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1. 发明申请

WO2012087350A3 SPRAY DRYING TECHNIQUES 审中-公开
公开(公告)号：WO2012087350A3
公开(公告)日：2012-06-28
申请号：PCT/US2011/001993
申请日：2011-12-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , ABATE, Adam, R. , THIELE, Julian, W.P. , WEITZ, David, A. , WINDBERGS, Maike , HOLTZE, Christian
发明人： ABATE, Adam, R. , THIELE, Julian, W.P. , WEITZ, David, A. , WINDBERGS, Maike , HOLTZE, Christian
IPC分类号： B01J2/04 , B05B7/04
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfiuidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.

2. 发明申请

WO2012162296A3 CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS 审中-公开
公开(公告)号：WO2012162296A3
公开(公告)日：2012-11-29
申请号：PCT/US2012/038957
申请日：2012-05-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , ROTEM, Assaf , WEITZ, David A. , ABATE, Adam R. , HOLTZE, Christian
发明人： ROTEM, Assaf , WEITZ, David A. , ABATE, Adam R. , HOLTZE, Christian
IPC分类号： B01F13/00 , B01F3/08
摘要： The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels (11, 12, 13, 14, 15, 16), where a first fluid (21) flows through one channel (11), a second fluid (22) flows through two channels (12, 13), and a third or carrying fluid (23) flows through two more channels (14, 15), such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel (16). Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

3. 发明申请

WO2009120254A1 SURFACES, INCLUDING MICROFLUIDIC CHANNELS, WITH CONTROLLED WETTING PROPERTIES 审中-公开
标题翻译：表面，包括微流通道，具有受控的润湿性能
公开(公告)号：WO2009120254A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/000850
申请日：2009-02-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , ABATE, Adam, R. , KRUMMEL, Amber, T. , HOLTZE, Christian , WEITZ, David, A.
发明人： ABATE, Adam, R. , KRUMMEL, Amber, T. , HOLTZE, Christian , WEITZ, David, A.
IPC分类号： B81B1/00 , B01F13/00 , B01J19/00
CPC分类号： F16L9/14 , B01F3/0807 , B01F13/0062 , B01J2219/00619 , B01J2219/00635 , B01J2219/00637 , B01L3/502707 , B81B2201/058 , B81B2203/0338 , B81C1/00206
摘要： The present invention generally relates to coating materials, including photoactive coating materials. In some aspects of the invention, a sol-gel is provided that can be formed as a coating on a microfluidic channel. One or more portions of the sol-gel can be reacted to alter its hydrophobicity, in some cases. For instance, in one set of embodiments, a portion of the sol-gel may be exposed to light, such as ultraviolet light, which can be used to induce a chemical reaction in the sol-gel that alters its hydrophobicity. In one set of embodiments, the sol-gel can include a photoinitiator, that upon exposure to light, produces radicals. Optionally, the photoinitiator may be conjugated to a silane or other material within the sol-gel. The radicals so produced may be used to cause a polymerization reaction to occur on the surface of the sol-gel, thus altering the hydrophobicity of the surface. In some cases, various portions may be reacted or left unreacted, e.g., by controlling exposure to light (for instance, using a mask). Such treated surfaces within a microfluidic channel may be useful in a wide variety of applications, for instance, in the creation of emulsions such as multiple emulsions.
摘要翻译：本发明一般涉及涂料，包括光活性涂料。在本发明的一些方面，提供可以形成为微流体通道上的涂层的溶胶 - 凝胶。在一些情况下，溶胶 - 凝胶的一个或多个部分可以反应以改变其疏水性。例如，在一组实施方案中，溶胶 - 凝胶的一部分可以暴露于光，例如紫外光，其可用于在溶胶 - 凝胶中诱导改变其疏水性的化学反应。在一组实施方案中，溶胶 - 凝胶可以包括光引发剂，其在暴露于光时产生自由基。任选地，光引发剂可以与溶胶 - 凝胶内的硅烷或其它材料缀合。这样生成的基团可以用于在溶胶 - 凝胶的表面上发生聚合反应，从而改变表面的疏水性。在一些情况下，例如通过控制曝光（例如，使用掩模），各种部分可以反应或未反应。微流体通道内的这样处理的表面可用于多种应用中，例如在产生诸如多重乳液的乳液中。

