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1. 发明申请

WO2005037848A3 GLYCEROPHOSPHOLIPIDS CONTAINING OMEGA-3 AND OMEGA-6 FATTY ACIDS 审中-公开
公开(公告)号：WO2005037848A3
公开(公告)日：2005-04-28
申请号：PCT/IL2004/000957
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori
发明人： BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori
IPC分类号： A61K31/683
摘要： Disclosed is a lipid preparation comprising a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The disclosed preparations possess an improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes, for example ADHD.

2. 发明申请

WO2005051091A1 MIMETIC LIPIDS AND DIETARY SUPPLEMENTS COMPRISING THE SAME 审中-公开
标题翻译：包括它的脂肪和脂肪的补充
公开(公告)号：WO2005051091A1
公开(公告)日：2005-06-09
申请号：PCT/IL2004/000959
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , BEN DROR, Gai , PELLED, Dori , BAR-ON, Zohar
发明人： SHULMAN, Avidor , BEN DROR, Gai , PELLED, Dori , BAR-ON, Zohar
IPC分类号： A23J7/00
CPC分类号： A23D9/013 , A23J7/00 , A23L33/115 , A23L33/40 , A23V2002/00 , A23V2250/1846 , A23V2250/1852 , A23V2250/185
摘要： Disclosed is substantially homogenous lipid preparation comprising a combination of glycerophospholipids being phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI), wherein the quantitative ratio between said glycerophospholipids essentially mimics their corresponding ratio in naturally occurring human milk fat (HMF), optionally further comprising sphingomyelin (SM) and/or cholesterol, wherein the quantitative ratio between the glycerophospholipids in said combination and the sphingomyelin and/or cholesterol essentially mimics their corresponding ratio in said naturally occurring HMF. Further disclosed is the lipid combination which upon dispersion or emulsification in an essentially aqueous medium with other ingredients of infant formula, especially protein and fat under suitable conditions, forms a substantially homogenous dispersion or emulsion having a fat, globule-containing microstructure which is essentially mimetic of the corresponding globular microstructure of naturally occurring HMF, said globules having a membrane which is essentially mimetic of naturally occurring human milk fat globule membrane (HMFGM). Further disclosed are methods for preparing the lipid combination, and various uses thereof, particularly uses related to the preparation of infant formulas.
摘要翻译：公开了基本均匀的脂质制剂，其包含磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）的甘油磷脂的组合，其中所述甘油磷脂之间的定量比基本上模拟其在天然存在的人乳脂中的相应比例（HMF），任选地还包含鞘磷脂（SM）和/或胆固醇，其中所述组合中的甘油磷脂与鞘磷脂和/或胆固醇之间的定量比例基本上模拟其在所述天然存在的HMF中的相应比例。进一步公开的是脂质组合，其在基本水性介质中与其它成分的婴儿配方食品，特别是蛋白质和脂肪在合适条件下分散或乳化，形成基本均匀的分散体或乳液，其具有基本上模拟的含脂肪，含球状微结构的天然存在的HMF的相应的球状微结构，所述小球具有基本上模拟天然存在的人乳脂肪球膜（HMFGM）的膜。进一步公开的是制备脂质组合的方法及其各种用途，特别是与制备婴儿配方相关的用途。

3. 发明申请

WO2009156991A2 GLYCEROPHOSPHOLIPIDS FOR THE IMPROVEMENT OF COGNITIVE FUNCTIONS 审中-公开
标题翻译：用于改善认知功能的甘油磷脂
公开(公告)号：WO2009156991A2
公开(公告)日：2009-12-30
申请号：PCT/IL2009/000626
申请日：2009-06-24
申请人： ENZYMOTEC LTD. , BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori , RICHTER, Yael
发明人： BEN DROR, Gai , PLATT, Dorit , FARKASH, Orly , ZUABI, Rassan , BAR-ON, Zohar , SHULMAN, Avidor , PELLED, Dori , RICHTER, Yael
IPC分类号： A61K47/48 , A61P25/28
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and eicosapentaenoyl (EPA), e.g. utilizing different sources of lipids, and uses thereof.
摘要翻译：本文描述的本发明提供了包含具有特异性含量和LA，亚麻酸（α-亚麻酸，γ-亚麻酸）DHA和二十碳五烯酰（EPA）的特异性缀合模式的丝氨酸甘油磷脂缀合物的非哺乳动物衍生的混合物的制剂，例如，利用不同的脂质来源及其用途。

