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1. 发明申请

WO2009132083A2 COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS 审中-公开
标题翻译：用于促进PDX1 +胰腺细胞产生的组合物和方法
公开(公告)号：WO2009132083A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041381
申请日：2009-04-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHEN, Shuibing , MELTON, Douglas, A. , BOROWIAK, Malgorzala , LAMENZO, Julia , SCHREIBER, Stuart, L. , PENG, Lee, F. , RUBIN, Lee, L. , DAVIDOW, Lance , LAM, Kevin
发明人： CHEN, Shuibing , MELTON, Douglas, A. , BOROWIAK, Malgorzala , LAMENZO, Julia , SCHREIBER, Stuart, L. , PENG, Lee, F. , RUBIN, Lee, L. , DAVIDOW, Lance , LAM, Kevin
IPC分类号： C12N5/08 , C12N5/02 , C12N1/38
CPC分类号： C12N5/0678 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02
摘要： Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
摘要翻译：本文公开的某些实施例涉及通过将人胚胎干细胞暴露于有效量的表I所列的至少一种化合物来产生胰腺细胞或胰腺细胞前体的方法，以将人胚胎干细胞分化成胰腺细胞或胰腺细胞细胞前体。还描述了使用这些方法生产的试剂盒和胰腺细胞系。

2. 发明申请

WO2012170977A1 MODULATION OF PANCREATIC BETA CELL PROLIFERATION 审中-公开
标题翻译： PANCREATIC BETA细胞增殖的调节
公开(公告)号：WO2012170977A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041804
申请日：2012-06-10
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MELTON, Douglas, A. , YI, Peng
发明人： MELTON, Douglas, A. , YI, Peng
IPC分类号： A61K48/00
CPC分类号： C07K14/575 , A61K48/005 , G01N33/5023 , G01N33/74
摘要： Work described herein provides, in one embodiment, a method for increasing proliferation or replication of pancreatic beta cells in a subject in need thereof, comprising administering to said subject an effective amount of an agent that increases the level or activity of hepatocellular carcinoma-associated protein TD26 (TD26), thereby increasing proliferation or replication of pancreatic beta cells. Such an agent may function by, for example, increasing the level of active TD26 in the subject or by increasing the functional activity of TD26 in the subject.
摘要翻译：本文所述的工作在一个实施方案中提供了一种用于在有需要的受试者中增加胰腺β细胞的增殖或复制的方法，包括向所述受试者施用有效量的增加肝细胞癌相关蛋白的水平或活性的试剂 TD26（TD26），从而增加胰腺β细胞的增殖或复制。这样的试剂可以通过例如增加受试者中活性TD26的水平或通过增加受试者中TD26的功能活性而起作用。

3. 发明申请

WO2010022395A2 METHODS OF REPROGRAMMING CELLS 审中-公开
标题翻译：转染细胞的方法
公开(公告)号：WO2010022395A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/054789
申请日：2009-08-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MELTON, Douglas, A. , ZHOU, Qiao
发明人： MELTON, Douglas, A. , ZHOU, Qiao
IPC分类号： C12N15/63 , C12N5/10 , C12N15/12
CPC分类号： C12N5/0676 , C12N2501/60 , C12N2799/022
摘要： The present invention provides methods of reprogramming cells, for example, directly reprogramming a somatic cell of a first cell type into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for reprogramming a cell of an endoderm origin to a cell having pancreatic β-cell characteristics. The present invention also relates to an isolated population comprising reprogrammed cells, compositions and their use in the treatment of diabetes mellitus. In particular, the present invention relates to reprogramming a cell of an endoderm origin to a cell having pancreatic β-cell characteristics by increasing the protein expression of at least one transcription factor selected from Pdx1, Ngn3 or MafA in the cell of endoderm origin to reprogram the cell of an endoderm cell to a cell which exhibits at least one or at least two characteristics of an endogenous pancreatic β-cell.
摘要翻译：本发明提供了将细胞重新编程的方法，例如将第一细胞类型的体细胞直接重编程为第二细胞类型的体细胞。特别地，本发明一般涉及将内胚层起源的细胞重新编程至具有胰腺β细胞特征的细胞的方法。本发明还涉及包含重编程细胞，组合物及其在治疗糖尿病中的用途的分离群体。特别地，本发明涉及通过增加内皮祖细胞中至少一种选自Pdx1，Ngn3或MafA的转录因子的蛋白质表达来重编程，将内胚层起源的细胞重编程为具有胰腺β细胞特征的细胞内胚层细胞的细胞呈现出内源性胰腺β细胞的至少一种或至少两种特征的细胞。

4. 发明申请

WO2009102983A3 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS 审中-公开
公开(公告)号：WO2009102983A3
公开(公告)日：2009-08-20
申请号：PCT/US2009/034102
申请日：2009-02-13
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HUANGFU, Danwei , MELTON, Douglas, A. , MAEHR, Rene
发明人： HUANGFU, Danwei , MELTON, Douglas, A. , MAEHR, Rene
IPC分类号： C12N5/00
摘要： The disclosure features a method of producing an induced pluripotent stem cell from a somatic cell. The method includes contacting a somatic cell with a DNA methyl transferase inhibitor or a histone deacetylase (HDAC) inhibitor, or a combination thereof, to produce a pluripotent stem cell.

