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1. 发明申请

WO2002090560A3 PROCESS FOR THE PRODUCTION OF PHOSPHOLIPIDS 审中-公开
公开(公告)号：WO2002090560A3
公开(公告)日：2002-11-14
申请号：PCT/IL2002/000344
申请日：2002-05-02
申请人： ENZYMOTEC LTD. , BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
发明人： BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
IPC分类号： C12P9/00
摘要： The present invention provides a new enzymatic process for preparing 1,2-diacylated phospholipids comprising the use of an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process of the present invention are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA 1 or PLA 1,2 ) and a solvent, in a microaqueous medium.

2. 发明申请

WO2005037848A3 GLYCEROPHOSPHOLIPIDS CONTAINING OMEGA-3 AND OMEGA-6 FATTY ACIDS 审中-公开
公开(公告)号：WO2005037848A3
公开(公告)日：2005-04-28
申请号：PCT/IL2004/000957
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori
发明人： BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori
IPC分类号： A61K31/683
摘要： Disclosed is a lipid preparation comprising a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The disclosed preparations possess an improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes, for example ADHD.

3. 发明申请

WO2006114790A2 POLAR LIPID MIXTURES, THEIR PREPARATION AND USES 审中-公开
标题翻译：极性混合物，其制备和用途
公开(公告)号：WO2006114790A2
公开(公告)日：2006-11-02
申请号：PCT/IL2006/000510
申请日：2006-04-27
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
发明人： SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
IPC分类号： A23L1/29 , A23J7/00 , A61P25/28 , C07F9/10
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译：本文公开了包含甘油磷脂，例如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI），以及鞘脂如鞘氨醇（SM））的极性脂质混合物。最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。本文还描述了制备所述混合物的方法及其用途。

4. 发明申请

WO2009156991A2 GLYCEROPHOSPHOLIPIDS FOR THE IMPROVEMENT OF COGNITIVE FUNCTIONS 审中-公开
标题翻译：用于改善认知功能的甘油磷脂
公开(公告)号：WO2009156991A2
公开(公告)日：2009-12-30
申请号：PCT/IL2009/000626
申请日：2009-06-24
申请人： ENZYMOTEC LTD. , BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori , RICHTER, Yael
发明人： BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori , RICHTER, Yael
IPC分类号： A61K47/48 , A61P25/28
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and eicosapentaenoyl (EPA), e.g. utilizing different sources of lipids, and uses thereof.
摘要翻译：本文描述的本发明提供了包含具有特异性含量和LA，亚麻酸（α-亚麻酸，γ-亚麻酸）DHA和二十碳五烯酰（EPA）的特异性缀合模式的丝氨酸甘油磷脂缀合物的非哺乳动物衍生的混合物的制剂，例如，利用不同的脂质来源及其用途。

5. 发明申请

WO2005027822A2 STABILIZED FORMULATIONS OF PHOSPHATIDYLSERINE 审中-公开
标题翻译：稳定的磷脂酰丝氨酸的制剂
公开(公告)号：WO2005027822A2
公开(公告)日：2005-03-31
申请号：PCT/IL2004/000895
申请日：2004-09-26
申请人： ENZYMOTEC LTD. , PLATT, Dorit , SHULMAN, Avidor , BEN DROR, Gai , SCHEINMAN, Neta , TWITO, Yoni , ZUABI, Rassan
发明人： PLATT, Dorit , SHULMAN, Avidor , BEN DROR, Gai , SCHEINMAN, Neta , TWITO, Yoni , ZUABI, Rassan
IPC分类号： A61K
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322
摘要： Disclosed are stable PS preparations, in powder, liquid and dispersion forms, as well as methods of producing thereof. Most importantly, the stable PS preparations are particularly devoid of residual phospholipase D activity, and the methods of eliminating such activity are also described herein. Lastly, uses of these PS preparations in nutraceuticals or as active agents of pharmaceutical compositions are also provided herein.
摘要翻译：公开了稳定的PS制剂，粉末，液体和分散体形式，以及其制备方法。最重要的是，稳定的PS制剂特别缺乏残余的磷脂酶D活性，并且本文还描述了消除这种活性的方法。最后，本文还提供了这些PS制剂在营养保健品中或作为药物组合物的活性剂的用途。

6. 发明申请

WO2016132354A1 OIL BLENDS, PROCESSES FOR THE PREPARATION THEREOF AND THEIR USE IN FORMULAS 审中-公开
标题翻译：油混合物，其制备方法及其在配方中的用途
公开(公告)号：WO2016132354A1
公开(公告)日：2016-08-25
申请号：PCT/IL2016/050180
申请日：2016-02-16
申请人： ENZYMOTEC LTD.
发明人： WIDBERG, Asher , NUMA, Ran , BAR-YOSEPH, Fabiana , ZUABI, Rassan , HERZOG, Yael , BEN-DROR, Gai
IPC分类号： A23D9/00 , A23D9/007 , A23D9/06 , C11B5/00
CPC分类号： A23D9/007 , A23D9/04 , A23L33/11 , A23L33/40 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/48 , A61K36/889 , C11B3/12 , A61K2300/00
摘要： The invention provides oil blends, processes for the preparation thereof and their uses.
摘要翻译：本发明提供油混合物，其制备方法及其用途。