4. 发明申请

WO2009020633A2 METAL OXIDE COATING ON SURFACES 审中-公开
标题翻译：表面金属氧化物涂层
公开(公告)号：WO2009020633A2
公开(公告)日：2009-02-12
申请号：PCT/US2008/009477
申请日：2008-08-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WEITZ, David, A. , HOLTZE, Christian , ABATE, Adam, R. , LEE, Daeyeon , DO, Thao
发明人： WEITZ, David, A. , HOLTZE, Christian , ABATE, Adam, R. , LEE, Daeyeon , DO, Thao
IPC分类号： C23C18/12
CPC分类号： C23C18/1295 , C03C1/008 , C23C18/1216 , C23C18/1233 , C23C18/1254 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744
摘要： The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the reactive PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfiuidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
摘要翻译：本发明提供了用于在PDMS表面上涂覆金属氧化物的方法。该方法包括制备含有溶胶 - 凝胶前体的混合物，使混合物反应以形成预转化的溶胶 - 凝胶前体，其中预转化的溶胶 - 凝胶前体不扩散到PDMS中并且不是凝胶形式，形成将预转化的溶胶 - 凝胶前体施加到反应性PDMS表面上，将预转化的溶胶 - 凝胶前体结合到反应性PDMS表面上，并且将结合的预转化的溶胶 - 凝胶前体转化成金属氧化物以在其上形成金属氧化物涂层 PDMS表面。本发明还提供了一种PDMS微流体装置，其中微流体装置的一个或多个通道设有共价结合在一个或多个通道表面上的金属氧化物涂层。

5. 发明申请

WO2013032709A3 SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
公开(公告)号：WO2013032709A3
公开(公告)日：2013-03-07
申请号：PCT/US2012/050916
申请日：2012-08-15
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , WEITZ, David, A. , SHUM, Ho, Cheung , ZHAO, Yuanjin , SUN, Bingjie , HOLTZE, Christian
发明人： WEITZ, David, A. , SHUM, Ho, Cheung , ZHAO, Yuanjin , SUN, Bingjie , HOLTZE, Christian
IPC分类号： B01J13/20 , A01N25/28 , A23P1/04 , A61K9/50 , C09B67/00 , C11D3/50 , C11D17/00
摘要： The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.

6. 发明申请

WO2011116154A2 MELT EMULSIFICATION 审中-公开
公开(公告)号：WO2011116154A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/028754
申请日：2011-03-17
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , SHUM, Ho, Cheung , SUN, Bingjie , WEITZ, David, A. , HOLTZE, Christian
发明人： SHUM, Ho, Cheung , SUN, Bingjie , WEITZ, David, A. , HOLTZE, Christian
IPC分类号： B01J13/00 , B01J13/04 , A01N25/28 , A61K9/50 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
摘要翻译：本发明一般涉及胶体体系，其可以包括胶体颗粒和/或其它类型的颗粒。本发明的一个方面通常涉及包含流体液滴的系统，其可以至少部分地固化，例如形成胶体颗粒。在一些实施方案中，形成包含至少部分固体外层的包封内相的颗粒。内相可以是任何相，例如固体，液体或气体。在一些情况下，固化液滴的外相的至少一部分以形成颗粒可以增加包含颗粒的颗粒和/或胶体体系的稳定性。在一组实施方案中，熔化或液化颗粒的外相（例如，通过将颗粒加热到高于阈值温度的温度）可以允许包含在内相内的试剂的释放和/或允许内相以颗粒外部的相合并。在一些实施方案中，可以控制外相的熔融温度，使得外相将在预定温度以上熔化。在一些实施方案中，颗粒可以形成为基本上不含辅助稳定剂。在一些实施方案中，试剂可以以相对高的效率封装在颗粒内。本发明的其它方面通常涉及制备和使用这种胶体体系的方法，例如含有这种颗粒，涉及这种胶体系的试剂盒等。

