instruments (e.g., balloon stent catheters) for treating stenosis and other similar conditions.
摘要翻译：本发明在某些方面提供了用于保护身体免受下游栓塞的装置和方法。在一个实施例中，远侧保护装置包括轴和夹套，其中轴被容纳在护套内。该装置还包括一个过滤器，该过滤器由电线锥体支撑，其中一端连接到护套上，另一端连接到轴上。轴可相对于护套旋转以减小用于捕获线锥内的栓塞碎片的锥体的尺寸。本发明还提供了用于治疗狭窄和其他类似病症的器械（例如气囊支架导管）的这种装置。

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