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1. 发明专利

DE102012107475A1 BENZOCYANINVERBINDUNGEN 未知
公开(公告)号：DE102012107475A1
公开(公告)日：2013-02-21
申请号：DE102012107475
申请日：2012-08-15
申请人： DYOMICS GMBH , PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI , HERMANSON GREG , NLEND MARIE CHRISTINE , DWORECKI BOGUSLAWA , CZERNEY PETER , WENZEL MATTHIAS , LEHMANN FRANK
IPC分类号： C07D403/06 , C09K11/06 , G01N33/52 , G01N33/53
摘要： Als Marker brauchbare Verbindungen, die mit bekannten fluoreszierenden Verbindungen vergleichbar sind. Die Verbindungen werden an Proteine und Nukleinsäuren zur biologischen Bildgebung und Analyse konjugiert. Synthese der Verbindungen, Bildung und Verwendung der konjugierten Verbindungen, sowie entsprechende spezifische, nicht einschränkende Beispiele sind ebenfalls beschrieben.

2. 发明专利

GB2493843A Benzocyanine compounds as labels for biological imaging 未知
公开(公告)号：GB2493843A
公开(公告)日：2013-02-20
申请号：GB201214580
申请日：2012-08-15
申请人： PIERCE BIOTECHNOLOGY INC , DYOMICS GMBH
发明人： HERMANSON GREG , CZERNEY PETER , DESAI SURBHI , WENZEL MATTHIAS S , DWORECKI BOGUSLAWA , LEHMANN FRANK G , NLEND CHRISTINE MARIE
IPC分类号： C09B23/08 , A61K49/00 , C09B23/00 , C09B23/02 , C09B23/06
摘要： Dihydrobenzo[e]indol-(2E)-ylidene compounds of formulae IIa, IIb, IIIa and IIIb: wherein R1, R2, R5, R6 are aliphatic, heteroaliphatic, sulfoalkyl, heteroaliphatic with terminal SO3, a PEG group P-Z where P is an ethylene glycol, diethylene glycol or polyethylene glycol group, a sulfonamide group L-SO2NH-P-Z or a carboxamide group L-CONH-P-Z; Z is H, CH3, alkyl or heteroalkyl; R7, R8, R11, R12, R13and R14 are H or substituents; X is -OH, -SH, -NH2, -NH-NH2, -F, -Cl, -Br, -I, -NHS (N-hydroxysuccinimidyl/sulfosuccinimidyl), -O-TFP (2,3,5,6-tetrafluorophenoxy), -O-STP (4-sulfo-2,3,5,6-tetrafluorophenoxy), -O-benzotriazole, benzotriazole, -NR-L-O-phosphoramidite, -NR-L-SH, -NR-L-NH-NH2, -NR-L-CO2H, -NR-L-CO-NHS , -NR-L-CO-STP, -NR-L-CO-TFP, -NR-L-CO-benzotriazole, -NR-L-CHO, -NR-L-maleimide or NR-L-NH-CO-CH2I, where R is H or an aliphatic or heteroaliphatic group; L is a divalent linear, crossed or cyclic alkyl group optionally substituted by at least one oxygen or sulfur atom; and Kat is a number of Na+, K+, Ca2+, ammonia or other cation(s) needed to compensate for the negative charge brought by the cyanine; may be useful as labels for conjugation to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds are provided.

3. 发明公开

EP2850078A4 BENZOPYRYLIUM COMPOUNDS 有权
标题翻译： BENZOPYRYLIUMVERBINDUNGEN
公开(公告)号：EP2850078A4
公开(公告)日：2016-01-27
申请号：EP13833348
申请日：2013-08-20
申请人： PIERCE BIOTECHNOLOGY INC , DYOMICS GMBH
发明人： HERMANSON GREG , CZERNEY PETER T , DESAI SURBHI , WENZEL MATTHIAS S , LEHMANN FRANK G , NLEND MARIE CHRISTINE
IPC分类号： C07D405/06 , A61K49/10 , C07D405/14 , C09B23/06 , C09B23/08
CPC分类号： C07D491/147 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C07D405/06 , C07D405/14 , C07D491/052 , C07D491/16 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译：用作具有与已知荧光化合物相当的特性的标签的化合物。化合物与蛋白质和核酸缀合，用于生物成像和分析。提供化合物的合成，共轭化合物的形成和使用以及各自的具体非限制性实例。

