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1. 发明申请

WO2020016854A1 AN ELECTROMAGNETIC COIL ASSEMBLY STRUCTURE FOR PROCESSING FLUIDS AND METHODS FOR MAKING SAME 审中-公开
公开(公告)号：WO2020016854A1
公开(公告)日：2020-01-23
申请号：PCT/IB2019/056209
申请日：2019-07-19
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , COVEY, Thomas R. , LIU, Chang , POTYRALA, Stanislaw , TSIPIROVICH, Alexander
IPC分类号： B01L3/00 , B03C1/32 , G01N35/00
摘要： Electromagnetic systems and corresponding methods for assembling the electromagnetic systems are described. The electromagnetic systems can be used in fluid processing systems that include a plurality of fluid containers, each configured to define a fluid chamber that receives a fluid and a plurality of magnetic particles, and a plurality of electromagnets configured to generate a magnetic field within at least one of the plurality of the fluid containers. The fluid processing system can also include a PCB board that supplies the electromagnets with electrical current by establishing an electrical connection between electrical contact terminals included on the PCB board and spring loaded connections included on each electromagnet. A control component controls the electromagnetic field generated by each electromagnet to generate a plurality of magnetic field gradients within the at least one fluid container sufficient to magnetically influence the plurality of magnetic particles within the fluid in each fluid container.

2. 发明申请

WO2020003233A1 SAMPLING PROBE AND SAMPLING INTERFACE FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020003233A1
公开(公告)日：2020-01-02
申请号：PCT/IB2019/055505
申请日：2019-06-28
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , COVEY, Thomas R. , LIU, Chang
IPC分类号： H01J49/04 , H01J49/16 , H01J49/26
摘要： Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.

3. 发明申请

WO2019008492A1 ELECTROSPRAY INTERFACE DEVICE AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2019008492A1
公开(公告)日：2019-01-10
申请号：PCT/IB2018/054873
申请日：2018-06-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W.
IPC分类号： H01J49/16 , G01N30/72
摘要： Apparatus, systems, and methods in accordance with various aspects of the applicant's teachings provide for improved interfaces for providing a sample flow from a sample conduit (e.g., an analytical conduit or capillary), including those used in sample separation techniques such as CE and HPLC, to an ESI source for ionization thereby.

4. 发明申请

WO2020016809A1 OPEN PORT PROBE INTERFACES 审中-公开
公开(公告)号：WO2020016809A1
公开(公告)日：2020-01-23
申请号：PCT/IB2019/056124
申请日：2019-07-17
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W.
IPC分类号： H01J49/04 , G01N30/72
摘要： Integrated system for delivering sample to a mass spectrometer, which includes a chamber extending from a top to bottom end, an open port probe disposed in the chamber such that an open end of the probe, which is configured for receiving a sample, is positioned in proximity to top end of the chamber. The system can further include a solvent inlet port coupled to said chamber for receiving a solvent and directing said solvent to said probe, and a solvent outlet port for receiving a flow of the solvent from the open port probe and directing the received solvent out of the chamber. The system can also include an adapter for receiving a sample holder having an outlet port, the adapter is releasable and replaceable and couple with chamber to align the outlet port of sample holder with open end of probe for delivering sample to the probe.

5. 发明申请

WO2019102355A1 3-D MIXING AND PARTICLE DELIVERY VIA MOVABLE ELECTROMAGNETS ASSEMBLIES 审中-公开
公开(公告)号：WO2019102355A1
公开(公告)日：2019-05-31
申请号：PCT/IB2018/059146
申请日：2018-11-20
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , COVEY, Thomas R. , LIU, Chang
IPC分类号： B03C1/06 , B03C1/30 , B03C1/32 , G01R33/12
CPC分类号： B03C1/30 , B03C1/01 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01R33/1276
摘要： A fluid processing system that can include a sample container having a sample chamber for containing a fluid and a plurality of magnetic particles and at least one movable magnetic assembly configured to be movably inserted into or out of the sample chamber. The movable magnetic assembly can include a plurality of electromagnets that generate a magnetic field within at least a portion of the sample chamber when the assembly is inserted at least partially into the sample chamber. The fluid processing system can also include a signal generator that applies electrical signals, e.g., AC electrical signals, to the electromagnets of the magnetic assembly and a controller coupled to the signal generator that is configured to control phases of the electrical signals applied to the electromagnets to generate magnetic field gradients within the portion of the sample chamber effective to magnetically influence the plurality of the magnetic particles.

