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1. 发明专利

DE102012107475A1 BENZOCYANINVERBINDUNGEN 未知
公开(公告)号：DE102012107475A1
公开(公告)日：2013-02-21
申请号：DE102012107475
申请日：2012-08-15
申请人： DYOMICS GMBH , PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI , HERMANSON GREG , NLEND MARIE CHRISTINE , DWORECKI BOGUSLAWA , CZERNEY PETER , WENZEL MATTHIAS , LEHMANN FRANK
IPC分类号： C07D403/06 , C09K11/06 , G01N33/52 , G01N33/53
摘要： Als Marker brauchbare Verbindungen, die mit bekannten fluoreszierenden Verbindungen vergleichbar sind. Die Verbindungen werden an Proteine und Nukleinsäuren zur biologischen Bildgebung und Analyse konjugiert. Synthese der Verbindungen, Bildung und Verwendung der konjugierten Verbindungen, sowie entsprechende spezifische, nicht einschränkende Beispiele sind ebenfalls beschrieben.

2. 发明专利

GB2493843A Benzocyanine compounds as labels for biological imaging 未知
公开(公告)号：GB2493843A
公开(公告)日：2013-02-20
申请号：GB201214580
申请日：2012-08-15
申请人： PIERCE BIOTECHNOLOGY INC , DYOMICS GMBH
发明人： HERMANSON GREG , CZERNEY PETER , DESAI SURBHI , WENZEL MATTHIAS S , DWORECKI BOGUSLAWA , LEHMANN FRANK G , NLEND CHRISTINE MARIE
IPC分类号： C09B23/08 , A61K49/00 , C09B23/00 , C09B23/02 , C09B23/06
摘要： Dihydrobenzo[e]indol-(2E)-ylidene compounds of formulae IIa, IIb, IIIa and IIIb: wherein R1, R2, R5, R6 are aliphatic, heteroaliphatic, sulfoalkyl, heteroaliphatic with terminal SO3, a PEG group P-Z where P is an ethylene glycol, diethylene glycol or polyethylene glycol group, a sulfonamide group L-SO2NH-P-Z or a carboxamide group L-CONH-P-Z; Z is H, CH3, alkyl or heteroalkyl; R7, R8, R11, R12, R13and R14 are H or substituents; X is -OH, -SH, -NH2, -NH-NH2, -F, -Cl, -Br, -I, -NHS (N-hydroxysuccinimidyl/sulfosuccinimidyl), -O-TFP (2,3,5,6-tetrafluorophenoxy), -O-STP (4-sulfo-2,3,5,6-tetrafluorophenoxy), -O-benzotriazole, benzotriazole, -NR-L-O-phosphoramidite, -NR-L-SH, -NR-L-NH-NH2, -NR-L-CO2H, -NR-L-CO-NHS , -NR-L-CO-STP, -NR-L-CO-TFP, -NR-L-CO-benzotriazole, -NR-L-CHO, -NR-L-maleimide or NR-L-NH-CO-CH2I, where R is H or an aliphatic or heteroaliphatic group; L is a divalent linear, crossed or cyclic alkyl group optionally substituted by at least one oxygen or sulfur atom; and Kat is a number of Na+, K+, Ca2+, ammonia or other cation(s) needed to compensate for the negative charge brought by the cyanine; may be useful as labels for conjugation to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds are provided.

3. 发明公开

EP2850078A4 BENZOPYRYLIUM COMPOUNDS 有权
标题翻译： BENZOPYRYLIUMVERBINDUNGEN
公开(公告)号：EP2850078A4
公开(公告)日：2016-01-27
申请号：EP13833348
申请日：2013-08-20
申请人： PIERCE BIOTECHNOLOGY INC , DYOMICS GMBH
发明人： HERMANSON GREG , CZERNEY PETER T , DESAI SURBHI , WENZEL MATTHIAS S , LEHMANN FRANK G , NLEND MARIE CHRISTINE
IPC分类号： C07D405/06 , A61K49/10 , C07D405/14 , C09B23/06 , C09B23/08
CPC分类号： C07D491/147 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C07D405/06 , C07D405/14 , C07D491/052 , C07D491/16 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译：用作具有与已知荧光化合物相当的特性的标签的化合物。化合物与蛋白质和核酸缀合，用于生物成像和分析。提供化合物的合成，共轭化合物的形成和使用以及各自的具体非限制性实例。

