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1. 发明公开

US20230203193A1 ISOLATED ANTIBODIES AND FRAGMENTS THEREOF WITH SPECIFICITY FOR OSTEOPONTIN-C 审中-公开
公开(公告)号：US20230203193A1
公开(公告)日：2023-06-29
申请号：US18000315
申请日：2021-06-02
申请人： GEORG F. WEBER
发明人： GEORG F. WEBER
IPC分类号： C07K16/32 , G01N33/574
CPC分类号： C07K16/32 , G01N33/57415 , C07K2317/565 , C07K2317/55
摘要： This disclosure relates to isolated polypeptides with antigen specificity to OPN-c and to methods of their use for treating or determining or screening the presence of an invasive cancer. Included are three heavy chains CDRs and three light chain CDRs with binding specificity to OPN-c with little to no cross-reactivity to OPN-a and OPN-b. The ability to bind and detect OPN-c expression as well an OPN-c neutralization are also included.

2. 发明授权

US07807790B2 Peptide sequence that promotes tumor invasion 有权
标题翻译：促进肿瘤侵袭的肽序列
公开(公告)号：US07807790B2
公开(公告)日：2010-10-05
申请号：US12093340
申请日：2006-11-14
申请人： Georg F. Weber
发明人： Georg F. Weber
IPC分类号： C07K16/00
CPC分类号： G01N33/57484 , G01N2333/52
摘要： An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction of OPN variant-c (OPN-c). OPN-c was expressed in a variety of tumor cell lines, but not in normal tissues (e.g., non-cancerous tissue) or in benign tumors. OPN-c antibody may be administered to a patient with a cancer associated with OPN-c expression to prevent the formation and growth of metastases. OPN-c may be used as a diagnostic to determine whether a patient has a malignant, rather than a benign, growth. OPN-c may be used to detect or identify agents that inhibit or mimic OPN-c expression or activity.
摘要翻译：分离序列SGSSEEKQNAVSSEET（OPNcPEP）SEQ ID NO：8及其用途。肽增强软琼脂克隆形成，但不支持塑料盘中细胞的生长，与支持锚固独立而不是生长一致。该序列表示并且对于OPN变体c（OPN-c）的剪接点周围的结构域是唯一的。 OPN-c在多种肿瘤细胞系中表达，但不在正常组织（例如非癌性组织）或良性肿瘤中表达。 OPN-c抗体可以与患有与OPN-c表达相关的癌症的患者施用以防止转移的形成和生长。 OPN-c可用作诊断，以确定患者是否具有恶性，而不是良性生长。 OPN-c可用于检测或鉴定抑制或模拟OPN-c表达或活性的药剂。

3. 发明授权

US07160986B2 BCL-xγ, a novel BCL-x isoform, and uses related thereto 有权
标题翻译： BCL-xgamma，一种新型的BCL-x同种型，并且与之相关
公开(公告)号：US07160986B2
公开(公告)日：2007-01-09
申请号：US10208155
申请日：2002-07-29
申请人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
发明人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The present invention relates to BCL-xγ, a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.
摘要翻译：本发明涉及BCL-xgamma，BCL-x蛋白家族的新型同工型主要在T淋巴细胞中表达并与凋亡抵抗相关。描述了可用于治疗或预防免疫系统疾病的物质和方法的两种组合物。

4. 发明授权

US06472170B1 BCL-XY, a novel BCL-X isoform, and uses related thereto 失效
标题翻译： BCL-Xy，一种新型的BCL-X同种型，并且与之相关
公开(公告)号：US06472170B1
公开(公告)日：2002-10-29
申请号：US08899367
申请日：1997-07-23
申请人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
发明人： Xiao-Feng Yang , Georg F. Weber , Harvey Cantor
IPC分类号： C12N1512
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The present invention relates to BCL-x&ggr;, a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.
摘要翻译：本发明涉及BCL-xgamma，BCL-x蛋白家族的新型同工型主要在T淋巴细胞中表达并与凋亡抵抗相关。描述了可用于治疗或预防免疫系统疾病的物质和方法的两种组合物。

