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1. 发明申请

WO2011031665A2 METHOD AND APPARATUS FOR CONVERSION OF MULTIPLE ANALYTE CATION TYPES TO A SINGLE ANALYTE ANION TYPE VIA ION/ION CHARGE INVERSION 审中-公开
标题翻译：用于通过离子/离子电荷反转将多种分析物类型转换为单分析阴离子类型的方法和装置
公开(公告)号：WO2011031665A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/047970
申请日：2010-09-07
申请人： PURDUE RESEARCH FOUNDATION , DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , HASSELL, Kerry, Marie , MCLUCKEY, Scott, A. , LEBLANC, Yves
发明人： HASSELL, Kerry, Marie , MCLUCKEY, Scott, A. , LEBLANC, Yves
IPC分类号： G01N30/72 , G01N27/62 , G01N30/12
CPC分类号： H01J49/0072 , H01J49/004 , H01J49/165 , Y10T436/24
摘要： An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.
摘要翻译：描述了使用质谱仪的样品的装置和方法，包括使用电喷雾离子化从分析物产生具有第一极性的离子; 从试剂产生第二极性的离子; 将第一极性的离子和第二极性的离子依次注入质谱仪的室中，使得第一极性的离子和第二极性的离子在室中相互作用以形成具有第二极性的分析物离子; 并分析第二极性的分析物离子的质谱。选择诸如聚酰胺胺的试剂优先产生具有所需质荷比的具有第二极性的分析物离子。

2. 发明申请

WO2013061142A1 METHOD FOR MASS SPECTROMETRY 审中-公开
标题翻译：大量光谱法
公开(公告)号：WO2013061142A1
公开(公告)日：2013-05-02
申请号：PCT/IB2012/002154
申请日：2012-10-26
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , BONNER, Ron , LEBLANC, Yves , TATE, Stephen
发明人： BONNER, Ron , LEBLANC, Yves , TATE, Stephen
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： A method is provided for mass spectrometry. The method includes generating precursor ions from a sample; transmitting the precursor ions into a collision cell; generating product ions in the collision cell; detecting the precursor and product ions; applying modulation to one or more of the precursor ion intensity and the product ion intensity; and identifying precursor ion and product ion relationships by analyzing intensity profiles defined by the modulation.
摘要翻译：提供了用于质谱的方法。该方法包括从样品中产生前体离子; 将前体离子传输到碰撞池中; 在碰撞池中产生产物离子; 检测前体和产物离子; 对一种或多种前体离子强度和产物离子强度进行调制; 并通过分析由调制定义的强度分布来识别前体离子和产物离子关系。

3. 发明申请

WO2013061141A1 APPARATUS AND METHOD FOR FRACTIONATION 审中-公开
标题翻译：装置和分离方法
公开(公告)号：WO2013061141A1
公开(公告)日：2013-05-02
申请号：PCT/IB2012/002152
申请日：2012-10-26
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , LEBLANC, Yves , CAMPBELL, John, L.
发明人： LEBLANC, Yves , CAMPBELL, John, L.
IPC分类号： G01N27/62 , G01N30/06 , G01N1/28
CPC分类号： G01N27/624
摘要： An apparatus is disclosed for fractionation of a sample prepared by differential mobility spectrometry. The apparatus includes an ion source for generating ions, a differential mobility spectrometer (DMS) for receiving and separating the ions from the ion source, the DMS having at least two planar electrodes spaced around a central axis, a power supply for applying an asymmetric waveform to the at least two planar electrodes, a DC power supply for applying a DC voltage to one of the at least two planar electrodes, a vacuum for generating gas flow through the DMS, and a collection plate for collecting separated ions from the DMS, the collection plate connect! vely sealed by an insulator to the DMS.
摘要翻译：公开了一种用于分级通过差示迁移率光谱法制备的样品的装置。该装置包括用于产生离子的离子源，用于从离子源接收和分离离子的差分迁移率光谱仪（DMS），DMS具有围绕中心轴间隔开的至少两个平面电极，用于施加不对称波形的电源至少两个平面电极，用于向至少两个平面电极中的一个施加DC电压的DC电源，用于产生通过DMS的气体流的真空和用于从DMS收集分离的离子的收集板，收集板连接！通过绝缘子密封到DMS。

