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1. 发明申请

WO2011107990A1 STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF 审中-公开
标题翻译：稳定的阿尔法胶质糖苷酶及其用途
公开(公告)号：WO2011107990A1
公开(公告)日：2011-09-09
申请号：PCT/IL2011/000209
申请日：2011-03-02
申请人： PROTALIX LTD. , SHULMAN, Avidor , RUDERFER, Ilya , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv , SHAALTIEL, Yoseph , KIZHNER, Tali
发明人： SHULMAN, Avidor , RUDERFER, Ilya , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv , SHAALTIEL, Yoseph , KIZHNER, Tali
IPC分类号： C12N9/40
CPC分类号： C12Y302/01022 , C12N9/2465
摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构来治疗法布里病的方法。根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多聚体蛋白质结构表现出改进的性能。

2. 发明申请

WO2011107992A2 MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF 审中-公开
标题翻译：治疗性蛋白质的多种形式及其用途
公开(公告)号：WO2011107992A2
公开(公告)日：2011-09-09
申请号：PCT/IL2011/000211
申请日：2011-03-02
申请人： PROTALIX LTD. , RUDERFER, Ilya , SHILOVITTZKY, Orit , SHULMAN, Avidor , SHAALTIEL, Yoseph , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv
发明人： RUDERFER, Ilya , SHILOVITTZKY, Orit , SHULMAN, Avidor , SHAALTIEL, Yoseph , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv
IPC分类号： C07K14/525
CPC分类号： C07K14/525
摘要： Multimeric protein structures are disclosed herein, as well a process for preparing same, and methods employing same for treating various diseases or disorders. The multimeric protein structures comprise at least two monomers of a therapeutic protein, including a TNF-alpha, a luteinizing hormone, an immunoglobin, a TNF-alpha receptor, a CTLA-4, a urate oxidase, a VEGF, a PDGF, a VEGF receptor, a PDGF receptor, an interleukin-17, and/or fragments thereof, the monomers being covalently linked to one another via a linking moiety. The multimeric protein structures exhibit improved performance as compared to the corresponding native proteins, including a longer lasting activity in vivo.
摘要翻译：本文公开了多聚蛋白质结构，以及制备它们的方法，以及使用它们治疗各种疾病或病症的方法。多聚蛋白质结构包含至少两种治疗性蛋白质的单体，包括TNF-α，黄体生成素，免疫球蛋白，TNF-α受体，CTLA-4，尿酸氧化酶，VEGF，PDGF，VEGF 受体，PDGF受体，白细胞介素-17和/或其片段，所述单体通过连接部分彼此共价连接。与相应的天然蛋白质相比，多聚体蛋白质结构表现出改善的性能，包括体内持久的持久活性。

3. 发明申请

WO2011107991A1 GLUCOCEREBROSIDASE MULTIMERS AND USES THEREOF 审中-公开
标题翻译：葡萄糖苷酶多聚体及其用途
公开(公告)号：WO2011107991A1
公开(公告)日：2011-09-09
申请号：PCT/IL2011/000210
申请日：2011-03-02
申请人： PROTALIX LTD. , RUDERFER, Ilya , KIZHNER, Tali , SHULMAN, Avidor , SHAALTIEL, Yoseph
发明人： RUDERFER, Ilya , KIZHNER, Tali , SHULMAN, Avidor , SHAALTIEL, Yoseph
IPC分类号： C12N9/24
CPC分类号： C07K14/525
摘要： Multimeric protein structures comprising at least two glucocerebrosidase molecules being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and uses thereof in the treatment of Gaucher disease. The multimeric protein structures are characterized by longer-lasting activity as compared to native glucocerebrosidase both in serum and in lysosomes.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两种葡糖脑苷脂酶分子的多聚体蛋白质结构，以及其制备方法及其在治疗戈谢病中的用途。与血浆和溶酶体中的天然葡糖脑苷脂酶相比，多聚体蛋白质结构的特征在于持久的活性。