5. 发明授权

US09873915B2 Grading, staging and prognosing cancer using osteopontin-C 有权
公开(公告)号：US09873915B2
公开(公告)日：2018-01-23
申请号：US12682310
申请日：2008-10-16
申请人： Mana Mirza , Elizabeth Shaughnessy , Georg F. Weber , John K. Hurley , Kristie A. Vanpatten , Gary Pestano
发明人： Mana Mirza , Elizabeth Shaughnessy , Georg F. Weber , John K. Hurley , Kristie A. Vanpatten , Gary Pestano
IPC分类号： C12Q1/68 , A61K47/68
CPC分类号： C12Q1/6886 , A61K47/6855 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade, stage, or aggressiveness of a cancer, appropriate therapeutic regiments can be selected and administered to the patient with the cancer. The method includes detecting osteopontin-c (OPN-c), wherein the presence of high amounts of OPN-c in the cancer sample indicates that the subject has a more aggressive form of cancer (e.g., grade 3).

6. 发明申请

US20110033857A1 PEPTIDE SEQUENCE THAT PROMOTES TUMER INVASION 有权
标题翻译：促进肿瘤侵入的肽序列
公开(公告)号：US20110033857A1
公开(公告)日：2011-02-10
申请号：US12854011
申请日：2010-08-10
申请人： Georg F. Weber
发明人： Georg F. Weber
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/26
CPC分类号： G01N33/57484 , G01N2333/52
摘要： An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction of OPN variant-c (OPN-c). OPN-c was expressed in a variety of tumor cell lines, but not in normal tissues (e.g., non-cancerous tissue) or in benign tumors. OPN-c antibody may be administered to a patient with a cancer associated with OPN-c expression to prevent the formation and growth of metastases. OPN-c may be used as a diagnostic to determine whether a patient has a malignant, rather than a benign, growth. OPN-c may be used to detect or identify agents that inhibit or mimic OPN-c expression or activity.
摘要翻译：分离序列SGSSEEKQNAVSSEET（OPNcPEP）SEQ ID NO：8及其用途。肽增强软琼脂克隆形成，但不支持塑料盘中细胞的生长，与支持锚固独立而不是生长一致。该序列表示并且对于OPN变体c（OPN-c）的剪接点周围的结构域是唯一的。 OPN-c在多种肿瘤细胞系中表达，但不在正常组织（例如非癌性组织）或良性肿瘤中表达。 OPN-c抗体可以与患有与OPN-c表达相关的癌症的患者施用以防止转移的形成和生长。 OPN-c可用作诊断，以确定患者是否具有恶性，而不是良性生长。 OPN-c可用于检测或鉴定抑制或模拟OPN-c表达或活性的药剂。

7. 发明授权

US08969020B2 Peptide sequence that promotes tumor invasion 有权
标题翻译：促进肿瘤侵袭的肽序列
公开(公告)号：US08969020B2
公开(公告)日：2015-03-03
申请号：US12854011
申请日：2010-08-10
申请人： Georg F. Weber
发明人： Georg F. Weber
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N2333/52
摘要： An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction of OPN variant -c (OPN-c). OPN-c was expressed in a variety of tumor cell lines, but not in normal tissues (e.g., non-cancerous tissue) or in benign tumors. OPN-c antibody may be administered to a patient with a cancer associated with OPN-c expression to prevent the formation and growth of metastases. OPN-c may be used as a diagnostic to determine whether a patient has a malignant, rather than a benign, growth. OPN-c may be used to detect or identify agents that inhibit or mimic OPN-c expression or activity.
摘要翻译：分离序列SGSSEEKQNAVSSEET（OPNcPEP）SEQ ID NO：8及其用途。肽增强软琼脂克隆形成，但不支持塑料盘中细胞的生长，与支持锚固独立而不是生长一致。该序列表示并且对于OPN变体-c（OPN-c）的剪接点周围的结构域是唯一的。 OPN-c在多种肿瘤细胞系中表达，但不在正常组织（例如非癌性组织）或良性肿瘤中表达。 OPN-c抗体可以与患有与OPN-c表达相关的癌症的患者施用以防止转移的形成和生长。 OPN-c可用作诊断，以确定患者是否具有恶性，而不是良性生长。 OPN-c可用于检测或鉴定抑制或模拟OPN-c表达或活性的药剂。