4. 发明公开

EP2475986A2 METHOD AND APPARATUS FOR CONVERSION OF MULTIPLE ANALYTE CATION TYPES TO A SINGLE ANALYTE ANION TYPE VIA ION/ION CHARGE INVERSION 审中-公开
标题翻译：方法和装置，通过ION离子充电反演在单一ANALYTANIONENTYP几种ANALYTKATIONENTYPEN的转换
公开(公告)号：EP2475986A2
公开(公告)日：2012-07-18
申请号：EP10815963.3
申请日：2010-09-07
申请人： Purdue Research Foundation , DH Technologies Development Pte. Ltd.
发明人： HASSELL, Kerry, Marie , MCLUCKEY, Scott, A. , LEBLANC, Yves
IPC分类号： G01N30/72 , G01N27/62 , G01N30/12
CPC分类号： H01J49/0072 , H01J49/004 , H01J49/165 , Y10T436/24
摘要： An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.

5. 发明申请

WO2019003188A1 APPARATUS AND METHOD FOR GLYCOPEPTIDE ANALYSIS 审中-公开
公开(公告)号：WO2019003188A1
公开(公告)日：2019-01-03
申请号：PCT/IB2018/054823
申请日：2018-06-28
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi , LEBLANC, Yves
IPC分类号： H01J49/42 , G01N33/68
摘要： A system and method is described for characterizing glycopeptides which includes a first quadrupole mass filter, a multipole rod set of an ion guide, a lens electrode, an ExD device and a mass analyzer. The multipole rod set is adapted to receive a radial radio frequency (RF) trapping voltage and a radial dipole direct current (DC) voltage The lens electrode is adapted to receive an axial trapping alternating current (AC) voltage and a DC voltage. The ExD device performs electron capture dissociation or electron transfer dissociation, the ExD device being positioned so that an entrance of the ExD device is disposed on the other side of the lens electrode opposite the multipole rod set. The mass analyzer is positioned at an exit of the ExD device for receiving ions from the ExD device.

6. 发明申请

WO2017093898A1 ISOMERIC REAGENT TAGS FOR DIFFERENTIAL MOBILITY SPECTROMETRY 审中-公开
标题翻译：用于差示扫描量热法的异构化试剂标签
公开(公告)号：WO2017093898A1
公开(公告)日：2017-06-08
申请号：PCT/IB2016/057192
申请日：2016-11-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John L. , LEBLANC, Yves , LIU, Chang
IPC分类号： H01J49/00
CPC分类号： G01N33/58 , G01N27/624
摘要： Methods and systems for separating and/or quantifying compounds, using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can provide for the quantification of one or more compounds, for example, using isomeric labels that can be less costly to produce relative to conventional tags that incorporate stable-isotope labels. The present teachings can quantify the relative amount of a compound based on the effect of using an easily charged functional group as well as a functional group positioned at a resonant or non-resonant position through a DMS. In some aspects, methods and systems in accordance with various aspects of the present teachings provide for the detection and/or quantification of the analytes labeled with isomeric tags that can be differentiated via a DMS upstream of a first stage mass analyzer and/or prior to fragmentation of the labeled analyte, for example.
摘要翻译：本文提供了使用差分迁移率谱（DMS）分离和/或定量化合物的方法和系统。根据申请人的教导的各个方面，所述方法和系统可以提供一种或多种化合物的定量，例如使用异构标记，相对于掺入稳定同位素标记的常规标记，其生产成本可以较低。本教导可以基于使用容易带电的官能团以及通过DMS定位在共振或非共振位置的官能团的效果来量化化合物的相对量。在一些方面，根据本教导的各个方面的方法和系统提供了用异构体标签标记的分析物的检测和/或定量，所述异构体标签可以经由第一级质量分析器上游的DMS和/或在例如，标记分析物的碎裂。