5. 发明申请

WO2014201167A4 SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME 审中-公开
公开(公告)号：WO2014201167A4
公开(公告)日：2014-12-18
申请号：PCT/US2014/041992
申请日：2014-06-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： PETERSON, Quinn, P. , PAGLIUCA, Felicia, J. , MELTON, Douglas, A. , MILLMAN, Jeffrey, R. , SEGEL, Michael, Saris , GURTLER, Mads
IPC分类号： C12N5/071
摘要： Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

6. 发明申请

WO2021080642A1 COMPOSITIONS AND METHODS FOR ENHANCING DIFFERENTIATION OF STEM CELL-DERIVED BETA CELLS 审中-公开
公开(公告)号：WO2021080642A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/026041
申请日：2020-03-31
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MELTON, Douglas, A. , ROSADO-OLIVIERI, Edwin
IPC分类号： C12N5/071 , C12N5/0789 , A61P3/10
摘要： Disclosed herein are methods for generating stem cell-derived beta cells and compositions including stem cell-derived beta cells.

7. 发明申请

WO2017120450A1 TREATMENT WITH GDF11 PREVENTS WEIGHT GAIN, IMPROVES GLUCOSE TOLERANCE AND REDUCES HEPATOSTEATOSIS 审中-公开
标题翻译： GDF11治疗预防体重增加，改善葡萄糖耐量并减少肝硬化
公开(公告)号：WO2017120450A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012505
申请日：2017-01-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： BARRANDON, Ornella , POGGLIOLI, Tommaso , MELTON, Douglas, A. , LEE, Richard, T.
IPC分类号： A61K38/19 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K14/00 , C12N5/071
CPC分类号： A61K38/18 , A61K38/1841 , C07K14/00
摘要： Disclosed herein are a means to prevent and/or ameliorate age, disease and obesity associated metabolic diseases, such as diabetes and impaired glucose tolerance. Also disclosed are compositions and methods that relate to the findings that GDF11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis in aged mice administered a high fat diet. In particular, the methods and compositions described herein relate to increasing the level of GDF11 in a subject, thereby treating or preventing the development of obesity in the subject, reducing the metabolic consequences of obesity and improving the subject's metabolic health.
摘要翻译：本文公开了预防和/或改善年龄，疾病和肥胖相关代谢疾病（例如糖尿病和葡萄糖耐量受损）的手段。还公开了涉及GDF11防止体重增加，改善葡萄糖耐受性和降低给予高脂肪饮食的老年小鼠的肝脏脂肪变性的发现的组合物和方法。具体而言，本文所述的方法和组合物涉及提高受试者中GDF11的水平，从而治疗或预防受试者中肥胖的发展，减少肥胖的代谢后果并改善受试者的代谢健康。

8. 发明申请

WO2016100898A1 SERUM-FREE IN VITRO DIRECTED DIFFERENTIATION PROTOCOL FOR GENERATING STEM CELL-DERIVED B CELLS AND USES THEREOF 审中-公开
标题翻译：用于生成干细胞衍生的B细胞的体外方向指导的差异免疫球蛋白免疫球蛋白及其用途
公开(公告)号：WO2016100898A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066840
申请日：2015-12-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MELTON, Douglas, A. , GÜRTLER, Mads
IPC分类号： A61K35/545 , C12N5/0735 , C12N5/074
CPC分类号： C12N5/0676 , C12N2500/12 , C12N2500/22 , C12N2500/30 , C12N2500/34 , C12N2500/36 , C12N2500/38 , C12N2500/46 , C12N2500/90 , C12N2501/33 , C12N2501/91
摘要： Disclosed herein are methods for generating SC-β cells using chemically defined, completely serum free media, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
摘要翻译：本文公开了使用化学定义的完全无血清培养基和用于各种应用如细胞治疗的分离的SC-β细胞群体产生SC-β细胞的方法。

9. 发明申请

WO2019217487A1 STEM CELL-DERIVED ALPHA CELLS AND METHODS OF GENERATING SAME 审中-公开
公开(公告)号：WO2019217487A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031214
申请日：2019-05-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MELTON, Douglas, A. , PETERSON, Quinn, P. , VERES, Adrian
IPC分类号： A61K45/06 , A61K35/39
摘要： Disclosed herein are methods, differentiation protocols and compositions useful for inducing a cell maturation, and isolated populations of SC-α cells for use in various applications, such as cell therapy.

10. 发明申请

WO2015148980A3 METHODS FOR DETECTING AND REVERSING BETA CELL DE-DIFFERENTIATION AND USES THEREOF 审中-公开
公开(公告)号：WO2015148980A3
公开(公告)日：2015-10-01
申请号：PCT/US2015/023100
申请日：2015-03-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： BLUM, Barak , MELTON, Douglas, A.
IPC分类号： C12N5/0735
摘要： Disclosed herein are methods for detecting, preventing, and/or reversing β cell dedifferentiation. In some aspects, the disclosure provides a method for detecting dedifferentiation or re-differentiation of a β cell, the method comprising: a) obtaining a β cell; b) detecting the level of urocortin 3 (Ucn3) expression in the β cell; c) comparing the level of Ucn3 expression detected in the β cell to the level of Ucn3 expression detected in a normal mature β cell; and d) detecting de-differentiation or re-differentiation of the β cell, wherein de-differentiation of the β cell is detected if the level of Ucn3 expression detected in the β cell is decreased relative to the level of Ucn3 expression detected in the normal mature β cell.

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