8. 发明申请

US20100209928A1 Grading, Staging and prognosing Cancer using Osteopontin-C 有权
标题翻译：使用骨桥蛋白C分级，分期和预后
公开(公告)号：US20100209928A1
公开(公告)日：2010-08-19
申请号：US12682310
申请日：2008-10-16
申请人： Mana Mirza , Elizabeth Shaughnessy , Georg F. Weber , John K. Hurley , Kristie A. Vanpatten , Gary Pestano
发明人： Mana Mirza , Elizabeth Shaughnessy , Georg F. Weber , John K. Hurley , Kristie A. Vanpatten , Gary Pestano
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53
CPC分类号： C12Q1/6886 , A61K47/6855 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade, stage, or aggressiveness of a cancer, appropriate therapeutic regiments can be selected and administered to the patient with the cancer. The method includes detecting osteopontin-c (OPN-c), wherein the presence of high amounts of OPN-c in the cancer sample indicates that the subject has a more aggressive form of cancer (e.g., grade 3).
摘要翻译：本公开提供了可用于确定乳腺或其他癌症（例如原位导管癌（DCIS））的等级或阶段的方法和试剂盒。通过确定癌症的分级，阶段或侵略性，可以选择适当的治疗团并将其施用于患有癌症的患者。该方法包括检测骨桥蛋白c（OPN-c），其中癌症样品中大量OPN-c的存在表明受试者具有更具侵袭性的癌症形式（例如3级）。

9. 发明申请

US20090061436A1 PEPTIDE SEQUENCE THAT PROMOTES TUMOR INVASION 有权
标题翻译：促进肿瘤侵入的肽类序列
公开(公告)号：US20090061436A1
公开(公告)日：2009-03-05
申请号：US12093340
申请日：2006-11-14
申请人： Georg F. Weber
发明人： Georg F. Weber
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53 , C12N5/06 , C12N15/87
CPC分类号： G01N33/57484 , G01N2333/52
摘要： An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction of OPN variant -c (OPN-c). OPN-c was expressed in a variety of tumor cell lines, but not in normal tissues (e.g., non-cancerous tissue) or in benign tumors. OPN-c antibody may be administered to a patient with a cancer associated with OPN-c expression to prevent the formation and growth of metastases. OPN-c may be used as a diagnostic to determine whether a patient has a malignant, rather than a benign, growth. OPN-c may be used to detect or identify agents that inhibit or mimic OPN-c expression or activity.
摘要翻译：分离序列SGSSEEKQNAVSSEET（OPNcPEP）SEQ ID NO：8及其用途。肽增强软琼脂克隆形成，但不支持塑料盘中细胞的生长，与支持锚固独立而不是生长一致。该序列表示并且对于OPN变体-c（OPN-c）的剪接点周围的结构域是唯一的。 OPN-c在多种肿瘤细胞系中表达，但不在正常组织（例如非癌性组织）或良性肿瘤中表达。 OPN-c抗体可以与患有与OPN-c表达相关的癌症的患者施用以防止转移的形成和生长。 OPN-c可用作诊断，以确定患者是否具有恶性，而不是良性生长。 OPN-c可用于检测或鉴定抑制或模拟OPN-c表达或活性的药剂。

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