4. 发明申请

WO2006114791A1 HUMAN MILK FAT SUBSTITUTES 审中-公开
标题翻译：人奶粉替代品
公开(公告)号：WO2006114791A1
公开(公告)日：2006-11-02
申请号：PCT/IL2006/000511
申请日：2006-04-27
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , BEN DROR, Gai , LAOUZ, Hala , YAAKOBI, Dov , BAR-ON, Zohar , BLINDER, Gregory , MEIRI-BENDEK, Iris , HERZOG, Yael
发明人： SHULMAN, Avidor , BEN DROR, Gai , LAOUZ, Hala , YAAKOBI, Dov , BAR-ON, Zohar , BLINDER, Gregory , MEIRI-BENDEK, Iris , HERZOG, Yael
IPC分类号： A23L1/29 , A23D9/00 , C11C3/10 , C11C3/08
CPC分类号： A23D9/00 , A23L33/115 , A23L33/30 , A23L33/40 , A23V2002/00 , C11C3/08 , C11C3/10
摘要： Disclosed are human milk fat (HMF) substitutes, processes for their preparation, uses thereof and fat blends and infants formulae containing them. A fat base composition of the invention comprises a mixture of vegetable-derived triglycerides, with less than 50% of the fatty acid residues bonded at the sn-2 position being saturated; and/or with the amount of saturated fatty acid residues bonded at the sn-2 position of the glycerol backbone less than about 43.5% of the total amount of saturated fatty acid residues. Typically, substantially all of the saturated fatty acids bonded at the sn-2 position of the glycerol backbone are palmitic acid residues. Also disclosed are substitute HMF compositions comprising a blend of at least 25% or at least 30% of the said fat base composition of the invention with up to 75%, or respectively up to 70%, of at least one vegetable oil. Processes for preparing the fat base compositions and blend are also disclosed. Further disclosed are infant formulas comprising the fat base composition or substitute human milk fat composition.
摘要翻译：公开了人乳脂肪（HMF）替代品，其制备方法，其用途和含有它们的脂肪混合物和婴儿配方。本发明的脂肪基组合物包含植物来源的甘油三酯的混合物，其中在sn-2位置处键合的少于50％的脂肪酸残基是饱和的; 和/或与在甘油骨架的sn-2位键合的饱和脂肪酸残基的量小于饱和脂肪酸残基总量的约43.5％。通常，在甘油骨架的sn-2位上键合的基本上所有的饱和脂肪酸都是棕榈酸残基。还公开了替代HMF组合物，其包含本发明所述脂肪基础组合物的至少25％或至少30％的共混物与至多一种植物油的至多75％，或分别达70％的混合物。还公开了制备脂肪基础组合物和共混物的方法。进一步公开的是包含脂肪基础组合物或替代人乳脂肪组合物的婴儿配方食品。

5. 发明申请

WO2005036987A1 HUMAN BREAST MILK LIPID MIMETIC AS DIETARY SUPPLEMENT 审中-公开
标题翻译：人乳酪奶油脂肪作为膳食补充剂
公开(公告)号：WO2005036987A1
公开(公告)日：2005-04-28
申请号：PCT/IL2004/000960
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , MEIRI-BENDEK, Iris , BEN DROR, Gai , LAOUZ, Hala , YAAKOBI, Dov , BAR-ON, Zohar , SHULMAN, Avidor
发明人： MEIRI-BENDEK, Iris , BEN DROR, Gai , LAOUZ, Hala , YAAKOBI, Dov , BAR-ON, Zohar , SHULMAN, Avidor
IPC分类号： A23L1/29
CPC分类号： A21D2/165 , A23C11/04 , A23D7/001 , A23D9/00 , A23G3/346 , A23G2200/08 , A23G2200/12 , C11C3/08
摘要： Disclosed is an enzymatically prepared fat base composition comprising a mixture of vegetable-derived triglycerides, characterized in that it has a total palmitic acid residues content of at most 38% of the total fatty acid residues, and in that at least 60%, preferably 62% of the fatty acid moieties at the sn-2 position of the glycerol backbone are palmitic acid residues, at least 70% of the fatty acid moieties at the sn-1 and sn-3 positions of the glycerol backbone are unsaturated, at least 40%, preferably 40-60%, of the unsaturated fatty acid moieties at the sn-1 and sn-3 positions are oleic acid moieties and at least 6%, preferably 6-17%, of the unsaturated fatty acid moieties at the sn-1 and sn-3 positions are linoleic acid moieties, its preparation and its various uses in the field of infant formulas.
摘要翻译：公开了一种酶制备的脂肪基组合物，其包含植物来源的甘油三酯的混合物，其特征在于其总棕榈酸残基含量为总脂肪酸残基的至多38％，并且其中至少60％，优选为62 在甘油主链的sn-2位置的脂肪酸部分的％为棕榈酸残基，甘油主链的sn-1和sn-3位置上至少70％的脂肪酸部分是不饱和的，至少40 sn-1和sn-3位置处的不饱和脂肪酸部分的％，优选40-60％是油酸部分，并且sn- 1和sn-3位置处的不饱和脂肪酸部分的至少6％，优选6-17％ 1和sn-3位置是亚油酸部分，其制备及其在婴儿配方领域的各种用途。

