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1. 发明申请

US20080275661A1 On-machine methods for identifying and compensating force-ripple and side-forces produced by actuators on a multiple-axis stage 有权
标题翻译：用于识别和补偿由多个执行器在多轴平台上产生的力 - 波动和侧力的机上方法
公开(公告)号：US20080275661A1
公开(公告)日：2008-11-06
申请号：US11986314
申请日：2007-11-19
申请人： Pai-Hsueh Yang , Bausan Yuan , Kazuo Masaki , Kazuhiro Hirano , Xiao-Feng Yang , Scott Coakley , Michael B. Binnard
发明人： Pai-Hsueh Yang , Bausan Yuan , Kazuo Masaki , Kazuhiro Hirano , Xiao-Feng Yang , Scott Coakley , Michael B. Binnard
IPC分类号： G01L25/00
CPC分类号： G03F7/70758 , G03F7/70725
摘要： Methods, apparatus, and systems are disclosed for identifying force-ripple and/or side-forces in actuators used for moving a multiple-axis stage. The identified force-ripple and/or side-forces can be mapped, and maps of corresponding position-dependent compensation ratios useful for correcting same are obtained. The methods are especially useful for stages providing motion in at least one degree of freedom using multiple (redundant) actuators. In an exemplary method a stage member is displaced, using at least one selected actuator, multiple times over a set distance in the range of motion of the subject actuator(s). Each displacement has a predetermined trajectory and respective starting point in the range. For each displacement, respective section force-command(s) are extracted and normalized to a reference section force-command to define a section compensation-ratio. Multiple section compensation-ratios are assembled, as functions of displacement in the range, to provide a map of compensation ratios for the actuator(s) throughout the range.
摘要翻译：公开了用于识别用于移动多轴平台的致动器中的力波动和/或侧向力的方法，装置和系统。可以对所识别的力 - 纹波和/或侧向力进行映射，并且获得用于校正相应的位置相关的补偿比的映射。这些方法对于使用多个（冗余）致动器在至少一个自由度中提供运动的阶段特别有用。在示例性方法中，使用至少一个所选择的致动器，在主体致动器的运动范围内的设定距离上移动台架构件多次。每个位移具有预定的轨迹和该范围内的相应起始点。对于每个位移，提取相应的截面力命令并将其归一化为参考部分力命令以定义截面补偿比。组合多段补偿比作为该范围内的位移的函数，以提供在整个范围内的致动器的补偿比的图。

2. 发明授权

US08140288B2 On-machine methods for identifying and compensating force-ripple and side-forces produced by actuators on a multiple-axis stage 有权
标题翻译：用于识别和补偿由多个执行器在多轴平台上产生的力 - 波动和侧力的机上方法
公开(公告)号：US08140288B2
公开(公告)日：2012-03-20
申请号：US11986314
申请日：2007-11-19
申请人： Pai-Hsueh Yang , Bausan Yuan , Kazuo Masaki , Kazuhiro Hirano , Xiao-Feng Yang , Scott Coakley , Michael B. Binnard
发明人： Pai-Hsueh Yang , Bausan Yuan , Kazuo Masaki , Kazuhiro Hirano , Xiao-Feng Yang , Scott Coakley , Michael B. Binnard
IPC分类号： G01L25/00
CPC分类号： G03F7/70758 , G03F7/70725
摘要： Methods, apparatus, and systems are disclosed for identifying force-ripple and/or side-forces in actuators used for moving a multiple-axis stage. The identified force-ripple and/or side-forces can be mapped, and maps of corresponding position-dependent compensation ratios useful for correcting same are obtained. The methods are especially useful for stages providing motion in at least one degree of freedom using multiple (redundant) actuators. In an exemplary method a stage member is displaced, using at least one selected actuator, multiple times over a set distance in the range of motion of the subject actuator(s). Each displacement has a predetermined trajectory and respective starting point in the range. For each displacement, respective section force-command(s) are extracted and normalized to a reference section force-command to define a section compensation-ratio. Multiple section compensation-ratios are assembled, as functions of displacement in the range, to provide a map of compensation ratios for the actuator(s) throughout the range.
摘要翻译：公开了用于识别用于移动多轴平台的致动器中的力波动和/或侧向力的方法，装置和系统。可以对所识别的力 - 纹波和/或侧向力进行映射，并且获得用于校正相应的位置相关的补偿比的映射。这些方法对于使用多个（冗余）致动器在至少一个自由度中提供运动的阶段特别有用。在示例性方法中，使用至少一个所选择的致动器，在主体致动器的运动范围内的设定距离上移动台架构件多次。每个位移具有预定的轨迹和该范围内的相应起始点。对于每个位移，提取相应的截面力命令并将其归一化为参考部分力命令以定义截面补偿比。组合多段补偿比作为该范围内的位移的函数，以提供在整个范围内的致动器的补偿比的图。

