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1. 发明申请

WO2003027234A3 SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION 审中-公开
公开(公告)号：WO2003027234A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/029522
申请日：2002-09-18
申请人： CURIS, INC. , BAXTER, Anthony, David , BOYD, Edward, Andrew , FRANK-KAMENETSKY, Maria , PORTER, Jeffery , PRICE, Stephen , RUBIN, Lee, L. , STIBBARD, John, Harry, Alexander
发明人： BAXTER, Anthony, David , BOYD, Edward, Andrew , FRANK-KAMENETSKY, Maria , PORTER, Jeffery , PRICE, Stephen , RUBIN, Lee, L. , STIBBARD, John, Harry, Alexander
IPC分类号： C07D409/00
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in Figures 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

2. 发明申请

WO2012174537A3 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION 审中-公开
标题翻译：小分子筛选小鼠卫星细胞增殖
公开(公告)号：WO2012174537A3
公开(公告)日：2013-02-28
申请号：PCT/US2012042964
申请日：2012-06-18
申请人： HARVARD COLLEGE , RUBIN LEE L , GEE AMANDA , WAGERS AMY
发明人： RUBIN LEE L , GEE AMANDA , WAGERS AMY
IPC分类号： A61K31/56 , A61K31/4045 , A61K31/417 , A61K31/606 , A61K31/7076 , A61P21/00 , C12N9/12
CPC分类号： A61K39/3955 , A61K31/136 , A61K31/404 , A61K31/4164 , A61K31/4439 , A61K31/47 , A61K31/4706 , A61K31/485 , A61K31/553 , A61K31/58 , A61K31/7076 , C07D498/22 , G01N33/5044
摘要： The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject.
摘要翻译：本发明提供诱导，增强或增加卫星细胞增殖的方法，以及用于筛选用于诱导，增强或增加卫星细胞增殖的候选化合物的测定法。还提供了用于修复或再生受试者的损伤的肌肉组织的方法。

3. 发明申请

WO2005061002A3 COMPOSITION AND METHODS FOR MODULATING CNS ACTIVITY 审中-公开
标题翻译：用于调节CNS活性的组合物和方法
公开(公告)号：WO2005061002A3
公开(公告)日：2005-09-29
申请号：PCT/US2004042271
申请日：2004-12-15
申请人： CURIS INC , RUBIN LEE L
发明人： RUBIN LEE L
IPC分类号： A61K38/17 , A61K48/00 , C12Q1/68 , A61P25/00 , A61P25/24
CPC分类号： A61K38/1709
摘要： The present invention concerns the methods and compositions for treating depression and other behavioral and/or emotional disorders of the central nervous system by administering an agonist of hedgehog signaling. Other disorders amenable to treatment by the subject method include attention deficit hyperactive disorders, non-Alzheimer dementia, and various symptoms of memory loss. The present invention also concerns the methods and compositions for enhancing memory and/or cognitive functions, both in a patient suffering from ailment affecting these functions, and in a subject with no diagnosed deficit in memory or cognitive function. The methods and compositions of the present invention stimulate neurogenesis and differentiation, and enhance synaptic transmission of neurons.
摘要翻译：本发明涉及通过施用刺猬蛋白信号传导的激动剂来治疗中枢神经系统的抑郁症和其它行为和/或情绪障碍的方法和组合物。适用于本发明方法治疗的其它障碍包括注意缺陷多动障碍，非阿尔茨海默痴呆和记忆丧失的各种症状。本发明还涉及用于增强记忆和/或认知功能的方法和组合物，在患有影响这些功能的疾病的患者中，以及在记忆或认知功能中没有诊断出缺陷的受试者中。本发明的方法和组合物刺激神经发生和分化，并增强神经元的突触传递。

