专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004101810A3 METHODS FOR THE IDENTIFICATION OF PROTOCHLOROPHYLLIDE OXIDOREDUCTASE INHIBITORS 审中-公开
标题翻译：用于鉴定原甲基胆碱氧化酶抑制剂的方法
公开(公告)号：WO2004101810A3
公开(公告)日：2007-08-16
申请号：PCT/US2004009244
申请日：2004-03-26
申请人： PARADIGM GENETICS INC , DAVIS KEITH R , ZAYED ADEL M , ASCENZI ROBERT A , BOYES DOUGLAS C , MULPURI RAO V , HOFFMAN NEIL E , KJEMTRUP SUSANNE , HAMILTON CAROL M , WOESSNER JEFFREY P , GORLACH JORN , GUO LINING , SEVALA VEERESH
发明人： DAVIS KEITH R , ZAYED ADEL M , ASCENZI ROBERT A , BOYES DOUGLAS C , MULPURI RAO V , HOFFMAN NEIL E , KJEMTRUP SUSANNE , HAMILTON CAROL M , WOESSNER JEFFREY P , GORLACH JORN , GUO LINING , SEVALA VEERESH
IPC分类号： C12Q1/00 , C07H21/04 , C12N9/02 , C12Q1/26 , C12Q1/32
CPC分类号： C12Q1/32 , C12Q1/26 , G01N2500/00
摘要： The present inventors have discovered that NADPH:protochlorophyllide oxidoreductase (POR) is essential for plant growth. Specifically, the inhibition of POR gene expression in plant seedlings results in reduced growth and chlorosis. Thus, POR is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of a POR in the presence and absence of a compound, wherein an alteration of POR activity in the presence of the compound indicates the compound as a candidate for a herbicide.
摘要翻译：本发明人已经发现，NADPH：原氯氟石氧化还原酶（POR）是植物生长所必需的。具体来说，植物幼苗中POR基因表达的抑制导致生长和萎黄症的减少。因此，POR可用作鉴定除草剂的靶标。因此，本发明提供了通过在化合物存在和不存在下测量POR的活性来鉴定除草剂的方法，其中在化合物存在下POR活性的改变表示作为除草剂候选物的化合物。

2. 发明申请

WO2004087867A3 METHODS FOR THE IDENTIFICATION OF INHIBITORS OF SERINE ACETYLTRANSFERASE ACTIVITY IN PLANTS 审中-公开
标题翻译：乙型肝炎病毒活性抑制剂鉴定方法
公开(公告)号：WO2004087867A3
公开(公告)日：2005-03-17
申请号：PCT/US2004008822
申请日：2004-03-23
申请人： PARADIGM GENETICS INC , RICE JOHN W , GUO LINING , DAVIS KEITH , ZAYED ADEL , ASCENZI ROBERT , MITCHELL J CAMERON , RIGGSBEE DANIEL N , BOYES DOUGLAS , MULPURI RAO , HOFFMAN NEIL E , KJEMTRUP SUSANNE , HAMILTON CAROL , WOESSNER JEFFREY , GORLACH JORN
发明人： RICE JOHN W , GUO LINING , DAVIS KEITH , ZAYED ADEL , ASCENZI ROBERT , MITCHELL J CAMERON , RIGGSBEE DANIEL N , BOYES DOUGLAS , MULPURI RAO , HOFFMAN NEIL E , KJEMTRUP SUSANNE , HAMILTON CAROL , WOESSNER JEFFREY , GORLACH JORN
IPC分类号： C12N9/10 , C12N15/82 , C12Q1/48 , C12N15/09
CPC分类号： C12N9/1029 , C12N15/8261 , C12N15/8274 , C12Q1/48 , G01N2333/91057 , G01N2500/02 , Y02A40/146
摘要： The present inventors have discovered that serine acetyltransferase (SAT) is essential for plant growth. Specifically, the inhibition of SAT gene expression in plant seedlings results in reduced growth and altered pigmentation. Thus, SAT is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of an SAT polypeptide in the presence and absence of a compound, wherein an alteration of SAT activity in the presence of the compound indicates the compound as a candidate for a herbicide.
摘要翻译：本发明人发现丝氨酸乙酰转移酶（SAT）对于植物生长是必需的。具体地说，在植物幼苗中抑制SAT基因表达导致生长减少和色素沉着改变。因此，SAT可用作鉴定除草剂的靶标。因此，本发明提供了通过在存在和不存在化合物的情况下测量SAT多肽的活性来鉴定除草剂的方法，其中在化合物存在下SAT活性的改变表示该化合物作为除草剂的候选物。