3. 发明申请

US20100136036A1 UNCONVENTIONAL ANTIGEN TRANSLATED BY A NOVEL INTERNAL RIBOSOME ENTRY SITE ELICITS ANTITUMOR HUMORAL IMMUNE REACTIONS 有权
标题翻译：一个新的内部入侵者网站转载的非传统抗原抗体抗体免疫反应
公开(公告)号：US20100136036A1
公开(公告)日：2010-06-03
申请号：US12377444
申请日：2007-08-16
申请人： Xiao-Feng Yang
发明人： Xiao-Feng Yang
IPC分类号： A61K39/00 , C07H21/00 , C12N15/12 , C12N15/63 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , C12Q1/68 , B01L3/00 , G01N33/535 , G01N33/53 , C12Q1/02 , G01N33/68 , A61P37/04 , A61P31/12 , A61P35/00
CPC分类号： C07K14/4702 , A61K39/00 , A61K39/0011 , A61K2039/53 , C07K14/4748 , C12N2840/002 , C12N2840/105 , C12N2840/203 , C12N2840/85
摘要： The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′ untranslated region (3′UTR) of myotrophin mRNA. MPD6 elicits IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD6 was mediated by a novel internal ribosome entry site (IRES) upstream of the MPD6 reading frame. Furthermore, the MPD6-IRES mediated translation, but not myotrophin-MPD6 transcription, was significantly upregulated in response to IFN-α stimulation. These findings demonstrate that a novel IRES-mediated mechanism is responsible for the translation of unconventional self-antigen MPD6 in responsive to IFN-α stimulation. The eliciting anti-tumor immune response against unconventional antigen MPD6 in patients with myeloproliferative diseases indicates MPD6 as a target of novel immunotherapy.
摘要翻译：本发明提供了一种新颖的抗原，MPD6属于没有常规基因组结构的隐性抗原组，由位于myotrophin mRNA的3'非翻译区（3'UTR）的隐性开放阅读框编码。 MPD6在PV患者的一个子集以及慢性骨髓性白血病和前列腺癌患者中引发IgG抗体应答。 MPD6的翻译由MPD6阅读框上游的新型内部核糖体进入位点（IRES）介导。此外，MPD6-IRES介导的翻译，但不是myotrophin-MPD6转录，在IFN-α刺激响应中显着上调。这些研究结果表明，一种新的IRES介导的机制负责非传统自身抗原MPD6在IFN-α刺激反应中的翻译。在骨髓增生性疾病患者中引发针对非常规抗原MPD6的抗肿瘤免疫应答表明MPD6是新型免疫治疗的靶标。

4. 发明授权

US06472170B1 BCL-XY, a novel BCL-X isoform, and uses related thereto 失效
标题翻译： BCL-Xy，一种新型的BCL-X同种型，并且与之相关
公开(公告)号：US06472170B1
公开(公告)日：2002-10-29
申请号：US08899367
申请日：1997-07-23
申请人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
发明人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
IPC分类号： C12N1512
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The present invention relates to BCL-x&ggr;, a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.
摘要翻译：本发明涉及BCL-xgamma，BCL-x蛋白家族的新型同工型主要在T淋巴细胞中表达并与凋亡抵抗相关。描述了可用于治疗或预防免疫系统疾病的物质和方法的两种组合物。

5. 发明申请

US20090304736A1 NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA 有权
标题翻译：新型肿瘤抗原在多发性硬化症患者中的抗肿瘤免疫反应
公开(公告)号：US20090304736A1
公开(公告)日：2009-12-10
申请号：US12446849
申请日：2007-10-26
申请人： Xiao-Feng Yang
发明人： Xiao-Feng Yang
IPC分类号： A61K39/12 , C07H21/00 , C12N15/74 , C12N1/00 , C07K14/00 , A61K39/00 , C07K16/00 , C12Q1/68 , G01N33/53 , A61P37/04
CPC分类号： C07K16/30
摘要： The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′untranslated region (3′UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and/or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy.
摘要翻译：本发明提供新型抗原，MPD5，PV13和PV65，属于没有常规基因组结构的隐性抗原组，由位于肌营养蛋白mRNA的3'非翻译区（3'UTR）的隐性开放阅读框编码。抗原在PV患者的一个子集中以及患有慢性骨髓性白血病和前列腺癌的患者中引起IgG抗体应答。 MPD5，PV13和PV65的翻译由开放阅读框架上游的新型内部核糖体进入位点（IRES）介导。在骨髓增生性疾病患者中引起针对MPD5，PV13和/或PV65抗原的抗肿瘤免疫应答是一种新型免疫治疗。