4. 发明申请

WO2012174537A2 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION 审中-公开
标题翻译：小分子筛选小鼠卫星细胞增殖
公开(公告)号：WO2012174537A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042964
申请日：2012-06-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , RUBIN, Lee L. , GEE, Amanda , WAGERS, Amy
发明人： RUBIN, Lee L. , GEE, Amanda , WAGERS, Amy
IPC分类号： A61K31/56
CPC分类号： A61K39/3955 , A61K31/136 , A61K31/404 , A61K31/4164 , A61K31/4439 , A61K31/47 , A61K31/4706 , A61K31/485 , A61K31/553 , A61K31/58 , A61K31/7076 , C07D498/22 , G01N33/5044
摘要： The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject.
摘要翻译：本发明提供诱导，增强或增加卫星细胞增殖的方法，以及用于筛选用于诱导，增强或增加卫星细胞增殖的候选化合物的测定法。还提供了用于修复或再生受试者的损伤的肌肉组织的方法。

5. 发明申请

WO2009132083A2 COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS 审中-公开
标题翻译：用于促进PDX1 +胰腺细胞产生的组合物和方法
公开(公告)号：WO2009132083A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041381
申请日：2009-04-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHEN, Shuibing , MELTON, Douglas, A. , BOROWIAK, Malgorzala , LAMENZO, Julia , SCHREIBER, Stuart, L. , PENG, Lee, F. , RUBIN, Lee, L. , DAVIDOW, Lance , LAM, Kevin
发明人： CHEN, Shuibing , MELTON, Douglas, A. , BOROWIAK, Malgorzala , LAMENZO, Julia , SCHREIBER, Stuart, L. , PENG, Lee, F. , RUBIN, Lee, L. , DAVIDOW, Lance , LAM, Kevin
IPC分类号： C12N5/08 , C12N5/02 , C12N1/38
CPC分类号： C12N5/0678 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02
摘要： Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
摘要翻译：本文公开的某些实施例涉及通过将人胚胎干细胞暴露于有效量的表I所列的至少一种化合物来产生胰腺细胞或胰腺细胞前体的方法，以将人胚胎干细胞分化成胰腺细胞或胰腺细胞细胞前体。还描述了使用这些方法生产的试剂盒和胰腺细胞系。

6. 发明申请

WO2011075665A2 BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE 审中-公开
标题翻译： β细胞复制促进化合物及其使用方法
公开(公告)号：WO2011075665A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/061075
申请日：2010-12-17
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , JOSLIN DIABETES CENTER, INC. , ANNES, Justin P. , MELTON, Douglas A. , RUBIN, Lee L. , WEIR, Gordon
发明人： ANNES, Justin P. , MELTON, Douglas A. , RUBIN, Lee L. , WEIR, Gordon
IPC分类号： C12N5/071 , C12N5/02 , A61K31/7042 , A61K35/39 , A61P3/10
CPC分类号： A61K31/7042 , C12N5/0676 , C12N2500/40 , C12N2501/65 , G01N33/507
摘要： In the invention provides for a method of stimulating or increasing β-cell replication or growth, by contacting a β-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
摘要翻译：在本发明中提供了刺激或增加β细胞复制或生长的方法，通过使β细胞与腺苷激酶（ADK）抑制剂，S-腺苷高同型半胱氨酸水解酶抑制剂（ SAHH）或AMP激活的蛋白激酶（AMPK）的激活剂。

7. 发明申请

WO2011075665A3 BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE 审中-公开
标题翻译： BETA-细胞复制促进其使用的化合物和方法
公开(公告)号：WO2011075665A3
公开(公告)日：2011-11-17
申请号：PCT/US2010061075
申请日：2010-12-17
申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , JOSLIN DIABETES CENTER INC , ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
IPC分类号： C12N5/071 , A61K31/7042 , A61K35/39 , A61P3/10 , C12N5/02
CPC分类号： A61K31/7042 , C12N5/0676 , C12N2500/40 , C12N2501/65 , G01N33/507
摘要： In the invention provides for a method of stimulating or increasing ß-cell replication or growth, by contacting a ß-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
摘要翻译：在本发明提供了用于刺激或增加β-细胞复制或生长，由SS-细胞与腺苷激酶抑制剂（ADK）接触的方法，S-腺苷高半胱氨酸水解酶的抑制剂（SAHH）或AMP的活化剂活化蛋白激酶（AMPK）。