4. 发明申请

WO2012098537A1 NUCLEIC ACID CONSTRUCT FOR EXPRESSION OF ALPHA-GALACTOSIDASE IN PLANTS AND PLANT CELLS 审中-公开
标题翻译：用于在植物和植物细胞中表达ALPHA-糖蛋白酶的核酸构建体
公开(公告)号：WO2012098537A1
公开(公告)日：2012-07-26
申请号：PCT/IL2011/000719
申请日：2011-09-07
申请人： PROTALIX LTD. , SHULMAN, Avidor , HANANNIA, Uri , KIZHNER, Tati , SHAALTIEL, Yoseph
发明人： SHULMAN, Avidor , HANANNIA, Uri , KIZHNER, Tati , SHAALTIEL, Yoseph
IPC分类号： C12N9/40 , A61K38/47 , C12N15/82 , A61P3/00 , A61P43/00
CPC分类号： C12N9/2465 , A61K38/47 , C12N15/8257
摘要： Nucleic acid expression constructs are provided and, more particularly, nucleic acid constructs for expression of human alpha-galactosidase in plant cells, cells expressing the nucleic acid construct, producing the human alpha-galactosidase and uses thereof.
摘要翻译：提供核酸表达构建体，更具体地，涉及在植物细胞中表达人α-半乳糖苷酶的核酸构建体，表达核酸构建体的细胞，产生人α-半乳糖苷酶及其用途。

5. 发明申请

WO2009024977A3 SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF 审中-公开
公开(公告)号：WO2009024977A3
公开(公告)日：2009-02-26
申请号：PCT/IL2008/001143
申请日：2008-08-20
申请人： PROTALIX LTD. , SHULMAN, Avidor , RUDERFER, Ilya
发明人： SHULMAN, Avidor , RUDERFER, Ilya
IPC分类号： A61K47/48 , A61P43/00
摘要： Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

6. 发明申请

WO2006016363A2 TREATMENT METHODS REQUIRING PHYTO-INGREDIENTS 审中-公开
标题翻译：需要生物成分的处理方法
公开(公告)号：WO2006016363A2
公开(公告)日：2006-02-16
申请号：PCT/IL2005/000861
申请日：2005-08-10
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , PELLED, Dori , COHEN, Tzafra , FARKASH, Orly
发明人： SHULMAN, Avidor , PELLED, Dori , COHEN, Tzafra , FARKASH, Orly
IPC分类号： A61K45/06
CPC分类号： A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K2300/00 , A23V2200/332 , A23V2200/3262 , A23V2250/182 , A23V2250/2136
摘要： Methods of treatment of conditions which require phytosterol therapy without adversely affecting the bioavailability of lipophilic vitamins or lipophilic drugs, consisting of administering a mixture of phytosterol ester(s) (PS-E) and 1,3-diglyceride(s) (DAG) dissolved in an edible oil or fat are described herein, together with a method of improving weight management and a method of treating metabolic conditions that result in overweight. Dietary nutrients and food supplements containing said mixture are also described herein.
摘要翻译：治疗需要植物甾醇治疗而不会不利地影响亲脂性维生素或亲脂性药物的生物利用度的条件的方法，其包括施用溶解的植物甾醇酯（PS-E）和1,3-二甘油酯（DAG）的混合物本文描述了可食用的油或脂肪，以及改善体重管理的方法和治疗导致超重的代谢病症的方法。含有所述混合物的膳食营养素和食品补充剂也在本文中描述。

7. 发明申请

WO2005040334A2 SELECTIVE LIPASES AND METHODS OF SCREENING THEREFOR 审中-公开
标题翻译：选择性材料及其筛选方法
公开(公告)号：WO2005040334A2
公开(公告)日：2005-05-06
申请号：PCT/IL2004/000966
申请日：2004-10-24
申请人： ENZYMOTEC LTD. , PLATT, Dorit , SHULMAN, Avidor , FARKASH, Orly , KAIYAL, Muhammad , KATZ, Ariel , BASHEER, Sobhi
发明人： PLATT, Dorit , SHULMAN, Avidor , FARKASH, Orly , KAIYAL, Muhammad , KATZ, Ariel , BASHEER, Sobhi
IPC分类号： C12N
CPC分类号： C12N9/20 , C12P7/62 , C12P7/6418 , C12P7/6445 , C12P7/6454 , C12P7/6472 , C12Q1/045 , C12Q1/44 , G01N2333/918
摘要： The present invention relates to a novel lipase having enhanced selectivity towards the sn -2 position of glycerides and to one-step catalytic reactions using same. The one step catalytic reaction are directed to the synthesis and/or hydrolysis of glycerides and derivatives thereof at the sn -2 position. The present invention further relates to methods of screening for lipases with significantly enhanced regio-selectivity, in particular, sn -2 selectivity.
摘要翻译：本发明涉及对甘油酯的sn-2位置具有增强选择性的新型脂肪酶和使用其的一步催化反应。一步催化反应涉及在sn-2位置的甘油酯及其衍生物的合成和/或水解。本发明还涉及具有显着增强的区域选择性，特别是sn-2选择性的脂肪酶筛选方法。