7. 发明申请

WO2011028760A2 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：使用结果创建的多个乳液
公开(公告)号：WO2011028760A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047458
申请日：2010-09-01
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , WEITZ, David, A. , ROMANOWSKY, Mark , HOLTZE, Christian
发明人： WEITZ, David, A. , ROMANOWSKY, Mark , HOLTZE, Christian
IPC分类号： B01F5/00 , B01F3/08 , B01F15/04
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳液，并且更具体地涉及多重乳液。在一个方面，使用多个通道（诸如微流体通道）在相同的交叉点处相遇来形成多个乳液。在一些实施例中，可以在单个通用交叉点处创建多重乳液，这与需要多通道交叉点以产生多重乳液的其他现有技术系统不同。例如，在一组实施例中，三个，四个或更多个微流体通道可以在共同的交叉点处相交，其中两个或三个用作入口，一个用作出口。在一些实施例中，第一流体通道可以是相对疏水的，而第二流体通道是相对亲水的。取决于应用，第三通道（如果存在）可以是相对亲水的或疏水的。出口通道可以是疏水的，亲水的，或者可以包含至少一个相对亲水的部分和至少一个相对亲水的部分。通过控制通过通道的亲水部分和疏水部分的流体流动，由于流体进入共同交叉点之间的相互作用，可以在公共交叉点附近形成多个乳液。在其他实施例中，可以使用不同图案的亲水或疏水通道。本发明的其他方面通常涉及制造和使用这样的系统的方法，涉及这种系统的试剂盒，使用这种系统创建的乳剂等。

8. 发明申请

WO2008021123A1 FLUOROCARBON EMULSION STABILIZING SURFACTANTS 审中-公开
标题翻译：氟代乳液稳定表面活性剂
公开(公告)号：WO2008021123A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/017617
申请日：2007-08-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HOLTZE, Christian , GUERRA, Rodrigo, E. , AGRESTI, Jeremy , WEITZ, David, A.
发明人： HOLTZE, Christian , GUERRA, Rodrigo, E. , AGRESTI, Jeremy , WEITZ, David, A.
IPC分类号： B01F17/42 , C08G65/00
CPC分类号： B01F17/005 , B01F17/0035 , C08G65/007 , C08G65/332 , C08G65/337 , C08G81/00 , C08G2650/48 , C08L71/00 , C08L2201/52 , C08L2205/05
摘要： Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions. In another embodiment, aqueous droplets are stabilized in a fluorocarbon phase at least in part by the electrostatic attraction of two oppositely charged or polar components, one of which is at least partially soluble in the dispersed phase, the other at least partially soluble in the continuous phase. One component may provide colloidal stability of the emulsion, and the other may prevent the adsorption of biomolecules at the interface between a component and the discontinuous phase. Advantageously, surfactants and surfactant combinations of the invention may provide sufficient stabilization against coalescence of droplets, without interfering with processes that can be carried out inside the droplets.
摘要翻译：提出了用于稳定氟离子连续相中的水或碳氢化合物液滴的表面活性剂（如含氟表面活性剂）。在一些实施方案中，含氟表面活性剂包括可溶于氟亲核（例如，碳氟化合物）连续相的荧光尾部和可溶于水相或亲油（例如烃）相的头团。可以选择荧光尾巴和头组的组合，以便产生具有合适几何形状的表面活性剂，以在连续的氟亲水相中形成具有分散水性或亲油相的稳定的反相乳液液滴。在一些实施方案中，头基优选是非离子型的，并且可以防止或限制分子在表面活性剂与不连续相之间的界面处的吸附。这种构型可以使液滴例如用作某些化学和/或生物反应的反应位点。在另一个实施方案中，水性液滴至少部分地通过两个相反电荷或极性组分的静电吸引而稳定在碳氟化合物相中，其中之一至少部分地可溶于分散相，另一个至少部分可溶于连续的相。一种组分可以提供乳液的胶体稳定性，另一种可以防止生物分子在组分与不连续相之间的界面处的吸附。有利地，本发明的表面活性剂和表面活性剂组合可以提供足够的稳定性以防止液滴的聚结，而不干扰可在液滴内进行的方法。

