会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明申请
    • MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL
    • 混合和匹配TC蛋白进行病虫害防治
    • WO2004067727A2
    • 2004-08-12
    • PCT/US2004000394
    • 2004-01-07
    • DOW AGROSCIENCES LLCHEY TIMOTHY DSCHLEPER AMANDA DBEVAN SCOTT ABINTRIM SCOTT BMITCHELL JON CLI ZE SHENGNI WEITINGZHU BAOLONGMERLO DONALD JAPEL-BIRKHOLD PATRICIA C
    • HEY TIMOTHY DSCHLEPER AMANDA DBEVAN SCOTT ABINTRIM SCOTT BMITCHELL JON CLI ZE SHENGNI WEITINGZHU BAOLONGMERLO DONALD JAPEL-BIRKHOLD PATRICIA CMEADE THOMAS
    • A01N37/46A01N63/02C07K14/195C07K14/24C12N15/82C12N
    • C07K14/195A01N37/46A01N63/02C07K14/24C12N15/8286Y02A40/162
    • The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibucillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a "stand-alone" TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein "potentiators" derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will new be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand­ alone Photorlzabdus protein toxin. (As one skilled in the art knows, Xenorhabdus toxin proteins tend to be more desirable for controlling lepidopterans while Photorhabdus toxin proteins tend to be more desirable for controlling coleopterans.) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterolugous TC proteins are also disclosed herein. Other objects, advantages, and features of the subject invention will be apparent to cue skilled in the art having the benefit of the subject disclosure.
    • 本发明涉及令​​人惊奇的发现,可以从Xenorhabdus,Photorhabdus和Paenibucillus获得的毒素复合物(TC)蛋白质彼此互换使用。 在本发明的特别优选的实施方案中,“独立”TC蛋白(例如,来自Photorhabdus,Xenorhabdus或Paenibacillus的例如)的毒性由一种或多种衍生自以下的源生物体的TC蛋白“增强剂”增强 来源于毒素的不同属。 本领域技术人员将会认识到本公开的益处,这具有广泛的含义,并且扩展了新认证的各种类型的TC蛋白质具有的效用范围。 最重要的优点之一是,本领域技术人员现在将能够使用单组增效剂来增强独立的Xenorhabdus蛋白毒素的活性以及独立的Photorlzabdus蛋白毒素。 (如本领域技术人员所知,Xenorhabdus毒素蛋白质倾向于更有利于控制鳞翅目,而Photorhabdus毒素蛋白质倾向于更有利于控制鞘翅目)。这减少了需要表达的基因数量和转化事件 一个转基因植物,以实现更广泛的目标害虫的有效控制。 杂种TC蛋白的某些优选组合也在本文中公开。 本发明的其它目的,优点和特征对本领域的技术人员而言是显而易见的。