6. 发明申请

WO2006114790A2 POLAR LIPID MIXTURES, THEIR PREPARATION AND USES 审中-公开
标题翻译：极性混合物，其制备和用途
公开(公告)号：WO2006114790A2
公开(公告)日：2006-11-02
申请号：PCT/IL2006/000510
申请日：2006-04-27
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
发明人： SHULMAN, Avidor , ZUABI, Rassan , BEN DROR, Gai , TWITO, Yoni , PELLED, Dori , HERZOG, Yael
IPC分类号： A23L1/29 , A23J7/00 , A61P25/28 , C07F9/10
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译：本文公开了包含甘油磷脂，例如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI），以及鞘脂如鞘氨醇（SM））的极性脂质混合物。最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。本文还描述了制备所述混合物的方法及其用途。

7. 发明申请

WO2005037373A1 A LIPID PREPARATION FOR ENHANCING MINERAL ABSORPTION 审中-公开
标题翻译：一种用于增强矿物吸收的脂质制剂
公开(公告)号：WO2005037373A1
公开(公告)日：2005-04-28
申请号：PCT/IL2004/000961
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , BEN DROR, Gai , PELLED, Dori
发明人： SHULMAN, Avidor , BEN DROR, Gai , PELLED, Dori
IPC分类号： A61P19/10
CPC分类号： A21D2/165 , A23C11/04 , A23D7/001 , A23D9/00 , A23G3/346 , A23G2200/08 , A23G2200/12 , C11C3/08
摘要： Disclosed is a dietary ingredient comprising at least one edible lipid which does not inhibit mineral absorption, enhances mineral absorption and intake, particularly a chemically or enzymatically synthesized synthetic oil, particularly glyceride-based lipid with high levels of mono- or polyunsaturated fatty acids at positions sn-1 and sn-3 of the glycerol backbone, vegetable- and plant-derived oil, such as flax and canola oils, short and medium chains lipid, preferably MCT and an oil mimicking the triglyceride composition of human mother's milk fat and its various uses. The dietary ingredient is particularly intended for use in enhancing calcium absorption and in the prevention and/or treatment of disorders associated with depletion of bone calcium and bone density, prevention and treatment of osteoporosis, for the enhancement of bone formation and bone mass maximization and for the enhancement of bone formation in infants and young children.
摘要翻译：公开了包含至少一种不抑制矿物质吸收的可食用脂质，增强矿物质吸收和摄入的膳食成分，特别是化学或酶合成的合成油，特别是甘油酯类脂质，其具有高水平的单不饱和脂肪酸或多不饱和脂肪酸甘油骨架的sn-1和sn-3，植物和植物来源的油，例如亚麻和低芥酸菜子油，短链和中链脂质，优选MCT和模仿人母乳脂肪的甘油三酯组合物的油及其各种使用。膳食成分特别用于增强钙的吸收，以及预防和/或治疗与骨钙素和骨密度消耗相关的疾病，预防和治疗骨质疏松症，用于增强骨形成和骨量最大化以及增强婴幼儿骨骼形成。

