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1. 发明授权

US06585707B2 Drug delivery device having improved adhesion and attachment system for drug delivery device 有权
标题翻译：药物输送装置具有改进的用于药物递送装置的粘附和附着系统
公开(公告)号：US06585707B2
公开(公告)日：2003-07-01
申请号：US09315629
申请日：1999-05-20
申请人： Oz Cabiri , David Katz , Mario Rozanowich , Haim Danon , Joseph Gross , Izrail Tsals , Craig Brodeur , Robert Etheredge
发明人： Oz Cabiri , David Katz , Mario Rozanowich , Haim Danon , Joseph Gross , Izrail Tsals , Craig Brodeur , Robert Etheredge
IPC分类号： A61F1302
CPC分类号： A61M5/14248 , A61M25/02 , A61M2025/0253 , A61M2025/0266
摘要： A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.
摘要翻译：一种适于布置在刚性或半刚性装置与人体皮肤之间的系统，用于将装置可靠地连接到皮肤上较长时间。该系统包括用于粘附到人体皮肤的皮肤接触表面和用于附接到刚性或半刚性装置的相对表面。该系统沿其相对表面附接到装置的相邻表面的总区域的一部分。当设备受到外部应力时，应力通过附件区域传递，并分配到未附着的区域。这最大限度地减少了皮肤上的压力，减少了从皮肤脱落的机会。

2. 发明授权

US06530900B1 Drug delivery device 有权
公开(公告)号：US06530900B1
公开(公告)日：2003-03-11
申请号：US09577033
申请日：2000-05-23
申请人： David Daily , Oz Cabiri , Mario Rozanowich , Miki Sahar , Jacob Stern , Diana Davidson , Izrail Tsals , Gilad Lavi , Avi Azoulay , Eran Shor , Craig Brodeur
发明人： David Daily , Oz Cabiri , Mario Rozanowich , Miki Sahar , Jacob Stern , Diana Davidson , Izrail Tsals , Gilad Lavi , Avi Azoulay , Eran Shor , Craig Brodeur
IPC分类号： A61M3700
CPC分类号： A61M5/14248 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M2005/14204 , A61M2005/14252 , A61M2005/1426 , A61M2005/14264 , A61M2206/22
摘要： A drug delivery device having a housing having an internal reservoir in communication with a drug delivery outlet via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the outlet when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the outlet and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. In a preferred embodiment, an electrical circuit has a current stabilizing element in electrical communication with an electrolytic cell which supplies the gas. A throttling device maintains a higher pressure in the device to reduce possible clogging of the fluid path. In a preferred embodiment, the drug delivery device is packaged to insulate the device from atmospheric pressure and humidity.

3. 发明授权

US06186982B1 Subcutaneous drug delivery device with improved filling system 失效
标题翻译：具有改善灌装系统的皮下给药装置
公开(公告)号：US06186982B1
公开(公告)日：2001-02-13
申请号：US09072875
申请日：1998-05-05
申请人： Joseph Gross , Zvi Nitzan , Izrail Tsals , Mario Razonowich , Oz Cabiri , Haim Danon , Gilad Lavi
发明人： Joseph Gross , Zvi Nitzan , Izrail Tsals , Mario Razonowich , Oz Cabiri , Haim Danon , Gilad Lavi
IPC分类号： A61M3700
CPC分类号： A61M5/14248 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M2005/14252 , A61M2005/1426 , A61M2005/14264
摘要： A subcutaneous drug delivery device having a housing having an internal reservoir in communication with a drug delivery needle via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the needle when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the needle and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. The device also includes an improved filling system that enables the reservoir within the device to be filled with drug from a source without regard to filling position and with a decreased risk of injury from needles. Moreover, the filling system provides an accurate measure of drug transferred into the device thus enabling patients to fill the devices and to ensure proper dosage upon delivery.
摘要翻译：一种具有壳体的皮下药物输送装置，该壳体具有经由流体路径与药物输送针连通的内部储存器。邻近储存器设置的可膨胀室在供应气体时迫使药物从储存器到针头。与流体路径连通的流量调节室能够响应于温度和/或压力变化而发生体积变化。流量调节室的体积的增加增加了对针的流动阻力，从而抵消由于响应于温度和/或压力的相同的体积变化而导致的可膨胀室膨胀导致的输送速率的相应增加。还包括一种改进的填充系统，其使装置内的储存器能够从源处填充药物，而不考虑填充位置并且降低针头受伤的风险。此外，填充系统提供了转移到装置中的药物的精确测量，从而使得患者能够填充装置并确保递送时的适当剂量。

4. 发明授权

US06520941B1 Method and device for entrapping gas within a liquid drug container 有权
标题翻译：在液体药物容器内捕集气体的方法和装置
公开(公告)号：US06520941B1
公开(公告)日：2003-02-18
申请号：US09415961
申请日：1999-10-12
申请人： Kevin Durand , Izrail Tsals , Craig Brodeur
发明人： Kevin Durand , Izrail Tsals , Craig Brodeur
IPC分类号： A61M514
CPC分类号： A61M5/2429 , A61M5/283 , A61M2005/3123
摘要： A stopper for use in preventing any volume of gas from escaping from a drug container when used in connection therewith. The stopper has a body having a perimeter for slidable engagement with the interior of a drug receptacle; an outer surface; and an inner surface facing the bottom of the drug receptacle, the inner surface shaped so as to trap any volume of gas located within the drug receptacle when the body is slidably engaged therein. The invention is further directed to a drug container having a hollow body for holding a liquid. The body has an open end and a closed end. The container also has a stopper slidably received in the hollow body, and a feature for entrapping any volume of gas within the container.
摘要翻译：用于防止任何体积的气体在与药物容器相连用时从药物容器逸出的塞子。止动器具有具有用于与药物容器的内部可滑动接合的周边的主体; 外表面以及面向药物容器的底部的内表面，内表面成形为当主体可滑动地接合在其中时捕获位于药物容器内的任何体积的气体。本发明进一步涉及具有用于保持液体的中空体的药物容器。身体有一个开放的一端和封闭的一端。容器还具有可滑动地容纳在中空体中的止动件，以及用于将任何体积的气体捕获在容器内的特征。

