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1. 发明申请

US20050073068A1 Formation of indicia in the base of a blister pack for transference to a body cast therein 审中-公开
标题翻译：在泡罩包装底部形成标记，以转移到其中铸造的身体
公开(公告)号：US20050073068A1
公开(公告)日：2005-04-07
申请号：US10119198
申请日：2002-06-04
申请人： Patrick Kearney , Mark Davies
发明人： Patrick Kearney , Mark Davies
IPC分类号： B65D75/36 , A61J1/03 , B29C33/00 , B29C33/42 , B29C51/08 , B29C51/14 , B29C59/02 , B29C67/00 , B29C59/00 , B29C43/32
CPC分类号： B29C59/026 , A61J1/035 , B29C33/0011 , B29C33/42 , B29C33/424 , B29C51/08 , B29C51/082 , B29C51/14 , B29C59/02 , B29C67/0029 , B29C2791/001 , B29K2705/02 , B29L2031/7164 , Y10T428/31681 , Y10T428/31692
摘要： A laminated film in which a metal foil is sandwiched between two polymeric films is cold formed to define one or more blisters, and the base of the blister stamped with indicia, in two discrete stages. The blister is formed in the first stage using a standard technique of advancing a pin in a direction transverse relative to the plane of the film. According to the invention, once the blister forming stage is completed, indicia are stamped into the base of the blister in the second stage by advancing a die from one side thereof to clamp the blister base against a mold held against the other side. The direction of the die and disposition of the die and mold may be selected such that the indicia project inwardly or outwardly from the blister base.
摘要翻译：将金属箔夹在两个聚合物膜之间的层压膜被冷成型以限定一个或多个水泡，并且在两个不连续的阶段中将具有标记的泡罩的底部冲压。泡罩在第一阶段中使用在相对于薄膜的平面横向的方向推进销的标准技术形成。根据本发明，一旦泡罩形成阶段完成，在第二阶段通过从其一侧推进模具将标记冲压到泡罩的基部中，以将泡罩基座夹在抵靠另一侧的模具上。可以选择模具的方向和模具和模具的布置，使得标记从泡罩底部向内或向外突出。

2. 发明授权

US06391237B1 Formation of indicia in the base of a blister pack for transference to a body cast therein 有权
标题翻译：在泡罩包装底部形成标记，以转移到其中铸造的身体
公开(公告)号：US06391237B1
公开(公告)日：2002-05-21
申请号：US09507250
申请日：2000-02-18
申请人： Patrick Kearney , Mark Davies
发明人： Patrick Kearney , Mark Davies
IPC分类号： B29C3340
CPC分类号： B29C59/026 , A61J1/035 , B29C33/0011 , B29C33/42 , B29C33/424 , B29C51/08 , B29C51/082 , B29C51/14 , B29C59/02 , B29C67/0029 , B29C2791/001 , B29K2705/02 , B29L2031/7164 , Y10T428/31681 , Y10T428/31692
摘要： A laminated film in which a metal foil is sandwiched between two polymeric films is cold formed to define one or more blisters, and the base of the blister stamped with indicia, in two discrete stages. The blister is formed in the first stage using a standard technique of advancing a pin in a direction transverse relative to the plane of the film. According to the invention, once the blister forming stage is completed, indicia are stamped into the base of the blister in the second stage by advancing a die from one side thereof to clamp the blister base against a mold held against the other side. The direction of the die and disposition of the die and mold may be selected such that the indicia project inwardly or outwardly from the blister base.
摘要翻译：将金属箔夹在两个聚合物膜之间的层压膜被冷成型以限定一个或多个水泡，并且在两个不连续的阶段中将具有标记的泡罩的底部冲压。泡罩在第一阶段中使用在相对于薄膜的平面横向的方向推进销的标准技术形成。根据本发明，一旦泡罩形成阶段完成，在第二阶段通过从其一侧推进模具将标记冲压到泡罩的基部中，以将泡罩基座夹在抵靠另一侧的模具上。可以选择模具的方向和模具和模具的布置，使得标记从泡罩底部向内或向外突出。

