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1. 发明申请

WO2022101782A1 METHODS FOR DETECTION OF ISOMERIC STEROIDS USING DIFFERENTIAL MOBILITY SPECTROMETRY 审中-公开
公开(公告)号：WO2022101782A1
公开(公告)日：2022-05-19
申请号：PCT/IB2021/060368
申请日：2021-11-09
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John Lawrence , PURKAYASTHA, Subhasish
IPC分类号： G01N27/624
摘要： Method for separating, detecting, and/or quantifying steroid isomers using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the method can provide for the separation of racemic or non-racemic mixtures of steroid isomers that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), including both steroid stereoisomers and constitutional steroid isomers. The method may further comprise detecting the ionized derivatized steroids transported from the differential mobility spectrometer at a first combination of compensation voltage and separation voltage and at a second combination of compensation voltage and separation voltage applied to the differential mobility spectrometer, wherein the first combination is configured to optimize transmission of a first ionized derivatized steroid corresponding to a first steroid of an isomeric steroid pair and the second combination is configured to optimize transmission of a second ionized derivatized steroid corresponding to a second steroid of the isomeric steroid pair.

2. 发明申请

WO2020194095A1 AGNOSTIC COMPOUND ELUTION DETERMINATION 审中-公开
公开(公告)号：WO2020194095A1
公开(公告)日：2020-10-01
申请号：PCT/IB2020/052060
申请日：2020-03-10
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BLOOMFIELD, Nic G. , BURTON, Lyle , CAMPBELL, John Lawrence , COX, David M. , DUCHOSLAV, Eva , LAU, Adam San-Ho
IPC分类号： H01J49/00 , H01J49/10 , H01J49/40 , H01J49/04
摘要： Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.

3. 发明申请

WO2019106483A1 PREDICTING MOLECULAR COLLISION CROSS-SECTION USING DIFFERENTIAL MOBILITY SPECTROMETRY 审中-公开
公开(公告)号：WO2019106483A1
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059109
申请日：2018-11-20
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , HOPKINS, Scott
发明人： HOPKINS, Scott , CAMPBELL, John Lawrence
IPC分类号： G01N27/62 , G06N99/00
CPC分类号： G01N27/62 , G06N99/00
摘要： A plurality of known compounds with known CCS values is analyzed using a DMS device. The DMS device determines how the intensities of their transmitted ions vary with different separation voltages (SVs) and compensation voltages (CVs). A machine learning algorithm builds a data model from the known m/z value, known CCS value, and measured pairs of CV and SV values that provide optimal transmission through the DMS device for each of the known compounds. An unknown compound with an unknown CCS value is then analyzed. The DMS device determines how the intensity of its ions varies with the same different SVs and CVs. Finally, the machine learning algorithm predicts the CCS value of the unknown compound from the data model, the known m/z of the unknown compound, and the measured pairs of CV and SV values that provide optimal transmission through the DMS device for the unknown compound.

4. 发明申请

WO2023275693A1 ELECTRON-BASED FRAGMENTATION METHOD 审中-公开
公开(公告)号：WO2023275693A1
公开(公告)日：2023-01-05
申请号：PCT/IB2022/055906
申请日：2022-06-24
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John Lawrence , LOYD, Bill , RYUMIN, Pavel
IPC分类号： H01J49/00 , H01J49/0054
摘要： The present disclosure provides methods and systems for performing mass spectrometry in which at least two batches of precursor ions generated via ionization of at least two different portions of a sample are exposed to electron beams at different energies to cause fragmentation of at least a portion of the precursor ions. In some embodiments, the electron energies can be selected such at one of the electron energies, EIEIO fragmentation can occur while at the other electron energy, EIEO fragmentation channel is not available. The mass spectra corresponding to the two energies can then be utilized to generate a resultant mass spectrum in which mass peaks corresponding to ion fragments generated by EIEIO dissociation are more readily identifiable.

5. 发明申请

WO2016055886A1 DYNAMIC ORTHOGONAL ANALYSIS METHOD 审中-公开
标题翻译：动态正交分析方法
公开(公告)号：WO2016055886A1
公开(公告)日：2016-04-14
申请号：PCT/IB2015/057260
申请日：2015-09-21
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John Lawrence , DUCHOSLAV, Eva , LE BLANC, Yves , COX, David M.
IPC分类号： H01J49/26
CPC分类号： G01N27/624 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/0045
摘要： Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.
摘要翻译：提供了提供DMS前体离子测量扫描的系统和方法。指示配置成接收样品的离子源使用处理器离子化样品。指示配置成从离子源接收离子的DMS装置分离从离子源接收的前体离子，并使用处理器使用两个或更多个CoV发射前体离子。指示配置成从DMS装置接收传输的前体离子的质量分析器，使用处理器在两个或更多个CoV的每个CoV处测量跨越m / z范围的透射前体离子的m / z强度。从质量分析器接收的传输的前体离子的测量的m / z强度作为m / z值和CoV的函数使用处理器存储。这产生了样品的前体离子的m / z强度的存储的二维映射。

6. 发明申请

WO2021144733A1 DETERMINING CURTAIN PLATE INTEGRITY IN DIFFERENTIAL MOBILITY SPECTROMETRY 审中-公开
公开(公告)号：WO2021144733A1
公开(公告)日：2021-07-22
申请号：PCT/IB2021/050256
申请日：2021-01-14
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John Lawrence , SEALE, Brendon
IPC分类号： G01N27/624 , G01N27/623 , H01J49/00 , H01J49/004
摘要： A DMS device receives a curtain gas that includes a chemical modifier into its curtain plate. Before or while receiving ions of an analyte, the DMS device steps the CoV through a series of values in order to apply different CoV values to at least one precursor ion derived from the chemical modifier. For each CoV value of the series of values, a mass spectrometer selects and mass analyzes the at least one precursor ion. An intensity is produced for each CoV value of the series of values. An intensity versus CoV value peak is calculated from the intensities measured. A representative CoV value is calculated for the peak. The difference between the representative CoV value and known CoV values that represent an uncontaminated curtain plate is calculated. If the difference is greater than or equal to a predetermined threshold value, the curtain plate is determined to be contaminated.