7. 发明申请

WO2017093896A1 ELECTROMAGNETIC ASSEMBLIES FOR PROCESSING FLUIDS 审中-公开
标题翻译：用于处理流体的电磁组件
公开(公告)号：WO2017093896A1
公开(公告)日：2017-06-08
申请号：PCT/IB2016/057189
申请日：2016-11-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , CAMPBELL, John L. , COVEY, Thomas R. , LEBLANC, Yves , LIU, Chang
IPC分类号： B03C5/00 , B03C1/14
CPC分类号： B03C1/30 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N35/0098
摘要： Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.
摘要翻译：描述了用于处理流体的方法和设备。在各个方面，流体处理系统可以包括磁性组件，该磁性组件包括被配置为在流体容器内产生磁场梯度的多个磁性结构。磁结构可以形成为配置成由控制器单独致动的多个电磁体。每个电磁体可以在流体容器内产生磁场。电磁体可以被差动致动以在流体容器内产生磁场梯度以搅动，混合或以其他方式影响设置在流体容器内的磁性粒子。电磁结构的电磁体的激活可以产生影响磁性粒子在x-y方向上的磁场梯度。另外，多个电磁结构的电磁体的激活可以产生影响磁性粒子在x-y方向和z方向上的磁场梯度。

8. 发明申请

WO2015170268A1 FLUID TRANSFER FROM DIGITAL MICROFLUIDIC DEVICE 审中-公开
标题翻译：从数字微流体装置流体转移
公开(公告)号：WO2015170268A1
公开(公告)日：2015-11-12
申请号：PCT/IB2015/053313
申请日：2015-05-06
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John Lawrence , CHOI, Kihwan , LEBLANC, Yves , LIU, Chang , WHEELER, Aaron
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： B01L3/502792 , B01L2300/0645 , B01L2300/0887 , B01L2400/0415 , B01L2400/0427 , G01N30/16 , G01N35/00871 , G01N2030/162
摘要： Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in some aspects enable the integration of a digital microfluidic device as a direct, in-line sample processing platform from which a droplet can be transferred to a downstream analyzer.
摘要翻译：本文描述了利用数字微流体装置处理流体并将液滴从数字微流体装置转移到下游分析器的方法和系统。根据本教导的方法和系统可以允许从数字微流体装置中取出流体，并且在某些方面，可以将数字微流体装置整合为直接的在线样品处理平台，液滴可从该样品处理平台转移到下游分析仪。

9. 发明申请

WO2013171574A1 METHOD AND SYSTEM FOR INTRODUCING MAKE-UP FLOW IN AN ELECTROSPRAY ION SOURCE SYSTEM 审中-公开
标题翻译：用于介绍电泳离子源系统中的制备流程的方法和系统
公开(公告)号：WO2013171574A1
公开(公告)日：2013-11-21
申请号：PCT/IB2013/000976
申请日：2013-05-17
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John, L. , COVEY, Thomas , LEBLANC, Yves , SCHNEIDER, Bradley
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/165 , G01N27/622 , H01J49/0081 , H01J49/0431
摘要： An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample. A make-up flow channel is provided for introducing make-up flow of liquid to the sample post-column, wherein the make-up flow normalizes the spray current. An electrospray ionization source is provided having one or more electrospray ionization emitter nozzles for receiving the make-up flow containing sample. A power supply can provide a voltage to the one or more emitter nozzles, and a measurement device can measure and monitor the spray current.
摘要翻译：提供了一种用于检测发射器故障的电喷雾离子源方法和系统，其包括适于样品色谱分离的液相色谱柱。该柱可以具有用于接收样品的入口; 以及用于喷射样品的出口。提供了补充流动通道，用于将液体的补充流引入样品后柱，其中补充流使标准化喷雾电流。提供了具有一个或多个电喷雾电离发射器喷嘴的电喷雾离子源，用于接收含有补充流的样品。电源可以向一个或多个发射器喷嘴提供电压，并且测量装置可以测量和监测喷射电流。

10. 发明申请

WO2022264091A1 AUTOMATED OPTIMIZATION OF DIFFERENTIAL MOBILITY SPECTROMETRY (DMS) SEPARATIONS USING ALPHA FUNCTIONS 审中-公开
公开(公告)号：WO2022264091A1
公开(公告)日：2022-12-22
申请号：PCT/IB2022/055615
申请日：2022-06-16
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： SCHNEIDER, Bradley B. , BEDFORD, Leigh , LEBLANC, Yves , DUCHOSLAV, Eva
IPC分类号： G01N27/624
摘要： An automated method of operating a mass spectrometer (MS) comprising a differential mobility spectrometer (DMS) includes: introducing a first compound to the DMS; calculating a first alpha function for the first compound; introducing a second compound to the DMS; calculating a second alpha function for the second compound; and determining operation parameters of the DMS to achieve sufficient separation of the first compound and the second compound, based on the first alpha function and the second alpha function.

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