3. 发明申请

US20110207712A1 Phosphatidylinositol 3-Kinase Inhibitors And Methods Of Their Use 有权
标题翻译：磷脂酰肌醇3-激酶抑制剂及其使用方法
公开(公告)号：US20110207712A1
公开(公告)日：2011-08-25
申请号：US13096942
申请日：2011-04-28
申请人： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
发明人： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
IPC分类号： C07D403/12 , A61K31/498 , C07D487/04 , C07D241/54 , A61K31/4985 , C07D413/12 , C07D401/12 , A61P35/00
CPC分类号： C07D401/12 , C07D241/44 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.
摘要翻译：本发明包括与许多恶性肿瘤如卵巢癌，宫颈癌，乳腺癌，结肠癌，直肠癌和成胶质细胞瘤等相关的磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂。因此，本发明的化合物可用于治疗，预防和/或抑制这些疾病。

4. 发明申请

US20070208166A1 Tao Kinase Modulators And Method Of Use 审中-公开
标题翻译：陶激酶调节剂及其使用方法
公开(公告)号：US20070208166A1
公开(公告)日：2007-09-06
申请号：US10576932
申请日：2004-10-22
申请人： Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
发明人： Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
IPC分类号： C07D471/02
CPC分类号： C07C237/22 , C07C275/16 , C07C275/34 , C07C2602/10 , C07D207/16 , C07D209/20 , C07D209/42 , C07D209/44 , C07D213/56 , C07D213/75 , C07D215/48 , C07D215/54 , C07D217/06 , C07D217/22 , C07D233/56 , C07D233/58 , C07D263/32 , C07D277/46 , C07D277/66 , C07D277/82 , C07D295/155 , C07D295/185 , C07D319/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
摘要翻译：本发明提供了用于抑制激酶的化合物和方法，例如TAO族的那些，更具体地是KIAA1361，TAO和JIK激酶。本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。本发明的化合物抑制，调节和/或调节与上述细胞活性变化相关的激酶受体信号转导途径，本发明包括含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。

5. 发明申请

US20060180609A1 Apparatus for pipetting power 审中-公开
标题翻译：移液器的设备
公开(公告)号：US20060180609A1
公开(公告)日：2006-08-17
申请号：US10527230
申请日：2003-09-08
申请人： David Hager , Patrick Kearney
发明人： David Hager , Patrick Kearney
IPC分类号： B67D5/56
CPC分类号： G01F11/34 , B01J2219/00315 , B01J2219/00364 , B01J2219/00414 , B01J2219/00416 , B01J2219/00745 , B01J2219/00756 , B01L3/021 , B01L2200/0657 , B01L2300/0681 , B01L2300/0829 , B01L2400/049 , B65B1/38 , C40B40/18 , C40B60/14 , G01N2035/00188
摘要： The present invention provides apparatus and methods for collecting a plurality of measured quantities of a powdered material and dispensing each of the measured quantities to, for example, a multi-well vessel. Vacuum is used to collect the powdered material and at least one of gravity, a gas push, or a physical push is used to dispense the powdered material. Apparatus and methods of the invention are particularly useful for collection and delivery of powdered materials in high throughput chemical synthesis and biological assay environments where accurate measurement and dispensing of powders is critical.
摘要翻译：本发明提供了用于收集多个测量量的粉末材料并将每个测量量分配到例如多孔容器的装置和方法。真空用于收集粉末材料，并且使用重力，气体推动或物理推动中的至少一种来分配粉末材料。本发明的装置和方法对于在高通量化学合成和生物测定环境中的粉末材料的收集和递送特别有用，其中粉末的精确测量和分配至关重要。