4. 发明专利

JP2008231093A Sulfonamide derivative of xanthene compound 有权
标题翻译： XANTHENE化合物的磺酰胺衍生物
公开(公告)号：JP2008231093A
公开(公告)日：2008-10-02
申请号：JP2008010915
申请日：2008-01-21
申请人： Pierce Biotechnology Inc , ピアス・バイオテクノロジー・インコーポレーテッド
发明人： FRANK WILHELM G , WENZEL MATTHIAS S , CZERNEY PETER T , DESAI SURBHI , HERMANSON GREG
IPC分类号： C07D311/82 , C07D405/12 , G01N33/533 , G01N33/58
CPC分类号： C07D311/82 , G01N33/582 , Y10S436/80
摘要： PROBLEM TO BE SOLVED: To provide a sulfonamide derivative of a xanthene compound and to provide a method for using the same. SOLUTION: The invention relates to the compounds represented by general formula I and/or general formula II, and to a composition comprising the compounds. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供呫吨化合物的磺酰胺衍生物并提供使用它们的方法。解决方案：本发明涉及由通式I和/或通式II表示的化合物以及包含该化合物的组合物。版权所有（C）2009，JPO＆INPIT

5. 发明专利

AT534641T 未知
公开(公告)号：AT534641T
公开(公告)日：2011-12-15
申请号：AT08250265
申请日：2008-01-22
申请人： PIERCE BIOTECHNOLOGY INC
发明人： FRANK WILHELM G , WENZEL MATTHIAS S , CZERNEY PETER T , DESAI SURBHI , HERMANSON GREG
IPC分类号： C07D311/84 , G01N33/58
摘要： Compounds having the general of formula I and/or formula II wherein R 1 and R 2 are the same or different and are independently selected from the group consisting of -H, -C 1 -C 18 -alkyl or -É-sulfoalkyl; X and Y are the same or different and are independently selected from the group consisting of -O - , -OH, -SH, -NH-NH 2 . -F, -Cl, -Br, -1, -O-Su (succinimidyl/sulfosuccinimidyl), -O-STP (4-sulfo-2,3,5,6-tetrafluorophenyl), -O-TFP (2,3,5,6-tatraflucrophenyl), -O-benzotriazole, -benzotriazole, -NR-CO-CH 2 -I, -NR 2 , -NR-biomolecule, -NR-L-COO', -NR-L-COOH. -NR-L-COO-Su, -NR-L-COO-STP,-NR-L-COO-TFP, -NR-L-CONR 2 , -NR-L-CO-biomolecule, -NR-L-CO-NH-NH 2 , -NR-L-OH, -NR-L-O-phosphoramidite, -NR-L-CHO, -NR-L-maleimid, or -NR-L-NH-CO-CH 2 -1; where R is equal to R 1 and R 2 and L is selected from the group consisting of a divalent linear (-(CH 2 ) o - , o = 1 to 15), crossed, or cyclic alkane group that can be substituted by at least one atom selected from the group consisting of oxygen, substituted nitrogen, and/or sulfur, and the biomolecule is a protein, antibody, nucleotide, oligonucleotide, biotin, or hapten; Z is -O - or OH; U is -O - , -OH, or NH-L-SO 2 Z; Kat is Li, Na, K, ammonium (mono-, di- or trialkyl) or another cation; An is F, Cl, Br, I, BF 4 , ClO 4' CH 3 CO 2 , CF 3 CO 2 or another anion; m is an integer from 1 - 6 necessary to compensate the negative or positive charge from the dye moiety in formula I or formula II; and n is an integer from 0 - 12; compositions containing these compounds, and methods using these compounds, are disclosed.

6. 发明申请

WO2012088054A2 DETECTION OF AN ANALYTE IN A SAMPLE 审中-公开
标题翻译：在样品中检测分析物
公开(公告)号：WO2012088054A2
公开(公告)日：2012-06-28
申请号：PCT/US2011066066
申请日：2011-12-20
申请人： UNIV MICHIGAN , PIERCE BIOTECHNOLOGY INC , GESTWICKI JASON E , WEBB BRIAN , HERMANSON GREG
发明人： GESTWICKI JASON E , WEBB BRIAN , HERMANSON GREG
IPC分类号： G01N33/58 , G01N33/52 , G01N33/53 , G01N33/68
CPC分类号： G01N33/582
摘要： Disclosed herein are methods of detecting an analyte in a sample. The methods can provide detection of an analyte in small volume samples (up to 12 µ?). Further provided herein are devices for detecting analytes, wherein the device is selected based upon an absorbance spectrum of a chromophore resulting from the association of the analyte and a precursor agent.
摘要翻译：本文公开了检测样品中的分析物的方法。这些方法可以检测小体积样品中的分析物（高达12μ？）。本文还提供了用于检测分析物的装置，其中基于由分析物和前体试剂的缔合产生的发色团的吸收光谱来选择该装置。