6. 发明申请

US20090208450A1 METHOD FOR ENHANCING THE EFFICACY OF ANTIGEN SPECIFIC TUMOR IMMUNOTHERAPY 审中-公开
标题翻译：提高抗原特异性肿瘤免疫功能的方法
公开(公告)号：US20090208450A1
公开(公告)日：2009-08-20
申请号：US12438820
申请日：2007-08-24
申请人： Xiao-Feng Yang
发明人： Xiao-Feng Yang
IPC分类号： A61K38/20 , C12Q1/02 , A61K39/00 , A61K38/21
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/29 , A61K39/292 , C12N2730/10134 , C12N2740/16034 , C12N2760/16134 , C12N2770/24234
摘要： The invention provides a method for the improved processing efficiency of T cell tumor antigen epitopes using bioinformatic means. The proteolytic sites in the generation of 47 experimentally identified HLA-A2.1-restricted immunodominant tumor antigen epitopes was compared to those of 52 documented HLA-A2.1-restricted immunodominant viral antigen epitopes. The amino acid frequencies in the C-terminal cleavage sites of the tumor antigen epitopes, as well as several positions within the 10 amino acid (aa) flanking regions, were significantly different from those of the viral antigen epitopes. These two groups of epitopes may be cleaved by distinct sets of proteasomes and peptidases or similar enzymes with lower efficiencies for tumor epitopes, targeted activation of the immunoproteasomes and peptidases can be achieved that mediate the cleavage of viral epitopes in order to more effectively generate tumor antigen epitopes thus enhancing antigen-specific tumor immunotherapy.
摘要翻译：本发明提供使用生物信息学手段提高T细胞肿瘤抗原表位的处理效率的方法。将47个实验鉴定的HLA-A2.1限制免疫显性肿瘤抗原表位的蛋白水解位点与52个记录的HLA-A2.1限制性免疫显性病毒抗原表位的蛋白水解位点进行比较。肿瘤抗原表位的C末端切割位点的氨基酸频率以及10个氨基酸（aa）侧翼区域内的几个位置与病毒抗原表位的氨基酸频率显着不同。这两组表位可以被不同组的蛋白酶体和肽酶或相似的酶切割，对肿瘤表位具有较低的效率，可以实现介导病毒表位的切割以更有效地产生肿瘤抗原的免疫蛋白酶体和肽酶的靶向激活表位因此增强抗原特异性肿瘤免疫治疗。

7. 发明授权

US09163088B2 Tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera 有权
标题翻译：肿瘤抗原在红细胞增多症患者的一小部分中引起抗肿瘤体液免疫反应
公开(公告)号：US09163088B2
公开(公告)日：2015-10-20
申请号：US12446849
申请日：2007-10-26
申请人： Xiao-Feng Yang
发明人： Xiao-Feng Yang
IPC分类号： C07K7/00 , C07K16/30
CPC分类号： C07K16/30
摘要： The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′untranslated region (3′UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and/or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy.
摘要翻译：本发明提供新型抗原，MPD5，PV13和PV65，属于没有常规基因组结构的隐性抗原组，由位于肌营养蛋白mRNA的3'非翻译区（3'UTR）的隐性开放阅读框编码。抗原在PV患者的一个子集中以及患有慢性骨髓性白血病和前列腺癌的患者中引起IgG抗体应答。 MPD5，PV13和PV65的翻译由开放阅读框架上游的新型内部核糖体进入位点（IRES）介导。在骨髓增生性疾病患者中引起针对MPD5，PV13和/或PV65抗原的抗肿瘤免疫应答是一种新型免疫治疗。