9. 发明申请

WO2014047236A9 SYSTEMS AND METHODS FOR SPRAY DRYING IN MICROFLUIDIC AND OTHER SYSTEMS 审中-公开
公开(公告)号：WO2014047236A9
公开(公告)日：2014-03-27
申请号：PCT/US2013/060522
申请日：2013-09-19
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE
发明人： AMSTAD, Esther , HOLTZE, Christian , WEITZ, David, A.
IPC分类号： B01J2/02
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. By at least partially drying fluids within a microfluidic channel, instead of or in addition to conventional spray drying techniques, better control of the drying process can be achieved in certain aspects of the invention. In addition, various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, gases such as air may be directed into a channel containing a fluid, which may facilitate drying of the fluid. In some cases, the fluid may be accelerated due to the introduction of gases into the channel, and in certain embodiments, droplets of fluid may be disrupted to form smaller droplets as a result. In certain cases, the fluids may also be dried to form supersaturated droplets.

10. 发明申请

WO2013163246A2 POLYMERIZATION REACTIONS WITHIN MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置中的聚合反应
公开(公告)号：WO2013163246A2
公开(公告)日：2013-10-31
申请号：PCT/US2013/037895
申请日：2013-04-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE
发明人： ZIERINGER, Maximilian , HOLTZE, Christian , WEITZ, David, A. , SIEBERT, Joerg Max, Georg, Erich
IPC分类号： C08F293/00
CPC分类号： C08F2/22 , B01F3/0807 , B01F13/0062 , B01F13/0093 , B01F2005/0031 , B01J19/0093 , B01J2219/00792 , B01J2219/00833 , B01J2219/0084 , B01J2219/00891 , B01J2219/00903 , B01J2219/00936 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , B01J2219/0097 , C08F2/01 , C08F293/005
摘要： The present invention generally relates to polymerization reactions within microfluidic devices. In certain cases, the invention allows for precise control of the polymerization of different types of monomers to form a copolymer by controlling the steps of polymerization and/or controlling the addition of monomers at various time scales within a microfluidic droplet and/or a microfluidic environment, often to a degree that is unattainable by other block polymerization techniques. For example, in one aspect, the present invention is directed to systems and methods for producing polymers such as block copolymers, gradient polymers, random copolymers, etc. For instance, in one set of embodiments, a first monomer contained within a channel, such as a microfluidic channel, is allowed to polymerize to form a first block of a block copolymer. Additional blocks may be added, for example, by flowing the first block and other monomers through a second channel (which may be an extension of the first channel), by polymerizing additional blocks of the copolymer in other channels, by creating droplets containing one or more blocks and allowing the blocks to polymerize, or the like. In some embodiments, a droplet, such as a multiple emulsion droplet, may be creating containing two or more monomers, which are allowed to polymerize together. Still other embodiments of the invention are generally directed to methods of creating such devices, methods of using such devices, kits involving such devices, or the like.
摘要翻译：本发明一般涉及微流体装置内的聚合反应。在某些情况下，本发明允许通过控制聚合和/或控制在微流体液滴和/或微流体环境内的各种时间尺度添加单体的步骤来精确控制不同类型的单体的聚合以形成共聚物，通常达到其它嵌段聚合技术无法达到的程度。例如，在一个方面，本发明涉及用于生产聚合物如嵌段共聚物，梯度聚合物，无规共聚物等的体系和方法。例如，在一组实施方案中，包含在通道内的第一单体，例如作为微流体通道，被允许聚合以形成嵌段共聚物的第一嵌段。可以通过例如通过使第一块和其它单体流过第二通道（其可以是第一通道的延伸），通过在其它通道中聚合共聚物的附加嵌段，通过产生含有一个或多个更多的块和允许块聚合等。在一些实施方案中，液滴，例如多重乳液液滴可能产生含有两种或更多种单体，这些单体可一起聚合。本发明的其它实施例通常涉及创建这种设备的方法，使用这种设备的方法，涉及这种设备的套件等。

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