3. 发明申请

WO2004101761A3 METHODS FOR THE IDENTIFICATION OF INHIBITORS OF CAX1-LIKE Ca+2/H+ANTIPORTER ACTIVITY IN PLANTS 审中-公开
标题翻译： CAX1型抑制剂Ca + 2 / H +抗体活性在植物中的鉴定方法
公开(公告)号：WO2004101761A3
公开(公告)日：2006-07-06
申请号：PCT/US2004014733
申请日：2004-05-12
申请人： PARADIGM GENETICS INC , DEZWAAN TODD M , GUO LINING , DAVIS KEITH , ZAYED ADEL , KJEMTRUP SUSANNE , BOYES DOUGLAS , WARRICK BRENDA , MITCHELL CAMERON JOSEPH , ASCENZI ROBERT , HAMILTON CAROL , WOESSNER JEFFREY , GORLACH JORN , HOFFMAN NEIL , MULPURI RAO
发明人： DEZWAAN TODD M , GUO LINING , DAVIS KEITH , ZAYED ADEL , KJEMTRUP SUSANNE , BOYES DOUGLAS , WARRICK BRENDA , MITCHELL CAMERON JOSEPH , ASCENZI ROBERT , HAMILTON CAROL , WOESSNER JEFFREY , GORLACH JORN , HOFFMAN NEIL , MULPURI RAO
IPC分类号： C12Q1/00 , C12N20060101 , C12Q1/02 , G01N33/68
CPC分类号： G01N33/6872 , C12Q1/025
摘要： The present inventors have discovered that CAX1 -like H+/Ca +2 antiporter is essential for plant growth. Specifically, the inhibition of CAX1-like H+/Ca +2 antiporter gene expression in plant seedlings results in reduced growth and abnormal development. Thus, CAX1-like H+/Ca +2 antiporter is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of a CAX 1 -like H+/Ca +2 antiporter in the presence and absence of a compound, where an alteration of CAX 1 -like H+/Ca +2 antiporter activity in the presence of the compound indicates the compound as a candidate for a herbicide.
摘要翻译：本发明人发现，CAX1样H + / Ca +2反向转运体对于植物生长是必需的。具体来说，植物幼苗中CAX1样H + / Ca +2反转录酶基因表达的抑制导致生长减少和异常发育。因此，CAX1样H + / Ca +2反向转运体可用作鉴定除草剂的靶标。因此，本发明提供了通过在存在和不存在化合物的情况下测量CAX 1样H + / Ca 2+反向转运体的活性来鉴定除草剂的方法，其中CAX 1 在化合物存在下的类似H + / Ca +2反向转运体活性表示作为除草剂候选物的化合物。