4. 发明专利

JP2008231093A Sulfonamide derivative of xanthene compound 有权
标题翻译： XANTHENE化合物的磺酰胺衍生物
公开(公告)号：JP2008231093A
公开(公告)日：2008-10-02
申请号：JP2008010915
申请日：2008-01-21
申请人： Pierce Biotechnology Inc , ピアス・バイオテクノロジー・インコーポレーテッド
发明人： FRANK WILHELM G , WENZEL MATTHIAS S , CZERNEY PETER T , DESAI SURBHI , HERMANSON GREG
IPC分类号： C07D311/82 , C07D405/12 , G01N33/533 , G01N33/58
CPC分类号： C07D311/82 , G01N33/582 , Y10S436/80
摘要： PROBLEM TO BE SOLVED: To provide a sulfonamide derivative of a xanthene compound and to provide a method for using the same. SOLUTION: The invention relates to the compounds represented by general formula I and/or general formula II, and to a composition comprising the compounds. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供呫吨化合物的磺酰胺衍生物并提供使用它们的方法。解决方案：本发明涉及由通式I和/或通式II表示的化合物以及包含该化合物的组合物。版权所有（C）2009，JPO＆INPIT

5. 发明专利

AU2002248556A1 Direct detection of biomolecules in polyacrylamide gel 未知
公开(公告)号：AU2002248556A1
公开(公告)日：2002-09-24
申请号：AU2002248556
申请日：2002-03-07
申请人： PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI
IPC分类号： G01N33/58 , C12Q1/28 , C12Q1/42 , C12Q1/68 , C12Q1/6813 , G01N21/76 , G01N21/78 , G01N27/447 , G01N33/561 , G01N33/53 , G01N33/542
摘要： An improved method for detecting a target biomolecule directly in a polyacrylamide gel in which it has been separated from other substances. The improvement resides in, prior to binding the target to a probe and while the target biomolecule remains in the gel, (1) immersing the gel in a water miscible, aqueous extracting medium to shrink the gel by at least about ten percent and then (2) washing the gel with water to restore the gel to substantially its original size.

6. 发明专利

GB2442544A Protein detection and quantitation using hydroxyquinolone dyes 未知
公开(公告)号：GB2442544A
公开(公告)日：2008-04-09
申请号：GB0710515
申请日：2007-06-01
申请人： PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI , WOLF BRIAN , SCHWEDER BERND , LEHMANN FRANK , WENZEL MATTHIAS , CZERNEY PETER
IPC分类号： G01N33/533 , C07D209/02 , C07D221/02 , C07D403/02 , C09B23/00 , G01N33/68
摘要： Hydroxyquinolone compounds are formulated as fluorescent dyes for protein detection, assay, quantitation etc. These hydroxyquinolone compounds may be modified, for example, by adding or removing sulphate groups, changing hydrocarbon chain lengths etc. to result in more desirable properties such as enhanced binding to protein stains, and may be used to stain proteins in solution, proteins separated on a gel, proteins transferred to solid supports etc. methods of using the dyes are also disclosed.

7. 发明专利

DE102007025546A1 未知
公开(公告)号：DE102007025546A1
公开(公告)日：2008-08-14
申请号：DE102007025546
申请日：2007-05-31
申请人： PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI , WOLF BRIAN , LEHMANN FRANK , WENZEL MATTHIAS , SCHWEDER BERND , CZERNEY PETER
IPC分类号： C09K11/06 , C09B57/00 , G01N33/52 , G01N33/68
摘要： A hydroxyquinolone compound formulated as a fluorescent dye for protein detection, assay, quantitation, etc. The hydroxyquinolone compound may be modified, for example, by adding or removing sulfate groups, changing hydrocarbon chain lengths, etc. to result in more desirable properties such as enhanced binding to basic proteins, enhanced solubility, etc. The dye has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc. Methods of using the dyes are also disclosed.

