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1. 发明专利

GB2479833A8 Modified nucleotides 未知
公开(公告)号：GB2479833A8
公开(公告)日：2011-11-23
申请号：GB201106948
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN-SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/10 , C12Q1/68

2. 发明专利

FR2959228B1 NUCLEOTIDES MODIFIES 未知
公开(公告)号：FR2959228B1
公开(公告)日：2018-11-30
申请号：FR1153465
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/067 , C07H19/10 , C07H19/167 , C07H19/20 , C07H21/02 , C12Q1/68 , G01N33/531

3. 发明专利

FR2959228A1 NUCLEOTIDES MODIFIES 未知
公开(公告)号：FR2959228A1
公开(公告)日：2011-10-28
申请号：FR1153465
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/067 , C07H19/10 , C07H19/167 , C07H19/20 , C07H21/02 , C12Q1/68 , G01N33/531
摘要： Nucléotides modifiés, et procédés pour modifier les nucléotides avec un fragment ou un marqueur, tel que la biotine, qui permet leur détection et donne un nucléotide modifié, et procédés d'utilisation du nucléotide modifié dans des analyses quantitatives et qualitatives. 790431

4. 发明专利

GB2479833A Modified nucleotides 未知
公开(公告)号：GB2479833A
公开(公告)日：2011-10-26
申请号：GB201106948
申请日：2011-04-21
申请人： PIERCE BIOTECHNOLOGY INC
发明人： OPPERMAN KAY , KABOORD BARBARA J , SCHULTZ JEAN-SAMUEL , ETIENNE CHRISTOPHER L , HERMANSON GREG
IPC分类号： C07H19/10 , C12Q1/68
摘要： Modified nucleotides, and methods to modify nucleotides with a moiety or label, such as biotin, that permits their detection and results in a modified nucleotide, and methods of use of the modified nucleotide in quantitative and qualitative assays are outlined. In particular the modified nucleotide is a nucleoside bis-phosphate of structure (I):P1-P2-Nus-Alk-Lnk-Obs (I)or a salt, conjugate base, tautomer or ionised form thereof, wherein P1 and P2 are phosphate groups; Nus is a nucleoside moiety comprising a sugar bound to a purine or pyrimidine base; Alk is a connecting group having the structure —(CH2)m-Y- where Y is a bond or NH, NR, O, C(O),S(O)2, S or Si, where m is 3-6; Lnk is a linking group of formula —A1-CH2-(CH2OCH2)n-CH2-A2- or —A1-X-A3-CH2-(CH2OCH2)n-CH2-A2- where n is 2-48; Al is CH2. C(O), C(O)NH, C(O)O, S(O)2, C(S)NH, C(NR)NH, NH, NR or O; A2and A3are NH, NR, NHC(O), NHS(O)2, NHC(S)NH, NHC(NR)NH, NHC(O)NH, OC(O), SC(O), C(O), C(O)NH or C(O)); X is a cleavable group that can undergo silicon-carbon, redox, photochemical, enzymatic or exchange-based cleavage; and Obs is an observable label such as biotin, a fluorophore or an azide. A preferred compound of formula (I) is:

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