4. 发明申请

WO2004087866A3 METHODS FOR THE IDENTIFICATION OF INHIBITORS OF LIPID TRANSFER PROTEIN ACTIVITY IN PLANTS 审中-公开
标题翻译：鉴定植物中脂肪转运蛋白活性的抑制剂的方法
公开(公告)号：WO2004087866A3
公开(公告)日：2006-06-08
申请号：PCT/US2004008658
申请日：2004-03-19
申请人： PARADIGM GENETICS INC , REICHERT ANGELIKA , GUO LINING , DAVIS KEITH , ZAYED ADEL , ASCENZI ROBERT , BOYES DOUGLAS , MULPURI RAO , HOFFMAN NEIL , KJEMTRUP SUSANNE , HAMILTON CAROL , WOESSNER JEFFREY , GORLACH JORN
发明人： REICHERT ANGELIKA , GUO LINING , DAVIS KEITH , ZAYED ADEL , ASCENZI ROBERT , BOYES DOUGLAS , MULPURI RAO , HOFFMAN NEIL , KJEMTRUP SUSANNE , HAMILTON CAROL , WOESSNER JEFFREY , GORLACH JORN
IPC分类号： C12Q1/68 , A01N63/00 , C07K14/415 , C12N15/82 , C12Q1/18 , C12Q1/42 , G01N33/92
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8274 , C12Q1/18 , G01N33/92 , G01N2333/415 , Y02A40/146
摘要： The present inventors have discovered that Lipid Transfer Protein (LTP) is essential for plant growth. Specifically, the inhibition of LTP gene expression in plant seedlings results in reduced growth and chlorosis. Thus, LTP is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of a LTP in the presence and absence of a compound, wherein an alteration of LTP activity in the presence of the compound indicates the compound as a candidate for a herbicide.
摘要翻译：本发明人已经发现，脂质转移蛋白（LTP）是植物生长所必需的。具体来说，植物幼苗中LTP基因表达的抑制导致生长和萎黄症的减少。因此，LTP可用作鉴定除草剂的靶标。因此，本发明提供了通过在化合物存在和不存在下测量LTP的活性来鉴定除草剂的方法，其中在化合物存在下LTP活性的改变表示作为除草剂候选物的化合物。

5. 发明申请

WO2005005652A3 METHODS FOR THE IDENTIFICATION OF INHIBITORS OF C4 LONG CHAIN BASE HYDROXYLASE ACTIVITY IN PLANTS 审中-公开
标题翻译： C4长链碱羟基酶活性抑制剂鉴定方法
公开(公告)号：WO2005005652A3
公开(公告)日：2005-03-03
申请号：PCT/US2004021118
申请日：2004-06-30
申请人： PARADIGM GENETICS INC , DEZWAAN TODD M , GUO LINING , DAVIS KEITH , ZAYED ADEL , KJEMTRUP SUSANNE , BOYES DOUGLAS , WARRICK BRENDA , MITCHELL J CAMERON , ASCENZI ROBERT , HAMILTON CAROL , WOESSNER JEFFREY , MULPURI RAO
发明人： DEZWAAN TODD M , GUO LINING , DAVIS KEITH , ZAYED ADEL , KJEMTRUP SUSANNE , BOYES DOUGLAS , WARRICK BRENDA , MITCHELL J CAMERON , ASCENZI ROBERT , HAMILTON CAROL , WOESSNER JEFFREY , MULPURI RAO
IPC分类号： A01N63/00 , A61K38/00 , C12N15/00 , C12N15/09 , C12Q20060101 , C12Q1/34 , C12Q1/68
CPC分类号： C12Q1/6895 , C12Q2600/158
摘要： The present inventors have discovered that LCBH is essential for plant growth. Specifically, the inhibition of LCBH gene expression in Arabidopsis results in reduced growth and abnormal development. Thus, LCBH is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of a LCBH in the presence and absence of a compound, where an alteration of LCBH activity in the presence of the compound indicates the compound as a candidate for a herbicide.
摘要翻译：本发明人发现LCBH对植物生长至关重要。具体地说，拟南芥中LCBH基因表达的抑制导致生长减少和异常发育。因此，LCBH可用作鉴定除草剂的目标。因此，本发明提供了通过在存在和不存在化合物的情况下测量LCBH的活性来鉴定除草剂的方法，其中在化合物存在下LCBH活性的改变表示作为除草剂候选物的化合物。