7. 发明申请

WO2016198984A1 METHOD FOR DECONVOLUTION 审中-公开
标题翻译：解卷积方法
公开(公告)号：WO2016198984A1
公开(公告)日：2016-12-15
申请号：PCT/IB2016/053099
申请日：2016-05-26
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： TATE, Stephen A. , CAMPBELL, John Lawrence
IPC分类号： G01N27/62 , H01J49/26 , G01N33/48
CPC分类号： H01J49/0036 , H01J49/0027 , H01J49/0031 , H01J49/0072
摘要： Systems and methods prevent potentially convolved precursor ion peaks from being excluded in subsequent cycles of an IDA experiment so that additional product ion data is collected. A sample is ionized producing an ion beam. A plurality of cycles of an IDA experiment are performed on the ion beam. During each cycle of the IDA experiment and for each precursor ion peak on a filtered peak list produced in the filtering step of each cycle, several steps are performed. The precursor ion peak is identified in the precursor ion spectrum produced in the MS survey scan step of the cycle. It is determined if the precursor ion peak in the precursor ion spectrum includes a feature of convolution. If the precursor ion peak includes a feature of convolution, the precursor ion peak is prevented from being excluded in a filtering step of one or more subsequent cycles.
摘要翻译：系统和方法防止潜在的卷积前体离子峰被排除在IDA实验的后续循环中，以便收集额外的产物离子数据。电离样品产生离子束。对离子束进行IDA实验的多个循环。在IDA实验的每个循环期间以及在每个循环的过滤步骤中产生的过滤的峰值列表上的每个前体离子峰进行几个步骤。在该循环的MS测量扫描步骤中产生的前体离子谱中鉴定前体离子峰。确定前体离子谱中的前体离子峰是否包括卷积特征。如果前体离子峰包括卷积的特征，则在一个或多个后续循环的过滤步骤中防止前体离子峰被排除。

8. 发明申请

WO2015189749A1 METHODS FOR ANALYSIS OF LIPIDS USING MASS SPECTROMETRY 审中-公开
标题翻译：使用大量光谱分析脂肪的方法
公开(公告)号：WO2015189749A1
公开(公告)日：2015-12-17
申请号：PCT/IB2015/054236
申请日：2015-06-04
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi , CAMPBELL, John Lawrence
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0054 , H01J49/0072 , H01J49/4225
摘要： A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules.
摘要翻译：公开了使用质谱分析样品的方法和装置。该装置包括反应装置，其被配置为通过使样品离子与带电物质（例如电子）例如通过ECD，EID或EIEIO反应来将样品离子分离成片段。带电物质的动能使得可以检测碎片并产生允许测定样品中异构物质和样品分子双键位置的光谱。片段可以包括自由基片段和非自由基片段。该装置还可以包括配置成与自由基片段反应以产生氧自由基碎片的氧气源。由片段分析产生的光谱可以允许测定样品分子解离产生的氧自由基片段。

9. 发明申请

WO2015170268A1 FLUID TRANSFER FROM DIGITAL MICROFLUIDIC DEVICE 审中-公开
标题翻译：从数字微流体装置流体转移
公开(公告)号：WO2015170268A1
公开(公告)日：2015-11-12
申请号：PCT/IB2015/053313
申请日：2015-05-06
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： CAMPBELL, John Lawrence , CHOI, Kihwan , LEBLANC, Yves , LIU, Chang , WHEELER, Aaron
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： B01L3/502792 , B01L2300/0645 , B01L2300/0887 , B01L2400/0415 , B01L2400/0427 , G01N30/16 , G01N35/00871 , G01N2030/162
摘要： Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in some aspects enable the integration of a digital microfluidic device as a direct, in-line sample processing platform from which a droplet can be transferred to a downstream analyzer.
摘要翻译：本文描述了利用数字微流体装置处理流体并将液滴从数字微流体装置转移到下游分析器的方法和系统。根据本教导的方法和系统可以允许从数字微流体装置中取出流体，并且在某些方面，可以将数字微流体装置整合为直接的在线样品处理平台，液滴可从该样品处理平台转移到下游分析仪。

10. 发明公开

EP3942593A1 AGNOSTIC COMPOUND ELUTION DETERMINATION 审中-实审
公开(公告)号：EP3942593A1
公开(公告)日：2022-01-26
申请号：EP20779066.8
申请日：2020-03-10
申请人： DH Technologies Development Pte. Ltd.
发明人： BLOOMFIELD, Nic G. , BURTON, Lyle , CAMPBELL, John Lawrence , COX, David M. , DUCHOSLAV, Eva , LAU, Adam San-Ho
IPC分类号： H01J49/00 , H01J49/10 , H01J49/40 , H01J49/04

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