6. 发明授权

US6156339A Process for preparing solid pharmaceutical dosage forms 有权
标题翻译：制备固体药物剂型的方法
公开(公告)号：US6156339A
公开(公告)日：2000-12-05
申请号：US387702
申请日：1999-08-10
申请人： Leon Grother , Michael Hall , Douglas Bryans , Richard Green , Patrick Kearney
发明人： Leon Grother , Michael Hall , Douglas Bryans , Richard Green , Patrick Kearney
IPC分类号： A61K9/00 , A61K9/20 , A61K31/192 , A61K31/485 , A61K47/44 , A61K9/127
CPC分类号： A61K9/0056 , A61K9/2095
摘要： This invention relates to a process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises: (i) forming a solution or a suspension in a solvent of a water soluble or water dispersible carrier, a filler and the pharmaceutically active substance with the unacceptable taste in association with a lipid, the weight ratio of the pharmaceutically active substance to the lipid being in the range of from 1:1 to 1:10 and the weight ratio of the carrier to the lipid being in the range of from 5:1 to 1:15; (ii) forming discrete units of the suspension or solution; and (iii) removing the solvent from the discrete units under conditions whereby unit dosages are formed comprising a network of carrier/filler carrying a dosage of the pharmaceutically active substance in association with the lipid; oral solid rapidly disintegrating dosage forms prepared by such a process are also provided.
摘要翻译：本发明涉及制备具有不可接受味道的药物活性物质的口服固体快速崩解剂型的方法，该方法包括：（i）在水溶性或水分散性溶剂中形成溶液或悬浮液载体，填充剂和具有与脂质相关的不可接受的味道的药物活性物质，药物活性物质与脂质的重量比在1:1至1:10的范围内，载体的重量比脂质在5:1至1:15的范围内; （ii）形成悬浮液或溶液的离散单元; 和（iii）在形成单位剂量的条件下从离散单元中除去溶剂，其包含携带与脂质相关联的药物活性物质的剂量的载体/填料网络; 还提供了通过这种方法制备的口服固体快速崩解剂型。

7. 发明授权

US5837287A Process for preparing solid pharmaceutical dosage forms 失效
公开(公告)号：US5837287A
公开(公告)日：1998-11-17
申请号：US437925
申请日：1995-05-09
申请人： Richard J. Yarwood , Patrick Kearney , Andrew R. Thompson
发明人： Richard J. Yarwood , Patrick Kearney , Andrew R. Thompson
IPC分类号： A61K31/454 , A61K9/00 , A61K9/20
CPC分类号： A61K31/454
摘要： A process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises forming a solution or a suspension in a solvent of a form of the pharmaceutically active substance which is less soluble in water and more palatable than the form with the unacceptable taste together with a water-soluble or water-dispersible carrier material, forming discrete units of the suspension or solution and removing the solvent from the discrete units under conditions whereby a network of the carrier material carrying a dosage of the less soluble and more palatable form of the pharmaceutically active substance is formed.

8. 发明授权

US5738875A Process for preparing solid pharmaceutical dosage forms 失效
标题翻译：制备固体药物剂型的方法
公开(公告)号：US5738875A
公开(公告)日：1998-04-14
申请号：US330936
申请日：1994-10-28
申请人： Richard J. Yarwood , Patrick Kearney , Andrew R. Thompson
发明人： Richard J. Yarwood , Patrick Kearney , Andrew R. Thompson
IPC分类号： A61K9/00 , A61K9/20 , A61K9/26 , A61K31/454 , B01D25/176
CPC分类号： B01D25/176 , A61K31/454 , A61K9/0056 , A61K9/2095
摘要： A process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises forming a solution or a suspension in a solvent of a form of the pharmaceutically active substance which is less soluble in water and more palatable than the form with the unacceptable taste together with a water-soluble or water-dispersible carrier material, forming discrete units of the suspension or solution and removing the solvent from the discrete units under conditions whereby a network of the carrier material carrying a dosage of the less soluble and more palatable form of the pharmaceutically active substance is formed.
摘要翻译：一种制备口服固体快速崩解剂型的药物活性物质的方法，其具有不可接受的味道，该方法包括在溶于水的溶剂中溶解或溶解形式的药物活性物质形式的溶液或悬浮液，比具有不可接受味道的形式与水溶性或水分散性载体材料一起更可口，形成悬浮液或溶液的离散单元，并在条件下从离散单元除去溶剂，由此承载载体材料的网络形成药物活性物质不易溶解和更可口的形式。