6. 发明申请

WO2005033664A2 METHODS FOR IDENTIFYING INHIBITORS OF STEROL 14-alpha-DEMETHYLASE 审中-公开
标题翻译：用于鉴定甾体14-α-脱乙酰酶抑制剂的方法
公开(公告)号：WO2005033664A2
公开(公告)日：2005-04-14
申请号：PCT/US2004032633
申请日：2004-10-01
申请人： ICORIA INC , ASLAMKHAN ABUBAKR , GUO LINING , RICE JOHN W
发明人： ASLAMKHAN ABUBAKR , GUO LINING , RICE JOHN W
IPC分类号： C12Q1/26 , C12Q1/32 , G01N
CPC分类号： C12Q1/26 , C12Q1/32 , G01N2500/00
摘要： In the methods of the present invention, the change in absorbance of an obtusifoliol 14alpha-demethylase (OBT-DM) enzyme upon binding of an inhibitor is used to advantage for the identification of inhibitors of OBT-DM activity. Rather than measuring the absorbance of an OBT-DM/inhibitor complex over a spectrum of wavelengths as described previously, the present invention discloses methods for identifying type II inhibitors of OBT-DM by monitoring the absorbance only at 413nm and 432 nm. The methods of the invention enable the concurrent testing of multiple compounds using a high throughput format such as with 96- or 384-well plates. The OBT-DM polypeptides of the invention include plant, fungal and human OBT-DM polypeptides, and in particular, Arabidopsis thaliana OBT-DM polypeptide.
摘要翻译：在本发明的方法中，使用抑制剂结合时，obtusifoliol14α-去甲基化酶（OBT-DM）的吸光度变化有利于鉴定OBT-DM活性的抑制剂。本发明不是如上所述在波长谱上测量OBT-DM /抑制剂复合物的吸光度，而是通过仅在413nm和432nm监测吸光度来公开鉴定OBT-DM的II型抑制剂的方法。本发明的方法使得能够使用高通量形式（例如96孔或384孔板）同时测试多种化合物。本发明的OBT-DM多肽包括植物，真菌和人类OBT-DM多肽，尤其是拟南芥OBT-DM多肽。

7. 发明申请

WO2004067750A3 XENORHABDUS TC PROTEINS AND GENES FOR PEST CONTROL 审中-公开
标题翻译： XENORHABDUS TC蛋白和基因用于虫害控制
公开(公告)号：WO2004067750A3
公开(公告)日：2004-10-07
申请号：PCT/US2004000314
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC , BINTRIM SCOTT B , MITCHELL JON C , LARRINUA IGNACIO M , APEL-BIRKHOLD PATRICIA C , GREEN SUSAN B , SCHAFER BARRY W , BEVAN SCOTT A , YOUNG SCOTT A , GUO LINING
发明人： BINTRIM SCOTT B , MITCHELL JON C , LARRINUA IGNACIO M , APEL-BIRKHOLD PATRICIA C , GREEN SUSAN B , SCHAFER BARRY W , BEVAN SCOTT A , YOUNG SCOTT A , GUO LINING
IPC分类号： C12N5/02 , C12N15/82 , C07K14/24
CPC分类号： C12N15/8286 , Y02A40/162
摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.
摘要翻译：本发明涉及新的Xenorhabdus毒素复合物（TC）蛋白质和编码这些蛋白质的基因。更具体地说，本发明涉及可从Xenorhabdus菌株Xwi获得的TC基因和蛋白质。本发明还提供可从Xwi菌株获得的外切壳多糖酶。该外切壳多糖酶可用于使用本领域已知的方法来控制昆虫。

8. 发明申请

WO9710328A3 COMPOSITIONS AND METHOD FOR MODULATION OF GENE EXPRESSION IN PLANTS 审中-公开
标题翻译：用于调制植物中基因表达的组合物和方法
公开(公告)号：WO9710328A3
公开(公告)日：1997-05-15
申请号：PCT/US9611689
申请日：1996-07-12
申请人： RIBOZYME PHARM INC , DOWELANCO , ZWICK MICHAEL G , EDINGTON BRENT E , MCSWIGGEN JAMES A , MERLO PATRICIA ANN OWENS , GUO LINING , SKOKUT THOMAS A , YOUNG SCOTT A , FOLKERTS OTTO , MERLO DONALD J
发明人： ZWICK MICHAEL G , EDINGTON BRENT E , MCSWIGGEN JAMES A , MERLO PATRICIA ANN OWENS , GUO LINING , SKOKUT THOMAS A , YOUNG SCOTT A , FOLKERTS OTTO , MERLO DONALD J
IPC分类号： A01H5/00 , C12N5/10 , C12N9/02 , C12N9/10 , C12N15/09 , C12N15/82 , C12N
CPC分类号： C12N9/0083 , C12N9/1051 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/8255
摘要： An enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of a gene in a plant. A transgenic plant comprising nucleic acids encoding for an enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of a gene in said plant.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式