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1. 发明申请

WO2016100898A1 SERUM-FREE IN VITRO DIRECTED DIFFERENTIATION PROTOCOL FOR GENERATING STEM CELL-DERIVED B CELLS AND USES THEREOF 审中-公开
标题翻译：用于生成干细胞衍生的B细胞的体外方向指导的差异免疫球蛋白免疫球蛋白及其用途
公开(公告)号：WO2016100898A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066840
申请日：2015-12-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MELTON, Douglas, A. , GÜRTLER, Mads
IPC分类号： A61K35/545 , C12N5/0735 , C12N5/074
CPC分类号： C12N5/0676 , C12N2500/12 , C12N2500/22 , C12N2500/30 , C12N2500/34 , C12N2500/36 , C12N2500/38 , C12N2500/46 , C12N2500/90 , C12N2501/33 , C12N2501/91
摘要： Disclosed herein are methods for generating SC-β cells using chemically defined, completely serum free media, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
摘要翻译：本文公开了使用化学定义的完全无血清培养基和用于各种应用如细胞治疗的分离的SC-β细胞群体产生SC-β细胞的方法。

2. 发明申请

WO2016100925A1 METHODS FOR GENERATING AUGMENTED STEM CELL-DERIVED β CELLS AND USES THEREOF 审中-公开
标题翻译：生成受体干细胞衍生的β细胞的方法及其用途
公开(公告)号：WO2016100925A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066888
申请日：2015-12-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MELTON, Douglas, A. , MILLMAN, Jeffrey, R. , GÜRTLER, Mads
IPC分类号： C12N5/0735
CPC分类号： C12N5/0678 , A61K9/0024 , A61K9/50 , A61K9/7007 , A61K35/39 , A61K47/32 , G01N33/507 , G01N33/5073
摘要： Disclosed herein are methods for generating augmented SC-P cells, and isolated populations of augmented SC-P cells for use in various applications, such as cell therapy. There is a need for methods of generating augmented stem cell-derived P (SC-P) cells. The present invention is directed toward solutions to address this need, in addition to having other desirable characteristics. In accordance with an embodiment of the present invention, a method for generating augmented stem cell-derived P (SC-3) cells is provided. The method includes contacting a cell population comprising SC-P cells, or precursors thereof, with an effective amount of an agent that decreases the level and/or activity of AXL receptor tyrosine kinase (AXL) and an antioxidant for a period of time sufficient for the level of MAFA gene expression to increase in the SC-P cells to at least 2 fold greater than the level of MAFA gene expression in the SC-P cells in the absence of contact with the agent and the antioxidant, thereby generating augmented SC-P cells.
摘要翻译：本文公开了用于产生增强的SC-P细胞的方法和用于各种应用例如细胞治疗的增强的SC-P细胞的分离群体。需要产生增强的干细胞衍生的P（SC-P）细胞的方法。除了具有其它期望的特征之外，本发明还涉及解决该需求的解决方案。根据本发明的实施例，提供了一种用于产生增强的干细胞衍生的P（SC-3）细胞的方法。该方法包括使包含SC-P细胞或其前体的细胞群与有效量的降低AXL受体酪氨酸激酶（AXL）和抗氧化剂的水平和/或活性的试剂接触足够长的时间在不与药剂和抗氧化剂接触的情况下，将SC-P细胞的MAFA基因表达水平增加至SC-P细胞中MAFA基因表达水平的至少2倍以上，从而产生增强的SC- P细胞。

3. 发明申请

WO2015002724A4 SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME 审中-公开
公开(公告)号：WO2015002724A4
公开(公告)日：2015-01-08
申请号：PCT/US2014/041988
申请日：2014-06-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： PETERSON, Quinn, P. , PAGLIUCA, Felicia, J. , MELTON, Douglas, A. , MILLMAN, Jeffrey, R. , SEGEL, Michael, Saris , GÜRTLER, Mads
IPC分类号： C12N5/02 , C12N5/071 , C12N5/00
摘要： Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

4. 发明公开

EP3008168A2 SC- CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME 有权转让
标题翻译： SC-细胞和组合物及其产生方法
公开(公告)号：EP3008168A2
公开(公告)日：2016-04-20
申请号：EP14819763.5
申请日：2014-06-11
申请人： President and Fellows of Harvard College
发明人： PETERSON, Quinn, P. , PAGLIUCA, Felicia, J. , MELTON, Douglas, A. , MILLMAN, Jeffrey, R. , SEGEL, Michael, Saris , GÜRTLER, Mads , REZANIA, Alireza , FRYER, Benjamin
IPC分类号： C12N5/02 , C12N5/071 , C12N5/00
摘要： Disclosed herein is a method for differentiating PDX1-positive pancreatic progenitor cells into NKX6.1 positive pancreatic progenitor cells with a culture medium comprising a) KGF and b) SANT1, wherein the culture medium is substantially free of (1) a Protein Kinase C (PKC) Activator or (2) a BMP signaling pathway inhibitor.
摘要翻译：本文公开了用于诱导β细胞成熟的方法，组合物，试剂盒和试剂，以及用于各种应用（例如细胞疗法）的分离的SC-β细胞群。

6. 发明公开

EP3569694A1 SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME 审中-公开
公开(公告)号：EP3569694A1
公开(公告)日：2019-11-20
申请号：EP19179173.0
申请日：2014-06-11
申请人： President and Fellows of Harvard College , Janssen Biotech, Inc.
发明人： PETERSON, Quinn, P , PAGLIUCA, Felicia, J. , MELTON, Douglas, A. , MILLMAN, Jeffrey, R. , SEGEL, Michael, Saris , GÜRTLER, Mads , REZANIA, Alireza , FRYER, Benjamin
IPC分类号： C12N5/071 , C12N5/074 , C12N5/0735
摘要： Disclosed herein is a method for differentiating PDX1-positive pancreatic progenitor cells into NKX6.1 positive pancreatic progenitor cells with a culture medium comprising a) KGF and b) SANT1, wherein the culture medium is substantially free of (1) a Protein Kinase C (PKC) Activator or (2) a BMP signaling pathway inhibitor.

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