8. 发明授权

US08333972B2 Unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions 有权
标题翻译：由新型内部核糖体进入位点翻译的非常规抗原引起抗肿瘤体液免疫反应
公开(公告)号：US08333972B2
公开(公告)日：2012-12-18
申请号：US12377444
申请日：2007-08-16
申请人： Xiao-Feng Yang
发明人： Xiao-Feng Yang
IPC分类号： A61K39/00 , C07H21/00 , C12N15/12 , C12N15/63 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , C12Q1/68 , C12Q1/02 , G01N33/535 , G01N33/53 , G01N33/68 , A61P37/04
CPC分类号： C07K14/4702 , A61K39/00 , A61K39/0011 , A61K2039/53 , C07K14/4748 , C12N2840/002 , C12N2840/105 , C12N2840/203 , C12N2840/85
摘要： The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′ untranslated region (3′UTR) of myotrophin mRNA. MPD6 elicits IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD6 was mediated by a novel internal ribosome entry site (IRES) upstream of the MPD6 reading frame. Furthermore, the MPD6-IRES mediated translation, but not myotrophin-MPD6 transcription, was significantly upregulated in response to IFN-α stimulation. These findings demonstrate that a novel IRES-mediated mechanism is responsible for the translation of unconventional self-antigen MPD6 in responsive to IFN-α stimulation. The eliciting anti-tumor immune response against unconventional antigen MPD6 in patients with myeloproliferative diseases indicates MPD6 as a target of novel immunotherapy.
摘要翻译：本发明提供了一种新颖的抗原，MPD6属于没有常规基因组结构的隐性抗原组，由位于myotrophin mRNA的3'非翻译区（3'UTR）的隐性开放阅读框编码。 MPD6在PV患者的一个子集以及慢性骨髓性白血病和前列腺癌患者中引发IgG抗体应答。 MPD6的翻译由MPD6阅读框上游的新型内部核糖体进入位点（IRES）介导。此外，MPD6-IRES介导的翻译，但不是myotrophin-MPD6转录，在IFN-α刺激响应中显着上调。这些研究结果表明，一种新的IRES介导的机制负责非传统自身抗原MPD6在IFN-α刺激反应中的翻译。在骨髓增生性疾病患者中引发针对非常规抗原MPD6的抗肿瘤免疫应答表明MPD6是新型免疫治疗的靶标。

9. 发明授权

US08113020B2 Lock and electronic device using the same 失效
标题翻译：锁和电子设备使用相同
公开(公告)号：US08113020B2
公开(公告)日：2012-02-14
申请号：US12764919
申请日：2010-04-21
申请人： Yu-Rong Liu , Xiao-Feng Yang , You-Xiang Ding
发明人： Yu-Rong Liu , Xiao-Feng Yang , You-Xiang Ding
IPC分类号： E05B9/04 , E05B15/00
CPC分类号： E05B29/0013 , E05B73/0005 , E05B73/0082 , Y10T70/40 , Y10T70/409 , Y10T70/443 , Y10T70/459 , Y10T70/483 , Y10T70/5009 , Y10T70/5279 , Y10T70/7627 , Y10T70/7633 , Y10T70/7751 , Y10T70/7768 , Y10T70/80 , Y10T70/8486 , Y10T292/0844 , Y10T292/0855 , Y10T292/096 , Y10T292/0977 , Y10T292/1016
摘要： A lock includes a housing, a cover, a lock cylinder holder, a lock cylinder, a cam, a resisting shaft, at least one latching block, and at least one first elastic member. The cover is secured to one end of the housing. A gap is formed between the cover and the housing. The lock cylinder holder is secured to the housing. The lock cylinder is rotatably mounted in the lock cylinder holder. The cam is received in the housing and secured to the lock cylinder. The resisting shaft is rotatably mounted in the housing and includes a frustum shaped end. The latching block is received in the gap. The latching block includes an inclined surface corresponding to the frustum shaped end. The first elastic member is configured to connect the latching block to the cover or the housing. An electronic device using the lock is also provided.
摘要翻译：锁具包括壳体，盖子，锁芯保持器，锁芯，凸轮，阻力轴，至少一个锁定块和至少一个第一弹性元件。盖子固定在壳体的一端。在盖和壳体之间形成间隙。锁芯保持架固定在外壳上。锁芯可旋转地安装在锁芯保持器中。凸轮容纳在壳体中并固定到锁芯上。阻力轴可旋转地安装在壳体中并且包括截头锥形的端部。锁定块被接收在间隙中。锁定块包括对应于截头锥形端部的倾斜表面。第一弹性构件被构造成将闩锁块连接到盖或壳体。还提供了使用锁的电子装置。

10. 发明授权

US07160986B2 BCL-xγ, a novel BCL-x isoform, and uses related thereto 有权
标题翻译： BCL-xgamma，一种新型的BCL-x同种型，并且与之相关
公开(公告)号：US07160986B2
公开(公告)日：2007-01-09
申请号：US10208155
申请日：2002-07-29
申请人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
发明人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The present invention relates to BCL-xγ, a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.
摘要翻译：本发明涉及BCL-xgamma，BCL-x蛋白家族的新型同工型主要在T淋巴细胞中表达并与凋亡抵抗相关。描述了可用于治疗或预防免疫系统疾病的物质和方法的两种组合物。

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