8. 发明申请

WO2002090560A3 PROCESS FOR THE PRODUCTION OF PHOSPHOLIPIDS 审中-公开
公开(公告)号：WO2002090560A3
公开(公告)日：2002-11-14
申请号：PCT/IL2002/000344
申请日：2002-05-02
申请人： ENZYMOTEC LTD. , BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
发明人： BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
IPC分类号： C12P9/00
摘要： The present invention provides a new enzymatic process for preparing 1,2-diacylated phospholipids comprising the use of an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process of the present invention are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA 1 or PLA 1,2 ) and a solvent, in a microaqueous medium.

9. 发明申请

WO2006114790A2 POLAR LIPID MIXTURES, THEIR PREPARATION AND USES 审中-公开
标题翻译：极性混合物，其制备和用途
公开(公告)号：WO2006114790A2
公开(公告)日：2006-11-02
申请号：PCT/IL2006/000510
申请日：2006-04-27
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
发明人： SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
IPC分类号： A23L1/29 , A23J7/00 , A61P25/28 , C07F9/10
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译：本文公开了包含甘油磷脂，例如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI），以及鞘脂如鞘氨醇（SM））的极性脂质混合物。最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。本文还描述了制备所述混合物的方法及其用途。

10. 发明申请

WO2005051091A1 MIMETIC LIPIDS AND DIETARY SUPPLEMENTS COMPRISING THE SAME 审中-公开
标题翻译：包括它的脂肪和脂肪的补充
公开(公告)号：WO2005051091A1
公开(公告)日：2005-06-09
申请号：PCT/IL2004/000959
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , BEN DROR, Gai , PELLED, Dori , BAR-ON, Zohar
发明人： SHULMAN, Avidor , BEN DROR, Gai , PELLED, Dori , BAR-ON, Zohar
IPC分类号： A23J7/00
CPC分类号： A23D9/013 , A23J7/00 , A23L33/115 , A23L33/40 , A23V2002/00 , A23V2250/1846 , A23V2250/1852 , A23V2250/185
摘要： Disclosed is substantially homogenous lipid preparation comprising a combination of glycerophospholipids being phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI), wherein the quantitative ratio between said glycerophospholipids essentially mimics their corresponding ratio in naturally occurring human milk fat (HMF), optionally further comprising sphingomyelin (SM) and/or cholesterol, wherein the quantitative ratio between the glycerophospholipids in said combination and the sphingomyelin and/or cholesterol essentially mimics their corresponding ratio in said naturally occurring HMF. Further disclosed is the lipid combination which upon dispersion or emulsification in an essentially aqueous medium with other ingredients of infant formula, especially protein and fat under suitable conditions, forms a substantially homogenous dispersion or emulsion having a fat, globule-containing microstructure which is essentially mimetic of the corresponding globular microstructure of naturally occurring HMF, said globules having a membrane which is essentially mimetic of naturally occurring human milk fat globule membrane (HMFGM). Further disclosed are methods for preparing the lipid combination, and various uses thereof, particularly uses related to the preparation of infant formulas.
摘要翻译：公开了基本均匀的脂质制剂，其包含磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）的甘油磷脂的组合，其中所述甘油磷脂之间的定量比基本上模拟其在天然存在的人乳脂中的相应比例（HMF），任选地还包含鞘磷脂（SM）和/或胆固醇，其中所述组合中的甘油磷脂与鞘磷脂和/或胆固醇之间的定量比例基本上模拟其在所述天然存在的HMF中的相应比例。进一步公开的是脂质组合，其在基本水性介质中与其它成分的婴儿配方食品，特别是蛋白质和脂肪在合适条件下分散或乳化，形成基本均匀的分散体或乳液，其具有基本上模拟的含脂肪，含球状微结构的天然存在的HMF的相应的球状微结构，所述小球具有基本上模拟天然存在的人乳脂肪球膜（HMFGM）的膜。进一步公开的是制备脂质组合的方法及其各种用途，特别是与制备婴儿配方相关的用途。

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