6. 发明申请

WO2019102350A1 METHODS AND SYSTEMS UTILIZING ULTRASOUND-ASSISTED SAMPLING INTERFACES FOR MASS SPECTROMETRIC ANALYSIS 审中-公开
公开(公告)号：WO2019102350A1
公开(公告)日：2019-05-31
申请号：PCT/IB2018/059138
申请日：2018-11-20
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , COVEY, Thomas R. , LIU, Chang
IPC分类号： G01N1/40 , H01J49/04 , G01N29/02 , G01N1/38
CPC分类号： G01N1/4055 , G01N29/02 , G01N29/222 , G01N2001/383 , G01N2001/4061 , G01N2001/4094 , G01N2291/02836 , H01J49/0454
摘要： An ultrasonic transmitter (95) and detector (e.g., integrated as an ultrasound transducer) utilized in a feedback control system automatically monitors and/or detects surface profile (e.g., shape) of the liquid-air interface and adjusts the flow rate of sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. The feedback control can provide for automated adjustment of the surface profile of the liquid-air interface in accordance with changes in desired set point according to an experimental workflow (e.g., automated adjustment between an interface corresponding to a vortex sampling set point and an overflow cleaning set point). Improvements in desorption efficiency and quality of mass spectrometry data by degassing of the liquid solvent utilized within the sampling interfaces, and/or utilization in a feedback control system for generating data indicative of a surface profile of the liquid-air interface within the interface's sampling port may be realized.

7. 发明申请

WO2018138631A1 ELECTROMAGNETIC ASSEMBLIES FOR PROCESSING FLUIDS 审中-公开
公开(公告)号：WO2018138631A1
公开(公告)日：2018-08-02
申请号：PCT/IB2018/050399
申请日：2018-01-23
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , COVEY, Thomas R. , LIU, Chang
IPC分类号： G01N33/00 , G01N1/34 , G01N1/40 , G01N30/14 , G01N35/00 , G01N30/06
摘要： Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.

8. 发明申请

WO2021176359A1 ELECTROMAGNETIC SAMPLING DEVICE PROTECTED IN A SEPTUM PIERCING NEEDLE 审中-公开
公开(公告)号：WO2021176359A1
公开(公告)日：2021-09-10
申请号：PCT/IB2021/051743
申请日：2021-03-02
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , COVEY, Thomas R. , LIU, Chang
IPC分类号： G01N30/00 , G01N1/40 , B01L3/00 , B01D43/00 , B03C1/28
摘要： An electromagnetic sampling device is disclosed, which comprises a needle having a hollow housing that extends from a proximal end to a distal end, and an electromagnet comprising an electromagnetic coil and a metal core, at least a portion of said metal core extending through said hollow housing of the needle and be configured to transition between an extended position in which the distal end of the metal core extends beyond the distal end of the needle's hollow housing and a retracted position in which the distal end of the metal core is positioned within the needle's housing, wherein an activation of said electromagnetic coil magnetizes the metal core.

9. 发明申请

WO2018069872A1 METHODS AND SYSTEMS FOR INCREASING SENSITIVITY OF DIRECT SAMPLING INTERFACES FOR MASS SPECTROMETRIC ANALYSIS 审中-公开
标题翻译：用于提高质谱分析的直接采样界面灵敏度的方法和系统
公开(公告)号：WO2018069872A1
公开(公告)日：2018-04-19
申请号：PCT/IB2017/056335
申请日：2017-10-12
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： LIU, Chang , COVEY, Thomas R. , ARNOLD, Don W.
IPC分类号： H01J49/04 , G01N30/72
摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
摘要翻译：本文提供了用于将液体样品输送到离子源以产生离子并随后通过质谱分析进行分析的方法和系统。根据本教导的各个方面，提供了基于MS的系统和方法，其中可以选择性地控制流体耦合到离子源的取样探针内的解吸溶剂流，使得一种或多种分析物物质可以从插入取样探针内的样品基底内的解吸溶剂体积减少，用于随后输送至离子源。在各个方面，由于解吸效率较高（例如，由于解吸时间增加）和/或解吸分析物的稀释度降低，所以灵敏度可以增加。本文所述的方法和系统可以附加地或可替代地提供对采样接口内的解吸溶剂的流速的选择性控制，以使得能够在采样探针内发生额外的处理步骤（例如，多次采样，反应） / p>

10. 发明申请

WO2017093896A1 ELECTROMAGNETIC ASSEMBLIES FOR PROCESSING FLUIDS 审中-公开
标题翻译：用于处理流体的电磁组件
公开(公告)号：WO2017093896A1
公开(公告)日：2017-06-08
申请号：PCT/IB2016/057189
申请日：2016-11-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： ARNOLD, Don W. , CAMPBELL, John L. , COVEY, Thomas R. , LEBLANC, Yves , LIU, Chang
IPC分类号： B03C5/00 , B03C1/14
CPC分类号： B03C1/30 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N35/0098
摘要： Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.
摘要翻译：描述了用于处理流体的方法和设备。在各个方面，流体处理系统可以包括磁性组件，该磁性组件包括被配置为在流体容器内产生磁场梯度的多个磁性结构。磁结构可以形成为配置成由控制器单独致动的多个电磁体。每个电磁体可以在流体容器内产生磁场。电磁体可以被差动致动以在流体容器内产生磁场梯度以搅动，混合或以其他方式影响设置在流体容器内的磁性粒子。电磁结构的电磁体的激活可以产生影响磁性粒子在x-y方向上的磁场梯度。另外，多个电磁结构的电磁体的激活可以产生影响磁性粒子在x-y方向和z方向上的磁场梯度。

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