8. 发明专利

DE112006003967B4 Farbstoffe, Farbstoffzusammensetzungen und Verfahren zum Anfärben von Proteinen 未知
公开(公告)号：DE112006003967B4
公开(公告)日：2017-09-21
申请号：DE112006003967
申请日：2006-07-28
申请人： PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI , WOLF BRIAN , LEHMANN FRANK , WENZEL MATTHIAS , CZERNEY PETER , MURTAZA ZAKIR , SCHWEDER BERND
IPC分类号： C09B23/01 , C09B23/04 , C09B23/10 , G01N33/58 , G01N33/68
摘要： Verbindung, die aus der Gruppe ausgewählt ist, die aus V07-03035, V07-03037, V07-05146, V07-05176, V07-05170, V02-06006, V07-05143, V07-03034 und Kombinationen davon besteht, wobei die Verbindungen wie folgt sind: ...

9. 发明专利

AT534641T 未知
公开(公告)号：AT534641T
公开(公告)日：2011-12-15
申请号：AT08250265
申请日：2008-01-22
申请人： PIERCE BIOTECHNOLOGY INC
发明人： FRANK WILHELM G , WENZEL MATTHIAS S , CZERNEY PETER T , DESAI SURBHI , HERMANSON GREG
IPC分类号： C07D311/84 , G01N33/58
摘要： Compounds having the general of formula I and/or formula II wherein R 1 and R 2 are the same or different and are independently selected from the group consisting of -H, -C 1 -C 18 -alkyl or -É-sulfoalkyl; X and Y are the same or different and are independently selected from the group consisting of -O - , -OH, -SH, -NH-NH 2 . -F, -Cl, -Br, -1, -O-Su (succinimidyl/sulfosuccinimidyl), -O-STP (4-sulfo-2,3,5,6-tetrafluorophenyl), -O-TFP (2,3,5,6-tatraflucrophenyl), -O-benzotriazole, -benzotriazole, -NR-CO-CH 2 -I, -NR 2 , -NR-biomolecule, -NR-L-COO', -NR-L-COOH. -NR-L-COO-Su, -NR-L-COO-STP,-NR-L-COO-TFP, -NR-L-CONR 2 , -NR-L-CO-biomolecule, -NR-L-CO-NH-NH 2 , -NR-L-OH, -NR-L-O-phosphoramidite, -NR-L-CHO, -NR-L-maleimid, or -NR-L-NH-CO-CH 2 -1; where R is equal to R 1 and R 2 and L is selected from the group consisting of a divalent linear (-(CH 2 ) o - , o = 1 to 15), crossed, or cyclic alkane group that can be substituted by at least one atom selected from the group consisting of oxygen, substituted nitrogen, and/or sulfur, and the biomolecule is a protein, antibody, nucleotide, oligonucleotide, biotin, or hapten; Z is -O - or OH; U is -O - , -OH, or NH-L-SO 2 Z; Kat is Li, Na, K, ammonium (mono-, di- or trialkyl) or another cation; An is F, Cl, Br, I, BF 4 , ClO 4' CH 3 CO 2 , CF 3 CO 2 or another anion; m is an integer from 1 - 6 necessary to compensate the negative or positive charge from the dye moiety in formula I or formula II; and n is an integer from 0 - 12; compositions containing these compounds, and methods using these compounds, are disclosed.

10. 发明专利

GB2442544B Protein detection and quantitation using hydroxyquinolone dyes 未知
公开(公告)号：GB2442544B
公开(公告)日：2011-04-20
申请号：GB0710515
申请日：2007-06-01
申请人： PIERCE BIOTECHNOLOGY INC
发明人： DESAI SURBHI , WOLF BRIAN , SCHWEDER BERND G , LEHMANN FRANK G , WENZEL MATTHIAS S , CZERNEY PETER
IPC分类号： G01N33/533 , C07D209/02 , C07D221/02 , C07D403/02 , C09B23/00 , G01N33/68
摘要： A hydroxyquinolone compound formulated as a fluorescent dye for protein detection, assay, quantitation, etc. The hydroxyquinolone compound may be modified, for example, by adding or removing sulfate groups, changing hydrocarbon chain lengths, etc. to result in more desirable properties such as enhanced binding to basic proteins, enhanced solubility, etc. The dye has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc. Methods of using the dyes are also disclosed.

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