7. 发明专利

GB2479833A8 Modified nucleotides 未知
公开(公告)号：GB2479833A8
公开(公告)日：2011-11-23
申请号：GB201106948
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN-SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/10 , C12Q1/68

8. 发明公开

EP3004861A4 ABSOLUTE QUANTITATION OF PROTEINS AND PROTEIN MODIFICATIONS BY MASS SPECTROMETRY WITH MULTIPLEXED INTERNAL STANDARDS 有权
标题翻译：免疫球蛋白免疫球蛋白在蛋白质组学染色体中的作用多克隆肝素标准品
公开(公告)号：EP3004861A4
公开(公告)日：2017-04-26
申请号：EP14806982
申请日：2014-06-06
申请人： PIERCE BIOTECHNOLOGY INC
发明人： HERMANSON GREG , ROGERS JOHN CHARLES , LOUETTE JOEL , BOMGARDEN RYAN DANIEL , PATEL BHAVINKUMAR
IPC分类号： G01N27/62 , G01N27/66 , G01N30/72 , G01N33/68 , H01J49/26
CPC分类号： G01N33/6848 , G01N33/60 , G01N2458/15 , H01J49/0027 , H01J49/0031 , H01J49/26
摘要： A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis. The sample is subjected to mass spectroscopy analysis at low resolution whereby a single additive mass spectroscopy peak is obtained, then is subjected to high resolution mass spectroscopy analysis whereby a plurality of mass spectroscopy peaks are obtained. The intensity of each of the plurality of mass spectroscopy peaks is quantitated either by comparison to an internal standard set, or by using a standard curve generated for each isotopologue set. Quantitation using a standard curve enhances quantitation across a dynamic range of analyte.
摘要翻译：通过质谱法进行绝对蛋白质或肽定量的方法。制备含有目标蛋白质或样品的样品进行质谱分析。以低分辨率对样品进行质谱分析，得到单一的添加剂质谱峰，然后进行高分辨率质谱分析，从而获得多个质谱峰。通过与内标组比较，或通过使用为每个同位素组产生的标准曲线来量化多个质谱峰中的每一个的强度。使用标准曲线的定量增强了分析物动态范围的定量。

9. 发明专利

FR2959228A1 NUCLEOTIDES MODIFIES 未知
公开(公告)号：FR2959228A1
公开(公告)日：2011-10-28
申请号：FR1153465
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/067 , C07H19/10 , C07H19/167 , C07H19/20 , C07H21/02 , C12Q1/68 , G01N33/531
摘要： Nucléotides modifiés, et procédés pour modifier les nucléotides avec un fragment ou un marqueur, tel que la biotine, qui permet leur détection et donne un nucléotide modifié, et procédés d'utilisation du nucléotide modifié dans des analyses quantitatives et qualitatives. 790431

10. 发明专利

GB2479833A Modified nucleotides 未知
公开(公告)号：GB2479833A
公开(公告)日：2011-10-26
申请号：GB201106948
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN-SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/10 , C12Q1/68
摘要： Modified nucleotides, and methods to modify nucleotides with a moiety or label, such as biotin, that permits their detection and results in a modified nucleotide, and methods of use of the modified nucleotide in quantitative and qualitative assays are outlined. In particular the modified nucleotide is a nucleoside bis-phosphate of structure (I):P1-P2-Nus-Alk-Lnk-Obs (I)or a salt, conjugate base, tautomer or ionised form thereof, wherein P1 and P2 are phosphate groups; Nus is a nucleoside moiety comprising a sugar bound to a purine or pyrimidine base; Alk is a connecting group having the structure —(CH2)m-Y- where Y is a bond or NH, NR, O, C(O),S(O)2, S or Si, where m is 3-6; Lnk is a linking group of formula —A1-CH2-(CH2OCH2)n-CH2-A2- or —A1-X-A3-CH2-(CH2OCH2)n-CH2-A2- where n is 2-48; Al is CH2. C(O), C(O)NH, C(O)O, S(O)2, C(S)NH, C(NR)NH, NH, NR or O; A2and A3are NH, NR, NHC(O), NHS(O)2, NHC(S)NH, NHC(NR)NH, NHC(O)NH, OC(O), SC(O), C(O), C(O)NH or C(O)); X is a cleavable group that can undergo silicon-carbon, redox, photochemical, enzymatic or exchange-based cleavage; and Obs is an observable label such as biotin, a fluorophore or an azide. A preferred compound of formula (I) is:

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