7. 发明授权

EP2307058B1 GLYCEROPHOSPHOLIPIDS FOR THE IMPROVEMENT OF COGNITIVE FUNCTIONS 有权
标题翻译：用于改善认知功能的糖皮质激素
公开(公告)号：EP2307058B1
公开(公告)日：2017-09-13
申请号：EP09769797.3
申请日：2009-06-24
申请人： Enzymotec Ltd.
发明人： BEN-DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori , RICHTER, Yael
IPC分类号： A61K47/50 , A61P25/28 , C07F9/10 , A23D7/01 , A23D9/013 , A21D2/32 , A61K31/66 , A61K31/685 , A23L33/12
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： This invention provides a preparation comprising serine glycerophospholipids which comprise a mixture of serine glycerophospholipids comprising eicosapentaenoic acid (EPA) and serine glycerophospholipids comprising docosahexaenoic acid (DHA), wherein each such serine glycerophospholipid comprising EPA and each such serine glycerophospholipid comprising DHA has the formula (I): wherein R″ is serine; wherein one of R or R′ is acyl EPA or acyl DHA and the other of R or R′ is hydrogen or an acyl group; wherein the combined amount of EPA and DHA present in such mixture of serine glycerophospholipids constitutes 10-50% by weight of the total fatty acids content of the serine glycerophospholipids in said preparation; and wherein the mixture is not identical to naturally occurring human or mammalian brain PS.
摘要翻译：本文所述的本发明提供了一种制剂，其包含具有特定含量和LA，亚麻酸（α-亚麻酸，γ-亚麻酸）DHA和EPA的特定偶联模式的非哺乳动物来源的丝氨酸甘油磷脂缀合物的混合物，其依赖于利用不同的脂质来源以及这些制剂的用途。

8. 发明授权

EP1663157B1 Stabilized formulations of phosphatidylserine 有权转让
标题翻译：稳定磷脂酰丝氨酸制剂
公开(公告)号：EP1663157B1
公开(公告)日：2012-11-28
申请号：EP04770566.0
申请日：2004-09-26
申请人： Enzymotec Ltd.
发明人： PLATT, Dorit , SHULMAN, Avidor , BEN DROR, Gai , SCHEINMAN, Neta , TWITO, Yoni , ZUABI, Rassan
IPC分类号： C12P13/06 , C12P9/00 , C07F9/10 , A61K31/685 , A23J7/00
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322

9. 发明公开

EP1898722A2 POLAR LIPID MIXTURES, THEIR PREPARATION AND USES 有权
标题翻译：极性脂质混合物，生产与使用
公开(公告)号：EP1898722A2
公开(公告)日：2008-03-19
申请号：EP06728307.7
申请日：2006-04-27
申请人： Enzymotec Ltd.
发明人： SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
IPC分类号： A23L1/29 , A23J7/00 , A61P25/28 , C07F9/10
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.

10. 发明公开

EP1412511A2 PROCESS FOR THE PRODUCTION OF PHOSPHOLIPIDS 有权
标题翻译：生产磷脂的方法
公开(公告)号：EP1412511A2
公开(公告)日：2004-04-28
申请号：EP02728001.5
申请日：2002-05-02
申请人： Enzymotec Ltd.
发明人： BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
IPC分类号： C12P9/00 , C07F9/10 , C12P7/62 , C12P13/00
CPC分类号： C07F9/10 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： The present invention provides a new enzymatic process for preparing 1,2-diacylated phospholipids comprising the use of an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process of the present invention are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.
摘要翻译：本发明提供了一种用于制备1,2-二酰化磷脂的新的酶促方法，包括在微水相反应体系中使用具有磷脂酶活性的酶制剂，用于在sn-1和sn-2位点进行酰化。更特别地，根据本发明的酯化/酯交换方法制备的1,2-二酰基 - 磷脂可以以高收率和纯度获得，并且在sn-1和sn上携带相同的期望的羧酸，优选脂肪酸，酰基 -2个职位。该方法包括在上述合适的酶制剂存在下，将甘油磷脂，优选甘油磷酰胆碱（GPC）与期望的羧酸，优选脂肪酸或其衍生物进行酯化/酯交换（酰化）。本发明的方法还涉及通过使甘油磷脂，优选甘油磷酰胆碱（GPC）与所需羧酸，优选脂肪酸反应来生产1-酰基-2-溶血甘油磷脂，优选2-溶血PC的方法，或它们的衍生物在存在sn-1特异性磷脂酶（PLA1或PLA1,2）和溶剂的情况下在微水介质中进行。

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