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1. 发明申请

WO2013032709A3 SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
公开(公告)号：WO2013032709A3
公开(公告)日：2013-03-07
申请号：PCT/US2012/050916
申请日：2012-08-15
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , WEITZ, David, A. , SHUM, Ho, Cheung , ZHAO, Yuanjin , SUN, Bingjie , HOLTZE, Christian
发明人： WEITZ, David, A. , SHUM, Ho, Cheung , ZHAO, Yuanjin , SUN, Bingjie , HOLTZE, Christian
IPC分类号： B01J13/20 , A01N25/28 , A23P1/04 , A61K9/50 , C09B67/00 , C11D3/50 , C11D17/00
摘要： The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.

2. 发明申请

WO2011116154A2 MELT EMULSIFICATION 审中-公开
公开(公告)号：WO2011116154A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/028754
申请日：2011-03-17
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , SHUM, Ho, Cheung , SUN, Bingjie , WEITZ, David, A. , HOLTZE, Christian
发明人： SHUM, Ho, Cheung , SUN, Bingjie , WEITZ, David, A. , HOLTZE, Christian
IPC分类号： B01J13/00 , B01J13/04 , A01N25/28 , A61K9/50 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
摘要翻译：本发明一般涉及胶体体系，其可以包括胶体颗粒和/或其它类型的颗粒。本发明的一个方面通常涉及包含流体液滴的系统，其可以至少部分地固化，例如形成胶体颗粒。在一些实施方案中，形成包含至少部分固体外层的包封内相的颗粒。内相可以是任何相，例如固体，液体或气体。在一些情况下，固化液滴的外相的至少一部分以形成颗粒可以增加包含颗粒的颗粒和/或胶体体系的稳定性。在一组实施方案中，熔化或液化颗粒的外相（例如，通过将颗粒加热到高于阈值温度的温度）可以允许包含在内相内的试剂的释放和/或允许内相以颗粒外部的相合并。在一些实施方案中，可以控制外相的熔融温度，使得外相将在预定温度以上熔化。在一些实施方案中，颗粒可以形成为基本上不含辅助稳定剂。在一些实施方案中，试剂可以以相对高的效率封装在颗粒内。本发明的其它方面通常涉及制备和使用这种胶体体系的方法，例如含有这种颗粒，涉及这种胶体系的试剂盒等。

3. 发明公开

EP2750787A2 SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
标题翻译：用于壳体封装的系统和方法
公开(公告)号：EP2750787A2
公开(公告)日：2014-07-09
申请号：EP12751233.3
申请日：2012-08-15
申请人： President and Fellows of Harvard College , BASF SE
发明人： WEITZ, David, A. , SHUM, Ho, Cheung , ZHAO, Yuanjin , SUN, Bingjie , HOLTZE, Christian
IPC分类号： B01J13/20
CPC分类号： B01J13/203 , A01N25/28 , A23L29/015 , A23P10/30 , A61K9/501 , A61K9/5036 , A61K9/5089 , C09B67/0097 , C11D17/0039 , A01N59/02 , A01N59/06 , A01N59/16
摘要： The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.
摘要翻译：本发明一般涉及颗粒，包括用于药物递送和其他应用的颗粒。本发明的某些方面通常涉及包含壳和至少部分由壳包含的内部的颗粒。在一些实施方案中，可对颗粒进行处理以增强内部的容纳，例如以减少试剂进入或离开内部的运输。这样的颗粒可以表现出增加的包封剂的能力和/或增加的存储寿命（例如，由于泄漏降低）。例如，在某些实施例中，壳体内的任何缺陷（例如裂纹，孔隙等）可被密封或以其他方式处理以减少通过其中的运输，例如用固体。在一些实施例中，例如，颗粒内部的第一反应物可以与颗粒外部的第二反应物接触以形成固体或其他合适的产物。在某些方面，壳还可以例如在稍后的时间点被处理，以引起包含在内部内的试剂的释放。例如，壳可以被加热以引起药剂从颗粒中释放，或壳可以暴露于化学或酶降解或渗透压变化，以引起药剂的释放。本发明的其他方面通常涉及制造或使用这种颗粒，包括这种颗粒的试剂盒或装置等的方法。

4. 发明公开

EP2547436A2 MELT EMULSIFICATION 审中-公开
标题翻译：融乳化
公开(公告)号：EP2547436A2
公开(公告)日：2013-01-23
申请号：EP11716682.7
申请日：2011-03-17
申请人： President and Fellows of Harvard College , BASF SE
发明人： SHUM, Ho, Cheung , SUN, Bingjie , WEITZ, David, A. , HOLTZE, Christian
IPC分类号： B01J13/00 , B01J13/04 , A01N25/28 , A61K9/50 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.

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