9. 发明授权

US5343672A Method for manufacturing freeze dried dosages in a multilaminate blister pack 失效
标题翻译：在多层泡罩包装中制造冷冻干燥剂量的方法
公开(公告)号：US5343672A
公开(公告)日：1994-09-06
申请号：US985040
申请日：1992-12-01
申请人： Patrick Kearney , Andrew R. Thompson , Richard J. Yarwood
发明人： Patrick Kearney , Andrew R. Thompson , Richard J. Yarwood
IPC分类号： B65B9/04 , A61J1/03 , A61J1/05 , A61J3/00 , A61K9/14 , A61K9/19 , A61K9/20 , B32B1/06 , B32B7/02 , B32B15/08 , B32B27/06 , B65D65/40 , B65D75/34 , B65D75/36 , B65B63/08
CPC分类号： A61K9/2095 , A61J1/035 , B32B27/06 , B65D75/327
摘要： An improved method for manufacturing freeze dried pharmaceutical tablets in blister packs is disclosed. Liquid dosages are introduced into a multilayer laminated blister sheet having an impermeable intermediate layer that is positioned between first and second outer layers, each of which has substantially the same coefficient of thermal expansion. The properties of the outer layers of the blister sheet are such that there are no inter-layer stresses that will cause curvature of the blister sheet when it is subjected to temperature changes during the freezing and freeze drying steps. Following the introduction of the dosages into the depressions of the blister sheet, the dosages are frozen and freeze dried. A lidding sheet is then attached to the blister sheet to seal the solid dosages into the blister pack.
摘要翻译：公开了一种用于在泡罩包装中制造冷冻干燥药片的改进方法。将液体剂量引入具有位于第一和第二外层之间的不可渗透的中间层的多层层状泡罩片，每层具有基本上相同的热膨胀系数。泡罩片的外层的特性使得当在冷冻和冷冻干燥步骤期间经受温度变化时，不会引起泡罩片的曲率的层间应力。在将剂量引入泡罩片的凹陷中之后，将剂量冷冻并冷冻干燥。然后将封盖片附接到泡罩片以将固体剂量密封到泡罩包装中。

10. 发明授权

US09192580B2 Fast-dispersing dosage forms containing fish gelatin 有权
标题翻译：含有明胶的快分散剂型
公开(公告)号：US09192580B2
公开(公告)日：2015-11-24
申请号：US10685728
申请日：2003-10-14
申请人： Richard Green , Owen Murray , Michael Hall , Patrick Kearney
发明人： Richard Green , Owen Murray , Michael Hall , Patrick Kearney
IPC分类号： A61K9/20 , A61K9/00 , A61K47/42
CPC分类号： A61K9/2063 , A61K9/0056 , A61K47/42
摘要： The invention disclosed herein relates to a pharmaceutical composition comprising a carrier and an active ingredient, wherein the carrier is fish gelatin and the composition is a fast-dispersing dosage form designed to release the active ingredient rapidly on contact with a fluid. In one embodiment, the composition is designed for oral administration and releases the active ingredient rapidly in the oral cavity on contact with saliva. The fish gelatin can be obtained from cold water fish sources and is preferably the non-gelling, non-hydrolyzed form. A process for preparing such a composition and a method of using fish gelatin in a fast dispersing dosage form are also provided.
摘要翻译：本文公开的本发明涉及包含载体和活性成分的药物组合物，其中所述载体是鱼明胶，并且所述组合物是快速分散剂型，其设计为在与流体接触时快速释放活性成分。在一个实施方案中，组合物被设计用于口服给药，并且在与唾液接触时在口腔中快速释放活性成分。鱼明胶可以从冷水鱼源获得，优选非胶凝，非水解形式。还提供了制备这种组合物的方法和以快速分散剂型使用鱼明胶的方法。

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