8. 发明申请

WO2005027822A2 STABILIZED FORMULATIONS OF PHOSPHATIDYLSERINE 审中-公开
标题翻译：稳定的磷脂酰丝氨酸的制剂
公开(公告)号：WO2005027822A2
公开(公告)日：2005-03-31
申请号：PCT/IL2004/000895
申请日：2004-09-26
申请人： ENZYMOTEC LTD. , PLATT, Dorit , SHULMAN, Avidor , BEN DROR, Gai , SCHEINMAN, Neta , TWITO, Yoni , ZUABI, Rassan
发明人： PLATT, Dorit , SHULMAN, Avidor , BEN DROR, Gai , SCHEINMAN, Neta , TWITO, Yoni , ZUABI, Rassan
IPC分类号： A61K
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322
摘要： Disclosed are stable PS preparations, in powder, liquid and dispersion forms, as well as methods of producing thereof. Most importantly, the stable PS preparations are particularly devoid of residual phospholipase D activity, and the methods of eliminating such activity are also described herein. Lastly, uses of these PS preparations in nutraceuticals or as active agents of pharmaceutical compositions are also provided herein.
摘要翻译：公开了稳定的PS制剂，粉末，液体和分散体形式，以及其制备方法。最重要的是，稳定的PS制剂特别缺乏残余的磷脂酶D活性，并且本文还描述了消除这种活性的方法。最后，本文还提供了这些PS制剂在营养保健品中或作为药物组合物的活性剂的用途。

9. 发明申请

WO2006016363A2 TREATMENT METHODS REQUIRING PHYTO-INGREDIENTS 审中-公开
标题翻译：需要生物成分的处理方法
公开(公告)号：WO2006016363A2
公开(公告)日：2006-02-16
申请号：PCT/IL2005/000861
申请日：2005-08-10
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , PELLED, Dori , COHEN, Tzafra , FARKASH, Orly
发明人： SHULMAN, Avidor , PELLED, Dori , COHEN, Tzafra , FARKASH, Orly
IPC分类号： A61K45/06
CPC分类号： A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K2300/00 , A23V2200/332 , A23V2200/3262 , A23V2250/182 , A23V2250/2136
摘要： Methods of treatment of conditions which require phytosterol therapy without adversely affecting the bioavailability of lipophilic vitamins or lipophilic drugs, consisting of administering a mixture of phytosterol ester(s) (PS-E) and 1,3-diglyceride(s) (DAG) dissolved in an edible oil or fat are described herein, together with a method of improving weight management and a method of treating metabolic conditions that result in overweight. Dietary nutrients and food supplements containing said mixture are also described herein.
摘要翻译：治疗需要植物甾醇治疗而不会不利地影响亲脂性维生素或亲脂性药物的生物利用度的条件的方法，其包括施用溶解的植物甾醇酯（PS-E）和1,3-二甘油酯（DAG）的混合物本文描述了可食用的油或脂肪，以及改善体重管理的方法和治疗导致超重的代谢病症的方法。含有所述混合物的膳食营养素和食品补充剂也在本文中描述。

10. 发明申请

WO2005038037A2 METHODS FOR PREPARING PHOSPHOLIPIDS CONTAINING OMEGA-3 AND OMEGA-6 MOIETIES 审中-公开
标题翻译：制备含OMEGA-3和OMEGA-6时代的磷脂的方法
公开(公告)号：WO2005038037A2
公开(公告)日：2005-04-28
申请号：PCT/IL2004/000958
申请日：2004-10-21
申请人： ENZYMOTEC LTD. , PLATT, Dorit , LAOUZ, Hala , PELLED, Dori , SHULMAN, Avidor
发明人： PLATT, Dorit , LAOUZ, Hala , PELLED, Dori , SHULMAN, Avidor
IPC分类号： C12P9/00
CPC分类号： C12P7/6481 , A23J7/00 , A23L33/12 , A23V2002/00 , A61K31/685 , C07F9/10 , C12P7/6472 , C12P9/00 , C12P13/06 , A23V2250/185 , A23V2250/1868 , A23V2250/187 , A23V2250/1852 , A23V2250/1862 , A23V2250/1872 , A23V2250/1846 , A23V2250/1874
摘要： Methods for the production of omega-3 and/or omega-6 enriched glycerophospholipids are provided, which are based on enzymatic transesterification and esterification through phospholipases PLA1 and PLA2, chemical synthesis, and enzymatic synthesis through phospholipase D. Phosphatidylserine, phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine preparations are also provided, as well as food articles, pharmaceutical compositions and capsules comprising thereof.
摘要翻译：提供了生产富含ω-3和/或ω-6的甘油磷脂的方法，其基于通过磷脂酶PLA1和PLA2的酶促酯交换和酯化，化学合成和通过磷脂酶D的酶促合成还提供了磷脂酰丝氨酸，磷脂酰胆碱，磷脂酰肌醇和磷脂酰乙醇胺制剂，以及食物制品，药物组合物和包含它们的胶囊。

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