8. 发明申请

WO2009132083A3 COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS 审中-公开
标题翻译：用于促进PDX1 +胰腺细胞产生的组合物和方法
公开(公告)号：WO2009132083A3
公开(公告)日：2010-03-25
申请号：PCT/US2009041381
申请日：2009-04-22
申请人： HARVARD COLLEGE , GEN HOSPITAL CORP , CHEN SHUIBING , MELTON DOUGLAS A , BOROWIAK MALGORZALA , LAMENZO JULIA , SCHREIBER STUART L , PENG LEE F , RUBIN LEE L , DAVIDOW LANCE , LAM KEVIN
发明人： CHEN SHUIBING , MELTON DOUGLAS A , BOROWIAK MALGORZALA , LAMENZO JULIA , SCHREIBER STUART L , PENG LEE F , RUBIN LEE L , DAVIDOW LANCE , LAM KEVIN
IPC分类号： C12N5/0735 , C12N1/38 , C12N5/071
CPC分类号： C12N5/0678 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02
摘要： Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
摘要翻译：本文公开的某些实施例涉及通过将人胚胎干细胞暴露于有效量的表I所列的至少一种化合物来产生胰腺细胞或胰腺细胞前体的方法，以将人胚胎干细胞分化成胰腺细胞或胰腺细胞细胞前体。还描述了使用这些方法生产的试剂盒和胰腺细胞系。

9. 发明申请

WO2005061002A2 COMPOSITION AND METHODS FOR MODULATING CNS ACTIVITY 审中-公开
标题翻译：调节CNS活性的组合物和方法
公开(公告)号：WO2005061002A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/042271
申请日：2004-12-15
申请人： CURIS, INC. , RUBIN, Lee, L.
发明人： RUBIN, Lee, L.
IPC分类号： A61K45/00
CPC分类号： A61K38/1709
摘要： The present invention concerns the methods and compositions for treating depression and other behavioral and/or emotional disorders of the central nervous system by administering an agonist of hedgehog signaling. Other disorders amenable to treatment by the subject method include attention deficit hyperactive disorders, non-Alzheimer dementia, and various symptoms of memory loss. The present invention also concerns the methods and compositions for enhancing memory and/or cognitive functions, both in a patient suffering from ailment affecting these functions, and in a subject with no diagnosed deficit in memory or cognitive function. The methods and compositions of the present invention stimulate neurogenesis and differentiation, and enhance synaptic transmission of neurons.
摘要翻译：本发明涉及通过施用刺猬信号激动剂治疗中枢神经系统的抑郁和其他行为和/或情绪障碍的方法和组合物。适用于主题方法治疗的其他病症包括注意力缺陷多动障碍，非阿尔茨海默痴呆以及各种记忆丧失症状。本发明还涉及用于增强记忆和/或认知功能的方法和组合物，无论是在患有影响这些功能的疾病的患者中，还是在记忆或认知功能中没有诊断缺陷的受试者中。本发明的方法和组合物刺激神经发生和分化，并增强神经元的突触传递。

10. 发明申请

WO2005010524A1 STEM CELL-BASED METHODS FOR IDENTIFYING AND CHARACTERIZING AGENTS 审中-公开
标题翻译：基于干细胞的识别和表征代理的方法
公开(公告)号：WO2005010524A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/018194
申请日：2004-06-04
申请人： CURIS, INC. , RUBIN, Lee, L. , KOTKOW, Karen , LAI, Cheng-Jung
发明人： RUBIN, Lee, L. , KOTKOW, Karen , LAI, Cheng-Jung
IPC分类号： G01N33/50
CPC分类号： G01N33/5073 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/5058
摘要： The present invention provides methods of identifying and/or characterizing agents that promote differentiation of stem cells to a particular differentiated cell type. The invention further provides methods of treating injuries and degenerative diseases by administering agents that promote the differentiation of stem cells to particular differentiated cell types.
摘要翻译：本发明提供鉴定和/或表征促进干细胞分化为特定分化细胞类型的药剂的方法。本发明还提供了通过施用促进干细胞分化为特定分化细胞类型的药剂来治疗损伤和退行性疾病的方法。

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