5. 发明授权

US09132231B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US09132231B2
公开(公告)日：2015-09-15
申请号：US13617126
申请日：2012-09-14
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M5/20 , B23P11/00 , A61M5/142 , A61M5/158 , A61K33/22 , A61M5/145 , A61M5/315 , A61M5/14
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to undergo incremental advancement. The device may also be provided with manual control for delivering a bolus dose of drug when necessary.
摘要翻译：一种具有包含由电子控制器控制的气体发生器的壳体的药物输送装置。气体发生器将气体产生到可往复运动的腔室中，由此腔室的往复运动导致杆使棘爪往复运动，并且该动作导致棘轮经历增量进给。该装置还可以被提供手动控制，用于在需要时递送药丸剂量。

6. 发明申请

US20130079747A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20130079747A1
公开(公告)日：2013-03-28
申请号：US13617041
申请日：2012-09-14
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M5/158
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.

7. 发明授权

US06830560B1 Automatic syringe 有权
标题翻译：自动注射器
公开(公告)号：US06830560B1
公开(公告)日：2004-12-14
申请号：US09617340
申请日：2000-07-17
申请人： Joseph Gross , Gilad Lavi , Izrail Tsals
发明人： Joseph Gross , Gilad Lavi , Izrail Tsals
IPC分类号： A61M3700
CPC分类号： A61M5/2046 , A61M5/3202 , A61M5/3257 , A61M5/3272 , A61M5/46 , A61M2005/2013 , A61M2005/3247 , A61M2005/3267
摘要： A syringe comprises a barrel containing an internal cylindrical body containing a liquid and communicating with a delivery needle. The needle is covered before use by a removable sheath, and after the sheath is removed, the needle is concealed by a displaceable sleeve. In use the sleeve is pressed against the skin by applying pressure while holding the barrel. The sleeve is thereby retracted into the barrel allowing the needle to penetrate the skin. The movement of the sleeve also activates a gas generator which expels the liquid from the needle. When delivery is complete and the syringe is taken from the skin, a coil spring moves the sleeve back to the starting position again concealing the needle. The coil spring is torsionally biased before use and causes a rotational movement of the sleeve relative to the barrel when the sleeve moves into and out of the barrel. This rotational movement engages a locking mechanism which prevents further movement of the sleeve and thereby permanently conceals the needle.
摘要翻译：注射器包括容纳含有液体并与输送针连通的内部圆柱体的筒体。针在使用前被可移除的护套覆盖，并且在护套被移除之后，针被可移位的套管隐藏。在使用中，通过在保持桶的同时施加压力将套筒压靠在皮肤上。因此套筒被缩回到镜筒中，允许针穿透皮肤。套筒的运动还激活排出针头液体的气体发生器。当输送完成并且从皮肤取出注射器时，螺旋弹簧将套筒移回到再次隐藏针的起始位置。螺旋弹簧在使用前被扭转偏压，并且当套筒移入和移出筒体时，使套筒相对于筒体旋转运动。该旋转运动接合锁定机构，该锁定机构防止套筒的进一步运动，从而永久地隐藏针头。

8. 发明授权

US06595956B1 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US06595956B1
公开(公告)日：2003-07-22
申请号：US09275464
申请日：1999-03-23
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M3700
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocate chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.
摘要翻译：一种具有包含由电子控制器控制的气体发生器的壳体的药物输送装置。气体发生器将气体产生到往复运动的腔室中，由此腔室的往复运动导致杆使棘爪往复运动，并且该动作引起棘轮。该装置还可以被提供手动控制，用于在需要时输送推注剂量的药物。

9. 发明授权

US06478771B1 Drug delivery systems and methods 失效
标题翻译：药物输送系统和方法
公开(公告)号：US06478771B1
公开(公告)日：2002-11-12
申请号：US09439963
申请日：1999-11-12
申请人： Gilad Lavi , Gil Yigal , Izrail Tsals , Joseph Gross
发明人： Gilad Lavi , Gil Yigal , Izrail Tsals , Joseph Gross
IPC分类号： A61M3700
CPC分类号： A61J1/2089 , A61J1/201 , A61J1/2013 , A61J1/2017 , A61J1/2051 , A61J1/2058 , A61J1/2082 , A61M5/148 , A61M5/162 , A61M5/1782 , A61M5/19 , A61M5/2046 , A61M5/2053 , A61M5/2425 , A61M5/2448 , A61M5/3234 , A61M2005/14252 , A61M2005/1581 , A61M2005/3128 , A61M2005/3223 , A61M2205/215 , A61M2205/583
摘要： The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.
摘要翻译：本发明涉及通过注射混合和输送药物的药物递送装置。该装置包括具有其中的第一端口或开口的壳体，其容纳包含流体或粉末状药物的第一容器，例如冻干药物。壳体还可以包括接收第二容器的第二端口或开口，第二容器包含待与药物混合以形成可注射流体的流体。该装置包括具有流体连接第一和第二容器的通道的歧管。使用诸如针的穿透膜将药物注射到与第一容器流体连通的患者体内。针可以从壳体中的存储位置移动到延伸穿过壳体的注射位置。

10. 发明申请

US20130012872A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20130012872A1
公开(公告)日：2013-01-10
申请号：US13616896
申请日：2012-09-14
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M5/20
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.

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